Cited by 61MicroRNA in disease regulationTreatment of Major DepressionTryptophan and brain disorders

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MicroRNAs as Critical Biomarkers of Major Depressive Disorder: A Comprehensive Perspective

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Ortega, Miguel A., Alvarez-Mon, Miguel Angel, García-Montero, Cielo, Fraile-Martinez, Oscar, Lahera, Guillermo, Monserrat, Jorge, Muñoz-Merida, Luis, Mora, Fernando, Rodríguez-Jiménez, Roberto, Fernandez-Rojo, Sonia, Quintero, Javier, Álvarez-Mon, Melchor·2021·Biomedicines

DOI 10.3390/biomedicines9111659PMC PMC8615526

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Abstract

Major Depressive Disorder (MDD) represents a major global health concern, a body-mind malady of rising prevalence worldwide nowadays. The complex network of mechanisms involved in MDD pathophysiology is subjected to epigenetic changes modulated by microRNAs (miRNAs). Serum free or vesicles loaded miRNAs have starred numerous publications, denoting a key role in cell-cell communication, systematically and in brain structure and neuronal morphogenesis, activity and plasticity. Upregulated or downregulated expression of these signaling molecules may imply the impairment of genes implicated in pathways of MDD etiopathogenesis (neuroinflammation, brain-derived neurotrophic factor (BDNF), neurotransmitters, hypothalamic-pituitary-adrenal (HPA) axis, oxidative stress, circadian rhythms...). In addition, these miRNAs could serve as potential biomarkers with diagnostic, prognostic and predictive value, allowing to classify severity of the disease or to make decisions in clinical management. They have been considered as promising therapy targets as well and may interfere with available antidepressant treatments. As epigenetic malleable regulators, we also conclude emphasizing lifestyle interventions with physical activity, mindfulness and diet, opening the door to new clinical management considerations.

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Figure 1 Mechanisms involved in the etiopathogenesis of MDD in which miRNAs may be key mediators BBB: blood brain barrier. 5-HT: serotonin. DA: dopamine. NE: norepinephrine. GABA: gamma-aminobutyric acid. MGB axis: microbiota-gut-brain axis. HPA axis: hypothalamic-pituitary-adrenal axis. Kyn: kynurenine. LPS: lipopolysaccharide.CC BY · PubMed Central

Figure 2 A general picture of the molecular background of miRNAs in MDD. As showed, there are multiple pathways affected by the dysregulation of a set of miRNAs in this mental disorder. Some of their molecular targets are involved in critical pathophysiological mechanisms of MDD, and either the upregulation (represented in green) or downregulation (In red) may be partly responsible for the changes in the neurons and glial cells of depressed individuals. Some of these alterations have been reported in critical areas of the brain such as the amygdala or the hippocampus, clearly implicated in the etiopathogenesis of MDD. Finally, there are some miRNAs that may be regulated by the exposure to the pathological environment including after acute or prolonged stress or due to the endotoxemia and neuroinflammation.CC BY · PubMed Central

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Ryan, K. M., O'Donovan, S. M., & McLoughlin, D. M. (2013) · Neuroscience Letters · doi:10.1016/j.neulet.2013.05.035 · Cited by 44
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Ferrúa, C. P., Giorgi, R., Camerini, L., do Amaral, C. C., Ghisleni, G., Pinheiro, R. T., & Nedel, F. (2019) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2019.101650 · Cited by 44
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He, C., Bai, Y., Wang, Z., Fan, D., Wang, Q., Liu, X., Zhang, H., Zhang, H., Zhang, Z., Yao, H., et al. (2021) · NeuroImage · doi:10.1016/j.neuroimage.2020.117428 · Cited by 44
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Ng, C., How, C., & Ng, Y. (2016) · Singapore Medical Journal · doi:10.11622/smedj.2016174 · Cited by 42
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Aten, S., Page, C. E., Kalidindi, A., Wheaton, K. L., Niraula, A., Godbout, J. P., Hoyt, K. R., & Obrietan, K. H. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.10.020 · Cited by 40
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Xie, L., Chen, J., Yong-min, D., Gui, X., Wu, L., Tian, S., & Wu, W. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.02.078 · Cited by 38
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Cattaneo, A., Suderman, M. J., Cattane, N., Mazzelli, M., Begni, V., Maj, C., D'Aprile, I., Pariante, C. M., Luoni, A., Berry, A., et al. (2020) · Neurobiology of Stress · doi:10.1016/j.ynstr.2020.100271 · Cited by 38
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Liu, C., Zhong, M., Sun, J., Jin, H., Gao, Y., & Qin, F.-X. (2021) · Molecular Medicine Reports · doi:10.3892/mmr.2021.12102 · Cited by 38
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Lopizzo, N., Zonca, V., Cattane, N., Pariante, C. M., & Cattaneo, A. (2019) · Journal of Neural Transmission · doi:10.1007/s00702-019-02048-2 · Cited by 37
Screening of specific microRNA in hippocampus of depression model rats and intervention effect of Chaihu Shugan San
Cao, M.-Q., Chen, D.-H., Zhang, C., & Wu, Z. (2013) · China Journal of Chinese Materia Medica · doi:10.4268/cjcmm201301027 · Cited by 36
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Zhao, L., Li, H., Guo, R.-Y., Ma, T., Hou, R., Ma, X., & Du, Y. (2013) · PubMed Central · doi:10.3969/j.issn.1673-5374.2013.26.005 · Cited by 34
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Choi, J., Kang, S., Lee, Y., Hong, S., Sanek, N. A., Young, W. S., & Lee, H. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12308 · Cited by 34
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Feng, J., Wang, M., Li, M., Yang, J., Jia, J., Liu, L., Zhou, J. F., Zhang, C., & Wang, X. (2019) · Brain Research · doi:10.1016/j.brainres.2019.06.015 · Cited by 34
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Bahí, A., & Dreyer, J. (2018) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2018.09.004 · Cited by 33
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Qi, B., Fiori, L. M., Turecki, G., & Trakadis, Y. J. (2020) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyaa029 · Cited by 33
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Jiang, T., Hu, S., Dai, S., Yi, Y., Wang, T., Li, X., Luo, M., Li, K., Chen, L., Wang, H., et al. (2022) · Cell Biology and Toxicology · doi:10.1007/s10565-021-09590-4 · Cited by 33
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Liu, Y., Liu, D., Xu, J., Jiang, H., & Pan, F. (2017) · Developmental Psychobiology · doi:10.1002/dev.21558 · Cited by 32
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Sun, X., Song, M.-F., Song, H., Wang, Y., Luo, M., & Yin, L. (2019) · Molecular Medicine Reports · doi:10.3892/mmr.2019.9917 · Cited by 32
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Ciernia, A. V., Laufer, B. I., Dunaway, K. W., Mordaunt, C. E., Coulson, R. L., Totah, T. S., Stolzenberg, D. S., Frahm, J. C., Singh-Taylor, A., Baram, T. Z., et al. (2018) · Epigenetics · doi:10.1080/15592294.2018.1451720 · Cited by 31
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Peruga, I., Hartwig, S., Merkler, D., Thöne, J., Hovemann, B. T., Juckel, G., Gold, R., & Linker, R. A. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.01.020 · Cited by 28
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Liang, Y., Zhao, G., Sun, R., Mao, Y., Li, G., Chen, X., Gao, L., & Hu, Z. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.04.035 · Cited by 28
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Iacono, L. L., Ielpo, D., Accoto, A., Segni, M. D., Babicola, L., D’Addario, S. L., Ferlazzo, F., Pascucci, T., Ventura, R., & Andolina, D. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-01750-2 · Cited by 28
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Yi, L., Zhu, J., Dong, S., Li, C., Zhang, Q., Cheng, J., & Liu, Q. (2020) · Neurobiology of Stress · doi:10.1016/j.ynstr.2020.100243 · Cited by 27
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Camkurt, M. A., Güneş, S., Coşkun, S., & Fındıklı, E. (2017) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2017.15.4.313 · Cited by 26
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Wei, Y. B., Melas, P. A., Villaescusa, J. C., Liu, J. J., Xu, N., Christiansen, S. H., Elbrønd-Bek, H., Woldbye, D. P. D., Wegener, G., Mathé, A. A., et al. (2016) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyw069 · Cited by 25
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Wang, X., Sundquist, K., Palmér, K., Hedelius, A., Memon, A. A., & Sundquist, J. (2018) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyy001 · Cited by 25
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Παπανώτα, Α.-Μ., Karousi, P., Kontos, C. K., Ntanasis‐Stathopoulos, I., Scorilas, A., & Terpos, E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052375 · Cited by 25
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Xu, F. (2013) · Medical Science Monitor · doi:10.12659/msm.883935 · Cited by 24
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Yi, L., Mu, R.-H., Dong, S., Wang, S., Li, C., Geng, D., & Liu, Q. (2018) · Journal of Psychopharmacology · doi:10.1177/0269881118758304 · Cited by 23
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Suento, W. J., Kunisawa, K., Wulaer, B., Kosuge, A., Iida, T., Fujigaki, S., Fujigaki, H., Yamamoto, Y., Tanra, A. J., Saito, K., et al. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15222 · Cited by 22
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Soares, E. F. P., Reis, J., Rodrigues, M. F., Ribeiro, C., & Pereira, F. C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020542 · Cited by 22
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Li, Y., Wang, N., Pan, J., Wang, X., Zhao, Y., & Guo, Z. (2021) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s263079 · Cited by 22
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Artemaki, P. I., Letsos, P. A., Zoupa, I. C., Katsaraki, K., Karousi, P., Papageorgiou, S. G., Pappa, V., Scorilas, A., & Kontos, C. K. (2021) · Biomedicines · doi:10.3390/biomedicines9040333 · Cited by 22
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Tolahunase, M., Gautam, S., Sagar, R., Kumar, M., & Dada, R. (2021) · Frontiers in Bioscience-Scholar · doi:10.52586/s553 · Cited by 22
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Schatzberg, A. F. (2019) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2019.19030273 · Cited by 21
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Xiao, P., Zhang, X., Li, Y., Ma, Z., Si, S., & Gao, X. (2019) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2019.8228 · Cited by 21
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Ma, Z.-Y., Chen, F., Xiao, P., Zhang, X., & Xx, G. (2019) · PubMed · doi:10.26355/eurrev_201906_18087 · Cited by 21
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Liu, L., Wang, H., Yu, Y., Zeng, B., Rao, X., Chen, J., Zhou, C., Zheng, P., Pu, J., Yang, L., et al. (2020) · Epigenomics · doi:10.2217/epi-2019-0307 · Cited by 20
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Dwivedi, Y. (2013) · PubMed · Cited by 19
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Miao, N., Jin, J., Kim, S.-N., & Sun, T. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19030671 · Cited by 19
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Bourin, M. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-981-33-6044-0_10 · Cited by 19
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Sun, L., Bai, D., Lin, M., Eerdenidalai, Zhang, L., Wang, F., & Jin, S.-W. (2021) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2020.575345 · Cited by 16
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Hashizume, S., Nakano, M., Kubota, K., Sato, S., Himuro, N., Kobayashi, E., Takaoka, A., & Fujimiya, M. (2021) · Scientific Reports · doi:10.1038/s41598-021-01318-y · Cited by 16
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Hu, J., Zhou, W., Zhou, Z., Yang, Q., Xu, J., & Dong, W. (2020) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x20209162 · Cited by 15
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Serafini, G., Trabucco, A., Corsini, G. P., Escelsior, A., Amerio, A., Aguglia, A., Nasrallah, H. A., & Amore, M. (2021) · Biomarkers in Neuropsychiatry · doi:10.1016/j.bionps.2021.100035 · Cited by 14
The Italian dementia with Lewy bodies study group (DLB-SINdem): toward a standardization of clinical procedures and multicenter cohort studies design
On behalf of DLB-SINdem study group, Bonanni, L., Cagnin, A., Agosta, F., Babiloni, C., Borroni, B., Bozzali, M., Bruni, A. C., Filippi, M., Galimberti, D., et al. (2016) · Neurological Sciences · doi:10.1007/s10072-016-2713-8 · Cited by 13
A Functional Polymorphism in the DRD1 Gene, That Modulates Its Regulation by miR-504, Is Associated with Depressive Symptoms
Jiménez, K. M., Pereira‐Morales, A. J., & Forero, D. A. (2018) · Psychiatry Investigation · doi:10.30773/pi.2017.10.16.1 · Cited by 13
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Solich, J., Kuśmider, M., Faron-Górecka, A., Pabian, P., & Dziedzicka-Wasylewska, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249469 · Cited by 13
MicroRNA’s impact on neurotransmitter and neuropeptide systems: small but mighty mediators of anxiety
Martinetz, S. (2016) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-016-1814-9 · Cited by 12
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Xu, C., Yang, C., Zhang, A., Xu, Y. J., Li, X., Liu, Z., Liu, S., Sun, N., & Zhang, K. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.04.061 · Cited by 11
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Lin, C. C., Lee, C. T., Sun, M. H., & Huang, T. L. (2017) · Neuropsychiatry · doi:10.4172/neuropsychiatry.1000297 · Cited by 11
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Shimada, M., Otowa, T., Miyagawa, T., Umekage, T., Kawamura, Y., Bundo, M., Iwamoto, K., Ikegame, T., Tochigi, M., Kasai, K., et al. (2018) · Journal of Human Genetics · doi:10.1038/s10038-017-0382-y · Cited by 11
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Cui, Y., Ma, G., Kong, F., & Song, L. (2021) · Iranian Journal of Public Health · doi:10.18502/ijph.v50i6.6423 · Cited by 11
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Kaadt, E., Højgaard, K., Mumm, B. H., Christiansen, S. L., Müller, H. K., Damgaard, C. K., & Elfving, B. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110052 · Cited by 9
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The association between placebo arm inclusion and adverse event rates in antidepressant randomized controlled trials: An examination of the Nocebo Effect.
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Hashizume, S., Nakano, M. H., Kubota, K., Kobayashi, E., & Fujimiya, M. (2021) · Research Square · doi:10.21203/rs.3.rs-199928/v1 · Cited by 1
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Authors: Ortega, M. A., Alvarez-Mon, M. A., García-Montero, C., Fraile-Martinez, O., Lahera, G., Monserrat, J., Muñoz-Merida, L., Mora, F., Rodríguez-Jiménez, R., Fernandez-Rojo, S., Quintero, J., & Álvarez-Mon, M.
Affiliations: Universidad de Alcalá (ES)
Department of Medicine and Medical Specialities, University of Alcala, 28801 Alcalá de Henares, Spain
Universidad Complutense de Madrid (ES)
Department of Legal Medicine and Psychiatry, Complutense University, 28040 Madrid, Spain
Cancer Registry and Pathology Department, Hospital Universitario Principe de Asturias, 28806 Alcalá de Henares, Spain
ORCID: Ortega, Miguel A.
García-Montero, Cielo
Fraile-Martinez, Oscar
Lahera, Guillermo
Monserrat, Jorge
Mora, Fernando
Fernandez-Rojo, Sonia
Venue: Biomedicines
Publisher: MDPI AG
Published: 2021-11-10
Volume: 9
Issue: 11
Pages: 1659
ISSN: 2227-9059 (ISSN-L)
DOI: 10.3390/biomedicines9111659
PMC: PMC8615526
OpenAlex: W3211397738
Cited by: 57
References: 296
Citations by year: 2026: 13 · 2025: 14 · 2024: 11 · 2023: 10 · 2022: 9
FWCI: 0.90
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Biomedicines (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Instituto de Salud Carlos III (PI18/01726)
Comunidad de Madrid (B2017/BMD3804)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords: major depressive disorder, microRNA, biomarkers, epigenetics, serum microRNA, extracellular vesicles, neuroinflammation, brain-derived neurotrophic factor, hypothalamic-pituitary-adrenal axis, oxidative stress, circadian rhythm, antidepressant targets, lifestyle intervention, physical activity, mindfulness, diet

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MicroRNAs as Critical Biomarkers of Major Depressive Disorder: A Comprehensive Perspective

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