The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
The Antimicrobial Resistance Crisis: Causes, Consequences, and Management
Open accessAbstract
The antimicrobial resistance (AMR) crisis is the increasing global incidence of infectious diseases affecting the human population, which are untreatable with any known antimicrobial agent. This crisis will have a devastating cost on human society as both debilitating and lethal diseases increase in frequency and scope. Three major factors determine this crisis: (1) the increasing frequency of AMR phenotypes among microbes is an evolutionary response to the widespread use of antimicrobials; (2) the large and globally connected human population allows pathogens in any environment access to all of humanity; and (3) the extensive and often unnecessary use of antimicrobials by humanity provides the strong selective pressure that is driving the evolutionary response in the microbial world. Of these factors, the size of the human population is least amenable to rapid change. In contrast, the remaining two factors may be affected, so offering a means of managing the crisis: the rate at which AMR, as well as virulence factors evolve in microbial world may be slowed by reducing the applied selective pressure. This may be accomplished by radically reducing the global use of current and prospective antimicrobials. Current management measures to legislate the use of antimicrobials and to educate the healthcare world in the issues, while useful, have not comprehensively addressed the problem of achieving an overall reduction in the human use of antimicrobials. We propose that in addition to current measures and increased research into new antimicrobials and diagnostics, a comprehensive education program will be required to change the public paradigm of antimicrobial usage from that of a first line treatment to that of a last resort when all other therapeutic options have failed.
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Cited by
Environmental hotspots for antibiotic resistance genes
Kunhikannan, S., Thomas, C. J., Franks, A. E., Mahadevaiah, S., Kumar, S., & Petrovski, S. (2021) · MicrobiologyOpen · doi:10.1002/mbo3.1197 · Cited by 184
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Targeting Efflux Pumps to Overcome Antifungal Drug Resistance
Holmes, A. R., Cardno, T. S., Strouse, J. J., Ivnitski-Steele, I., Keniya, M. V., Lackovic, K., Monk, B. C., Sklar, L. A., & Cannon, R. D. (2016) · Future Medicinal Chemistry · doi:10.4155/fmc-2016-0050 · Cited by 156
Over-the-counter medicines: global perspective and Indian scenario
Marathe, P., Kamat, S., Tripathi, R., Raut, S., & Khatri, N. (2020) · Journal of Postgraduate Medicine · doi:10.4103/jpgm.jpgm_381_19 · Cited by 106
Alrasheedy, A. A., Alsalloum, M. A., Almuqbil, F. A., Almuzaini, M. A., Aba Alkhayl, B. S., Albishri, A. S., Alharbi, F. F., Alharbi, S. R., Alodhayb, A. K., Alfadl, A. A., et al. (2020) · Expert Review of Anti-infective Therapy · doi:10.1080/14787210.2020.1705156 · Cited by 102
Metadata
- Authors
- Michael, C. A., Dominey-Howes, D., & Labbate, M.
- Venue
- Frontiers in Public Health
- Publisher
- Frontiers Media SA
- Published
- 2014-09-16
- Volume
- 2
- Pages
- 145-145
- ISSN
- 2296-2565 (ISSN-L)
- OpenAlex
- W2001330064
- Cited by
- 974
- References
- 9
- FWCI
- 17.34
- Type
- journal article
- Language
- en
- Open access
- gold
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