Tissue Engineering and Targeted Drug Delivery in Cardiovascular Disease: The Role of Polymer Nanocarrier for Statin Therapy
Open accessAbstract
Atherosclerosis-related coronary artery disease (CAD) is the leading cause of mortality and morbidity worldwide. This requires effective primary and secondary prevention in reducing the complications related to CAD; the regression or stabilization of the pathology remains the mainstay of treatment. Statins have proved to be the most effective treatment in reducing adverse effects, but there are limitations related to the administration and achievement of effective doses as well as side effects due to the lack of target-related molecular specificity. The implemented technological steps are polymers and nanoparticles for the administration of statins, as it has been seen how the conjugation of drug delivery systems (DDSs) with statins increases bioavailability by circumventing the hepatic–renal filter and increases the related target specificity, enhancing their action and decreasing side effects. Reduction of endothelial dysfunction, reduced intimal hyperplasia, reduced ischemia–reperfusion injury, cardiac regeneration, positive remodeling in the extracellular matrix, reduced neointimal growth, and increased reendothelialization are all drug-related effects of statins enhanced by binding with DDSs. Recent preclinical studies demonstrate how the effect of statins stimulates the differentiation of endogenous cardiac stem cells. Poly-lactic-co-glycolic acid (PLGA) seems to be the most promising DDS as it succeeds more than the others in enhancing the effect of the bound drug. This review intends to summarize the current evidence on polymers and nanoparticles for statin delivery in the field of cardiovascular disease, trying to shed light on this topic and identify new avenues for future studies.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Polymeric nanoparticles such as PLGA enable controlled and sustained drug release, with architectures tunable as nanospheres or nanocapsules.
“Polymeric nanoparticles, such as those fabricated from polylactic‐co‐glycolic acid (PLGA), enable controlled and sustained drug release, with architectures that can be tuned as nanospheres or nanocapsules depending on polymer arrangement [30].”
From Statins as Antifungal Agents: A Review on Drug Repurposing and Nanotechnology-Driven Delivery Strategies (2025) · cites this paper as [30]
Section 4.3, “Polymeric Nanoparticles,” says PLGA’s composition can regulate its degradation rate, enabling controlled drug release, and gives an example of slow release. The copy does not describe polymeric nanoparticles as tunable into nanospheres or nanocapsules depending on polymer arrangement (searched: “nanospheres nanocapsules” and “polymer arrangement”). (LLM, conf=0.88)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Ibanez, B., James, S., Agewall, S., Antunes, M. J., Bucciarelli-Ducci, C., Bueno, H., Caforio, A. L. P., Crea, F., Goudevenos, J. A., Halvorsen, S., et al. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehx393 · Cited by 9,728 · see citing works
Stone, N. J., Robinson, J. G., Lichtenstein, A. H., Bairey Merz, C. N., Blum, C. B., Eckel, R. H., Goldberg, A. C., Gordon, D., Levy, D., Lloyd-Jones, D. M., et al. (2014) · Circulation · doi:10.1161/01.cir.0000437738.63853.7a · Cited by 7,081 · see citing works
Progress and challenges in translating the biology of atherosclerosis
Libby, P., Ridker, P. M., & Hansson, G. K. (2011) · Nature · doi:10.1038/nature10146 · Cited by 4,010 · see citing works
Yellon, D. M., & Hausenloy, D. J. (2007) · New England Journal of Medicine · doi:10.1056/nejmra071667 · Cited by 3,797 · see citing works
High-Dose Atorvastatin after Stroke or Transient Ischemic Attack
The Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) Investigators (2006) · New England Journal of Medicine · doi:10.1056/nejmoa061894 · Cited by 2,887 · see citing works
Basic and Therapeutic Aspects of Angiogenesis
Potente, M., Gerhardt, H., & Carmeliet, P. (2011) · Cell · doi:10.1016/j.cell.2011.08.039 · Cited by 2,771 · see citing works
Nanoparticle-Based Medicines: A Review of FDA-Approved Materials and Clinical Trials to Date
Bobo, D., Robinson, K. J., Islam, J., Thurecht, K. J., & Corrie, S. R. (2016) · Pharmaceutical Research · doi:10.1007/s11095-016-1958-5 · Cited by 2,586 · see citing works
Nanomedicine: current status and future prospects
Moghimi, S. M., Hunter, A. C., & Murray, J. C. (2005) · The FASEB Journal · doi:10.1096/fj.04-2747rev · Cited by 2,029 · see citing works
PLGA nanoparticles containing various anticancer agents and tumour delivery by EPR effect
Acharya, S., & Sahoo, S. K. (2010) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2010.10.008 · Cited by 1,116 · see citing works
Mechanisms of adverse effects of anti-VEGF therapy for cancer
Kamba, T., & McDonald, D. M. (2007) · British Journal of Cancer · doi:10.1038/sj.bjc.6603813 · Cited by 991 · see citing works
Imaging macrophages with nanoparticles
Weissleder, R., Nahrendorf, M., & Pittet, M. J. (2014) · Nature Materials · doi:10.1038/nmat3780 · Cited by 809 · see citing works
Statins Have Biphasic Effects on Angiogenesis
Weis, M., Heeschen, C., Glassford, A. J., & Cooke, J. P. (2002) · Circulation · doi:10.1161/hc0602.103393 · Cited by 677 · see citing works
Cheng, G., Huang, Q., Liu, C., Kwong, C. H. T., Yue, L., Wan, J., Lee, S. M., & Wang, R. (2020) · Nature Communications · doi:10.1038/s41467-020-16439-7 · Cited by 635 · see citing works
A Comparison of Two LDL Cholesterol Targets after Ischemic Stroke
Amarenco, P., Js, K., Labreuche, J., Charles, H., Abtan, J., Béjot, Y., Cabrejo, L., Jk, C., Ducrocq, G., Giroud, M., et al. (2019) · New England Journal of Medicine · doi:10.1056/nejmoa1910355 · Cited by 572 · see citing works
Ovize, M., Baxter, G. F., Lisa, F. D., Ferdinandy, P., David Garcia-dorado, A., Hausenloy, D. J., Heusch, G., Vinten-Johansen, J., Yellon, D. M., & Schulz, R. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq129 · Cited by 502 · see citing works
Targeting vascular (endothelial) dysfunction
Daiber, A., Steven, S., Weber, A., Shuvaev, V. V., Muzykantov, V. R., Laher, I., Li, H., Lamas, S., & Münzel, T. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13517 · Cited by 501 · see citing works
Duivenvoorden, R., Tang, J., Cormode, D. P., Mieszawska, A. J., Izquierdo‐Garcia, D., Ozcan, C., Otten, M. J., Zaidi, N., Lobatto, M. E., van Rijs, S. M., et al. (2014) · Nature Communications · doi:10.1038/ncomms4065 · Cited by 444 · see citing works
Winter, P. M., Neubauer, A. M., Caruthers, S. D., Harris, T. D., Robertson, J. D., Williams, T. A., Schmieder, A. H., Hu, G., Allen, J. S., Lacy, E. K., et al. (2006) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000235724.11299.76 · Cited by 379 · see citing works
Cholesterol Levels and Risk of Hemorrhagic Stroke
Wang, X., Dong, Y., Qi, X., Huang, C.-G., & Hou, L. (2013) · Stroke · doi:10.1161/strokeaha.113.001326 · Cited by 336 · see citing works
Bell, S., Daskalopoulou, M., Rapsomaniki, E., George, J., Britton, A. R., Bobák, M., Casas, J. P., Dale, C. E., Denaxas, S., Shah, A. D., et al. (2017) · BMJ · doi:10.1136/bmj.j909 · Cited by 332 · see citing works
Förstermann, U., & Li, H. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.01196.x · Cited by 299 · see citing works
Mulder, W. J. M., Strijkers, G. J., van Tilborg, G. A. F., Cormode, D. P., Fayad, Z. A., & Nicolay, K. (2009) · Accounts of Chemical Research · doi:10.1021/ar800223c · Cited by 267 · see citing works
The crossroads of inflammation, fibrosis, and arrhythmia following myocardial infarction
Stuart, S. D. F., Jesus, N. M. D., Lindsey, M. L., & Ripplinger, C. M. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.12.024 · Cited by 249 · see citing works
Inhibiting macrophage proliferation suppresses atherosclerotic plaque inflammation
Tang, J., Lobatto, M. E., Hassing, L., van der Staay, S. E. M., van Rijs, S. M., Calcagno, C., Braza, M. S., Baxter, S., Fay, F., Sánchez-Gaytán, B. L., et al. (2015) · Science Advances · doi:10.1126/sciadv.1400223 · Cited by 223 · see citing works
Wasilewska, K., & Winnicka, K. (2019) · Materials · doi:10.3390/ma12203386 · Cited by 205 · see citing works
Low-density lipoprotein cholesterol and risk of intracerebral hemorrhage
Ma, C., Gurol, M. E., Huang, Z., Lichtenstein, A. H., Wang, X., Wang, Y., Neumann, S., Wu, S., & Gao, X. (2019) · Neurology · doi:10.1212/wnl.0000000000007853 · Cited by 198 · see citing works
Dunmore, B. J., McCarthy, M. J., Naylor, A. R., & Brindle, N. P. J. (2007) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2006.08.072 · Cited by 187 · see citing works
From Detecting the Vulnerable Plaque to Managing the Vulnerable Patient
Arbab‐Zadeh, A., & Fuster, V. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.07.062 · Cited by 187 · see citing works
Pinal‐Fernandez, I., Casal-Domínguez, M., & Mammen, A. L. (2017) · Medicina Clínica · doi:10.1016/j.medcli.2017.11.030 · Cited by 185 · see citing works
Katsuki, S., Matoba, T., Nakashiro, S., Sato, K., Koga, J.-I., Nakano, K., Nakano, Y., Egusa, S., Sunagawa, K., & Egashira, K. (2014) · Circulation · doi:10.1161/circulationaha.113.002870 · Cited by 179 · see citing works
Winter, P. M., Caruthers, S. D., Zhang, H., Williams, T. A., Wickline, S. A., & Lanza, G. M. (2008) · JACC: Cardiovascular Imaging · doi:10.1016/j.jcmg.2008.06.003 · Cited by 166 · see citing works
Detection and treatment of atherosclerosis using nanoparticles
Zhang, J., Zu, Y., Dhanasekara, C. S., Li, J., Wu, D., Fan, Z., & Wang, S. F. (2016) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1412 · Cited by 131 · see citing works
Moroni, F., Ammirati, E., Norata, G. D., Magnoni, M., & Camici, P. G. (2019) · Mediators of Inflammation · doi:10.1155/2019/7434376 · Cited by 124 · see citing works
Nakashiro, S., Matoba, T., Umezu, R., Koga, J., Tokutome, M., Katsuki, S., Nakano, K., Sunagawa, K., & Egashira, K. (2016) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.115.307057 · Cited by 121 · see citing works
Nagaoka, K., Matoba, T., Mao, Y., Nakano, Y., Ikeda, G., Egusa, S., Tokutome, M., Nagahama, R., Nakano, K., Sunagawa, K., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0132451 · Cited by 114 · see citing works
Frick, M., Dulak, J., Cisowski, J., et al. (2003) · Atherosclerosis · doi:10.1016/s0021-9150(03)00299-5 · Cited by 96 · see citing works
Anti-inflammatory Nanomedicine for Cardiovascular Disease
Katsuki, S., Matoba, T., Koga, J., Nakano, K., & Egashira, K. (2017) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2017.00087 · Cited by 96 · see citing works
Premium ethylcellulose polymer based architectures at work in drug delivery
Adeleke, O. A. (2019) · International Journal of Pharmaceutics X · doi:10.1016/j.ijpx.2019.100023 · Cited by 93 · see citing works
Nasr, S. H., Rashidijahanabad, Z., Ramadan, S., Kauffman, N., Parameswaran, N., Zinn, K. R., Qian, C., Arora, R., Agnew, D., & Huang, X. (2020) · Nanoscale · doi:10.1039/d0nr00308e · Cited by 90 · see citing works
Brož, P., Ben-Haim, N., Grzelakowski, M., Marsch, S. C. U., Meier, W. P., & Hunziker, P. (2008) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e3181624aed · Cited by 83 · see citing works
Fibrate/Statin Initiation in Warfarin Users and Gastrointestinal Bleeding Risk
Schelleman, H., Bilker, W. B., Brensinger, C. M., et al. (2010) · The American Journal of Medicine · doi:10.1016/j.amjmed.2009.07.020 · Cited by 79 · see citing works
Ziff, O. J., Banerjee, G., Ambler, G., et al. (2018) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2018-318483 · Cited by 79 · see citing works
Spontaneously beating cardiomyocytes derived from white mature adipocytes
Jumabay, M., Zhang, R., Yao, Y., et al. (2009) · Cardiovascular Research · doi:10.1093/cvr/cvp267 · Cited by 75 · see citing works
Spadaccio, C., Antoniades, C. A., Nenna, A., Chung, C., Will, R., Chello, M., & Gaudino, M. F. L. (2019) · Cardiovascular Research · doi:10.1093/cvr/cvz214 · Cited by 75 · see citing works
Self-citationShaker, M. A., Elbadawy, H. M., & Shaker, M. A. (2019) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2019.118891 · Cited by 73 · see citing works
Application of targeted therapy strategies with nanomedicine delivery for atherosclerosis
Ou, L.-C., Zhong, S., Ou, J., & Tian, J. (2020) · Acta Pharmacologica Sinica · doi:10.1038/s41401-020-0436-0 · Cited by 71 · see citing works
Dendritic supramolecular assemblies for drug delivery
Morgan, M. T., Carnahan, M. A., Finkelstein, S., Prata, C. A. H., Degoricija, L., Lee, S. J., & Grinstaff, M. W. (2005) · Chemical Communications · doi:10.1039/b502411k · Cited by 69 · see citing works
High-dose Atorvastatin After Stroke or Transient Ischemic Attack
Amarenco, P., Bogousslavsky, J., & Callahan, A. (2006) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2006.10.008 · Cited by 62 · see citing works
Targeted Strategy in Lipid-Lowering Therapy
Dayar, E., & Pecháňová, O. (2022) · Biomedicines · doi:10.3390/biomedicines10051090 · Cited by 59 · see citing works
Atorvastatin decreases vascular endothelial growth factor in patients with coronary artery disease
Alber, H. F., Dulak, J., Frick, M., Dichtl, W., Schwarzacher, S. P., Pachinger, O. M., & Weidinger, F. F. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)01884-3 · Cited by 56 · see citing works
New possible pharmacological targets for statins and ezetimibe
Niedzielski, M., Broncel, M., Gorzelak‐Pabiś, P., & Woźniak, E. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110388 · Cited by 55 · see citing works
Mao, Y., Koga, J., Tokutome, M., Matoba, T., Ikeda, G., Nakano, K., & Egashira, K. (2017) · International Heart Journal · doi:10.1536/ihj.16-457 · Cited by 54 · see citing works
Jiang, T., Xu, L., Zhao, M., Kong, F., Lu, X.-R., Tang, C., & Yin, C.-H. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.121324 · Cited by 52 · see citing works
Yokoyama, R., Ii, M., Tabata, Y., Hoshiga, M., Ishizaka, N., & Asahi, M. (2019) · Stem Cells Translational Medicine · doi:10.1002/sctm.18-0244 · Cited by 51 · see citing works
Post, S., Post, M. C., den Branden, B. J. V., Eefting, F. D., Goumans, M., Stella, P. R., van Es, H. W., Wildbergh, T. X., Rensing, B. J. W. M., & Doevendans, P. A. (2012) · Catheterization and Cardiovascular Interventions · doi:10.1002/ccd.23449 · Cited by 50 · see citing works
Heinen, Y., Stegemann, E., Sansone, R., Benedens, K., Wagstaff, R., Balzer, J., Rassaf, T., Lauer, T., Kelm, M., & Heiß, C. (2015) · Journal of the American Heart Association · doi:10.1161/jaha.114.001472 · Cited by 49 · see citing works
Simvastatin Ameliorates Matrix Stiffness-Mediated Endothelial Monolayer Disruption
Lampi, M. C., Faber, C. J., Huynh, J., Bordeleau, F., Zanotelli, M. R., & Reinhart‐King, C. A. (2016) · PLoS ONE · doi:10.1371/journal.pone.0147033 · Cited by 48 · see citing works
Effect of Statins on Platelet Activation and Function: From Molecular Pathways to Clinical Effects
Nenna, A., Nappi, F., Lusini, M., Satriano, U. M., Schiliró, D., Spadaccio, C., & Chello, M. (2021) · BioMed Research International · doi:10.1155/2021/6661847 · Cited by 47 · see citing works
Self-citationNanotechnology for Targeted Therapy of Atherosclerosis
Nasr, S. H., & Huang, X. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.755569 · Cited by 46 · see citing works
Nenna, A., Nappi, F., Larobina, D., Verghi, E., Chello, M., & Ambrosio, L. (2021) · Polymers · doi:10.3390/polym13050711 · Cited by 44 · see citing works
Self-citationRibe, A. R., Vestergaard, C. H., Vestergaard, M., Fenger‐Grøn, M., Pedersen, H. S., Lietzen, L. W., & Brynningsen, P. K. (2019) · EClinicalMedicine · doi:10.1016/j.eclinm.2019.02.007 · Cited by 43 · see citing works
Cells and extracellular matrix interplay in cardiac valve disease: because age matters
Spadaccio, C., Mozetic, P., Nappi, F., Nenna, A., Sutherland, F. W. H., Trombetta, M., Chello, M., & Rainer, A. (2016) · Basic Research in Cardiology · doi:10.1007/s00395-016-0534-9 · Cited by 42 · see citing works
Self-citationNano-medicine and Vascular Endothelial Dysfunction: Options and Delivery Strategies
Taneja, G., Sud, A., Pendse, N., Panigrahi, B. P., Kumar, A., & Sharma, A. K. (2018) · Cardiovascular Toxicology · doi:10.1007/s12012-018-9491-x · Cited by 41 · see citing works
Enhancement of atorvastatin oral bioavailability via encapsulation in polymeric nanoparticles
Shaker, M. A., Elbadawy, H. M., Thagfan, S. S. A., & Shaker, M. A. (2020) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2020.120077 · Cited by 41 · see citing works
Class-specific pro-apoptotic effect of statins on human vascular endothelial cells
Wallwiener, D. R., M�ck, A. O., & Seeger, H. (2004) · Zeitschrift für Kardiologie · doi:10.1007/s00392-004-0081-5 · Cited by 39 · see citing works
Atar, S., Cannon, C. P., Murphy, S. A., et al. (2006) · American Heart Journal · doi:10.1016/j.ahj.2006.02.013 · Cited by 39 · see citing works
Meola, T. R., Abuhelwa, A. Y., Joyce, P., Clifton, P. M., & Prestidge, C. A. (2020) · Drug Delivery and Translational Research · doi:10.1007/s13346-020-00853-x · Cited by 37 · see citing works
Nanoparticle-Mediated Delivery of Anticancer Agents to Tumor Angiogenic Vessels
Asai, T. (2012) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b212013 · Cited by 36 · see citing works
Sugimoto, M., Yamanouchi, D., & Komori, K. (2009) · Surgery Today · doi:10.1007/s00595-008-3912-6 · Cited by 36 · see citing works
Cianflone, E., Cappetta, D., Mancuso, T., Sabatino, J., Marino, F., Scalise, M., Albanese, M., Salatino, A., Parrotta, E. I., Cuda, G., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21217927 · Cited by 36 · see citing works
Reichert, K., do Carmo, H. R. P., Torina, A. G., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0166845 · Cited by 35 · see citing works
Groner, J., Göpferich, A. M., & Breunig, M. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.03.034 · Cited by 34 · see citing works
Vascular Inflammation: A Novel Access Route for Nanomedicine
Molinaro, R., Boada, C., del Rosal, G. M., Hartman, K. A., Corbo, C., Andrews, E. D., Furman, N. E. T., Cooke, J. P., & Tasciotti, E. (2016) · Methodist DeBakey Cardiovascular Journal · doi:10.14797/mdcj-12-3-169 · Cited by 33 · see citing works
Schaefer, C. A., Kuhlmann, C. R. W., Gast, C., et al. (2004) · Vascular Pharmacology · doi:10.1016/j.vph.2004.05.002 · Cited by 32 · see citing works
The Role of Angiogenesis and Arteriogenesis in Myocardial Infarction and Coronary Revascularization
Spadaccio, C., Nenna, A., Rose, D., Piccirillo, F., Nusca, A., Grigioni, F., Chello, M., & Vlahakes, G. J. (2022) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-022-10241-0 · Cited by 32 · see citing works
Self-citationLiposomal nanocarriers for statins: A pharmacokinetic and pharmacodynamics appraisal
Askarizadeh, A., Butler, A. E., Badiee, A., & Sahebkar, A. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27121 · Cited by 31 · see citing works
Treating Coronary Artery Disease: Beyond Statins, Ezetimibe, and PCSK9 Inhibition
Musunuru, K. (2020) · Annual Review of Medicine · doi:10.1146/annurev-med-080819-044918 · Cited by 31 · see citing works
Chu, J., Chen, L., Mo, Z., Bowlin, G. L., Minden‐Birkenmaier, B. A., Morsi, Y., Aldalbahi, A. K., El-Newehy, M. H., Wang, W., & Mo, X. (2020) · Acta Biomaterialia · doi:10.1016/j.actbio.2020.04.044 · Cited by 30 · see citing works
PD-PK evaluation of freeze-dried atorvastatin calcium-loaded poly-ε-caprolactone nanoparticles
Ahmed, I. S., Hosary, R. E., Shalaby, S. H., Abd‐Rabo, M. M., ElKhateeb, D. G., & Nour, S. A. E.-K. (2016) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2016.03.045 · Cited by 28 · see citing works
Katsuki, S., Koga, J., Matoba, T., Umezu, R., Nakashiro, S., Nakano, K., Tsutsui, H., & Egashira, K. (2021) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.54379 · Cited by 26 · see citing works
Badillo, R., Schmidt, R., Mortensen, E. M., et al. (2015) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.3817 · Cited by 21 · see citing works
Fluvastatin induces apoptosis of vascular endothelial cells: blockade by glucocorticoids
NEWTON, C. J. (2003) · Cardiovascular Surgery · doi:10.1016/s0967-2109(02)00117-5 · Cited by 20 · see citing works
Wijaya, A., Wang, Y., Tang, D., Zhong, Y., Liu, B., Meng, Y., Jiu, Q., Wu, W., & Wang, G. (2021) · Journal of Materials Chemistry B · doi:10.1039/d1tb01455b · Cited by 20 · see citing works
Atanasio, G. D. N., Ferrari, P. F., Baião, A., et al. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.08.063 · Cited by 20 · see citing works
Hide, D., Gil, M., Andrade, F., Rafael, D. F. D. S., Raurell, I., Bravo, M., Barberá, A., Gracia‐Sancho, J., Vargas, V., Augustín, S., et al. (2020) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2020.102267 · Cited by 19 · see citing works
Buabeid, M. A., Arafa, E. A., Yaseen, H. S., Umar, M. I., & Murtaza, G. (2022) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2022.2098306 · Cited by 19 · see citing works
Matsumoto, T., Yamashita, S., Yoshino, S., et al. (2020) · Annals of Vascular Diseases · doi:10.3400/avd.ra.19-00130 · Cited by 18 · see citing works
Combined Therapeutics for Atherosclerosis Treatment Using Polymeric Nanovectors
Leal-Martínez, B. H., Velasco, B., Cambón, A., Pardo, A., Fernández‐Vega, J., Arellano, L., Al‐Modlej, A., Mosquera, V., Bouzas‐Mosquera, A., Prieto, G., et al. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14020258 · Cited by 17 · see citing works
Nenna, A., Spadaccio, C., Prestipino, F., et al. (2015) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2015.11.040 · Cited by 16 · see citing works
Self-citationNappi, F., Nenna, A., Larobina, D., Martuscelli, G., Singh, S., Chello, M., & Ambrosio, L. (2021) · Polymers · doi:10.3390/polym13030446 · Cited by 16 · see citing works
Self-citationRikala, M., Hauta‐aho, M., Helin‐Salmivaara, A., Lassila, R., Korhonen, M. J., & Huupponen, R. (2014) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.12373 · Cited by 15 · see citing works
Shin, D., Yoon, D., Lim, S. G., Hong, J. M., Park, R. W., & Lee, J. S. (2016) · PLoS ONE · doi:10.1371/journal.pone.0158130 · Cited by 15 · see citing works
Macrophage-targeted nanomedicine for the diagnosis and management of atherosclerosis
Hu, P. P., Luo, S. X., Fan, X. Q., Li, D., & Tong, X. Y. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1000316 · Cited by 15 · see citing works
Intraluminal Delivery of Simvastatin Attenuates Intimal Hyperplasia After Arterial Injury
Helkin, A. W., Bruch, D., Wilson, D. R., Gruessner, A. C., Bader, R. A., Maier, K. G., & Gahtan, V. (2019) · Vascular and Endovascular Surgery · doi:10.1177/1538574419833224 · Cited by 14 · see citing works
Statin use decreases coagulation in users of vitamin K antagonists
van Rein, N., Biedermann, J. S., Bonafacio, S. M., et al. (2016) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-016-2138-6 · Cited by 11 · see citing works
Yao, G.-T., Song, L., Xue, W., et al. (2017) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2017.03.015 · Cited by 11 · see citing works
Nenna, A., Lusini, M., Spadaccio, C., Nappi, F., Prestipino, F., Barbato, R., Casacalenda, A., Pugliese, G., Barberi, F., Giacinto, O., et al. (2017) · Journal of Cardiovascular Medicine · doi:10.2459/jcm.0000000000000550 · Cited by 11 · see citing works
Self-citationMontelione, N., Catanese, V., Nenna, A., et al. (2022) · Diagnostics · doi:10.3390/diagnostics12092207 · Cited by 8 · see citing works
Self-citationRiva, N., Minno, M. N. D. D., Mumoli, N., et al. (2015) · Haematologica · doi:10.3324/haematol.2015.127183 · Cited by 7 · see citing works
What is new in lipid‐lowering therapies in diabetes?
Cheung, Y.-M. M., O’Brien, R., & Ekinci, E. I. (2019) · Internal Medicine Journal · doi:10.1111/imj.14291 · Cited by 7 · see citing works
Hu, H.-J., Zhou, S., & Liu, Q. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.03.286 · Cited by 5 · see citing works
Nenna, A., Spadaccio, C., Lusini, M., Nappi, F., Mastroianni, C., Giacinto, O., Pugliese, G., Casacalenda, A., Barbato, R., Barberi, F., et al. (2019) · Interactive Cardiovascular and Thoracic Surgery · doi:10.1093/icvts/ivz012 · Cited by 5 · see citing works
Self-citationWang, H., Li, J., Fu, X., Liu, Y., Xu, Q., & Sang, L. (2018) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2018.6583 · Cited by 3 · see citing works
Can Statins Modify the Wound Healing Process After Myocardial Infarction?
Hasegawa, H. (2017) · International Heart Journal · doi:10.1536/ihj.17-303 · Cited by 2 · see citing works
Fluvastatin Induces Apoptosis of Vascular Endothelial Cells: Blockade by Glucocorticoids
NEWTON, C. J., Xie, Y.-X., Burgoyne, C. H., et al. (2003) · Cardiovascular Surgery · doi:10.1177/096721090301100110 · Cited by 2 · see citing works
Killing the Culprit: Pharmacological Solutions to Get Rid of Cholesterol Crystals
Iranshahy, M., Banach, M., Hasanpour, M., Lavie, C. J., & Sahebkar, A. (2022) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2022.101274 · Cited by 1 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
e Silva, D. M., de Souza Lacerda, L., de Souza Andrioli, A., Braz, W. R., Campos, L. M., de Paiva, M. R. B., Pittella, F., Fabri, R. L., & Tavares, G. D. (2025) · Fundamental & Clinical Pharmacology · doi:10.1111/fcp.70046 · Cited by 7 · see citing works
“Polymeric nanoparticles, such as those fabricated from polylactic- co-glycolic acid (PLGA), enable controlled and sustained drug release, with architectures that can be tuned as nanospheres or nanocapsules depending on polymer arrangement [30].”
- Authors
- Montelione, N., Loreni, F., Nenna, A., Catanese, V., Scurto, L., Ferrisi, C., Jawabra, M., Gabellini, T., Codispoti, F. A., Spinelli, F., Chello, M., & Stilo, F.
- Affiliations
- Università Campus Bio-Medico (IT)
- University of Ferrara (IT)
- Corresponding author
- Nenna, Antonio
- ORCID
- Venue
- Biomedicines
- Publisher
- MDPI AG
- Published
- 2023-03-06
- Volume
- 11
- Issue
- 3
- Pages
- 798
- ISSN
- 2227-9059 (ISSN-L)
- PMC
- PMC10045667
- OpenAlex
- W4323365158
- Cited by
- 30
- References
- 107
- Citations by year
- 2026: 8 · 2025: 10 · 2024: 9 · 2023: 3
- FWCI
- 0.53
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Biomedicines (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Keywords
- statins, targeted drug delivery, polymeric nanocarriers, atherosclerosis, coronary artery disease, PLGA nanoparticles, drug delivery systems, bioavailability, endothelial dysfunction, intimal hyperplasia, re-endothelialization, tissue engineering, ischemia-reperfusion injury
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
