Towards a human-on-chip: Culturing multiple cell types on a chip with compartmentalized microenvironments

Exploring and Engineering the Cell Surface Interface

Stevens, M. M., & George, J. H. (2005) · Science · doi:10.1126/science.1106587 · Cited by 2,607 · see citing works

Comparison of the Abilities of Ambient and Manufactured Nanoparticles To Induce Cellular Toxicity According to an Oxidative Stress Paradigm

Xia, T., Kovochich, M., Brant, J. A., Hotze, M., Sempf, J. M., Oberley, T. D., Sioutas, C., Yeh, J. I., Wiesner, M. R., & Nel, A. E. (2006) · Nano Letters · doi:10.1021/nl061025k · Cited by 1,921 · see citing works

Lab-on-a-chip: microfluidics in drug discovery

Dittrich, P. S., & Manz, A. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd1985 · Cited by 1,848 · see citing works

Microscale technologies for tissue engineering and biology

Khademhosseini, A., Langer, R., Borenstein, J. T., & Vacanti, J. P. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507681102 · Cited by 1,553 · see citing works

HK-2: An immortalized proximal tubule epithelial cell line from normal adult human kidney

Ryan, M. J., Johnson, G., KIRK, J. M. W., Fuerstenberg, S. M., Zager, R. A., & Torok‐Storb, B. (1994) · Kidney International · doi:10.1038/ki.1994.6 · Cited by 891 · see citing works

Characterization of the A549 Cell Line as a Type II Pulmonary Epithelial Cell Model for Drug Metabolism

Foster, K. A., Oster, C. G., Mayer, M. M., Avery, M. L., & Audus, K. L. (1998) · Experimental Cell Research · doi:10.1006/excr.1998.4172 · Cited by 716 · see citing works

Effects of Obesity on Pharmacokinetics: Implications for Drug Therapy

Cheymol, G. (2000) · Clinical Pharmacokinetics · doi:10.2165/00003088-200039030-00004 · Cited by 631 · see citing works

Integration of Cell Culture and Microfabrication Technology

Park, T., & Shuler, M. (2003) · Biotechnology progress (Print) · doi:10.1021/bp020143k · Cited by 495 · see citing works

A microfluidic 3D hepatocyte chip for drug toxicity testing

Toh, Y., Lim, T. C., Tai, D., Xiao, G., van Noort, D., & Yu, H. (2009) · Lab on a Chip · doi:10.1039/b900912d · Cited by 422 · see citing works

A novel 3D mammalian cell perfusion-culture system in microfluidic channels

Toh, Y.-C., Zhang, C., Zhang, J., Khong, Y. M., Chang, S., Samper, V. D., van Noort, D., Hutmacher, D. W., & Yu, H. (2007) · Lab on a Chip · doi:10.1039/b614872g · Cited by 414 · see citing works

Development of a Microscale Cell Culture Analog To Probe Naphthalene Toxicity

Viravaidya‐Pasuwat, K., Sin, A., & Shuler, M. L. (2004) · Biotechnology Progress · doi:10.1021/bp0341996 · Cited by 306 · see citing works

Patterned cell culture inside microfluidic devices

Rhee, S. W., Taylor, A. M., Tu, C. H., Cribbs, D. H., Cotman, C. W., & Jeon, N. L. (2004) · Lab on a Chip · doi:10.1039/b403091e · Cited by 283 · see citing works

Microfluidic arrays for logarithmically perfused embryonic stem cell culture

Kim, L. Y., Vahey, M. D., Lee, H.-Y., & Joel Voldman, B. (2006) · Lab on a Chip · doi:10.1039/b511718f · Cited by 262 · see citing works

Cell lines with extended in vitro growth potential from human renal proximal tubule: Characterization, response to inducers, and comparison with established cell lines

Racusen, L. C., Monteil, C., Sgrignoli, A. R., et al. (1997) · Journal of Laboratory and Clinical Medicine · doi:10.1016/s0022-2143(97)90180-3 · Cited by 237 · see citing works

Utility of physiologically based pharmacokinetic models to drug development and rational drug discovery candidate selection

Theil, F., Guentert, T. W., Haddad, S., & Poulin, P. (2003) · Toxicology Letters · doi:10.1016/s0378-4274(02)00374-0 · Cited by 201 · see citing works

Incorporation of 3T3‐L1 Cells To Mimic Bioaccumulation in a Microscale Cell Culture Analog Device for Toxicity Studies

Viravaidya‐Pasuwat, K., & Shuler, M. L. (2004) · Biotechnology Progress · doi:10.1021/bp034238d · Cited by 184 · see citing works

A gel-free 3D microfluidic cell culture system

Ong, S.-M., Zhang, C., Toh, Y.-C., Kim, S. H., Foo, H. L., Tan, C. H., van Noort, D., Park, S., & Yu, H. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.04.022 · Cited by 172 · see citing works

The microcirculation as a functional system.

Ellis, C. G., Jagger, J. E., & Sharpe, M. D. (2005) · Critical Care · doi:10.1186/cc3751 · Cited by 159 · see citing works

Journal of Visualized Experiments (JoVE)

Europe PMC Team (2009) · doi:10.59350/nvsnv-ktt98 · Cited by 143 · see citing works

Hepatocyte Encapsulation for Enhanced Cellular Functions

Chia, S., Leong, K. W., Li, J., Xu, X., Zeng, K., Er, P.-N., Gao, S., & Yu, H. (2000) · Tissue Engineering · doi:10.1089/107632700750022134 · Cited by 117 · see citing works

IVF within microfluidic channels requires lower total numbers and lower concentrations of sperm

Suh, R. S., Zhu, X., Phadke, N., et al. (2005) · Human Reproduction · doi:10.1093/humrep/dei323 · Cited by 106 · see citing works

Microengineering the Environment of Mammalian Cells in Culture

Chen, C. S., Jiang, X., & Whitesides, G. M. (2005) · MRS Bulletin · doi:10.1557/mrs2005.52 · Cited by 106 · see citing works

Blood Flow and Diffusion through Mammalian Organs

Bassingthwaighte, J. B. (1970) · Science · doi:10.1126/science.167.3923.1347 · Cited by 98 · see citing works

Cell culture methods for the establishment of the NCI series of lung cancer cell lines

Oie, H. K., RUSSELL, E. K., Carney, D. N., et al. (1996) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240630504 · Cited by 94 · see citing works

TGF-β-mediated hepatocellular apoptosis by rat and human hepatoma cells and primary rat hepatocytes

Gressner, A. M., Lahme, B., Mannherz, H. G., & Polzar, B. (1997) · Journal of Hepatology · doi:10.1016/s0168-8278(97)80117-1 · Cited by 93 · see citing works

Growth factor and peptide receptors in small cell lung cancer

Moody, T. W., & Cuttitta, F. F. (1993) · Life Sciences · doi:10.1016/0024-3205(93)90098-n · Cited by 89 · see citing works

Factors affecting the storage and excretion of toxic lipophilic xenobiotics

Jandacek, R. J., & Tso, P. (2001) · Lipids · doi:10.1007/s11745-001-0844-z · Cited by 83 · see citing works

Microfluidic environment for high density hepatocyte culture

Zhang, M. Y., Lee, P. J., Hung, P. J., Johnson, T., Lee, L. P., & Mofrad, M. R. K. (2007) · Biomedical Microdevices · doi:10.1007/s10544-007-9116-9 · Cited by 72 · see citing works

Microfluidics and multielectrode array-compatible organotypic slice culture method

Berdichevsky, Y., Sabolek, H. R., Levine, J. B., Staley, K. J., & Yarmush, M. L. (2008) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2008.11.016 · Cited by 61 · see citing works

Vital circuits: on pumps, pipes, and the workings of circulatory systems

(1992) · Choice Reviews Online · doi:10.5860/choice.30-0916 · Cited by 55 · see citing works

T-cell epitopes of the major peach allergen, Pru p 3: Identification and differential T-cell response of peach-allergic and non-allergic subjects

Tordesillas, L., Cuesta‐Herranz, J., González‐Muñoz, M., et al. (2008) · Molecular Immunology · doi:10.1016/j.molimm.2008.10.018 · Cited by 55 · see citing works

Adiponectin: an intriguing hormone for paediatricians

Savino, F., Petrucci, E., & GE, N. (2008) · Acta Paediatrica · doi:10.1111/j.1651-2227.2008.00750.x · Cited by 45 · see citing works

Evaluation and optimization of hepatocyte culture media factors by design of experiments (DoE) methodology

Dong, J., Mandenius, C., Lübberstedt, M., Urbaniak, T., Nussler, A. K., Knobeloch, D., Gerlach, J. C., & Zeilinger, K. (2008) · Cytotechnology · doi:10.1007/s10616-008-9168-6 · Cited by 44 · see citing works

Acrylamide: Consideration of species differences and nonlinear processes in estimating risk and safety for human ingestion

Gargas, M. L., Kirman, C. R., Sweeney, L. M., & Tardiff, R. G. (2009) · Food and Chemical Toxicology · doi:10.1016/j.fct.2008.12.032 · Cited by 39 · see citing works

Microfluidic platform for hepatitis B viral replication study

Sodunke, T. R., Bouchard, M. J., & Noh, H. (. (2008) · Biomedical Microdevices · doi:10.1007/s10544-007-9148-1 · Cited by 38 · see citing works

The controlled presentation of TGF-β1 to hepatocytes in a 3D-microfluidic cell culture system

Zhang, C., Chia, S., Ong, S., Zhang, S., Toh, Y., van Noort, D., & Yu, H. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.03.052 · Cited by 36 · see citing works

Characterisation of some cytotoxic endpoints using rat liver and HepG2 spheroids as in vitro models and their application in hepatotoxicity studies. II. Spheroid cell spreading inhibition as a new cytotoxic marker

Xu, J., Ma, M., & Purcell, W. M. (2003) · Toxicology and Applied Pharmacology · doi:10.1016/s0041-008x(03)00090-5 · Cited by 34 · see citing works

Meet the stripped down rat

Khamsi, R. (2005) · Nature · doi:10.1038/435012a · Cited by 29 · see citing works

Species differences in the multiple-dose pharmacokinetics of the non-nucleoside reverse transcriptase inhibitor (NNRTI) UK-453,061 in animals and man: implications for safety considerations

Walker, D. K., Davis, J. D., Houle, C. D., et al. (2009) · Xenobiotica · doi:10.1080/00498250902903079 · Cited by 13 · see citing works

Reconstituting organ-level lung functions on a chip

Huh, D., Matthews, B. D., Mammoto, A., Montoya-Zavala, M., Hsin, H. Y., & Ingber, D. E. (2010) · Science · doi:10.1126/science.1188302 · Cited by 4,250 · see citing works

Microfluidic organs-on-chips

Bhatia, S. N., & Ingber, D. E. (2014) · Nature Biotechnology · doi:10.1038/nbt.2989 · Cited by 3,305 · see citing works

Human organoids: model systems for human biology and medicine

Kim, J., Koo, B.-K., & Knoblich, J. A. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0259-3 · Cited by 2,187 · see citing works

Progress and potential in organoid research

Rossi, G., Manfrin, A., & Lutolf, M. P. (2018) · Nature Reviews Genetics · doi:10.1038/s41576-018-0051-9 · Cited by 1,182 · see citing works

A guide to the organ-on-a-chip

Leung, C. M., de Haan, P., Ronaldson-Bouchard, K., Kim, G.-A., Ko, J., Rho, H. S., Chen, Z., Habibovic, P., Jeon, N. L., Takayama, S., et al. (2022) · Nature Reviews Methods Primers · doi:10.1038/s43586-022-00118-6 · Cited by 1,116 · see citing works

Organs-on-chips: into the next decade

Low, L. A., Mummery, C., Berridge, B. R., Austin, C. P., & Tagle, D. A. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-020-0079-3 · Cited by 1,029 · see citing works

Organoids

Zhao, Z., Chen, X., Dowbaj, A. M., Sljukic, A., Bratlie, K., Lin, L., Fong, E. L. S., Balachander, G. M., Chen, Z., Soragni, A., et al. (2022) · Nature Reviews Methods Primers · doi:10.1038/s43586-022-00174-y · Cited by 1,001 · see citing works

A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents

Maschmeyer, I., Lorenz, A. K., Schimek, K., Hasenberg, T., Ramme, A. P., Hübner, J., Lindner, M., Drewell, C., Bauer, S., Thomas, A., et al. (2015) · Lab on a Chip · doi:10.1039/c5lc00392j · Cited by 861 · see citing works

Organs-on-a-Chip: A Fast Track for Engineered Human Tissues in Drug Development

Ronaldson-Bouchard, K., & Vunjak-Novakovic, G. (2018) · Cell Stem Cell · doi:10.1016/j.stem.2018.02.011 · Cited by 657 · see citing works

A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture

Wagner, I., Materne, E.-M., Brincker, S., Süßbier, U., Frädrich, C., Busek, M., Sonntag, F., Sakharov, D. A., Trushkin, E. V., Tonevitsky, A. G., et al. (2013) · Lab on a Chip · doi:10.1039/c3lc50234a · Cited by 476 · see citing works

Multi-Organ toxicity demonstration in a functional human in vitro system composed of four organs

Oleaga, C., Bernabini, C., Smith, A. S. T., Srinivasan, B., Jackson, M., McLamb, W., Platt, V., Bridges, R., Cai, Y., Santhanam, N., et al. (2016) · Scientific Reports · doi:10.1038/srep20030 · Cited by 442 · see citing works

Organ-on-a-chip platforms for studying drug delivery systems

Bhise, N. S., Ribas, J., Manoharan, V., Zhang, Y. S., Polini, A., Massa, S., Dokmeci, M. R., & Khademhosseini, A. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.05.004 · Cited by 381 · see citing works

Biomimetic tissues on a chip for drug discovery

Ghaemmaghami, A. M., Hancock, M. J., Harrington, H., Kaji, H., & Khademhosseini, A. (2012) · Drug Discovery Today · doi:10.1016/j.drudis.2011.10.029 · Cited by 359 · see citing works

Organ-on-a chip systems: microengineering to biomimic living systems

Zheng, F., Fu, F., Cheng, Y., Wang, C., Zhao, Y., & Gu, Z. (2016) · Small · doi:10.1002/smll.201503208 · Cited by 338 · see citing works

Organ-on-a-chip platforms: a convergence of advanced materials, cells, and microscale technologies

Ahadian, S., Civitarese, R., Bannerman, D., Mohammadi, M. H., Lu, R., Wang, E., Davenport‐Huyer, L., Lai, B., Zhang, B., Zhao, Y., et al. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201700506 · Cited by 315 · see citing works

Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing

Marx, U. (2016) · ALTEX · doi:10.14573/altex.1603161 · Cited by 295 · see citing works

Tumor-on-a-chip: from bioinspired design to biomedical application

Liu, X., Fang, J., Huang, S., Wu, X., Xie, X., Wang, J., Liu, F., Zhang, M., Peng, Z., & Hu, N. (2021) · Microsystems & Nanoengineering · doi:10.1038/s41378-021-00277-8 · Cited by 246 · see citing works

Organs-on-a-chip: a new tool for drug discovery

Polini, A., Prodanov, L., Bhise, N. S., Manoharan, V., Dokmeci, M. R., & Khademhosseini, A. (2014) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2014.886562 · Cited by 223 · see citing works

A multi-throughput multi-organ-on-a-chip system on a plate formatted pneumatic pressure-driven medium circulation platform

Satoh, T., Sugiura, S., Shin, K., Onuki-Nagasaki, R., Ishida, S., Kikuchi, K., Kakiki, M., & Kanamori, T. (2018) · Lab on a Chip · doi:10.1039/c7lc00952f · Cited by 181 · see citing works

Multi-cellular 3D human primary liver cell culture elevates metabolic activity under fluidic flow

Esch, M. B., Prot, J.-M., Wang, Y. I., Miller, P., Llamas-Vidales, J. R., Naughton, B. A., Applegate, D. R., & Shuler, M. L. (2015) · Lab on a Chip · doi:10.1039/c5lc00237k · Cited by 173 · see citing works

Hepatic organoids for microfluidic drug screening

Au, S. H., Chamberlain, M. D., Mahesh, S., Sefton, M. V., & Wheeler, A. R. (2014) · Lab on a Chip · doi:10.1039/c4lc00531g · Cited by 162 · see citing works

Cross talk between cancer and immune cells: exploring complex dynamics in a microfluidic environment

Businaro, L., De Ninno, A., Schiavoni, G., Lucarini, V., Ciasca, G., Gerardino, A., Belardelli, F., Gabriele, L., & Mattei, F. (2013) · Lab Chip · doi:10.1039/c2lc40887b · Cited by 162 · see citing works

Modeling human carcinomas: Physiologically relevant 3D models to improve anti-cancer drug development

Unger, C., Kramer, N., Walzl, A., Scherzer, M., Hengstschläger, M., & Dolznig, H. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.10.015 · Cited by 158 · see citing works

On being the right size: scaling effects in designing a human-on-a-chip

Moraes, C., Labuz, J. M., Leung, B. M., Inoue, M., Chun, T.-H., & Takayama, S. (2013) · Integrative Biology · doi:10.1039/c3ib40040a · Cited by 134 · see citing works

Cancer-on-a-chip systems at the frontier of nanomedicine

Zhang, Y. S., Zhang, Y.-N., & Zhang, W. (2017) · Drug Discovery Today · doi:10.1016/j.drudis.2017.03.011 · Cited by 127 · see citing works

3D spherical microtissues and microfluidic technology for multi-tissue experiments and analysis

Kim, J.-Y., Fluri, D. A., Marchan, R., Boonen, K., Mohanty, S., Singh, P., Hammad, S., Landuyt, B., Hengstler, J. G., Kelm, J. M., et al. (2015) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2015.01.003 · Cited by 126 · see citing works

Progress, obstacles, and limitations in the use of stem cells in organ-on-a-chip models

Wnorowski, A., Yang, H., & Wu, J. C. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.06.001 · Cited by 124 · see citing works

Microfluidic devices for in vitro studies on liver drug metabolism and toxicity

van Midwoud, P. M., Verpoorte, E., & Groothuis, G. M. M. (2011) · Integrative Biology · doi:10.1039/c0ib00119h · Cited by 115 · see citing works

Organ-on-a-chip technology and microfluidic whole-body models for pharmacokinetic drug toxicity screening

Lee, J. B., & Sung, J. H. (2013) · Biotechnology Journal · doi:10.1002/biot.201300086 · Cited by 92 · see citing works

Organ-Tumor-on-a-Chip for Chemosensitivity Assay: A Critical Review

Kashaninejad, N., Nikmaneshi, M., Moghadas, H., Kiyoumarsi Oskouei, A., Rismanian, M., Barisam, M., Saidi, M., & Firoozabadi, B. (2016) · Micromachines · doi:10.3390/mi7080130 · Cited by 79 · see citing works

Strategies for using mathematical modeling approaches to design and interpret multi-organ microphysiological systems (MPS)

Sung, J. H., Wang, Y., & Shuler, M. L. (2019) · APL Bioengineering · doi:10.1063/1.5097675 · Cited by 66 · see citing works

A 3D Microfluidic Model to Recapitulate Cancer Cell Migration and Invasion

Toh, Y.-C., Raja, A., Yu, H., & Van Noort, D. (2018) · Bioengineering · doi:10.3390/bioengineering5020029 · Cited by 57 · see citing works

Critical Considerations for the Design of Multi-Organ Microphysiological Systems (MPS)

Malik, M., Yang, Y., Fathi, P., Mahler, G. J., & Esch, M. B. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.721338 · Cited by 43 · see citing works

Effect of gut microbiome-derived metabolites and extracellular vesicles on hepatocyte functions in a gut-liver axis chip

Kang, S. G., Choi, Y. Y., Mo, S. J., Kim, T. H., Ha, J. H., Hong, D. K., Lee, H., Park, S. D., Shim, J.-J., Lee, J.-L., et al. (2023) · Nano Convergence · doi:10.1186/s40580-022-00350-6 · Cited by 37 · see citing works

Advances in microfluidic 3D cell culture for preclinical drug development

(2022) · Progress in Molecular Biology and Translational Science · doi:10.1016/bs.pmbts.2021.07.022 · Cited by 23 · see citing works

Effect of IFN-γ on A549 cell proliferation and expression of P21

Li, Y. (2006) · Zhongguo linchuang yaolixue yu zhiliaoxue

Mechanical Strain-Enabled Reconstitution of Dynamic Environment in Organ-on-a-Chip Platforms: A Review

Zhao, Q., Cole, T., Zhang, Y., & Tang, S. (2021) · Micromachines · doi:10.3390/mi12070765 · Cited by 28 · see citing works

How Microgels Can Improve the Impact of Organ-on-Chip and Microfluidic Devices for 3D Culture: Compartmentalization, Single Cell Encapsulation and Control on Cell Fate

Argentiere, S., Siciliano, P. A., & Blasi, L. (2021) · Polymers · doi:10.3390/polym13193216 · Cited by 21 · see citing works

Fabrication of a 3D microfluidic cell culture device for bone marrow-on-a-chip

Kefallinou, D., Grigoriou, M., Boumpas, D. T., Gogolides, Ε., & Tserepi, A. D. (2020) · Micro and Nano Engineering · doi:10.1016/j.mne.2020.100075 · Cited by 33 · see citing works

Microfluidic On-Chip Biomimicry for 3D Cell Culture: a Fit-For-Purpose Investigation From the End User Standpoint

Liu, Y., Gill, E., & Huang, Y. Y. S. (2017) · Future Science OA · doi:10.4155/fsoa-2016-0084 · Cited by 46 · see citing works