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Recognition of Local DNA Structures by p53 Protein

Brázda, Václav, Coufal, Jan·2017·International Journal of Molecular Sciences
DOI 10.3390/ijms18020375
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Abstract

p53 plays critical roles in regulating cell cycle, apoptosis, senescence and metabolism and is commonly mutated in human cancer. These roles are achieved by interaction with other proteins, but particularly by interaction with DNA. As a transcription factor, p53 is well known to bind consensus target sequences in linear B-DNA. Recent findings indicate that p53 binds with higher affinity to target sequences that form cruciform DNA structure. Moreover, p53 binds very tightly to non-B DNA structures and local DNA structures are increasingly recognized to influence the activity of wild-type and mutant p53. Apart from cruciform structures, p53 binds to quadruplex DNA, triplex DNA, DNA loops, bulged DNA and hemicatenane DNA. In this review, we describe local DNA structures and summarize information about interactions of p53 with these structural DNA motifs. These recent data provide important insights into the complexity of the p53 pathway and the functional consequences of wild-type and mutant p53 activation in normal and tumor cells.

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Cited by

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Metadata

Authors
Brázda, V., & Coufal, J.
Affiliations
Institute of Biophysics, Academy of Sciences of the Czech Republic v.v.i., Královopolská 135, 612 65 Brno, Czech Republic
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2017-02-10
Volume
18
Issue
2
Pages
375
ISSN
1422-0067
DOI
10.3390/ijms18020375
Cited by
38
References
10
Language
en
Update notices
correction (2017-02-10)
Licence
creativecommons.org/licenses/by/4.0/ (vor)
Funders
Grantová Agentura České Republiky (15-21855S)

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CoChat. (2026). Citation check: Recognition of Local DNA Structures by p53 Protein. https://app.cochat.ai/papers/10.3390/ijms18020375
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Brázda, V., & Coufal, J. (2017). Recognition of Local DNA Structures by p53 Protein. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms18020375

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