The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
The Role of MicroRNAs in Myocardial Infarction: From Molecular Mechanism to Clinical Application
Open accessAbstract
MicroRNAs (miRNAs) are a class of small single-stranded and highly conserved non-coding RNAs, which are closely linked to cardiac disorders such as myocardial infarction (MI), cardiomyocyte hypertrophy, and heart failure. A growing number of studies have demonstrated that miRNAs determine the fate of the heart by regulating cardiac cell death and regeneration after MI. A deep understanding of the pathophysiology of miRNA dependent regulatory pathways in these processes is required. The role of miRNAs as diagnostic, prognostic, and therapeutic targets also needs to be explored in order to utilize them in clinical settings. This review summarizes the role of miRNAs in myocardial infarction and focuses mainly on their influence on cardiomyocyte regeneration and cell death including apoptosis, necrosis, and autophagy. In addition, the targets of pro- and anti-MI miRNAs are comparatively described. In particular, the possibilities of miRNA-based diagnostic and therapeutic strategies for myocardial infarction are discussed in this review.
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Cites
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Cited by
miRNAS in cardiovascular diseases: potential biomarkers, therapeutic targets and challenges
Zhou, S.-S., Jin, J.-P., Wang, J.-Q., Zhang, Z.-G., Freedman, J. H., Zheng, Y., & Cai, L. (2018) · Acta Pharmacologica Sinica · doi:10.1038/aps.2018.30 · Cited by 675
Self-citationPotential Clinical Implications of miR-1 and miR-21 in Heart Disease and Cardioprotection
Kura, B., Kalocayova, B., Devaux, Y., & Bartekova, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21030700 · Cited by 106
Metadata
- Authors
- Sun, T., Dong, Y.-H., Du, W., Shi, C.-Y., Wang, K., Tariq, M.-A., Wang, J.-X., & Li, P.-F.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2017-03-31
- Volume
- 18
- Issue
- 4
- Pages
- 745
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W2604185487
- Cited by
- 166
- References
- 15
- FWCI
- 6.55
- Type
- journal article
- Language
- en
- Open access
- gold
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- Sun, T., Dong, Y.-H., Du, W., Shi, C.-Y., Wang, K., Tariq, M.-A., Wang, J.-X., & Li, P.-F. (2017). The Role of MicroRNAs in Myocardial Infarction: From Molecular Mechanism to Clinical Application. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms18040745
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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