Melatonin: A Mitochondrial Targeting Molecule Involving Mitochondrial Protection and Dynamics

Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options

Uttara, B., Singh, A., Zamboni, P., & Mahajan, R. (2009) · Current Neuropharmacology · doi:10.2174/157015909787602823 · Cited by 3,378

Pineal Melatonin: Cell Biology of Its Synthesis and of Its Physiological Interactions*

REITER, R. J. (1991) · Endocrine Reviews · doi:10.1210/edrv-12-2-151 · Cited by 2,192

Dynamin-related Protein Drp1 Is Required for Mitochondrial Division in Mammalian Cells

Smirnova, E., Griparić, L., Shurland, D., & van der Bliek, A. M. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.8.2245 · Cited by 1,938

On the origin of mitosing cells

Sagan, L. (1967) · Journal of Theoretical Biology · doi:10.1016/0022-5193(67)90079-3 · Cited by 1,870

Melatonin as an antioxidant: under promises but over delivers

Reiter, R. J., Mayo, J. C., Tan, D. X., Sainz, R. M., Alatorre-Jiménez, M. A., & Qin, L. (2016) · Journal of Pineal Research · doi:10.1111/jpi.12360 · Cited by 1,777

Melatonin : a potent, endogenous hydroxyl radical scavenger

Tan, D. (1993) · Endocrine Journal · Cited by 1,659

One molecule, many derivatives: A never-ending interaction of melatonin with reactive oxygen and nitrogen species?

Tan, D., Manchester, L. C., Terron, M. P., Flores, L. J., & Reiter, R. J. (2007) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2006.00407.x · Cited by 1,601

The Haber–Weiss reaction and mechanisms of toxicity

Kehrer, J. P. (2000) · Toxicology · doi:10.1016/s0300-483x(00)00231-6 · Cited by 1,418

Impacts of impaired mitochondrial dynamics in hearing loss: Potential therapeutic targets

Zou, T., Ye, B., Chen, K., Zhang, A., Guo, D., Pan, Y., Ding, R., Hu, H., Sun, X., & Xiang, M. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.998507 · Cited by 19

Melatonin promoted osteogenesis of human periodontal ligament cells by regulating mitochondrial functions through the translocase of the outer mitochondrial membrane 20

Sun, H., Zheng, M., Liu, J., Fan, W., He, H., & Huang, F. P. (2022) · Journal of Periodontal Research · doi:10.1111/jre.13068 · Cited by 18

Melatonin Improves Skeletal Muscle Structure and Oxidative Phenotype by Regulating Mitochondrial Dynamics and Autophagy in Zücker Diabetic Fatty Rat

Salagre, D., Álvarez, E. R., Cendán, C. M., Aouichat, S., & Agil, A. (2023) · Antioxidants · doi:10.3390/antiox12081499 · Cited by 20

Melatonin as a Therapy for Preterm Brain Injury: What Is the Evidence?

Häusler, S., Robertson, N. J., Golhen, K., van den Anker, J. N., Tucker, K., & Felder, T. K. (2023) · Antioxidants · doi:10.3390/antiox12081630 · Cited by 20

Melatonin acts through different mechanisms to control oxidative stress and primordial follicle activation and survival during in vitro culture of bovine ovarian tissue

Silva, B. R., Costa, F. C., Neto, M. F. D. L., Filho, F. F. C., de Assis, E. I. T., Aguiar, F. L. N., Silva, A. W. B., Martins, S. D., Araújo, V. R., Matos, M. H. T., et al. (2023) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2023.106824 · Cited by 18

The Reserve/Maximum Capacity of Melatonin’s Synthetic Function for the Potential Dimorphism of Melatonin Production and Its Biological Significance in Mammals

Tan, D. X., & Hardeland, R. (2021) · Molecules · doi:10.3390/molecules26237302 · Cited by 18

Melatonin and the nervous system: nanomedicine perspectives

Luo, F., Deng, Y., Angelov, B., & Angelova, A. (2025) · Biomaterials Science · doi:10.1039/d4bm01609b · Cited by 17

The Melatonin–Mitochondrial Axis: Engaging the Repercussions of Ultraviolet Radiation Photoaging on the Skin’s Circadian Rhythm

Gao, T., Li, Y., Wang, X., & Ren, F. (2023) · Antioxidants · doi:10.3390/antiox12051000 · Cited by 18

Pre- and post-natal melatonin administration partially regulates brain oxidative stress but does not improve cognitive or histological alterations in the Ts65Dn mouse model of Down syndrome

Corrales, A., Parisotto, E. B., Vidal, V., García-Cerro, S., Lantigua, S., Diego, M., Filho, D. W., Sánchez‐Barceló, E. J., Martínez‐Cué, C., & Rueda, N. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.07.022 · Cited by 18

Alterations in NO/ROS ratio and expression of Trx1 and Prdx2 in isoproterenol-induced cardiac hypertrophy

Su, H., Pistolozzi, M., Shi, X., Sun, X., & Tan, W. (2017) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmx102 · Cited by 17

Melatonin: Regulation of Viral Phase Separation and Epitranscriptomics in Post-Acute Sequelae of COVID-19

Loh, D., & Reiter, R. J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158122 · Cited by 17

Negative Conditioning of Mitochondrial Dysfunction in Age-related Neurodegenerative Diseases.

Selvaraji, S., Poh, L., Natarajan, V., Mallilankaraman, K. B., & Arumugam, T. V. (2019) · PubMed · Cited by 17

Melatonin enhances cell death and suppresses the metastatic capacity of ovarian cancer cells by attenuating the signaling of multiple kinases

Cucielo, M. S., Freire, P. P., Emílio-Silva, M. T., Romagnoli, G. G., Carvalho, R. F., Kaneno, R., Hiruma-Lima, C. A., Delella, F. K., Reiter, R. J., & Chuffa, L. G. D. A. (2023) · Pathology - Research and Practice · doi:10.1016/j.prp.2023.154637 · Cited by 16

The Complex Relationship between Hypoxia Signaling, Mitochondrial Dysfunction and Inflammation in Calcific Aortic Valve Disease: Insights from the Molecular Mechanisms to Therapeutic Approaches

Bouhamida, E., Morciano, G., Pedriali, G., Ramaccini, D., Tremoli, E., Giorgi, C., Pinton, P., & Patergnani, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241311105 · Cited by 19

Melatonin Improves Glucose Homeostasis and Insulin Sensitivity by Mitigating Inflammation and Activating AMPK Signaling in a Mouse Model of Sleep Fragmentation

Hong, S. H., Lee, D.-B., Kim, J., & Yoon, D. W. (2024) · Cells · doi:10.3390/cells13060470 · Cited by 16

Melatonin/Sericin Wound Healing Patches: Implications for Melanoma Therapy

Adamiak, K., Gaida, V. A., Schäfer, J. A., Bosse, L., Diemer, C., Reiter, R. J., Slominski, A. T., Steinbrink, K., Sionkowska, A., & Kleszczyński, K. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25094858 · Cited by 16

Maternal Melatonin Deficiency Leads to Endocrine Pathologies in Children in Early Ontogenesis

Иванов, Д. О., Evsyukova, I. I., Mironova, E. S., Polyakova, V. O., Kvetnoy, I. M., & Nasyrov, R. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22042058 · Cited by 18

Melatonin Protects Against Mdivi-1-Induced Abnormal Spindle Assembly and Mitochondrial Superoxide Production During Porcine Oocyte Maturation

Yang, S., Joe, S.-Y., Bae, J.-W., Heo, G., Park, H., & Koo, D. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.693969 · Cited by 16

Diplomats' Mystery Illness and Pulsed Radiofrequency/Microwave Radiation

Golomb, B. A. (2018) · Neural Computation · doi:10.1162/neco_a_01133 · Cited by 16

Mitophagy in fibrotic diseases: molecular mechanisms and therapeutic applications

Cui, X. T., Zhou, Z., Tu, H., Wu, J., Zhou, J. P., Yi, Q., Liu, O., & Dai, X. (2024) · Frontiers in Physiology · doi:10.3389/fphys.2024.1430230 · Cited by 17

Melatonin Attenuates Mitochondrial Damage in Aristolochic Acid-Induced Acute Kidney Injury

Sun, J. M., Pan, J., Liu, Q., Cheng, J., Tang, Q., Ji, Y., Cheng, K., wang, R., Liu, L., Wang, D., et al. (2022) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2022.054 · Cited by 15

Revealing Melatonin’s Mysteries: Receptors, Signaling Pathways, and Therapeutics Applications

Kulsoom, K., Ali, W., Saba, Z., Hussain, S., Yasin, M., Zahra, S., Irshad, M., & Ramzan, M. (2023) · Hormone and Metabolic Research · doi:10.1055/a-2226-3971 · Cited by 15

Role of melatonin in the dynamics of acute spinal cord injury in rats

Bi, J., Shen, J., Chen, C., Li, Z., Tan, H., Sun, P., & Lin, Y. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16325 · Cited by 15

Melatonin‐mediated malic enzyme 2 orchestrates mitochondrial fusion and respiratory functions to promote odontoblastic differentiation during tooth development

Zhang, F., Yang, S., Jiang, L., Liu, J., He, Y., Sheng, X., Chen, H., Kang, J., Jia, S., Fan, W., et al. (2023) · Journal of Pineal Research · doi:10.1111/jpi.12865 · Cited by 15

The environmental neurotoxin β‐N‐methylamino‐L‐alanine inhibits melatonin synthesis in primary pinealocytes and a rat model

Pierozan, P., Andersson, M., Brandt, I., & Karlsson, O. (2018) · Journal of Pineal Research · doi:10.1111/jpi.12488 · Cited by 15

Neuropharmacologic modulation of the melatonergic system

Aykan, U., Güvel, M. C., Paykal, G., & Uluoğlu, C. (2023) · Exploration of neuroscience · doi:10.37349/en.2023.00029 · Cited by 14

Role of melatonin in mitigation of insulin resistance and ensuing diabetic cardiomyopathy

Nath, A., Ghosh, S., & Bandyopadhyay, D. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122993 · Cited by 15

Melatonin: A Potential Antineoplastic Agent in Breast Cancer

Samanta, S. (2022) · Journal of Environmental Pathology Toxicology and Oncology · doi:10.1615/jenvironpatholtoxicoloncol.2022041294 · Cited by 14

Neuroprotective effects of melatonin‐mediated mitophagy through nucleotide‐binding oligomerization domain and leucine‐rich repeat‐containing protein X1 in neonatal hypoxic–ischemic brain damage

Zhang, Y., Chen, D., Wang, Y., Wang, X., Zhang, Z., & Xin, Y. (2023) · The FASEB Journal · doi:10.1096/fj.202201523r · Cited by 14

Amelioration of gamma irradiation‐induced salivary gland damage in mice using melatonin

Ren, J., Zhu, T., Wang, Z., Lu, L., & Fan, S. (2023) · Journal of Pineal Research · doi:10.1111/jpi.12897 · Cited by 14

Effects of rumen bypass melatonin feeding (RBMF) on milk quality and mastitis of Holstein cows

Yao, S., Wu, H., Ma, H., Fu, Y., Wei, W., Wang, T., Guan, S., Yang, H., Li, X., Guo, J., et al. (2020) · PeerJ · doi:10.7717/peerj.9147 · Cited by 14

Melatonin attenuates chemical-induced cardiotoxicity

Zare, S., Heydari, F., Hayes, A. W., Reiter, R., Zirak, M. R., & Karimi, G. (2020) · Human & Experimental Toxicology · doi:10.1177/0960327120959417 · Cited by 14

Unveiling the Protective Role of Melatonin in Osteosarcoma: Current Knowledge and Limitations

Al-Ansari, N., Samuel, S. M., & Büsselberg, D. (2024) · Biomolecules · doi:10.3390/biom14020145 · Cited by 13

Melatonin and Metabolic Disorders: Unraveling the Interplay With Glucose and Lipid Metabolism, Adipose Tissue, and Inflammation

Hong, S. H., & Kim, J. (2024) · Sleep Medicine Research · doi:10.17241/smr.2024.02159 · Cited by 13

Melatonin rescues cell respiration impaired by hypoxia/reoxygenation in aortic endothelial cells and affects the mitochondrial bioenergetics targeting the F1FO-ATPase

Algieri, C., Bernardini, C., Cugliari, A., Granata, S., Trombetti, F., Glogowski, P. A., Fabbri, M., Morciano, G., Pedriali, G., Pinton, P., et al. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103605 · Cited by 13

Melatonin mitigates type 1 diabetes‐aggravated cerebral ischemia‐reperfusion injury through anti‐inflammatory and anti‐apoptotic effects

Xu, Q., & Cheung, R. T. F. (2023) · Brain and Behavior · doi:10.1002/brb3.3118 · Cited by 12

Protective role of melatonin against diclofenac-induced acute kidney injury

Agaty, S. M. E., Khedr, S., Mostafa, D. K. M., Wanis, N. A., & Abou-Bakr, D. A. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122936 · Cited by 12

Melatonin in animal husbandry: functions and applications

Zhao, R., Bai, Y.-C., & Yang, F. (2024) · Frontiers in Veterinary Science · doi:10.3389/fvets.2024.1444578 · Cited by 12

L-Theanine Ameliorates Obesity-Related Complications Induced by High-Fat Diet in Mice: Insights from Transcriptomics and Metabolomics

Du, Z., Wu, G., Cheng, H., Han, T., Li, D., & Xie, Z. (2024) · Foods · doi:10.3390/foods13182977 · Cited by 12

Study of melatonin-mediated effects on various hepatic inflammatory responses stimulated by IL-6 in a new HepG2-on-a-chip platform

Jang, M., Manz, A., Volk, T. J., & Kleber, A. (2018) · Biomedical Microdevices · doi:10.1007/s10544-018-0300-x · Cited by 13

Melatonin: a Potential Shield against Electromagnetic Waves

Lawand, N., & Jammoul, M. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210609163946 · Cited by 14

Melatonin and Lipid Peroxidation: Antioxidant Shield and Therapeutic Potential

Volpe, O. A. J. N., Zuccari, D. A. P. D. C., Chuffa, L. G. D. A., & Reiter, R. J. (2025) · Frontiers in Bioscience-Landmark · doi:10.31083/fbl45321 · Cited by 12

Physiological relevance of autocrine melatonin signaling in pineal and extrapineal sites: a systematic review

Ndinganire, G., Ntamukunzi, G., & Alagbonsi, A. I. (2026) · Function · doi:10.1152/function.101.2025 · Cited by 13

Regulation of core body temperature and the immune system determines species longevity

Martins, I. J. (2017) · Australasian Journal of Paramedicine · Cited by 11

Combination of CNP, MT and FLI during IVM Significantly Improved the Quality and Development Abilities of Bovine Oocytes and IVF-Derived Embryos

Zhang, P., Yang, B., Xu, X., Zhang, H., Feng, X., Hao, H., Du, W., Zhu, H., Li, S., Yu, W., et al. (2023) · Antioxidants · doi:10.3390/antiox12040897 · Cited by 11

De�novo transcriptome analysis and gene expression profiling of fish scales isolated from Carassius�auratus during space flight: Impact of melatonin on gene expression in response to space radiation

Furusawa, Y., Yamamoto, T., Hattori, A., Suzuki, N., Hirayama, J., Sekiguchi, T., & Tabuchi, Y. (2020) · Molecular Medicine Reports · doi:10.3892/mmr.2020.11363 · Cited by 14

From vulnerability to resilience: unraveling the role of oxidative stress in preterm brain injury

Jiang, Q., Wen, J., Ding, Y., & Cui, H. (2025) · The Italian Journal of Pediatrics/Italian journal of pediatrics · doi:10.1186/s13052-025-02079-4 · Cited by 17

Exogenous Melatonin Activating Nuclear Factor E2-Related Factor 2 (Nrf2) Pathway via Melatonin Receptor to Reduce Oxidative Stress and Apoptosis in Antler Mesenchymal Stem Cells

Jing, H., Sun, X., Li, M., Peng, J., Gu, X., & Xiong, J. (2022) · Molecules · doi:10.3390/molecules27082515 · Cited by 10

Melatonin Rescues Influenza A Virus–Induced Cellular Energy Exhaustion via OMA1‐OPA1‐S in Acute Exacerbation of COPD

Wei, Y., Ye, J., Zhang, D., Hu, L., Wu, H., & Fei, G. (2024) · Journal of Pineal Research · doi:10.1111/jpi.12991 · Cited by 10

Role of Neurotransmitters (Biomediators) in Plant Responses to Stress

Dehghanian, Z., Ahmadabadi, M., Lajayer, B. A., Bagheri, N., Chamani, M., Gougerdchi, V., Hamedpour-Darabi, M., Shu, W., Price, G. W., & Dell, B. (2024) · Plants · doi:10.3390/plants13223134 · Cited by 12

Melatonin protects bovine oocyte from βHB-induced oxidative stress through the Nrf2 pathway

Zhang, K., Guo, J., Wang, S., Min, C.-G., Wang, J., Liu, H., Fang, Y., Ding, H., Zhao, J., Ma, X., et al. (2024) · Theriogenology · doi:10.1016/j.theriogenology.2024.11.025 · Cited by 10

Ni(II) Ions May Target the Entire Melatonin Biosynthesis Pathway—A Plausible Mechanism of Nickel Toxicity

Wezynfeld, N. E., Bonna, A., Płonka, D., Bal, W., & Frączyk, T. (2022) · Molecules · doi:10.3390/molecules27175582 · Cited by 10

Melatonin Preserves Fluidity in Cell and Mitochondrial Membranes against Hepatic Ischemia–Reperfusion

Zubero, E. E., López‐Pingarrón, L., Rodríguez, J. M. ́., Reyes-Gonzales, M. C., Azúa-Romeo, F. J., Soria-Aznar, M., Agil, A., & García, J. J. (2023) · Biomedicines · doi:10.3390/biomedicines11071940 · Cited by 10

ApoE4 dysregulation incites depressive symptoms and mitochondrial impairments in mice

Li, W., Ali, T., He, K., Zheng, C., Li, N., Yu, Z., & Li, S. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.18160 · Cited by 9

Effect of N-Amide Substitution on Antioxidative Activities of Melatonin Derivatives

Panyatip, P., Johns, N. P., Priprem, A., Nakagawa, K., & Puthongking, P. (2020) · Scientia Pharmaceutica · doi:10.3390/scipharm88010003 · Cited by 10

Potential therapeutic value of melatonin in diabetic nephropathy: improvement beyond anti-oxidative stress

Guo, C. Y., He, J., Deng, X., Wang, D., & Yuan, G. (2021) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2021.1933539 · Cited by 11

Gefitinib Enhances Mitochondrial Biological Functions in NSCLCs with EGFR Mutations at a High Cell Density

Takenaka, T., Katayama, M., Sugiyama, A., HAGIWARA, M., Fujii, I., Takatani‐Nakase, T., Kobayashi, S. S., & Nakase, I. (2017) · Anticancer Research · doi:10.21873/anticanres.11884 · Cited by 10

Melatonin Prevents Non-image-Forming Visual System Alterations Induced by Experimental Glaucoma in Rats

Fleitas, M. F. G., Devouassoux, J. D., Aranda, M. L., Diéguez, H. H., Calanni, J. S., Iaquinandi, A., Sande, P. H., Dorfman, D., & Rosenstein, R. E. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02374-1 · Cited by 10

Short-Wavelength Light–Blocking Filters and Oral Melatonin Administration in Patients With Retinitis Pigmentosa: Protocol for a Randomized Controlled Trial

Pastor‐Idoate, S., Mateos-Olivares, M., Sobas, E. M., Marcos, M., Toribio, A., Jimeno, J. C. P., & Usategui‐Martín, R. (2023) · JMIR Research Protocols · doi:10.2196/49196 · Cited by 9

Melatonin: A hypothesis regarding its use to treat Wilson disease

Sharma, R., Reiter, R. J., & Ma, Q. (2019) · Medical Hypotheses · doi:10.1016/j.mehy.2019.109408 · Cited by 9

Melatonin in Reproductive Medicine: A Promising Therapeutic Target?

Feng, X., Zhang, Y., Li, N., Zhang, Y., Zheng, Q., Sun, M., Tang, J., & Xu, Z. (2022) · Current Medicinal Chemistry · doi:10.2174/0929867329666221005101031 · Cited by 9

The Effect of Exogenous Melatonin on Milk Somatic Cell Count in Buffalo

Feng, L. (2021) · Pakistan Veterinary Journal · doi:10.29261/pakvetj/2020.074 · Cited by 9

Melatonin attenuates nicotine-induced autophagy and neurological changes by decreasing the production of reactive oxygen species

Feng, Y., Xu, F., Wang, S., Wu, S., Zhang, X., Gao, Y., Li, Y., Zhong, D.-B., Yin, J., & Feng, Y. (2019) · International Journal of Neuroscience · doi:10.1080/00207454.2019.1692833 · Cited by 10

Paraquat disrupts KIF5A-mediated axonal mitochondrial transport in midbrain neurons and its antagonism by melatonin

Hong, H., Li, J., Tong, T., Yang, T., Wang, H., Xu, Y., Lin, X., Lin, J., Liu, S., Luo, K., et al. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.173119 · Cited by 8

The mitochondria chronicles of melatonin and ATP: Guardians of phase separation

Loh, D., & Reiter, R. J. (2024) · Mitochondrial Communications · doi:10.1016/j.mitoco.2024.07.002 · Cited by 10

OPA1 Mediated Fatty Acid β‐Oxidation in Hepatocyte: The Novel Insight for Melatonin Attenuated Apoptosis in Concanavalin A Induced Acute Liver Injury

Chen, T., Shuang, R., Gao, T., Ai, L., Diao, J., Yuan, X., He, L., Tao, W., & Huang, X. (2024) · Journal of Pineal Research · doi:10.1111/jpi.70010 · Cited by 8

Melatonin in Glaucoma: Integrative Mechanisms of Intraocular Pressure Control and Neuroprotection

Hou, X., & Pan, Y. (2025) · Biomedicines · doi:10.3390/biomedicines13051213 · Cited by 8

Melatonin at the Crossroads of Oxidative Stress, Immunity, and Cancer Therapy

Lavado-Fernández, E., Pérez‐Montes, C., Robles-García, M., Santos‐Ledo, A., & Macia, M. G. (2026) · Antioxidants · doi:10.3390/antiox15010064 · Cited by 13

Cardiometabolic Changes in Sirtuin1-Heterozygous Mice on High-Fat Diet and Melatonin Supplementation

Favero, G., Golić, I., Arnaboldi, F., Cappella, A., Korać, A., Monsalve, M., Stacchiotti, A., & Rezzani, R. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25020860 · Cited by 8

Therapeutic applications of melatonin in disorders related to the gastrointestinal tract and control of appetite

Fard, A. M., Goodarzi, P., Mottahedi, M., Garousi, S., Zadabhari, H., Shahijan, M. K., Esmaeili, S., Nabi‐Afjadi, M., & Yousefi, B. (2024) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-024-02972-5 · Cited by 8

Cardiolipin in myocardial ischaemia-reperfusion injury: From molecular mechanisms to clinical strategies

Xing, Y., Xie, S.-Y., Deng, W., & Tang, Q. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116936 · Cited by 11

Melatonin Supplementation in Alzheimer’s disease: The Potential Role in Neurogenesis

Ebrahimi, R., Faramarzi, A., Salarvandian, S., Zarei, R., Heidari, M., Salehian, F., & Esmaeilpour, K. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05095-x · Cited by 8

Melatonin Attenuates Spinal Cord Injury by Regulating Ferroptosis Through the Nrf2/HO-1/GPX4 Pathway

Yu, Z., Wu, D., Shi, T., Chen, D., Feng, H., Chen, H., Lin, H., Sun, L., & Liu, W. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05226-4 · Cited by 7

Influence of hormones in multiple sclerosis: focus on the most important hormones

Soleimani, A., Ezabadi, S. G., Möhn, N., Esfandabadi, Z. M., Khosravizadeh, Z., Skripuletz, T., & Azimzadeh, M. (2023) · Metabolic Brain Disease · doi:10.1007/s11011-022-01138-7 · Cited by 7

A novel signaling transduction pathway of melatonin on lactose synthesis in cows via melatonin receptor 1 (MT1) and prolactin receptor (PRLR)

Liu, Y., Yao, S., Meng, Q., Liu, X., Han, H., Kan, C., Wang, T., Wei, W., Li, S.-J., Yu, W., et al. (2023) · PeerJ · doi:10.7717/peerj.15932 · Cited by 7

Insight into the cardioprotective effects of melatonin: shining a spotlight on intercellular Sirt signaling communication

Yaghoobi, A., Rezaee, M., Hedayati, N., Keshavarzmotamed, A., Khalilzad, M. A., Russel, R. C. G., Asemi, Z., Moghaddam, H. R., & Mafi, A. (2024) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-024-05002-3 · Cited by 9

Therapeutic potential of melatonin-induced mitophagy in the pathogenesis of Alzheimer’s disease

Goleij, P., Tabari, M. A. K., Poudineh, M., Sanaye, P. M., Khan, H. Z., Kumar, A. P., Larsen, D. S., & Daglia, M. (2025) · Inflammopharmacology · doi:10.1007/s10787-025-01859-y · Cited by 7

The Multiple Functions of Melatonin: Applications in the Military Setting

Gancitano, G., & Reiter, R. J. (2022) · Biomedicines · doi:10.3390/biomedicines11010005 · Cited by 7

Molecular Cloning and Characterization of a Serotonin N-Acetyltransferase Gene, xoSNAT3, from Xanthomonas oryzae pv. oryzae

Chen, X., Zhao, Y., Laborda, P., Yang, Y., & Liu, F. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20031865 · Cited by 7

Dietary Dityrosine Induces Oxidative Stress and Mitochondrial‐Lipid Imbalance in Mouse Liver via MiR‐144‐3p‐Mediated Downregulation of Nrf2

Xue Ming, T. A. N. G., Zeng, F., Wang, J., Lyu, Y., Yu, R., Lu, N., Zhou, Z., & Chen, A. (2023) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202200674 · Cited by 7

Psychotropic Medications for Sleep Disorders in Autism Spectrum Disorders

Rossignol, D. A., & Frye, R. E. (2022) · Autism and child psychopathology series · doi:10.1007/978-3-030-88538-0_53 · Cited by 8

Melatonin in the Treatment of Female Infertility: Update on Biological and Clinical Findings

Tesařík, J., & Mendoza‐Tesarik, R. (2025) · Biomedicines · doi:10.3390/biomedicines13102434 · Cited by 6

Melatonin orchestrates mitochondrial fusion dynamics-mediated WNT/β-catenin signaling to promote dopaminergic neuronal differentiation of human iPS and nerve regeneration in a MPTP-induced mouse model of Parkinson’s disease

Zhang, P., Huang, P., Dong, Q., Luo, J., Cui, G., Guo, X., Li, M., Xia, L., Zhang, H., Zheng, W., et al. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02906-x · Cited by 6

Obese mothers supplemented with melatonin during gestation and lactation ameliorate the male offspring’s pancreatic islet cellular composition and beta-cell function

Nagagata, B. A., Ajackson, M., Ornellas, F., Mandarim‐de‐Lacerda, C. A., & Águila, M. B. (2023) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174423000168 · Cited by 6

Post-Thaw Parameters of Buck Semen Quality after Soy Lecithin Extender Supplementation with Fumaric Acid

Saratsi, A., Samartzi, F., Panagiotidis, I., Basioura, A., Tsiokos, D., Ligda, C., & Rekkas, C. A. (2023) · Veterinary Sciences · doi:10.3390/vetsci10090569 · Cited by 6

Features of Circadian Rhythms in Patients with Cerebrovascular Diseases

Kostenko, E. V., & Петрова, Л. В. (2018) · InTech eBooks · doi:10.5772/intechopen.75963 · Cited by 6

Targeting Glioma Cells with Nutraceuticals: Therapeutic Effects Based on Molecular Mechanisms, New Evidence and Perspectives

Salami, M., Salami, R., Aarabi, M. H., Mafi, A., Ghorbanhosseini, S. S., Shafabakhsh, R., & Asemi, Z. (2022) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557522666220531151137 · Cited by 6

Enterovirus 71 leads to abnormal mitochondrial dynamics in human neuroblastoma SK-N-SH cells

Zhang, W., Yang, H., Liu, Z., Wang, S., Chen, T., Song, H., Xu, Y., Li, F., Luo, G., & Wang, H. (2023) · Virus Research · doi:10.1016/j.virusres.2023.199267 · Cited by 6

Melatonin attenuates chronic immobilization stress-induced muscle atrophy in rats: Influence on lactate-to-pyruvate ratios and Na+/K+ ATPase activity

Allah, E. S. H. A., & Mahmoud, A. M. (2018) · Pathophysiology · doi:10.1016/j.pathophys.2018.06.002 · Cited by 6

Aging: An evolutionary competition between host cells and mitochondria

Tan, D. X. (2019) · Medical Hypotheses · doi:10.1016/j.mehy.2019.04.007 · Cited by 6

Melatonin ultrastructural localization in mitochondria of human salivary glands

Isola, R., Lai, Y., Noli, R., Masala, C., Isola, M., & Loy, F. (2022) · Journal of Anatomy · doi:10.1111/joa.13775 · Cited by 6

Role of Melatonin in Attenuation of Vascular Angiotensin 1-7 Reactivity Via Calcium Channels and Endothelial Derived Relaxing Factors in Induced Diabetic Aortic Rats

Mahmood, N. M. S., Mahmud, A. M. R., & Maulood, I. M. (2024) · Iraqi Journal of Science · doi:10.24996/ijs.2024.65.8.11 · Cited by 5

Melatonin regulation of phase separation in Neuro-PASC: out-maneuvering Janus-faced amyloids

Loh, D., & Reiter, R. J. (2025) · Exploration of neuroscience · doi:10.37349/en.2025.100678 · Cited by 6

Precision redox oncology: Exploiting antioxidant dependencies and oxidative vulnerabilities in cancer

Sulaiman, S. H., Omer, R. A., Barzani, K. I. S., Barzani, H. A. H., Ashfaq, M., Smerat, A., & Feizi‐Dehnayebi, M. (2026) · Chemical Physics Impact · doi:10.1016/j.chphi.2026.101054 · Cited by 6

Cannabis sativa and/or melatonin do not alter brain lipid but alter oxidative mechanisms in female rats

Abdulrahim, H. A., Alagbonsi, A. I., Amuda, O., Omeiza, N. A., Feyitimi, A.-R. A., & Olayaki, L. A. (2021) · Journal of Cannabis Research · doi:10.1186/s42238-021-00095-9 · Cited by 5

Melatonin protects against defects induced by methoxychlor in porcine oocyte maturation

Geng, Z., Zhang, M., Shi, S., Hu, B., Liu, L., Chi, Z.-C., Qu, L.-Y., Jin, Y.-X., & Yu, X. (2024) · Cell Cycle · doi:10.1080/15384101.2024.2402190 · Cited by 5

Comparative efficacy of mitochondrial agents for bipolar disorder during depressive episodes: a network meta-analysis using frequentist and Bayesian approaches

Maiti, R., Mishra, A., Mishra, B. R., & Jena, M. (2021) · Psychopharmacology · doi:10.1007/s00213-021-06019-y · Cited by 5

Influence chronopharmacology therapy methionine (melaxen) on the dynamics of sleep disturbance, cognitive and emotional disorders, brain-derived neurotrophic factor (BDNF) in patients with cerebral stroke in the early and late recovery periods

Kostenko, E. V. (2017) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro20171173156-64 · Cited by 5

Involvement of Melatonin in the Regulation of the Circadian System in Crayfish

Mendoza-Vargas, L., Bañuelos, E. G., Báez‐Saldaña, A., Galicia-Mendoza, F., Flores‐Soto, E., Fuentes‐Pardo, B., Alvarado, R., Valdés‐Tovar, M., Sommer, B., Benítez‐King, G., et al. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19072147 · Cited by 5

Melatonin as mitochondria-targeted drug

Süzen, S., & Saso, L. (2023) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2023.03.006 · Cited by 5

Melatonin: A mitochondrial resident with a diverse skill set

Reiter, R. J., Sharma, R., Rosales‐Corral, S., Zuccari, D. A. P. D. C., & Chuffa, L. G. D. A. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.120612 · Cited by 68

Mitochondria: the birth place, battle ground and the site of melatonin metabolism in cells

Tan, D.-X., & Reiter, R. J. (2019) · Melatonin Research · doi:10.32794/mr11250011 · Cited by 172

Melatonin Targets Mitochondrial Redox Homeostasis: Optimizing the Intracellular Microenvironment

Reiter, R. J., Sharma, R., Loh, D., Chuffa, L. G. D. A., Bai, Y., Zuccari, D. A. P. D. C., Galano, A., & Manucha, W. A. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27104496 · Cited by 2

Melatonin role in the mitochondrial function

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The potential influence of melatonin on mitochondrial quality control: a review

Lei, X., Xu, Z., Huang, L., Huang, Y., Tu, S., Xu, L., & Liu, D. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1332567 · Cited by 36