SP-1, a Serine Protease from the Gut Microbiota, Influences Colitis and Drives Intestinal Dysbiosis in Mice
Open accessAbstract
Increased protease activity has been linked to the pathogenesis of IBD. While most studies have been focusing on host proteases in gut inflammation, it remains unclear how to address the potential contribution of their bacterial counterparts. In the present study, we report a functional characterization of a newly identified serine protease, SP-1, from the human gut microbiota. The serine protease repertoire of gut Clostridium was first explored, and the specificity of SP-1 was analyzed using a combinatorial chemistry method. Combining in vitro analyses and a mouse model of colitis, we show that oral administration of recombinant bacteria secreting SP-1 (i) compromises the epithelial barrier, (ii) alters the microbial community, and (ii) exacerbates colitis. These findings suggest that gut microbial protease activity may constitute a valuable contributor to IBD and could, therefore, represent a promising target for the treatment of the disease.
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Oral administration of the bacterial serine protease SP-1, produced by Clostridium spp, resulted in impaired epithelial barrier, altered microbiota community composition, and exacerbated DSS-induced colitis.
“Oral administration of the bacterial serine protease SP-1, produced by Clostridium spp resulted in impaired epithelial barrier, altered microbiota community compostion, and exacerbated DSS-induced colitis.129”
From The emerging roles of bacterial proteases in intestinal diseases (2023) · cites this paper as [129]
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- Authors
- Kriaa, A., Jablaoui, A., Rhimi, S., Soussou, S., Mkaouar, H., Mariaule, V., Gruba, N., Gargouri, A., Maguin, E., Lesner, A., & Rhimi, M.
- Affiliations
- Microbiota Interaction with Human and Animal Team (MIHA), Micalis Institute-UMR1319, AgroParisTech, Université Paris-Saclay, INRAE, F-78350 Jouy-en-Josas, France
- AgroParisTech (FR)
- University of Gdańsk (PL)
- University of Sfax (TN)
- Corresponding author
- Rhimi, Moez
- ORCID
- Venue
- Cells
- Publisher
- MDPI AG
- Published
- 2021-10-05
- Volume
- 10
- Issue
- 10
- Pages
- 2658
- ISSN
- 2073-4409 (ISSN-L)
- PMC
- PMC8534766
- OpenAlex
- W3204723949
- Cited by
- 16
- References
- 72
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 3 · 2023: 3 · 2022: 1
- FWCI
- 0.55
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cells (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion, cc-by)
- HAL (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Campus France
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
- Keywords
- gut microbiota, colitis, gut dysbiosis, inflammatory bowel disease, Clostridium, bacterial proteases, epithelial barrier function, microbial communities, mouse colitis model, protease specificity
- MeSH terms
- Gastrointestinal Microbiome, Amino Acid Sequence, Animals, Colitis, Feces, Inflammation, Intestinal Mucosa, Intestines, Kinetics, Lactobacillus, Male, Mice, Inbred C57BL, Phylogeny, Substrate Specificity, Dextran Sulfate, Conserved Sequence, Subtilisin, Mice, Serine Proteases, Dysbiosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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