Human Skin Lightening Efficacy of Resveratrol and Its Analogs: From in Vitro Studies to Cosmetic Applications
Open accessAbstract
Antioxidants are deemed useful in controlling oxidative stress associated with extrinsic skin aging and pigmentation disorders. Resveratrol is a polyphenol compound found in many edible plants such as Vitis vinifera, and its inhibitory effects on the catalytic activity, gene expression, and posttranslational modifications of tyrosinase, a key enzyme in the melanin biosynthetic pathway, provide a mechanistic basis for its antimelanogenic effects seen in melanocytic cells, three-dimensionally reconstituted skin models, and in vivo animal models. As a potent antioxidant and a modulator of nuclear factor erythroid 2-related factor 2 (Nrf2), and sirtuin 1, resveratrol can also regulate multiple signaling pathways associated with inflammation and premature aging. Recent clinical studies have supported the efficacy of resveratrol and its analogs, such as resveratryl triacetate (RTA) and resveratryl triglycolate (RTG), in human skin lightening and antiaging. These findings suggest that resveratrol and its analogs are potentially useful as skin lightening and antiaging agents in cosmetics.
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BOO et al. study on resveratrol skin-lightening was classified as Level II evidence but lacked sufficient clinical evidence.
“According to the Oxford Centre for Evidence‐Based Medicine, this study would be classified as Level II evidence, as it is a well‐designed cohort or case‐control analytical study.”
From Cosmeceuticals in photoaging: A review. (2024) · cites this paper as [23]
The Introduction identifies Boo (2019) as a review of the literature, not a cohort or case-control analytical study. The Abstract and Conclusions and Perspectives say that clinical studies support skin-lightening efficacy, rather than that clinical evidence is insufficient. The paper does not assign itself an Oxford evidence level. (LLM, conf=0.87)
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Oxidative stress in the skin: Impact and related protection
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Arbutin as a Skin Depigmenting Agent with Antimelanogenic and Antioxidant Properties
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Self-citationLiu, J.-K. (2022) · Natural Products and Bioprospecting · doi:10.1007/s13659-022-00363-y · Cited by 263 · see citing works
Natural Nrf2 Modulators for Skin Protection
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Self-citationCosmeceuticals in photoaging: A review.
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“The article by BOO et al. 23 titled “Human skin-lightening efficacy of resveratrol and its analogs: from in vitro studies to cosmetic applica-tions” published in the journal Antioxidants in 2019, aims to explore the potential skin-lightening effects of resveratrol and its analogs through in vitro…”
BackgroundWawrzyńczak, A. (2023) · Cosmetics · doi:10.3390/cosmetics10030086 · Cited by 19 · see citing works
- Authors
- Boo, Y. C.
- Affiliations
- Kyungpook National University (KR)
- Corresponding author
- Boo, Yong Chool
- ORCID
- Boo, Yong Chool
- Venue
- Antioxidants
- Publisher
- MDPI AG
- Published
- 2019-08-22
- Volume
- 8
- Issue
- 9
- Pages
- 332
- ISSN
- 2076-3921 (ISSN-L)
- PMC
- PMC6770230
- OpenAlex
- W2969996570
- Cited by
- 119
- References
- 145
- Citations by year
- 2026: 8 · 2025: 15 · 2024: 17 · 2023: 15 · 2022: 25 · 2021: 25 · 2020: 11 · 2019: 2 · 2018: 1
- FWCI
- 1.83
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Antioxidants (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Research Foundation of Korea (2019R1I1A2A01045132)
- Ministry of Small and Medium-Sized Enterprises and Startups, Republic of Korea (S2643749)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Keywords
- resveratrol, resveratrol analogues, skin lightening, melanogenesis inhibition, tyrosinase, melanogenesis, Nrf2, SIRT1, oxidative stress, extrinsic skin aging, skin pigmentation disorders, anti-aging cosmetics, melanocytic cells, 3D skin model
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