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Cited by 157Gastrointestinal motility and disordersGut microbiota and healthProbiotics and Fermented Foods

The microbiota-gut-brain axis in functional gastrointestinal disorders

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De Palma, Giada, Collins, Stephen M, Bercik, Premysl·2014·Gut Microbes
DOI 10.4161/gmic.29417PMC PMC4153782
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Abstract

Functional gastrointestinal disorders (FGIDs) are highly prevalent and pose a significant burden on health care and society, and impact patients' quality of life. FGIDs comprise a heterogeneous group of disorders, with unclear underlying pathophysiology. They are considered to result from the interaction of altered gut physiology and psychological factors via the gut-brain axis, where brain and gut symptoms are reciprocally influencing each other's expression. Intestinal microbiota, as a part of the gut-brain axis, plays a central role in FGIDs. Patients with Irritable Bowel Syndrome, a prototype of FGIDs, display altered composition of the gut microbiota compared with healthy controls and benefit, at the gastrointestinal and psychological levels, from the use of probiotics and antibiotics. This review aims to recapitulate the available literature on FGIDs and microbiota-gut-brain axis.

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  • The concept of the microbiota-gut-brain axis emerged based upon the historical legacy of scientific figures.

    “The concept of the microbiota-gut-brain axis thus emerged (Cryan and O'Mahony, 2011;De Palma et al., 2014;Rhee et al., 2009) based upon the rich historical legacy of the illustrious scientific figures discussed above, amongst many others.”

    From The Microbiota-Gut-Brain Axis (2019) · cites this paper as De Palma et al., 2014

    The Abstract describes the microbiota-gut-brain axis as an established subject of research, supporting the citation's reference to the concept. It does not trace when or how the concept emerged. The statement about the historical figures discussed above appears to be the citing authors’ own framing, not a history supplied by this source. (LLM, conf=0.78)

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Cited by

Sorted by citations

Authors
De Palma, G., Collins, S. M., & Bercik, P.
Affiliations
McMaster University (CA)
ORCID
Collins, Stephen M
Venue
Gut Microbes
Publisher
Informa UK Limited
Published
2014-05
Volume
5
Issue
3
Pages
419-429
ISSN
  • 1949-0976 (ISSN-L)
  • 1949-0984
DOI
10.4161/gmic.29417
PMC
PMC4153782
OpenAlex
W2079150934
Cited by
157
References
48
Citations by year
2026: 12 · 2025: 15 · 2024: 8 · 2023: 12 · 2022: 20 · 2021: 18 · 2020: 13 · 2019: 14 · 2018: 12 · 2017: 10 · 2016: 6 · 2015: 13 · 2014: 4
FWCI
1.80
Type
journal article
Language
en
Open access
Locations
  • Gut Microbes (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
Canadian Institutes of Health Research
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords
microbiota-gut-brain axis, functional gastrointestinal disorders, irritable bowel syndrome, gut microbiota, probiotics, antibiotics, gut-brain axis, psychological factors, pathophysiology
MeSH terms
Brain, Gastrointestinal Diseases, Humans, Prevalence, Gastrointestinal Tract, Microbiota

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