Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 21

The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.

Ethanol Extract of Mao Jian Green Tea Attenuates Gastrointestinal Symptoms in a Rat Model of Irritable Bowel Syndrome with Constipation via the 5-hydroxytryptamine Signaling Pathway

Wu, Lei, Gao, Liming, Jin, Xiang, Chen, Zhikang, Qiao, Xutong, Cui, Xiting, Gao, Jianhua, Zhang, Liwei·2023·Foods
DOI 10.3390/foods12051101
Open this paper in CoChat — free account

Abstract

In a previous study, we demonstrated that the hydro extract of Mao Jian Green Tea (MJGT) promotes gastrointestinal motility. In this study, the effect of MJGT ethanol extract (MJGT_EE) in treating irritable bowel syndrome with constipation (IBS-C) in a rat model constructed via maternal separation combined with an ice water stimulation was investigated. First, a successful model construction was confirmed through the determination of the fecal water content (FWC) and the smallest colorectal distension (CRD) volume. Then, the overall regulatory effects of MJGT_EE on the gastrointestinal tract were preliminarily evaluated through gastric emptying and small intestinal propulsion tests. Our findings indicated that MJGT_EE significantly increased FWC (p < 0.01) and the smallest CRD volume (p < 0.05) and promoted gastric emptying and small intestinal propulsion (p < 0.01). Furthermore, mechanistically, MJGT_EE reduced intestinal sensitivity by regulating the expression of proteins related to the serotonin (5-hydroxytryptamine; 5-HT) pathway. More specifically, it decreased tryptophan hydroxylase (TPH) expression (p < 0.05) and increased serotonin transporter (SERT) expression (p < 0.05), thereby decreasing 5-HT secretion (p < 0.01), activating the calmodulin (CaM)/myosin light chain kinase (MLCK) pathway, and increasing 5-HT4 receptor (5-HT4R) expression (p < 0.05). Moreover, MJGT_EE enhanced the diversity of gut microbiota, increased the proportion of beneficial bacteria, and regulated the number of 5-HT-related bacteria. Flavonoids may play the role of being active ingredients in MJGT_EE. These findings suggest that MJGT_EE could serve as a potential therapeutic pathway for IBS-C.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.3390/foods12051101

Cites

14 of 14 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Research works printed but not linked: 75

  1. Harper, 2018, An exploration into the motivation for gluten avoidance in the absence of coeliac disease, Gastroenterol. Hepatol. Bed Bench., 11, 259
  2. Shokryazdan, 2014, Probiotic potential of Lactobacillus strains with antimicrobial activity against some human pathogenic strains, Biomed. Res. Int., 2014, 927268, 10.1155/2014/927268 · DOI
  3. Xiao, 2020, Ethnic differences in genetic polymorphism associated with irritable bowel syndrome, World J. Gastroenterol., 26, 2049, 10.3748/wjg.v26.i17.2049 · DOI
  4. Holtmann, 2016, Pathophysiology of irritable bowel syndrome, Lancet Gastroenterol. Hepatol., 1, 133, 10.1016/S2468-1253(16)30023-1 · DOI · Paper page
  5. Barbara, 2019, Rome Foundation Working Team Report on Post-Infection Irritable Bowel Syndrome, Gastroenterology, 156, 46, 10.1053/j.gastro.2018.07.011 · DOI
  6. Gros, M., Gros, B., Mesonero, J.E., and Latorre, E. (2021). Neurotransmitter Dysfunction in Irritable Bowel Syndrome: Emerging Approaches for Management. J. Clin. Med., 10. · DOI
  7. Farzaei, 2016, The Role of Visceral Hypersensitivity in Irritable Bowel Syndrome: Pharmacological Targets and Novel Treatments, J. Neurogastroenterol. Motil., 22, 558, 10.5056/jnm16001 · DOI · Paper page
  8. Wang, 2014, A genetic association study of single nucleotide polymorphisms in GNbeta3 and COMT in elderly patients with irritable bowel syndrome, Med. Sci. Monit., 20, 1246, 10.12659/MSM.890315 · DOI
  9. Schoenfeld, 2016, Advances in IBS 2016: A Review of Current and Emerging Data, Gastroenterol. Hepatol., 12, 1
  10. Grundmann, 2010, Irritable bowel syndrome: Epidemiology, diagnosis and treatment: An update for health-care practitioners, J. Gastroenterol. Hepatol., 25, 691, 10.1111/j.1440-1746.2009.06120.x · DOI
  11. Vahora, 2020, How Serotonin Level Fluctuation Affects the Effectiveness of Treatment in Irritable Bowel Syndrome, Cureus, 12, e9871
  12. Chey, 2012, Linaclotide for irritable bowel syndrome with constipation: A 26-week, randomized, double-blind, placebo-controlled trial to evaluate efficacy and safety, Am. J. Gastroenterol., 107, 1702, 10.1038/ajg.2012.254 · DOI · Paper page
  13. Rao, 2012, A 12-week, randomized, controlled trial with a 4-week randomized withdrawal period to evaluate the efficacy and safety of linaclotide in irritable bowel syndrome with constipation, Am. J. Gastroenterol., 107, 1714, 10.1038/ajg.2012.255 · DOI
  14. Bassotti, 2021, Chronic Idiopathic Constipation in Adults: A Review on Current Guidelines and Emerging Treatment Options, Clin. Exp. Gastroenterol., 14, 413, 10.2147/CEG.S256364 · DOI
  15. Nakajima, 2021, A Systematic Review and Network Meta-Analysis on the Efficacy of Medications in the Treatment of Chronic Idiopathic Constipation in Japan, Gastroenterol. Res. Pract., 2021, 5534687, 10.1155/2021/5534687 · DOI
  16. Pei, 2020, Effect of Acupuncture in Patients With Irritable Bowel Syndrome: A Randomized Controlled Trial, Mayo Clin. Proc., 95, 1671, 10.1016/j.mayocp.2020.01.042 · DOI
  17. Zhao, 2021, Efficacy of acupuncture in refractory irritable bowel syndrome: Study protocol for a randomised controlled trial, BMJ Open, 11, e045655, 10.1136/bmjopen-2020-045655 · DOI
  18. Ma, 2020, Brain Functional Interaction of Acupuncture Effects in Diarrhea-Dominant Irritable Bowel Syndrome, Front. Neurosci., 14, 608688, 10.3389/fnins.2020.608688 · DOI
  19. Wu, 2020, Efficacy and Safety of Acupoint Catgut Embedding for Diarrhea-Predominant Irritable Bowel Syndrome and Constipation-Predominant Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis, Evid. Based Complement. Altern. Med., 2020, 5812320, 10.1155/2020/5812320 · DOI
  20. Kim, 2020, Herbal Therapies in Functional Gastrointestinal Disorders: A Narrative Review and Clinical Implication, Front. Psychiatry, 11, 601, 10.3389/fpsyt.2020.00601 · DOI
  21. Alammar, N., Wang, L., Saberi, B., Nanavati, J., Holtmann, G., Shinohara, R.T., and Mullin, G.E. (2019). The impact of peppermint oil on the irritable bowel syndrome: A meta-analysis of the pooled clinical data. BMC Complement. Altern. Med., 19. · DOI · Paper page
  22. Jafarzadeh, 2022, Turmeric for Treatment of Irritable Bowel Syndrome: A Systematic Review of Population-Based Evidence, Iran. J. Public Health, 51, 1223
  23. Xie, 2021, Atractylodes oil alleviates diarrhea-predominant irritable bowel syndrome by regulating intestinal inflammation and intestinal barrier via SCF/c-kit and MLCK/MLC2 pathways, J. Ethnopharmacol., 272, 113925, 10.1016/j.jep.2021.113925 · DOI
  24. Ren, D. (2007). Chemical and Bioactive Studies on Two Species of The Genus Dracocephalum. [Ph.D. Thesis, Shandong University].
  25. Gao, 2022, Metabolomic characterization of the chemical compositions of Dracocephalum rupestre Hance, Food Res. Int., 161, 111871, 10.1016/j.foodres.2022.111871 · DOI
  26. Zhao, T., Li, C., Wang, S., and Song, X. (2022). Green Tea (Camellia sinensis): A Review of Its Phytochemistry, Pharmacology, and Toxicology. Molecules, 27. · DOI · Paper page
  27. Mitscher, 1997, Chemoprotection: A review of the potential therapeutic antioxidant properties of green tea (Camellia sinensis) and certain of its constituents, Med. Res. Rev., 17, 327, 10.1002/(SICI)1098-1128(199707)17:4<327::AID-MED2>3.0.CO;2-Y · DOI
  28. Korolkiewicz, 2021, Commentary on: Impact of drinking Chinese green tea on postoperative short outcomes for gastric cancer: A randomized controlled trial, Eur. J. Clin. Nutr., 75, 1679, 10.1038/s41430-021-00944-z · DOI
  29. Ma, J.-y. (2020). Study on Functional Ingredients of Maojian Tea in the Lvliang Mountains. [Ph.D. Thesis, Shanxi University].
  30. Ye, 2022, Bitterness and astringency of tea leaves and products: Formation mechanism and reducing strategies, Trends Food Sci. Technol., 123, 14, 10.1016/j.tifs.2022.02.031 · DOI · Paper page
  31. Oteiza, 2018, Flavonoids and the gastrointestinal tract: Local and systemic effects, Mol. Aspects Med., 61, 41, 10.1016/j.mam.2018.01.001 · DOI · Paper page
  32. Singh, 2017, Overcoming the exacerbating effects of ranitidine on NSAID-induced small intestinal toxicity with quercetin: Providing a complete GI solution, Chem. Biol. Interact., 272, 53, 10.1016/j.cbi.2017.04.006 · DOI
  33. Cuervo, 2015, Association of polyphenols from oranges and apples with specific intestinal microorganisms in systemic lupus erythematosus patients, Nutrients, 7, 1301, 10.3390/nu7021301 · DOI
  34. Mendel, 2016, Modification of abomasum contractility by flavonoids present in ruminants diet: In vitro study, Animal, 10, 1431, 10.1017/S1751731116000513 · DOI
  35. Wu, L., Jin, X., Zheng, C., Ma, F., Zhang, X., Gao, P., Gao, J., and Zhang, L. (2023). Bidirectional Effects of Mao Jian Green Tea and Its Flavonoid Glycosides on Gastrointestinal Motility. Foods, 12. · DOI
  36. Chaves, 2020, Extraction of flavonoids from natural sources using modern techniques, Front. Chem., 8, 507887, 10.3389/fchem.2020.507887 · DOI · Paper page
  37. Stickney, 1959, Effect of gastric emptying upon propulsive motility of small intestine of rats, Proc. Soc. Exp. Biol. Med., 101, 582, 10.3181/00379727-101-25024 · DOI
  38. DuPont, 2014, Motility abnormalities in irritable bowel syndrome, Digestion, 89, 119, 10.1159/000356314 · DOI
  39. Zeppelin, 2019, Substrate and inhibitor binding to the serotonin transporter: Insights from computational, crystallographic, and functional studies, Neuropharmacology, 161, 107548, 10.1016/j.neuropharm.2019.02.030 · DOI
  40. Collins, 2014, The microbiota-gut-brain axis in functional gastrointestinal disorders, Gut Microbes, 5, 419, 10.4161/gmic.29417 · DOI · Paper page
  41. Carco, 2020, Increasing Evidence That Irritable Bowel Syndrome and Functional Gastrointestinal Disorders Have a Microbial Pathogenesis, Front. Cell. Infect. Microbiol., 10, 468, 10.3389/fcimb.2020.00468 · DOI
  42. Kwon, 2019, Modulation of Gut Microbiota Composition by Serotonin Signaling Influences Intestinal Immune Response and Susceptibility to Colitis, Cell. Mol. Gastroenterol. Hepatol., 7, 709, 10.1016/j.jcmgh.2019.01.004 · DOI
  43. Faure, 2007, Visceral hypersensitivity in irritable bowel syndrome: Does it really normalize over time?, Gastroenterology, 132, 464, 10.1053/j.gastro.2006.11.037 · DOI
  44. Muller, 2014, Crosstalk between muscularis macrophages and enteric neurons regulates gastrointestinal motility, Cell, 158, 300, 10.1016/j.cell.2014.04.050 · DOI · Paper page
  45. Dunlop, 2005, Abnormalities of 5-hydroxytryptamine metabolism in irritable bowel syndrome, Clin. Gastroenterol. Hepatol., 3, 349, 10.1016/S1542-3565(04)00726-8 · DOI
  46. Gershon, 1999, Review article: Roles played by 5-hydroxytryptamine in the physiology of the bowel, Aliment. Pharmacol. Ther., 13, 15, 10.1046/j.1365-2036.1999.00002.x-i2 · DOI · Paper page
  47. Camilleri, 2002, Serotonergic modulation of visceral sensation: Lower gut, Gut, 51, i81, 10.1136/gut.51.suppl_1.i81 · DOI
  48. Wang, 2021, Inflammation and Overlap of Irritable Bowel Syndrome and Functional Dyspepsia, J. Neurogastroenterol. Motil., 27, 153, 10.5056/jnm20175 · DOI
  49. Walther, 2003, Synthesis of serotonin by a second tryptophan hydroxylase isoform, Science, 299, 76, 10.1126/science.1078197 · DOI
  50. Park, S., Kim, Y., Lee, J., Lee, J.Y., Kim, H., Lee, S., and Oh, C.M. (2021). A Systems Biology Approach to Investigating the Interaction between Serotonin Synthesis by Tryptophan Hydroxylase and the Metabolic Homeostasis. Int. J. Mol. Sci., 22. · DOI
  51. Bertrand, 2010, Serotonin release and uptake in the gastrointestinal tract, Auton. Neurosci., 153, 47, 10.1016/j.autneu.2009.08.002 · DOI · Paper page
  52. Braun, 2007, Enterochromaffin cells of the human gut: Sensors for spices and odorants, Gastroenterology, 132, 1890, 10.1053/j.gastro.2007.02.036 · DOI · Paper page
  53. Jin, 2016, Regulation of the serotonin transporter in the pathogenesis of irritable bowel syndrome, World J. Gastroenterol., 22, 8137, 10.3748/wjg.v22.i36.8137 · DOI
  54. Lefebvre, 2016, Synergistic effect between 5-HT4 receptor agonist and phosphodiesterase 4-inhibitor in releasing acetylcholine in pig gastric circular muscle in vitro, Eur. J. Pharmacol., 781, 76, 10.1016/j.ejphar.2016.04.003 · DOI
  55. Zheng, Y., Yu, T., Tang, Y., Xiong, W., Shen, X., Jiang, L., and Lin, L. (2017). Efficacy and safety of 5-hydroxytryptamine 3 receptor antagonists in irritable bowel syndrome: A systematic review and meta-analysis of randomized controlled trials. PLoS ONE, 12. · DOI
  56. Zhao, 2016, Comparison of Electroacupuncture and Moxibustion for Relieving Visceral Hypersensitivity in Rats with Constipation-Predominant Irritable Bowel Syndrome, Evid. Based Complement. Altern. Med., 2016, 9410505, 10.1155/2016/9410505 · DOI
  57. Fu, 2019, Expression and clinical significance of 5-HT and 5-HT(3)R in the intestinal mucosa of patient with diarrhea-type irritable bowel syndrome, Exp. Ther. Med., 17, 3077
  58. Hillsley, 1998, Direct and indirect actions of 5-hydroxytryptamine on the discharge of mesenteric afferent fibres innervating the rat jejunum, J. Physiol., 506, 551, 10.1111/j.1469-7793.1998.551bw.x · DOI
  59. Bertrand, 2000, The terminals of myenteric intrinsic primary afferent neurons of the guinea-pig ileum are excited by 5-hydroxytryptamine acting at 5-hydroxytryptamine-3 receptors, Neuroscience, 101, 459, 10.1016/S0306-4522(00)00363-8 · DOI
  60. Grider, 1996, 5-HT released by mucosal stimuli initiates peristalsis by activating 5-HT4/5-HT1p receptors on sensory CGRP neurons, Am. J. Physiol., 270, G778
  61. Pan, 2000, Activation of intrinsic afferent pathways in submucosal ganglia of the guinea pig small intestine, J. Neurosci., 20, 3295, 10.1523/JNEUROSCI.20-09-03295.2000 · DOI
  62. Lukas, 2004, A signal transduction pathway model prototype II: Application to Ca2+-calmodulin signaling and myosin light chain phosphorylation, Biophys J., 87, 1417, 10.1529/biophysj.104.042721 · DOI
  63. Chong, 2019, The Microbiome and Irritable Bowel Syndrome-A Review on the Pathophysiology, Current Research and Future Therapy, Front. Microbiol., 10, 1136, 10.3389/fmicb.2019.01136 · DOI · Paper page
  64. Salem, 2018, The gut microbiome and irritable bowel syndrome: State of art review, Arab J. Gastroenterol., 19, 136, 10.1016/j.ajg.2018.02.008 · DOI
  65. Vervier, 2022, Two microbiota subtypes identified in irritable bowel syndrome with distinct responses to the low FODMAP diet, Gut, 71, 1821, 10.1136/gutjnl-2021-325177 · DOI
  66. Qi, 2019, Lactobacillus maintains healthy gut mucosa by producing L-Ornithine, Commun. Biol., 2, 171, 10.1038/s42003-019-0424-4 · DOI
  67. Heeney, 2018, Intestinal Lactobacillus in health and disease, a driver or just along for the ride?, Curr. Opin. Biotechnol., 49, 140, 10.1016/j.copbio.2017.08.004 · DOI · Paper page
  68. Yonekura, 2009, Effects of daily intake of Lactobacillus paracasei strain KW3110 on Japanese cedar pollinosis, Allergy Asthma Proc., 30, 397, 10.2500/aap.2009.30.3256 · DOI
  69. Rossoni, 2018, Inhibitory effect of probiotic Lactobacillus supernatants from the oral cavity on Streptococcus mutans biofilms, Microb. Pathog., 123, 361, 10.1016/j.micpath.2018.07.032 · DOI
  70. Xie, 2022, Short-Chain Fatty Acids Produced by Ruminococcaceae Mediate alpha-Linolenic Acid Promote Intestinal Stem Cells Proliferation, Mol. Nutr. Food Res., 66, e2100408, 10.1002/mnfr.202100408 · DOI
  71. Averina, O.V., Zorkina, Y.A., Yunes, R.A., Kovtun, A.S., Ushakova, V.M., Morozova, A.Y., Kostyuk, G.P., Danilenko, V.N., and Chekhonin, V.P. (2020). Bacterial Metabolites of Human Gut Microbiota Correlating with Depression. Int. J. Mol. Sci., 21. · DOI
  72. Koopman, N., Katsavelis, D., Hove, A.S.T., Brul, S., Jonge, W.J., and Seppen, J. (2021). The Multifaceted Role of Serotonin in Intestinal Homeostasis. Int. J. Mol. Sci., 22. · DOI
  73. Labus, 2019, Evidence for an association of gut microbial Clostridia with brain functional connectivity and gastrointestinal sensorimotor function in patients with irritable bowel syndrome, based on tripartite network analysis, Microbiome, 7, 45, 10.1186/s40168-019-0656-z · DOI
  74. Yang, 2021, Gut microbiota-dependent catabolites of tryptophan play a predominant role in the protective effects of turmeric polysaccharides against DSS-induced ulcerative colitis, Food Funct., 12, 9793, 10.1039/D1FO01468D · DOI
  75. Rinninella, E., Raoul, P., Cintoni, M., Franceschi, F., Miggiano, G.A.D., Gasbarrini, A., and Mele, M.C. (2019). What is the Healthy Gut Microbiota Composition? A Changing Ecosystem across Age, Environment, Diet, and Diseases. Microorganisms, 7. · DOI · Paper page

Cited by

See all 21

Metadata

Authors
Wu, L., Gao, L., Jin, X., Chen, Z., Qiao, X., Cui, X., Gao, J., & Zhang, L.
Venue
Foods
Publisher
MDPI AG
Published
2023-03-04
Volume
12
Issue
5
Pages
1101
ISSN
2304-8158
DOI
10.3390/foods12051101
Cited by
21
References
14
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)
Funders
  • Shanxi Agricultural University Youth Science and Technology Innovation Fund (2016020, 202105D121010)
  • Shanxi Key Laboratory of Minor Crops Germplasm Innovation and Molecular Breeding, Shanxi Agricultural University (2016020, 202105D121010)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.