Relationship of Seminal Oxidation-Reduction Potential with Sperm DNA Integrity and pH in Idiopathic Infertile Patients
Open accessAbstract
Seminal oxidative stress (OS) is one of the most promising factors to describe the causes of idiopathic male infertility. Redox balance is essential in several biological processes related to fertility, so alterations such as high reactive oxygen species (ROS) levels or low antioxidant agent levels can compromise it. MiOXSYS has been developed to evaluate the seminal static oxidation-reduction potential (sORP) and it has been proposed as an effective diagnostic biomarker. However, its relationship with parameters like sperm DNA fragmentation (SDF), chromatin compaction status or seminal pH requires further analysis, making it the object of this study. Semen and sORP analysis were performed for all samples. A terminal deoxynucleotidyl transferase dUTP nick end labeling assay (TUNEL) and Comet assay were used to assess SDF and chromomycin a3 (CMA3) test to assess sperm chromatin compaction. Regarding sORP measures, it was found that alkaline pH has an effect on sample reproducibility. To our knowledge, this unexpected effect has not been previously described. A statistical analysis showed that sORP correlated negatively with CMA3 positive cells and sperm motility, but not with SDF. As redox dysregulation, which occurs mainly at the testicular and epididymal level, causes chromatin compaction problems and leaves DNA exposed to damage, an excess of ROS could be counterbalanced further by a seminal supply of antioxidant molecules, explaining the negative correlation with CMA3 positive cells but no correlation with SDF. Our results show that the study of idiopathic infertility would benefit from a combined approach comprising OS analysis, SDF and chromatin compaction analysis.
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OS negatively affects all sperm functions, including sperm DNA integrity, and thereby the fertilization process and reproductive outcomes.
“Consequently, OS negatively affects all sperm functions, including sperm DNA integrity [47,48], and thereby the fertilization process and reproductive outcomes [49,50,51,52,53,54,55].”
From The Sixth Edition of the WHO Manual for Human Semen Analysis: A Critical Review and SWOT Analysis (2021) · cites this paper as [48]
The Introduction reports that redox dysregulation alters sperm motility and can cause sperm DNA fragmentation. It does not establish that oxidative stress negatively affects *all* sperm functions. The fertilization and reproductive-outcome clause is attached to other citations, not this source. (LLM, conf=0.86)
Experimental — accuracy not yet measuredCriticism of using OS as a parameter to predict male fertilizing potential, particularly for direct determination of ROS with luminometric methods or ORP using the MiOXSYS System, points at pH sensitivity of the measurement, especially at alkaline pH values.
“In addition, criticism of using OS as a parameter to predict the male fertilizing potential, particularly for the direct determination of either ROS with luminometric methods or ORP using the MiOXSYS System, is also pointing at the pH sensitivity of the measurement, especially at alkaline pH values [48].”
From The Sixth Edition of the WHO Manual for Human Semen Analysis: A Critical Review and SWOT Analysis (2021) · cites this paper as [48]
Split into 2 atoms — 0 confirmed, 2 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.
Experimental — accuracy not yet measuredThe 6th Edition is lacking recently published evidence indicating the predictive power of seminal OS as determined by means of ORP.
“Unfortunately, this 6th Edition of the WHO manual is lacking recently published evidence indicating the predictive power of seminal OS as determined by means of the ORP [48,57,58,59,60].”
From The Sixth Edition of the WHO Manual for Human Semen Analysis: A Critical Review and SWOT Analysis (2021) · cites this paper as [48]
The Introduction describes ORP measurement as a proposed diagnostic tool, and the Results (section 3.2) report associations between ORP and sperm motility and chromatin compaction. The paper does not establish predictive power; its Conclusions describe possible clinical applications and call for further work on measurement reliability. It does not assess what the WHO manual’s sixth edition includes. (LLM, conf=0.82)
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- Authors
- Garcia-Segura, S., Ribas-Maynou, J., Lara-Cerrillo, S., Garcia-Peiró, A., Castel, A. B., Benet, J., & Oliver-Bonet, M.
- Affiliations
- Unit of Cell Biology and Medical Genetics, Department of Cell Biology, Physiology and Immunology, Universitat Autònoma de Barcelona, Av. Can Domenech s/n, Bellaterra, 08193 Catalunya, Spain
- CIMAB, Barcelona Male Infertility Centre, C. Vallcorba 1-3, Sant Quirze del Vallès, 08192 Catalunya, Spain
- Instituto de Fertilidad, C. Calçat 6, 07011 Palma Mallorca, Spain
- Universitat Autònoma de Barcelona (ES)
- Corresponding author
- Benet, Jordi
- Venue
- Biology
- Publisher
- MDPI AG
- Published
- 2020-09-01
- Volume
- 9
- Issue
- 9
- Pages
- 262
- ISSN
- 2079-7737 (ISSN-L)
- PMC
- PMC7564726
- OpenAlex
- W3082498901
- Cited by
- 21
- References
- 64
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 3 · 2023: 4 · 2022: 4 · 2021: 3
- FWCI
- 2.43
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Biology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Dipòsit Digital de Documents de la UAB (Universitat Autònoma de Barcelona) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Instituto de Salud Carlos III (PI14/00119)
- Generalitat de Catalunya (2017SGR1796)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Keywords
- oxidative stress, idiopathic male infertility, sperm DNA fragmentation, sperm chromatin compaction, reactive oxygen species, antioxidant status, sperm motility, redox homeostasis, chromomycin A3
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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