Cited by 80Spaceflight effects on biologyBone Metabolism and DiseasesEffects of Radiation Exposure

The Impact of Oxidative Stress on the Bone System in Response to the Space Special Environment

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Tian, Ye, Ma, Xiaoli, Yang, Chaofei, Su, Peihong, Yin, Chong, Qian, Ai-Rong·2017·International Journal of Molecular Sciences

Abstract

The space special environment mainly includes microgravity, radiation, vacuum and extreme temperature, which seriously threatens an astronaut’s health. Bone loss is one of the most significant alterations in mammalians after long-duration habitation in space. In this review, we summarize the crucial roles of major factors—namely radiation and microgravity—in space in oxidative stress generation in living organisms, and the inhibitory effect of oxidative stress on bone formation. We discussed the possible mechanisms of oxidative stress-induced skeletal involution, and listed some countermeasures that have therapeutic potentials for bone loss via oxidative stress antagonism. Future research for better understanding the oxidative stress caused by space environment and the development of countermeasures against oxidative damage accordingly may facilitate human beings to live more safely in space and explore deeper into the universe.

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Authors
Tian, Y., Ma, X., Yang, C., Su, P., Yin, C., & Qian, A.-R.
Affiliations
  • Northwestern Polytechnical University (CN)
  • Key Laboratory for Space Bioscience and Biotechnology, Bone Metabolism Lab, School of Life Sciences, Northwestern Polytechnical University, Xi’an 710072, China
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2017-10-12
Volume
18
Issue
10
Pages
2132
ISSN
1422-0067 (ISSN-L)
OpenAlex
W2760884697
Cited by
80
References
79
Citations by year
2026: 6 · 2025: 8 · 2024: 12 · 2023: 12 · 2022: 4 · 2021: 18 · 2020: 7 · 2019: 5 · 2018: 8
FWCI
0.67
Type
journal article
Language
en
Open access
Locations
  • International Journal of Molecular Sciences (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
China Postdoctoral Science Foundation (2017M613210)
Topics
  • Health Sciences › Medicine › Physiology › Spaceflight effects on biology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
Keywords
oxidative stress, bone loss, space environment, microgravity, radiation, astronaut health, bone formation, countermeasures, long-duration spaceflight
MeSH terms
Animals, Bone and Bones, Bone Resorption, Environment, Humans, Osteogenesis, Radiation, Space Flight, Weightlessness, Oxidative Stress

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