miRNAs in depression vulnerability and resilience: novel targets for preventive strategies
Open accessAbstract
The exposure to stressful experiences during the prenatal period and through the first years of life is known to affect the brain developmental trajectories, leading to an enhanced vulnerability for the development of several psychiatric disorders later in life. However, not all the subjects exposed to the same stressful experience develop a pathologic condition, as some of them, activating coping strategies, become more resilient. The disclosure of mechanisms associated with stress vulnerability or resilience may allow the identification of novel biological processes and potential molecules that, if properly targeted, may prevent susceptibility or potentiate resilience. Over the last years, miRNAs have been proposed as one of the epigenetic mechanisms mediating the long-lasting effects of stress. Accordingly, they are associated with the development of stress vulnerability or resilience-related strategies. Moreover, miRNAs have been proposed as possible biomarkers able to identify subjects at high risk to develop depression and to predict the response to pharmacological treatments. In this review, we aimed to provide an overview of findings from studies in rodents and humans focused on the involvement of miRNAs in the mechanisms of stress response with the final goal to identify distinct sets of miRNAs involved in stress vulnerability or resilience. In addition, we reviewed studies on alterations of miRNAs in the context of depression, showing data on the involvement of miRNAs in the pathogenesis of the disease and in the efficacy of pharmacological treatments, discussing the potential utility of miRNAs as peripheral biomarkers able to predict the treatment response.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
MiRNAs may mediate these effects in depression by influencing neuronal production, differentiation, proliferation, and synaptic plasticity.
“MiRNAs may mediate these effects in depression by influencing neuronal production, differentiation, proliferation and synaptic plasticity.258”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [258]
The “Stress, depression, and miRNAs” section links miRNAs to depression vulnerability and to cell proliferation and differentiation generally. The sections on stress vulnerability and human studies also discuss miRNAs in neurogenesis, synapse formation, and neuroplasticity-related mechanisms. Our copy does not specifically establish that miRNAs mediate depression through all four named neuronal processes, particularly synaptic plasticity. (LLM, conf=0.84)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Bartel (2004) · doi:10.1016/s0092-8674(04)00045-5 · Cited by 34,714 · see citing works
Most mammalian mRNAs are conserved targets of microRNAs
Friedman, R. C., Farh, K. K.-H., Burge, C. B., & Bartel, D. P. (2009) · Genome Research · doi:10.1101/gr.082701.108 · Cited by 8,462 · see citing works
MicroRNA therapeutics: towards a new era for the management of cancer and other diseases
Rupaimoole, R., & Slack, F. J. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.246 · Cited by 4,741 · see citing works
A Neurotrophic Model for Stress-Related Mood Disorders
Duman, R. S., & Monteggia, L. M. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.02.013 · Cited by 3,375 · see citing works
Bushati, N., & Cohen, S. M. (2007) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.23.090506.123406 · Cited by 2,563 · see citing works
Roles for MicroRNAs in Conferring Robustness to Biological Processes
Ebert, M. S., & Sharp, P. A. (2012) · Cell · doi:10.1016/j.cell.2012.04.005 · Cited by 1,564 · see citing works
Mapping the Human miRNA Interactome by CLASH Reveals Frequent Noncanonical Binding
Helwak, A., Kudla, G., Dudnakova, T., & Tollervey, D. (2013) · Cell · doi:10.1016/j.cell.2013.03.043 · Cited by 1,269 · see citing works
The promises and pitfalls of RNA-interference-based therapeutics
Castanotto, D., & Rossi, J. J. (2009) · Nature · doi:10.1038/nature07758 · Cited by 1,219 · see citing works
Brain on stress: how the social environment gets under the skin
McEwen, B. S. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1121254109 · Cited by 1,200 · see citing works
MicroRNA in Control of Gene Expression: An Overview of Nuclear Functions
Catalanotto, C., Cogoni, C., & Zardo, G. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17101712 · Cited by 1,191 · see citing works
Kennedy, S. H., Lam, R. W., McIntyre, R. S., Tourjman, S. V., Bhat, V., Blier, P., Hasnain, M., Jollant, F., Levitt, A. J., MacQueen, G. M., et al. (2016) · The Canadian Journal of Psychiatry · doi:10.1177/0706743716659417 · Cited by 1,150 · see citing works
Keller, J., Gomez, R., Williams, G., Lembke, A., Lazzeroni, L., Murphy, G. M., & Schatzberg, A. F. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.120 · Cited by 922 · see citing works
MicroRNAs: Synthesis, mechanism, function, and recent clinical trials
Wahid, F., Shehzad, A., Khan, T., & Kim, Y. Y. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2010.06.013 · Cited by 902 · see citing works
Regulation of Neurotransmitter Release by Metabotropic Glutamate Receptors
Cartmell, J., & Schoepp, D. D. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0750889.x · Cited by 883 · see citing works
miR-124 regulates adult neurogenesis in the subventricular zone stem cell niche
Cheng, L.-C., Pastrana, E., Tavazoie, M., & Doetsch, F. (2009) · Nature Neuroscience · doi:10.1038/nn.2294 · Cited by 865 · see citing works
Therapeutic miRNA and siRNA: Moving from Bench to Clinic as Next Generation Medicine
Chakraborty, C., Sharma, A. R., Sharma, G., Doss, C. G. P., & Lee, S. (2017) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2017.06.005 · Cited by 731 · see citing works
Role of neurotrophic factors in depression
CASTREN, E., VOIKAR, V, & RANTAMAKI, T. (2007) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2006.08.009 · Cited by 667 · see citing works
MiR-16 Targets the Serotonin Transporter: A New Facet for Adaptive Responses to Antidepressants
Baudry, A., Mouillet-Richard, S., Schneider, B., Launay, J.-M., & Kellermann, O. (2010) · Science · doi:10.1126/science.1193692 · Cited by 480 · see citing works
The Roles of BDNF in the Pathophysiology of Major Depression and in Antidepressant Treatment
Lee, B.-H., & Kim, Y. (2010) · Psychiatry Investigation · doi:10.4306/pi.2010.7.4.231 · Cited by 447 · see citing works
Uchida, S., Hara, K., Kobayashi, A., Otsuki, K., Yamagata, H., Hobara, T., Suzuki, T., Miyata, N., & Watanabe, Y. (2011) · Neuron · doi:10.1016/j.neuron.2010.12.023 · Cited by 398 · see citing works
The mTOR signaling pathway in the prefrontal cortex is compromised in major depressive disorder
Jernigan, C. S., Goswami, D. B., Austin, M. C., Iyo, A. H., Chandran, A., Stockmeier, C. A., & Karolewicz, B. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2011.05.010 · Cited by 386 · see citing works
Glycogen Synthase Kinase-3 (GSK3) in Psychiatric Diseases and Therapeutic Interventions
Jope, R. S., & Roh, M. (2006) · Current Drug Targets · doi:10.2174/1389450110607011421 · Cited by 382 · see citing works
Juruena, M. F., Bocharova, M., Agustini, B., & Young, A. H. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.09.052 · Cited by 365 · see citing works
Epigenetics of Stress-Related Psychiatric Disorders and Gene × Environment Interactions
Klengel, T., & Binder, E. B. (2015) · Neuron · doi:10.1016/j.neuron.2015.05.036 · Cited by 353 · see citing works
Epigenetic basis of mental illness
Nestler, E. J., Peña, C. J., Kundakovic, M., Mitchell, A., & Akbarian, S. (2016) · The Neuroscientist · doi:10.1177/1073858415608147 · Cited by 342 · see citing works
Smalheiser, N. R., Lugli, G., Rizavi, H. S., Torvik, V. I., Turecki, G., & Dwivedi, Y. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033201 · Cited by 324 · see citing works
Issler, O., Haramati, S., Paul, E. D., Maeno, H., Navon, I., Zwang, R., Gil, S., Mayberg, H. S., Dunlop, B. W., Menke, A., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.05.042 · Cited by 318 · see citing works
Lopez, J. P., Lim, R., Cruceanu, C., Crapper, L., Fasano, C., Labonte, B., Maussion, G., Yang, J. P., Yerko, V., Vigneault, E., et al. (2014) · Nature Medicine · doi:10.1038/nm.3582 · Cited by 308 · see citing works
Role of MicroRNA Processing in Adipose Tissue in Stress Defense and Longevity
Mori, M. A., Raghavan, P., Thomou, T., Boucher, J., Robida-Stubbs, S., Macotela, Y., Russell, S. J., Kirkland, J. L., Blackwell, T. K., & Kahn, C. R. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.07.017 · Cited by 279 · see citing works
Childhood Determinants of Adult Psychiatric Disorder
Fryers, T., & Brugha, T. S. (2013) · Clinical Practice and Epidemiology in Mental Health · doi:10.2174/1745017901309010001 · Cited by 274 · see citing works
RNA silencing and genome regulation
Almeida, R., & Allshire, R. C. (2005) · Trends in Cell Biology · doi:10.1016/j.tcb.2005.03.006 · Cited by 260 · see citing works
microRNA as Repressors of Stress-Induced Anxiety: The Case of Amygdalar miR-34
Haramati, S., Navon, I., Issler, O., Ezra-Nevo, G., Gil, S., Zwang, R., Hornstein, E., & Chen, A. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.1673-11.2011 · Cited by 252 · see citing works
β-catenin mediates stress resilience through Dicer1/microRNA regulation
Dias, C., Feng, J., Sun, H., Shao, N. Y., Mazei-Robison, M. S., Damez-Werno, D., Scobie, K., Bagot, R., LaBonté, B., Ribeiro, E., et al. (2014) · Nature · doi:10.1038/nature13976 · Cited by 240 · see citing works
Blood microRNA changes in depressed patients during antidepressant treatment
Bocchio-Chiavetto, L., Maffioletti, E., Bettinsoli, P., Giovannini, C., Bignotti, S., Tardito, D., Corrada, D., Milanesi, L., & Gennarelli, M. (2013) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2012.06.013 · Cited by 238 · see citing works
Early-life stress and HPA axis trigger recurrent adulthood depression.
Juruena, M. F. (2014) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2013.10.020 · Cited by 232 · see citing works
MicroRNAs as biomarkers for CNS disease
Rao, P., Benito, E., & Fischer, A. (2013) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2013.00039 · Cited by 226 · see citing works
Cirulli, F., Francia, N., Berry, A., Aloe, L., Alleva, E., & Suomi, S. J. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.09.001 · Cited by 225 · see citing works
Belzeaux-R, R., Bergon, A., Jeanjean, V., Loriod, B., Formisano‐Tréziny, C., Verrier, L., Loundou, A., Baumstarck, K., Boyer, L., Gall, V., et al. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.112 · Cited by 222 · see citing works
Bradley, S., Levey, A. I., Hersch, S. M., & Conn, P. J. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-06-02044.1996 · Cited by 209 · see citing works
Reduced levels of miRNAs 449 and 34 in sperm of mice and men exposed to early life stress
Dickson, D. A., Paulus, J. K., Mensah, V., Lem, J., Saavedra-Rodriguez, L., Gentry, A., Pagidas, K., & Feig, L. A. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0146-2 · Cited by 208 · see citing works
Alterations of Serum Levels of BDNF-Related miRNAs in Patients with Depression
Li, Y., Xu, M., Zong-hua, G., Wang, Y., Yue, Z., Zhang, Y.-X., Li, X., Zhang, C. M., Xie, S., & Wang, P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063648 · Cited by 204 · see citing works
Identification of MicroRNA-124-3p as a Putative Epigenetic Signature of Major Depressive Disorder
Roy, B., Dunbar, M., Shelton, R. C., & Dwivedi, Y. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.175 · Cited by 199 · see citing works
Bai, M., Zhu, X., Zhang, Y., Zhang, S., Zhang, L., Xue, L., Yi, J., Yao, S., & Zhang, X. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046921 · Cited by 195 · see citing works
Anatomy of RISC : how do small RNAs and chaperones activate Argonaute proteins?
Nakanishi, K. (2016) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1356 · Cited by 195 · see citing works
The role of mTOR in depression and antidepressant responses
Abelaira, H. M., Réus, G. Z., Neotti, M. V., & Quevedo, J. (2014) · Life Sciences · doi:10.1016/j.lfs.2014.02.014 · Cited by 186 · see citing works
Brümmer, A., & Hausser, J. (2014) · BioEssays · doi:10.1002/bies.201300104 · Cited by 185 · see citing works
Peripheral whole blood microRNA alterations in major depression and bipolar disorder
Maffioletti, E., Cattaneo, A., Rosso, G., Maina, G., Maj, C., Gennarelli, M., Tardito, D., & Bocchio-Chiavetto, L. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.04.021 · Cited by 181 · see citing works
Self-citationPeripheral and central mechanisms of stress resilience
Pfau, M. L., & Russo, S. J. (2015) · Neurobiology of Stress · doi:10.1016/j.ynstr.2014.09.004 · Cited by 170 · see citing works
Ma, K., Xu, A., Cui, S., Sun, M.-R., Xue, Y.-C., & Wang, J.-H. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.181 · Cited by 168 · see citing works
Mood disorders: Regulation by metabotropic glutamate receptors
Pilc, A., Chaki, S., Nowak, G., & Witkin, J. M. (2008) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.09.021 · Cited by 163 · see citing works
Hippocampal MicroRNA-124 Enhances Chronic Stress Resilience in Mice
Higuchi, F., Uchida, S., Yamagata, H., Abe-Higuchi, N., Hobara, T., Hara, K., Kobayashi, A., Shintaku, T., Itoh, Y., Suzuki, T., et al. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0319-16.2016 · Cited by 158 · see citing works
Early Life Stress, Mood, and Anxiety Disorders
Syed, S. A., & Nemeroff, C. B. (2017) · Chronic Stress · doi:10.1177/2470547017694461 · Cited by 154 · see citing works
Torres-Berrío, A., Lopez, J. P., Bagot, R. C., Nouel, D., Dal Bo, G., Cuesta, S., Zhu, L., Manitt, C., Eng, C., Cooper, H. M., et al. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.08.017 · Cited by 153 · see citing works
MicroRNAs as biomarkers for major depression: a role for let-7b and let-7c
Gururajan, A., Naughton, M., Scott, K. A., O’Connor, R. M., Moloney, G. M., Clarke, G. A., Dowling, J. L., Walsh, A. E. L., Ismail, M. F., Shorten, G., et al. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.131 · Cited by 144 · see citing works
Chandran, A., Iyo, A. H., Jernigan, C. S., Legutko, B., Austin, M. C., & Karolewicz, B. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.08.001 · Cited by 137 · see citing works
Fan, H., Sun, X., Guo, W., Zhong, A., Niu, W., Zhao, L., Dai, Y.-H., Guo, Z.-M., Zhang, L.-Y., & Lu, J. Z. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.08.007 · Cited by 129 · see citing works
Manitt, C., Eng, C., Pokinko, M., Ryan, R. T., Torres-Berrío, A., Lopez, J. P., Yogendran, S. V., Daubaras, M. J. J., Grant, A., Schmidt, E. R. E., et al. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.105 · Cited by 125 · see citing works
Maffioletti, E., Tardito, D., Gennarelli, M., & Bocchio‐Chiavetto, L. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00075 · Cited by 121 · see citing works
Yi, L., Li, J., Liu, B., Luo, L., Liu, Q., & Geng, D. (2014) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.130169 · Cited by 119 · see citing works
Raphe-mediated signals control the hippocampal response to SRI antidepressants via miR-16
Launay, J., Mouillet‐Richard, S., Baudry, A., Pietri, M., & Kellermann, O. (2011) · Translational Psychiatry · doi:10.1038/tp.2011.54 · Cited by 118 · see citing works
MicroRNA: Small RNA mediators of the brains genomic response to environmental stress
Hollins, S. L., & Cairns, M. J. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.06.005 · Cited by 117 · see citing works
Pearson-Leary, J., Eacret, D., Chen, R. J., Takano, H., Nicholas, B., & Bhatnagar, S. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.122 · Cited by 114 · see citing works
Song, M.-F., Dong, J., Wang, Y.-W., He, J., Ju, X., Zhang, L., Zhang, Y., Shi, J., & Lv, Y.-Y. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.02.022 · Cited by 111 · see citing works
Blood biomarkers and treatment response in major depression
Mora, C., Zonca, V., Riva, M. A., & Cattaneo, A. (2018) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2018.1470927 · Cited by 107 · see citing works
Self-citationCattaneo, A., Bocchio‐Chiavetto, L., Zanardini, R., Milanesi, E., Placentino, A., & Gennarelli, M. (2009) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145709990812 · Cited by 106 · see citing works
Self-citationZhang, Y., Wang, Y., Wang, L., Bai, M., Zhang, X., & Zhu, X. (2015) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyv025 · Cited by 104 · see citing works
Estrogen receptor α drives pro-resilient transcription in mouse models of depression
Lorsch, Z. S., Loh, Y.-H. E., Purushothaman, I., Walker, D. M., Parise, E. M., Salery, M., Cahill, M. E., Hodes, G. E., Pfau, M. L., Kronman, H., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03567-4 · Cited by 104 · see citing works
miR-17-92 cluster regulates adult hippocampal neurogenesis, anxiety and depression
Jin, J., Kim, S.-N., Liu, X., Zhang, H., Zhang, C., Seo, J.-S., Kim, Y., & Sun, T. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.06.101 · Cited by 103 · see citing works
Circulating microRNA-144-5p is associated with depressive disorders
Wang, X., Sundquist, K., Hedelius, A., Palmér, K., Memon, A. A., & Sundquist, J. (2015) · Clinical Epigenetics · doi:10.1186/s13148-015-0099-8 · Cited by 102 · see citing works
O'Connor, R. M., Grenham, S., Dinan, T. G., & Cryan, J. F. (2013) · International Journal of Neuropsychopharmacology · doi:10.1017/s1461145713000448 · Cited by 101 · see citing works
MicroRNAs as biomarkers of resilience or vulnerability to stress
Chen, R. J., Kelly, G., Sengupta, A., Heydendael, W., Nicholas, B., Beltrami, S., Luz, S., Peixoto, L., Abel, T. G., & Bhatnagar, S. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.07.045 · Cited by 100 · see citing works
Epigenetics and depressive disorders: a review of current progress and future directions
Januar, V., Saffery, R., & Ryan, J. (2015) · International Journal of Epidemiology · doi:10.1093/ije/dyu273 · Cited by 99 · see citing works
DICER1 and microRNA regulation in post-traumatic stress disorder with comorbid depression
Wingo, A. P., Almli, L. M., Stevens, J. S., Klengel, T., Uddin, M., Li, Y., Bustamante, A. C., Lori, A., Koen, N., Stein, D. J., et al. (2015) · Nature Communications · doi:10.1038/ncomms10106 · Cited by 98 · see citing works
Lin, P., & Tseng, P. (2015) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2015.02.004 · Cited by 95 · see citing works
He, S., Liu, X., Jiang, K., Peng, D., Hong, W., Fang, Y., Qian, Y., Yu, S., & Li, H. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.03.015 · Cited by 94 · see citing works
Serafini, G., Pompili, M., Hansen, K. F., Obrietan, K. H., Dwivedi, Y., Shomron, N., & Girardi, P. (2013) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-013-9997-5 · Cited by 93 · see citing works
D'Sa, C. M., Tolbert, L. M., Conti, M., & Duman, R. S. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00878.x · Cited by 92 · see citing works
Bahí, A., Chandrasekar, V., & Dreyer, J. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.04.009 · Cited by 89 · see citing works
Resilience and vulnerability: a neurobiological perspective
Karatsoreos, I. N., & McEwen, B. S. (2013) · F1000Prime Reports · doi:10.12703/p5-13 · Cited by 84 · see citing works
Lin28 and let-7: ancient milestones on the road from pluripotency to neurogenesis
Rehfeld, F., Rohde, A. M., Nguyen, D. T. T., & Wulczyn, F. G. (2014) · Cell and Tissue Research · doi:10.1007/s00441-014-1872-2 · Cited by 84 · see citing works
Zhang, Y., Zhu, X., Bai, M., Zhang, L., Xue, L., & Yi, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069934 · Cited by 83 · see citing works
MicroRNA dysregulation in neuropsychiatric disorders and cognitive dysfunction
Xu, B., Hsu, P.-K., Karayiorgou, M., & Gogos, J. A. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.02.016 · Cited by 82 · see citing works
Amygdalar MicroRNA-15a Is Essential for Coping with Chronic Stress
Volk, N., Pape, J. C., Engel, M., Zannas, A. S., Cattane, N., Cattaneo, A., Binder, E. B., & Chen, A. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.10.038 · Cited by 79 · see citing works
Self-citationThe Roles of Neurotrophic Factor and Wnt Signaling in Depression
Voleti, B., & Duman, R. S. (2011) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2011.296 · Cited by 78 · see citing works
Xu, J., Wang, R., Liu, Y., Liu, D., Jiang, H., & Pan, F. (2017) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2017.08.010 · Cited by 75 · see citing works
Hong-luan, Y., Fan, C., Yang, L., Yu, S., Song, Q., Wang, P., & Mao, X. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000492684 · Cited by 74 · see citing works
ENĂTESCU, V. R., Papavă, I., Enătescu, I., Antonescu, M., Anghel, A., Șeclăman, E. P., Sîrbu, I. O., & Marian, C. (2016) · Psychiatry Investigation · doi:10.4306/pi.2016.13.5.549 · Cited by 73 · see citing works
MiR-335 is involved in major depression disorder and antidepressant treatment through targeting GRM4
Li, J., Meng, H., Cao, W., & Qiu, T. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.08.038 · Cited by 73 · see citing works
Fiori, L. M., Lopez, J. P., Richard-Devantoy, S., Berlim, M., Chachamovich, E., Jollant, F., Foster, J., Rotzinger, S., Kennedy, S. H., & Turecki, G. (2017) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyx034 · Cited by 71 · see citing works
Ha, T.-Y. (2011) · Immune Network · doi:10.4110/in.2011.11.5.227 · Cited by 70 · see citing works
Kuang, W.-H., Dong, Z.-Q., Tian, L.-T., & Li, J. (2018) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x20187212 · Cited by 70 · see citing works
Yang, X., Yang, Q., Wang, X., Luo, C., Wan, Y., Li, J., Liu, K., Zhou, M., & Zhang, C. (2014) · NeuroMolecular Medicine · doi:10.1007/s12017-014-8312-z · Cited by 69 · see citing works
Oved, K., Morag, A., Pasmanik-Chor, M., Rehavi, M., Shomron, N., & Gurwitz, D. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.86 · Cited by 66 · see citing works
Oved, K., Morag, A., Pasmanik-Chor, M., Oron-Karni, V., Shomron, N., Rehavi, M., Stingl, J. C., & Gurwitz, D. (2012) · Pharmacogenomics · doi:10.2217/pgs.12.93 · Cited by 66 · see citing works
Role of netrin-1 in the organization and function of the mesocorticolimbic dopamine system
Flores, C. (2011) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.100171 · Cited by 64 · see citing works
Liu, B., Luo, L., Liu, X., Geng, D., Liu, Q., & Yi, L. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3690-3 · Cited by 61 · see citing works
Maheu, M., López, J. P., Crapper, L., Davoli, M. A., Turecki, G., & Mechawar, N. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.11 · Cited by 61 · see citing works
Schmidt, U., Herrmann, L., Hagl, K., Novak, B., Huber, C., Holsboer, F., Wotjak, C., & Buell, D. R. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00066 · Cited by 58 · see citing works
Lim, D., Oh, C.-T., Lee, L., Hong, J.-S., Noh, S.-H., Hwang, S., Kim, S., Han, S., & Lee, Y. S. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.08.034 · Cited by 54 · see citing works
Genetic Variations in MicroRNA Processing Genes Are Associated with Susceptibility in Depression
He, Y., Zhou, Y., Xi, Q., Cui, H., Luo, T., Song, H., Nie, X., Wang, L., & Ying, B. (2012) · DNA and Cell Biology · doi:10.1089/dna.2012.1660 · Cited by 52 · see citing works
Lopez, J. P., Pereira, F., Richard-Devantoy, S., Berlim, M., Chachamovich, E., Fiori, L. M., Niola, P., Turecki, G., & Jollant, F. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.9 · Cited by 50 · see citing works
Fan, D., Cao, M.-Q., Liu, Q., Sun, N.-N., & Wu, Z. (2018) · Neural Regeneration Research · doi:10.4103/1673-5374.232478 · Cited by 47 · see citing works
Developmental trajectories of brain maturation and behavior: Relevance to major mental illnesses
Lockhart, S., Sawa, A., & Niwa, M. (2018) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2018.04.008 · Cited by 45 · see citing works
Lin, C.-C., Tsai, M.-C., Lee, C., Sun, M.-H., & Huang, T. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.09.025 · Cited by 43 · see citing works
Electroconvulsive stimulation alters levels of BDNF-associated microRNAs
Ryan, K. M., O'Donovan, S. M., & McLoughlin, D. M. (2013) · Neuroscience Letters · doi:10.1016/j.neulet.2013.05.035 · Cited by 42 · see citing works
(2015) · PubMed Central · Cited by 40 · see citing works
Żurawek, D., Kuśmider, M., Faron‐Górecka, A., Gruca, P., Pabian, P., Kolasa, M., Solich, J., Szafran‐Pilch, K., Papp, M., & Dziedzicka‐Wasylewska, M. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.11.013 · Cited by 38 · see citing works
Aas, M., Dieset, I., Mørch, R. H., Steen, N. E., Hope, S., Reponen, E. J., Laskemoen, J. F., Ueland, T., Aukrust, P., Melle, I. S., et al. (2018) · Schizophrenia Research · doi:10.1016/j.schres.2018.08.007 · Cited by 38 · see citing works
Nunes, P. V., Nascimento, C. F., Kim, H. K., Andreazza, A. C., Brentani, H., Suemoto, C. K., Leite, R. E. P., Ferretti‐Rebustini, R. E. D. L., Pasqualucci, C. A., Nitríni, R., et al. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.08.025 · Cited by 37 · see citing works
Cao, M.-Q., Chen, D.-H., Zhang, C., & Wu, Z. (2013) · China Journal of Chinese Materia Medica · doi:10.4268/cjcmm201301027 · Cited by 36 · see citing works
Jiang, Y., & Zhu, J.-F. (2015) · Europe PMC (PubMed Central) · Cited by 36 · see citing works
Kavuran, İ. B., Etem, E. Ö., Tektemur, A., & Elyas, H. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.07.017 · Cited by 35 · see citing works
Ihara, K., Yoshida, H., Jones, P. B., Hashizume, M., Suzuki, Y., Ishijima, H., Kim, H., Suzuki, T., & Hachisu, M. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.47 · Cited by 34 · see citing works
Liu, Y., Liu, D., Xu, J., Jiang, H., & Pan, F. (2017) · Developmental Psychobiology · doi:10.1002/dev.21558 · Cited by 32 · see citing works
MicroRNA-326 acts as a molecular switch in the regulation of midbrain urocortin 1 expression
Aschrafi, A., Verheijen, J., Gordebeke, P. M., Loohuis, N. F. M. O., Menting, K. W., Jager, A., Palkovits, M., Geenen, B., Kos, A., Martens, G. J. M., et al. (2016) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.150154 · Cited by 31 · see citing works
Belzeaux-R, R., Lin, C., Ding, Y., Bergon, A., Ibrahim, E. C., Turecki, G., Tseng, G. C., & Sibille, E. L. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.07.009 · Cited by 31 · see citing works
Liang, Y., Zhao, G., Sun, R., Mao, Y., Li, G., Chen, X., Gao, L., & Hu, Z. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.04.035 · Cited by 28 · see citing works
Duan, D. M., Dong, X., Tu, Y., & Liu, P. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.05.054 · Cited by 28 · see citing works
Regulation of Glycogen Synthase Kinase-3 in Patients with Affective Disorders
O’Brien, W. T., & Klein, P. S. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.11.008 · Cited by 24 · see citing works
MicroRNA-Mediated Regulation of ITGB3 and CHL1 Is Implicated in SSRI Action
Oved, K., Farberov, L., Gilam, A., Israel‐Elgali, I., Haguel, D., Gurwitz, D., & Shomron, N. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00355 · Cited by 22 · see citing works
Matsukura, S., Osakabe, Y., Sekiguchi, A., Inoue, D., Kakiuchi, Y., Funaki, T., Yamazaki, Y., Takayasu, H., Tateno, H., Katô, E., et al. (2016) · Allergology International · doi:10.1016/j.alit.2016.04.018 · Cited by 20 · see citing works
Hippocampal MicroRNAs Respond to Administration of Antidepressant Fluoxetine in Adult Mice
Miao, N., Jin, J., Kim, S.-N., & Sun, T. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19030671 · Cited by 19 · see citing works
Fluoxetine Increases the Expression of miR-572 and miR-663a in Human Neuroblastoma Cell Lines
Mundalil Vasu, M., Anitha, A., Takahashi, T., Thanseem, I., Iwata, K., Asakawa, T., & Suzuki, K. (2016) · PLOS ONE · doi:10.1371/journal.pone.0164425 · Cited by 17 · see citing works
Grieco, S. F., Velmeshev, D., Magistri, M., Eldar-Finkelman, H., Faghihi, M. A., Jope, R. S., & Beurel, E. (2016) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2016.1224927 · Cited by 17 · see citing works
Maffioletti, E., Salvi, A., Conde, I., Maj, C., Gennarelli, M., Petro, G. D., & Bocchio‐Chiavetto, L. (2017) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2017.10.005 · Cited by 13 · see citing works
Design and interpretation of microRNA–reporter gene activity
Carroll, A. P., Tooney, P. A., & Cairns, M. J. (2013) · Analytical Biochemistry · doi:10.1016/j.ab.2013.02.022 · Cited by 12 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- Bushati N Cohen SM miRNA functions Annu Rev Cell Dev Biol 2007 23 175 205 17506695
- Wu G Feder A Cohen H Kim JJ Calderon S Charney DS Understanding resilience. front Behav Neurosci 2013 7 10 PMC3573269 23422934
Cited by
Sorted by citations
Yuan, M., Yang, B., Rothschild, G., Mann, J. J., Sanford, L. D., Tang, X., Huang, C., Wang, C., & Zhang, W. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01519-z · Cited by 246 · see citing works
“258 262 Similarly, miR-26a-3p 263 and miR-132 264 can induce depressive symptoms by activating the phosphatase and tensin homolog (PTEN)/phosphoinositide 3-kinase (PI3K)/ Akt signaling pathway, which is one of the main pathways for regulating synaptic plasticity.”
BackgroundUkraintseva, S. V., Arbeev, K. G., Duan, M., Akushevich, I. V., Kulminski, A. M., Stallard, E., & Yashin, A. I. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111418 · Cited by 97 · see citing works
Qian, Z.-Y., Chang, J., Jiang, F., Ge, D.-W., Yang, L., Li, Y., Chen, H.-T., & Cao, X.-J. (2020) · Brain, behavior, and immunity · doi:10.1016/j.bbi.2020.01.025 · Cited by 63 · see citing works
MicroRNAs as critical biomarkers of major depressive disorder: a comprehensive perspective
Ortega, M. A., Alvarez-Mon, M. A., García-Montero, C., Fraile-Martinez, O., Lahera, G., Monserrat, J., Muñoz-Merida, L., Mora, F., Rodríguez-Jiménez, R., Fernandez-Rojo, S., et al. (2021) · Biomedicines · doi:10.3390/biomedicines9111659 · Cited by 57 · see citing works
Biological correlates of early life stressful events in major depressive disorder
Silva, R. C., Maffioletti, E., Gennarelli, M., Baune, B. T., & Minelli, A. (2020) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2020.105103 · Cited by 53 · see citing works
Epigenetic mechanisms impacted by chronic stress across the rodent lifespan
Dion, A., Muñoz, P., & Franklin, T. B. (2022) · Neurobiology of Stress · doi:10.1016/j.ynstr.2022.100434 · Cited by 54 · see citing works
Recent advances in the role of miRNAs in post-traumatic stress disorder and traumatic brain injury
Zhu, Z., Huang, X., Du, M., Wu, C., Fu, J., Tan, W., Wu, B., Zhang, J., & Liao, Z. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02126-8 · Cited by 39 · see citing works
MicroRNA regulation of prefrontal cortex development and psychiatric risk in adolescence
Morgunova, A., & Flores, C. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.04.011 · Cited by 33 · see citing works
Yan, X., Zeng, D., Zhu, H., Zhang, Y., Shi, Y., Wu, Y., Tang, H., & Li, D. (2020) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s251152 · Cited by 29 · see citing works
Roy, B., Ochi, S., & Dwivedi, Y. (2022) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyac068 · Cited by 25 · see citing works
Niu, J., Wang, B., Wang, T., & Zhou, T. (2022) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32892 · Cited by 23 · see citing works
Suento, W. J., Kunisawa, K., Wulaer, B., Kosuge, A., Iida, T., Fujigaki, S., Fujigaki, H., Yamamoto, Y., Tanra, A. J., Saito, K., et al. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15222 · Cited by 22 · see citing works
The Long-Term Effects of Early Life Stress on the Modulation of miR-19 Levels
Mazzelli, M., Maj, C., Mariani, N., Mora, C., Begni, V., Pariante, C. M., Riva, M. A., Cattaneo, A., & Cattane, N. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00389 · Cited by 21 · see citing works
Self-citationMahmud, A., Avramescu, R. G., Niu, Z., & Flores, C. (2023) · Frontiers in Neural Circuits · doi:10.3389/fncir.2023.1113023 · Cited by 19 · see citing works
Cellular Response to Unfolded Proteins in Depression
Kowalczyk, M., Kowalczyk, E., Kwiatkowski, P. A., Łopusiewicz, Ł., Talarowska, M. E., & Sienkiewicz, M. (2021) · Life · doi:10.3390/life11121376 · Cited by 19 · see citing works
Estévez-Cabrera, M. M., Sánchez‐Muñoz, F., Pérez‐Sánchez, G., Pavón, L., Hernández-Díazcouder, A., Cortes-Altamirano, J. L., Soria-Fregozo, C., Alfaro-Rodríguez, A., & Bonilla‐Jaime, H. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e13442 · Cited by 18 · see citing works
Li, S., Ma, H., Yuan, X., Zhou, X., Wan, Y., & Chen, S. (2020) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s243920 · Cited by 17 · see citing works
Ketamine—New Possibilities in the Treatment of Depression: A Narrative Review
Kowalczyk, M., Kowalczyk, E., Kwiatkowski, P. A., Łopusiewicz, Ł., Sienkiewicz, M., & Talarowska, M. E. (2021) · Life · doi:10.3390/life11111186 · Cited by 17 · see citing works
miR-218: A Stress-Responsive Epigenetic Modifier
Schell, G., Roy, B., Prall, K., & Dwivedi, Y. (2022) · Non-Coding RNA · doi:10.3390/ncrna8040055 · Cited by 17 · see citing works
Genistein: A promising ally in combating neurodegenerative disorders
Sharma, D., Singh, V., Kumar, A., & Singh, T. G. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177273 · Cited by 15 · see citing works
Popa, N., Bachar, D., Roberts, A., Santangelo, A. M., & Gascon, E. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2022.104159 · Cited by 13 · see citing works
Cuomo-Haymour, N., Kaiser, S., Hartmann-Riemer, M. N., Guetter, K., Klaus, F., Cathomas, F., Seifritz, E., Bergamini, G., Russo, G., & Pryce, C. R. (2022) · Biomarkers in Neuropsychiatry · doi:10.1016/j.bionps.2022.100049 · Cited by 13 · see citing works
Sex-specific roles of hippocampal microRNAs in stress vulnerability and resilience
Krispil-Alon, M., Jovasevic, V., Radulović, J., & Richter‐Levin, G. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02267-4 · Cited by 13 · see citing works
Preventive strategies for adolescent depression: What are we missing? A focus on biomarkers
Zonca, V. (2021) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2021.100385 · Cited by 12 · see citing works
Self-citationEpigenetic aging in major depressive disorder: Clocks, mechanisms and therapeutic perspectives
Shaikh, M., & Doshi, G. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.176757 · Cited by 12 · see citing works
Chen, Y., Yao, S.-Y., Shu, X., Wang, Y., & Liu, J. (2022) · Behavioural Brain Research · doi:10.1016/j.bbr.2022.114211 · Cited by 8 · see citing works
Rasheed, M., Wang, H., Wang, C., Sun, J., Chen, Z., & Deng, Y. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15766 · Cited by 7 · see citing works
Deciphering and manipulating the epigenome for the treatment of Parkinson’s and Alzheimer’s disease
Okechukwu, C. E. (2021) · MGM Journal of Medical Sciences · doi:10.4103/mgmj.mgmj_90_20 · Cited by 3 · see citing works
Li, B., Zhao, H., & Sun, J. (2022) · Computational and Mathematical Methods in Medicine · doi:10.1155/2022/4244425 · Cited by 3 · see citing works
RetractedEmerging role of microRNAs as novel targets of antidepressants
Manoharan, A., & Paul, A. (2021) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2021.102906 · Cited by 2 · see citing works
Integrative Analysis of the Impact of Prenatal Depression on the Newborn Intestinal Microbiota
Taha, W., Anachad, O., Taouil, A., Saadoune, C., Messal, M. E., Bennis, F., & Chegdani, F. (2025) · Central Nervous System Agents in Medicinal Chemistry · doi:10.2174/0118715249361952250209084153 · Cited by 1 · see citing works
Cattane, N. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819641-0.00082-7
Self-citationGene Expression in the Hippocampus
Taheri, S., & Abusalim, M. R. S. (2025) · Springer eBooks · doi:10.1007/978-3-031-88907-3_11
Shareef, A., Sameer, H. N., Yaseen, A., Athab, Z. H., Adil, M., & Allela, O. Q. B. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05459-3
Sunzeri, F. (2026) · Springer eBooks · doi:10.1007/978-3-032-14465-2_16
Dendrobium officinale nanovesicles: transcriptomic landscape and anti-inflammatory roles
Biren, W., Yang, Y., Zhang, S., Wu, J., Wei, Y., Xu, S., Li, Y., Chen, Q., & Yang, G. (2026) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2026.1848009
MicroRNAs as Diagnostic and Therapeutic Biomarkers in Major Depressive Disorder
Maroufi, M., Asgharzadeh, M. R., Dahmardeh, N., Valipour, A. M., & Kardan, N. (2026) · IGI Global eBooks · doi:10.4018/979-8-2600-4270-0.ch003
- Authors
- Lopizzo, N., Zonca, V., Cattane, N., Pariante, C. M., & Cattaneo, A.
- Affiliations
- Centro San Giovanni di Dio Fatebenefratelli (IT)
- King's College London (GB)
- Corresponding author
- Cattaneo, Annamaria
- Venue
- Journal of Neural Transmission
- Published
- 2019-07-26
- Volume
- 126
- Issue
- 9
- Pages
- 1241-1258
- ISSN
- 0300-9564 (ISSN-L)
- 1435-1463
- PMC
- PMC6746676
- OpenAlex
- W2966670099
- Cited by
- 37
- References
- 126
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 1 · 2023: 5 · 2022: 9 · 2021: 8 · 2020: 7
- FWCI
- 0.58
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Journal of Neural Transmission (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
- Research Portal (King's College London) (submittedVersion, cc-by)
- Funders
- Ministero della Salute (Ricerca Corrente)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- microRNA, depression, stress vulnerability, resilience, early life stress, prenatal stress, epigenetics, stress response, biomarkers, treatment response prediction, depression pathogenesis, preventive strategies
- MeSH terms
- Animals, Depression, Female, Humans, Pregnancy, Prenatal Exposure Delayed Effects, Stress, Psychological, Genetic Predisposition to Disease, MicroRNAs, Epigenesis, Genetic, Resilience, Psychological
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
