The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Skin Wound Healing Process and New Emerging Technologies for Skin Wound Care and Regeneration
Open accessAbstract
Skin wound healing shows an extraordinary cellular function mechanism, unique in nature and involving the interaction of several cells, growth factors and cytokines. Physiological wound healing restores tissue integrity, but in many cases the process is limited to wound repair. Ongoing studies aim to obtain more effective wound therapies with the intention of reducing inpatient costs, providing long-term relief and effective scar healing. The main goal of this comprehensive review is to focus on the progress in wound medication and how it has evolved over the years. The main complications related to the healing process and the clinical management of chronic wounds are described in the review. Moreover, advanced treatment strategies for skin regeneration and experimental techniques for cellular engineering and skin tissue engineering are addressed. Emerging skin regeneration techniques involving scaffolds activated with growth factors, bioactive molecules and genetically modified cells are exploited to overcome wound healing technology limitations and to implement personalized therapy design.
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Citations
Cites
Factors affecting wound healing
Guo, S., & DiPietro, L. A. (2010) · Journal of Dental Research · doi:10.1177/0022034509359125 · Cited by 5,792
Remodelling the extracellular matrix in development and disease
Bonnans, C., Chou, J., & Werb, Z. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3904 · Cited by 4,367
The Extracellular Matrix: Not Just Pretty Fibrils
Hynes, R. O. (2009) · Science · doi:10.1126/science.1176009 · Cited by 3,527
Reinke, J. M., & Sorg, H. (2012) · European Surgical Research · doi:10.1159/000339613 · Cited by 1,898
Formation and function of the myofibroblast during tissue repair
Hinz, B. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700613 · Cited by 1,658
Chen, L., Tredget, E. E., Wu, P. Y. G., & Wu, Y. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001886 · Cited by 1,610
The Basic Science of Wound Healing
Broughton, G., Janis, J. E., & Attinger, C. E. (2006) · Plastic and Reconstructive Surgery · doi:10.1097/01.prs.0000225430.42531.c2 · Cited by 1,519 · cited 1×
“Several cells are involved such as fibroblasts, keratinocytes and endothelial cells, and neutrophils, monocytes, macrophages, lymphocytes and dendritic cells as immune components [10].”
BackgroundThe signals and pathways activating cellular senescence
Ben-Porath, I., & Weinberg, R. A. (2005) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.10.013 · Cited by 1,046
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Cited by
Tissue macrophages: origin, heterogenity, biological functions, diseases and therapeutic targets
Guan, F., Wang, R., Yi, Z., Luo, P., Liu, W., Xie, Y., Liu, Z., Xia, Z., Zhang, H., & Cheng, Q. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02124-y · Cited by 371
Electrospun Medicated Nanofibers for Wound Healing: Review
Liu, X., Xu, H., Zhang, M., & Yu, D.-G. (2021) · Membranes · doi:10.3390/membranes11100770 · Cited by 311
Alberts, A., Moldoveanu, E.-T., Niculescu, A.-G., & Grumezescu, A. M. (2025) · Molecules · doi:10.3390/molecules30030748 · Cited by 161
Uhljar, L. É., & Ambrus, R. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15020417 · Cited by 108
Using bioprinting and spheroid culture to create a skin model with sweat glands and hair follicles
Zhang, Y., Enhejirigala, Yao, B., Li, Z., Song, W., Li, J., Zhu, D., Wang, Y., Duan, X., Yuan, X., et al. (2021) · Burns & Trauma · doi:10.1093/burnst/tkab013 · Cited by 69
Metadata
- Authors
- Tottoli, E. M., Dorati, R., Genta, I., Chiesa, E., Pisani, S., & Conti, B.
- Venue
- Pharmaceutics
- Publisher
- MDPI AG
- Published
- 2020-08-05
- Volume
- 12
- Issue
- 8
- Pages
- 735
- ISSN
- 1999-4923 (ISSN-L)
- OpenAlex
- W3047104964
- Cited by
- 1,340
- References
- 11
- FWCI
- 67.88
- Type
- journal article
- Language
- en
- Open access
- gold
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- CoChat. (2026). Citation check: Skin Wound Healing Process and New Emerging Technologies for Skin Wound Care and Regeneration. https://app.cochat.ai/papers/10.3390/pharmaceutics12080735
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- Tottoli, E. M., Dorati, R., Genta, I., Chiesa, E., Pisani, S., & Conti, B. (2020). Skin Wound Healing Process and New Emerging Technologies for Skin Wound Care and Regeneration. Pharmaceutics. https://doi.org/10.3390/pharmaceutics12080735
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
