The Impact of Oxidative Stress on the Bone System in Response to the Space Special Environment
Open accessAbstract
The space special environment mainly includes microgravity, radiation, vacuum and extreme temperature, which seriously threatens an astronaut’s health. Bone loss is one of the most significant alterations in mammalians after long-duration habitation in space. In this review, we summarize the crucial roles of major factors—namely radiation and microgravity—in space in oxidative stress generation in living organisms, and the inhibitory effect of oxidative stress on bone formation. We discussed the possible mechanisms of oxidative stress-induced skeletal involution, and listed some countermeasures that have therapeutic potentials for bone loss via oxidative stress antagonism. Future research for better understanding the oxidative stress caused by space environment and the development of countermeasures against oxidative damage accordingly may facilitate human beings to live more safely in space and explore deeper into the universe.
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During and after spaceflight, there is an increase of 8-iso-prostaglandin F2α and 8OHdG, which can be used for markers of damage to lipids and DNA.
“During and after spaceflight, there is an increase of 8-iso-prostaglandin F2α and 8OHdG, which can be used for markers of damage to lipids and DNA50.”
Study of markers of ROS damage have been done with research purposes, observing an increase in astronauts.
“However, the study of markers of ROS damage have been done with research purposes, observing an increase in astronauts48,50–52.”
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- Authors
- Tian, Y., Ma, X., Yang, C., Su, P., Yin, C., & Qian, A.-R.
- Affiliations
- Northwestern Polytechnical University (CN)
- Key Laboratory for Space Bioscience and Biotechnology, Bone Metabolism Lab, School of Life Sciences, Northwestern Polytechnical University, Xi’an 710072, China
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2017-10-12
- Volume
- 18
- Issue
- 10
- Pages
- 2132
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC5666814
- OpenAlex
- W2760884697
- Cited by
- 80
- References
- 79
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 12 · 2023: 12 · 2022: 4 · 2021: 18 · 2020: 7 · 2019: 5 · 2018: 8
- FWCI
- 0.67
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- China Postdoctoral Science Foundation (2017M613210)
- Topics
- Health Sciences › Medicine › Physiology › Spaceflight effects on biology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
- Keywords
- oxidative stress, bone loss, space environment, microgravity, radiation, astronaut health, bone formation, countermeasures, long-duration spaceflight
- MeSH terms
- Animals, Bone and Bones, Bone Resorption, Environment, Humans, Osteogenesis, Radiation, Space Flight, Weightlessness, Oxidative Stress
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