Cited by 106Amyotrophic Lateral Sclerosis ResearchAlzheimer's disease research and treatmentsHereditary Neurological Disorders

The DOI matches its Crossref record; 151 of the 154 references it cites were found in a registry or an index.

Risk Factors and Emerging Therapies in Amyotrophic Lateral Sclerosis

Open access

Nowicka, Natalia, Juranek, Jakub, Juranek, Judyta K., Wojtkiewicz, Joanna·2019·International Journal of Molecular Sciences

DOI 10.3390/ijms20112616PMC PMC6600314

Open this paper in CoChat — free account Open PDF

Abstract

Amyotrophic lateral sclerosis (ALS) is a fatal progressive neurodegenerative disease characterized by a permanent degeneration of both upper and lower motor neurons. Many different genes and pathophysiological processes contribute to this disease, however its exact cause remains unclear. Therefore, it is necessary to understand this heterogeneity to find effective treatments. In this review, we focus on selected environmental and genetic risk factors predisposing to ALS and highlight emerging treatments in ALS therapy. Of numerous defective genes associated with ALS, we focus on four principal genes that have been identified as definite causes of ALS: the SOD1 gene, C9orf72, TDP-43, as well as the recently identified TBK1. We also provide up-to-date information on selected environmental factors that have historically been considered as key players in ALS development and pathogenesis. In parallel to our survey of known risk factors, we also discuss emerging ALS stem cell therapies and experimental medicines currently undergoing phase II and III clinical trials.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.3390/ijms20112616

Cites

151 of 151 references verified0 citation errors · 0 not checkable

Statistics

Figure 1 Schematic depiction of risk factors in ALS. ALS risk factors can be divided into two main categories: genetic and environmental. Well-documented genetic factors include mutations in superoxide dismutase 1 (SOD1 gene), mutation in TAR DNA binding protein (TARDBP), a hexanucleotide repeat expansion (GGGGCC) in the first intron of the C9orf72 gene, and mutations in TANK-binding kinase 1 (TBK1). The researched environmental risk factors are BMI and nutritional state and exposure to heavy metals, pesticides, and electromagnetic fields.CC BY · PubMed Central

Figure 2 Overview of main approaches to ALS treatment. The therapies studied can be divided into seven general groups, mainly based on pathophysiological models of the disease. The groups include anti-apoptotic, anti-inflammatory, anti-excitotoxicitory, anti-oxidant, anti-aggregation, neurotrophic growth factor, and neuroprotective approaches, which all can be classified as pharmacological interventions. Additionally, a separate non-pharmacological group of stem cell therapies is discussed.CC BY · PubMed Central

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Superoxide Dismutase
McCord, J. M., & Fridovich, I. (1969) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)63504-5 · Cited by 12,952
Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity
Polazzi, E., Mengoni, I., Caprini, M., Peña‐Altamira, E., Kurtys, E., & Monti, B. (2012) · Neurosignals · doi:10.1159/000337115 · Cited by 9,023
Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis
Rosen, D. R., Siddique, T., Patterson, D., Figlewicz, D. A., Sapp, P., Hentati, A., Donaldson, D., Goto, J., O'Regan, J. P., Deng, H.-X., et al. (1993) · Nature · doi:10.1038/362059a0 · Cited by 7,062
Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS
DeJesus-Hernandez, M., Mackenzie, I. R., Boeve, B. F., Boxer, A. L., Baker, M., Rutherford, N. J., Nicholson, A. M., Finch, N. A., Flynn, H., Adamson, J., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.09.011 · Cited by 4,936 · cited 1×
“In FTD, it has been detected in 25% of all patients with familial ALS, underlining the importance of the hypothesis that classical ALS and FTD represent the extremes of a single mutation spectrum [41].”
Background
A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD
Renton, A. E., Majounie, E., Waite, A., Simón-Sánchez, J., Rollinson, S., Gibbs, J. R., Schymick, J. C., Laaksovirta, H., van Swieten, J. C., Myllykangas, L., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.09.010 · Cited by 4,409
TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
Arai, T., Hasegawa, M., Akiyama, H., Ikeda, K., Nonaka, T., Mori, H., Mann, D., Tsuchiya, K., Yoshida, M., Hashizume, Y., et al. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.10.093 · Cited by 2,732
Mutations in the FUS/TLS Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis
Kwiatkowski, T. J., Bosco, D. A., LeClerc, A. L., Tamrazian, E., Vanderburg, C. R., Russ, C., Davis, A., Gilchrist, J. M., Kasarskis, E. J., Munsat, T. L., et al. (2009) · Science · doi:10.1126/science.1166066 · Cited by 2,624
Superoxide dismutase multigene family: a comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression
Zelko, I. N., Mariani, T. J., & Folz, R. J. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00905-x · Cited by 2,212
Toxic Metals and Oxidative Stress Part I: Mechanisms Involved in Me-tal induced Oxidative Damage
Nuran Ercal, B. S. P., Hande Gurer-Orhan, B. S. P., & Nukhet Aykin-Burns, B. S. P. (2001) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026013394831 · Cited by 1,944
Amyotrophic Lateral Sclerosis
Rowland, L. P., & Shneider, N. A. (2001) · New England Journal of Medicine · doi:10.1056/nejm200105313442207 · Cited by 1,913

Show all 154 references

Research works printed but not linked: 1

Parry, 2016, Ursodeoxycholic Acid May Slow the Progression of Amyotrophic Lateral Sclerosis, Ann. Neurodegener. Dis., 1, 1013

Sorted by citations

Excitatory Amino Acid Transporters in Physiology and Disorders of the Central Nervous System
Malik, A. R., & Willnow, T. E. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20225671 · Cited by 170
The role of nitric oxide in brain disorders: Autism spectrum disorder and other psychiatric, neurological, and neurodegenerative disorders
Tripathi, M. K., Kartawy, M., & Amal, H. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101567 · Cited by 163
Role of Alcohol Drinking in Alzheimer’s Disease, Parkinson’s Disease, and Amyotrophic Lateral Sclerosis
Peng, B., Yang, Q., B Joshi, R., Liu, Y., Akbar, M., Song, B.-J., Zhou, S., & Wang, X. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072316 · Cited by 156
Role of Edaravone as a Treatment Option for Patients with Amyotrophic Lateral Sclerosis
Cho, H., & Shukla, S. (2020) · Pharmaceuticals · doi:10.3390/ph14010029 · Cited by 124
Silence superoxide dismutase 1 (SOD1): a promising therapeutic target for amyotrophic lateral sclerosis (ALS)
Abati, E., Bresolin, N., Comi, G. P., & Corti, S. P. (2020) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2020.1738390 · Cited by 107
Molecular Targets of Cannabidiol in Experimental Models of Neurological Disease
Silvestro, S., Schepici, G., Bramanti, P., & Mazzon, E. (2020) · Molecules · doi:10.3390/molecules25215186 · Cited by 93
Neuropsychological and neurophysiological aspects of brain‐computer‐interface (BCI) control in paralysis
Chaudhary, U., Mrachacz‐Kersting, N., & Birbaumer, N. (2020) · The Journal of Physiology · doi:10.1113/jp278775 · Cited by 88
Nearly 30 Years of Animal Models to Study Amyotrophic Lateral Sclerosis: A Historical Overview and Future Perspectives
Bonifacino, T., Zerbo, R. A., Balbi, M., Torazza, C., Frumento, G., Fedele, E., Bonanno, G., & Milanese, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212236 · Cited by 82
CRISPR/Cas9-mediated excision of ALS/FTD-causing hexanucleotide repeat expansion in C9ORF72 rescues major disease mechanisms in vivo and in vitro
Meijboom, K. E., Abdallah, A., Fordham, N. P., Nagase, H., Rodríguez, T., Kraus, C., Gendron, T. F., Krishnan, G., Esanov, R., Andrade, N. S., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-33332-7 · Cited by 78
Reduced mitochondrial D-loop methylation levels in sporadic amyotrophic lateral sclerosis
Stoccoro, A., Smith, A. R., Mosca, L., Marocchi, A., Gerardi, F., Lunetta, C., Cereda, C., Gagliardi, S., Lunnon, K., Migliore, L., et al. (2020) · Clinical Epigenetics · doi:10.1186/s13148-020-00933-2 · Cited by 57
11 C‐PK11195 PET–based molecular study of microglia activation in SOD1 amyotrophic lateral sclerosis
Tondo, G., Iaccarino, L., Cerami, C., Vanoli, G. E., Presotto, L., Masiello, V., Coliva, A., Salvi, F., Bartolomei, I., Mosca, L., et al. (2020) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.51112 · Cited by 56
“Overall, SOD1-ALS clinical phenotypes can be heterogeneous in regard to age of onset, severity and prognosis, which could be modulated by other determinants such as central nervous system dynamics, as well as by environmental factors.(25) How SOD1 pathogenic mutations trigger neurodegeneration is still a matter of deb…”
Background
Dissecting the Relationship Between Neuropsychiatric and Neurodegenerative Disorders
Gupta, R. V., Advani, D., Yadav, D., Ambasta, R. K., & Kumar, P. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03502-9 · Cited by 61
Skeletal Muscle-Restricted Expression of Human SOD1 in Transgenic Mice Causes a Fatal ALS-Like Syndrome
Martin, L. J., & Wong, M. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.592851 · Cited by 49
p62: Friend or Foe? Evidences for OncoJanus and NeuroJanus Roles
Emanuele, S., Lauricella, M., D’Anneo, A., Carlisi, D., Blasio, A. D., Liberto, D. D., & Giuliano, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21145029 · Cited by 48
One-carbon epigenetics and redox biology of neurodegeneration
Coppedè, F. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.12.002 · Cited by 48
Role of Oxidative Stress on the Etiology and Pathophysiology of Amyotrophic Lateral Sclerosis (ALS) and Its Relation with the Enteric Nervous System
López‐Pingarrón, L., Almeida, H., Soria-Aznar, M., Reyes-Gonzales, M. C., Terrón, M. P., & García, J. J. (2023) · Current Issues in Molecular Biology · doi:10.3390/cimb45040217 · Cited by 46
TDP-43 Mutation Affects Stress Granule Dynamics in Differentiated NSC-34 Motoneuron-Like Cells
Ding, Q., Chaplin, J., Morris, M. J., Hilliard, M. A., Wolvetang, E. J., Ng, D. C. H., & Noakes, P. G. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.611601 · Cited by 40
Modulation of the gut–brain axis via the gut microbiota: a new era in treatment of amyotrophic lateral sclerosis
Hong, D., Zhang, C., Wu, W., Lu, X., & Zhang, L. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1133546 · Cited by 38
GPX4 deficiency-dependent phospholipid peroxidation drives motor deficits of ALS
Tu, L., Zhang, T.-Z., Zhou, Y.-F., Zhou, Q., Gong, H., Liang, L., Hai, L.-N., You, N.-X., Su, Y., Chen, Y., et al. (2022) · Journal of Advanced Research · doi:10.1016/j.jare.2022.02.016 · Cited by 38
Nutrient effects on motor neurons and the risk of amyotrophic lateral sclerosis
Goncharova, P. S., Davydova, T. K., Popova, T. E., Novitsky, M. A., Petrova, M. M., Gavrilyuk, O. A., Al-Zamil, M., Zhukova, N. G., Nasyrova, R. F., & Shnayder, N. A. (2021) · Nutrients · doi:10.3390/nu13113804 · Cited by 35
Role of Polyphenols on Gut Microbiota and the Ubiquitin-Proteasome System in Neurodegenerative Diseases
Nargeh, H., Aliabadi, F., Ajami, M., & Pazoki–Toroudi, H. (2021) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.1c00923 · Cited by 32
A Review of the Common Neurodegenerative Disorders: Current Therapeutic Approaches and the Potential Role of Bioactive Peptides
Singh, K., Gupta, J. K., Kumar, S., & Soni, U. (2024) · Current Protein and Peptide Science · doi:10.2174/0113892037275221240327042353 · Cited by 32
The NGS technology for the identification of genes associated with the ALS. A systematic review
Pecoraro, V., Mandrioli, J., Carone, C., Chiò, A., Traynor, B. J., & Trenti, T. (2020) · European Journal of Clinical Investigation · doi:10.1111/eci.13228 · Cited by 25
Organ on a Chip: A Novel in vitro Biomimetic Strategy in Amyotrophic Lateral Sclerosis (ALS) Modeling
Arjmand, B., Hamidpour, S. K., Rabbani, Z. H., Tayanloo-Beik, A., Rahim, F., Aghayan, H. R., & Larijani, B. A. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2021.788462 · Cited by 24
Stem cells in central nervous system diseases: Promising therapeutic strategies
Ying, C., Zhang, J., Zhang, H., Gao, S., Guo, X., Lin, J., Wu, H., & Hong, Y. (2023) · Experimental Neurology · doi:10.1016/j.expneurol.2023.114543 · Cited by 22
Nanotheranostics revolutionizing neurodegenerative diseases: From precision diagnosis to targeted therapies
Joshi, R., Missong, H., Mishra, J., Kaur, S., Saini, S., Kandimalla, R. J. L., Reddy, P. H., Babu, A. M., Bhatti, G. K., & Bhatti, J. S. (2023) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2023.105067 · Cited by 23
In a search for efficient treatment for amyotrophic lateral sclerosis: Old drugs for new approaches
Kukharsky, M. S., Skvortsova, V. I., Бачурин, С. О., & Buchman, V. L. (2020) · Medicinal Research Reviews · doi:10.1002/med.21725 · Cited by 21
FUS gene mutation in amyotrophic lateral sclerosis: a new case report and systematic review
Xiao, X., Li, M., Ye, Z., He, X., Wei, J. S., & Zha, Y. (2023) · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration · doi:10.1080/21678421.2023.2272170 · Cited by 21
Neurodegenerative Marine Algae Bioactive Compounds: A Viable Cure to Treat Amyotrophic Lateral Sclerosis (ALS): A Review
Mani, A., Narayanan, M., & Rajinikanth, V. (2024) · Dubai Medical Journal · doi:10.18502/dmj.v7i3.17735 · Cited by 20
Amyotrophic lateral sclerosis (ALS) and the endocrine system: Are there any further ties to be explored?
Mentis, A. A., Bougea, A. M., & Chrousos, G. P. (2021) · Aging Brain · doi:10.1016/j.nbas.2021.100024 · Cited by 20
Incidence of amyotrophic lateral sclerosis in Sardinia, Italy: age–sex interaction and spatial–temporal variability
Borghero, G., Pierri, V., Vasta, R., Ercoli, T., Primicerio, G. C., Pili, F. M. G., Gigante, A. F., Rocchi, L., Chiò, A., & Defazio, G. (2022) · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration · doi:10.1080/21678421.2022.2041670 · Cited by 19
Omics-based exploration and functional validation of neurotrophic factors and histamine as therapeutic targets in ALS
Volonté, C., Morello, G., Spampinato, A. G., Amadio, S., Apolloni, S., D’Agata, V., & Cavallaro, S. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101121 · Cited by 19
Amyotrophic Lateral Sclerosis and Air Pollutants in the Province of Ferrara, Northern Italy: An Ecological Study
Antonioni, A., Govoni, V., Brancaleoni, L., Donà, A., Granieri, E., Bergamini, M., Gerdol, R., & Pugliatti, M. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20085591 · Cited by 19
Machine learning hypothesis-generation for patient stratification and target discovery in rare disease: our experience with Open Science in ALS
Geraci, J., Bhargava, R., Qorri, B., Leonchyk, P., Cook, D. J., Cook, M., Sie, F., & Pani, L. (2024) · Frontiers in Computational Neuroscience · doi:10.3389/fncom.2023.1199736 · Cited by 19
The Involvement of RAGE and Its Ligands during Progression of ALS in SOD1 G93A Transgenic Mice
Nowicka, N., Szymanska, K., Juranek, J. K., Zglejc‐Waszak, K., Korytko, A., Załęcki, M., Chmielewska‐Krzesińska, M., Wa̧sowicz, K., & Wojtkiewicz, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23042184 · Cited by 18
Self-citation
The Impact of ALS-Associated Genes hnRNPA1, MATR3, VCP and UBQLN2 on the Severity of TDP-43 Aggregation
Bajc Česnik, A., Motaln, H., & Rogelj, B. (2020) · Cells · doi:10.3390/cells9081791 · Cited by 17
Protection from the Pathogenesis of Neurodegenerative Disorders, including Alzheimer’s Disease, Amyotrophic Lateral Sclerosis, Huntington’s Disease, and Parkinson’s Diseases, through the Mitigation of Reactive Oxygen Species
Madireddy, S., & Madireddy, S. (2019) · Journal of Neuroscience and Neurological Disorders · doi:10.29328/journal.jnnd.1001026 · Cited by 16
Exploring Multiple Sclerosis (MS) and Amyotrophic Lateral Scler osis (ALS) as Neurodegenerative Diseases and their Treatments: A Review Study
Deeb, O., & Nabulsi, M. (2020) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026620666200924114827 · Cited by 18
Genetic architecture of amyotrophic lateral sclerosis: a comprehensive review
Yuan, L., Yang, Y., Guo, Y., & Deng, H. (2025) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2025.05.008 · Cited by 18
Neurodegenerative disease and antioxidant biomarkers: A bidirectional Mendelian randomization study
Zhang, Q., Li, Q., Zhao, H., Shu, M., Luo, M., Li, Y., Ding, Y., Shi, S., Cheng, X., & Niu, Q. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1158366 · Cited by 14
Association of Single Nucleotide Polymorphism at rs2275294 in the ZNF512B Gene with Prognosis in Amyotrophic Lateral Sclerosis
Jiang, H., Yang, B., Wang, F., Li, K., Zhu, Y., Liu, B., Ren, H. J., Tian, S., Xu, Y., Pang, A., et al. (2021) · NeuroMolecular Medicine · doi:10.1007/s12017-020-08634-y · Cited by 11
Dioxinodehydroeckol: A Potential Neuroprotective Marine Compound Identified by In Silico Screening for the Treatment and Management of Multiple Brain Disorders
Ahmad, F., Sachdeva, P., Sachdeva, B., Singh, G., Soni, H., Tandon, S., Rafeeq, M. M., Alam, M. Z., Baeissa, H. M., & Khalid, M. (2022) · Molecular Biotechnology · doi:10.1007/s12033-022-00629-3 · Cited by 10
Novel insights into RAGE signaling pathways during the progression of amyotrophic lateral sclerosis in RAGE-deficient SOD1 G93A mice
Nowicka, N., Zglejc‐Waszak, K., Juranek, J. K., Korytko, A., Wa̧sowicz, K., Chmielewska‐Krzesińska, M., & Wojtkiewicz, J. (2024) · PLoS ONE · doi:10.1371/journal.pone.0299567 · Cited by 9
Self-citation
Ensemble-imbalance-based classification for amyotrophic lateral sclerosis prognostic prediction: identifying short-survival patients at diagnosis
Papaiz, F., Júnior, M. E. T. D., Valentim, R. A. D. M., Pinto, R. D. M., de Morais, A. H. F., & Arrais, J. P. (2024) · BMC Medical Informatics and Decision Making · doi:10.1186/s12911-024-02484-5 · Cited by 9
Neurologic orphan diseases: Emerging innovations and role for genetic treatments
Kioutchoukova, I. P., Foster, D. T., Thakkar, R. N., Foreman, M. A., Burgess, B. J., Toms, R., Valero, E., & Lucke-Wold, B. P. (2023) · World Journal of Experimental Medicine · doi:10.5493/wjem.v13.i4.59 · Cited by 11
The preferences of people with amyotrophic lateral sclerosis on riluzole treatment in Europe
Ludolph, A. C., Grandjean, H., Reviers, E., Micheli, V. D., Bianchi, C., Cardosi, L., Russ, H., & Silani, V. (2023) · Scientific Reports · doi:10.1038/s41598-023-49424-3 · Cited by 9
Cerebrospinal fluid MFG-E8 as a promising biomarker of amyotrophic lateral sclerosis
Yang, B., Wu, Y., Wang, Y., Yang, H., Du, B., Wei, D., Xu, X., & Shi, X. (2020) · Neurological Sciences · doi:10.1007/s10072-020-04416-3 · Cited by 10
The rs2619566, rs10260404, and rs79609816 Polymorphisms Are Associated With Sporadic Amyotrophic Lateral Sclerosis in Individuals of Han Ancestry From Mainland China
Zhang, J., Qiu, W., Hu, F., Zhang, X., Deng, Y., Nie, H., & Xu, R. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.679204 · Cited by 9
Locus-specific analysis of Transposable Elements during the progression of ALS in the SOD1G93A mouse model
Valdebenito‐Maturana, B., Arancibia, E., Riadi, G., Tapia, J. C., & Carrasco, M. A. (2021) · PLoS ONE · doi:10.1371/journal.pone.0258291 · Cited by 9
Protective Effects of Choline against Inflammatory Cytokines and Characterization of Transport in Motor Neuron-like Cell Lines (NSC-34)
Latif, S., & Kang, Y. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14112374 · Cited by 7
A computational biology approach to identify potential protein biomarkers and drug targets for sporadic amyotrophic lateral sclerosis
Kumar, R., Malik, M. Z., Thanaraj, T. A., Bagabir, S. A., Haque, S., Tambuwala, M. M., & Haider, S. (2023) · Cellular Signalling · doi:10.1016/j.cellsig.2023.110915 · Cited by 7
Oxidative stress and neurodegenerative diseases: Exploring natural antioxidants for therapeutic potential
Doke, R. R., Kallur, S., Suryawanshi, A. P., Utarade, A., Kandalkar, P., Morde, R., & Bhagwat, A. A. (2023) · IP International Journal of Comprehensive and Advanced Pharmacology · doi:10.18231/j.ijcaap.2023.026 · Cited by 8
Resting-State EEG Oscillations in Amyotrophic Lateral Sclerosis (ALS): Toward Mechanistic Insights and Clinical Markers
Chmiel, J., & Stępień–Słodkowska, M. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14020545 · Cited by 9
Amyotrophic lateral sclerosis and the innate immune system: protocol for establishing a biobank and statistical analysis plan
Kjældgaard, A.-L., Pilely, K., Olsen, K. S., Lauritsen, A. Ø., Pedersen, S. W., Møller, K., & Garred, P. (2020) · BMJ Open · doi:10.1136/bmjopen-2020-037753 · Cited by 6
Improving prediction models of amyotrophic lateral sclerosis (ALS) using polygenic, pre-existing conditions, and survey-based risk scores in the UK Biobank
Jin, W., Boss, J., Bakulski, K. M., Goutman, S. A., Feldman, E. L., Fritsche, L. G., & Mukherjee, B. (2024) · Journal of Neurology · doi:10.1007/s00415-024-12644-2 · Cited by 5
Advancing Future Amyotrophic Lateral Sclerosis Medicines by Incorporating The Patient Voice Into Patient-Centered Holistic Measurement Strategies for Clinical and Real-World Studies: Results from Targeted Literature Reviews
Rofail, D., Chladek, M. R., Williams, B., Patel, N., Nowell, W. B., Karantzoulis, S., & Levy, O. (2025) · Neurology and Therapy · doi:10.1007/s40120-025-00740-y · Cited by 5
Amyotrophic lateral sclerosis
Vacca, V. M. (2020) · Nursing · doi:10.1097/01.nurse.0000662348.31823.44 · Cited by 5
Head Injury and Amyotrophic Lateral Sclerosis: Population-Based Study from the National ALS Registry
Raymond, J., Howard, I. M., Berry, J., Larson, T., Horton, D. K., & Mehta, P. (2025) · Brain Sciences · doi:10.3390/brainsci15020143 · Cited by 4
Polyphenols and Stem Cells for Neuroregeneration in Parkinson’s Disease and Amyotrophic Lateral Sclerosis
Goyal, S., Seth, B., & Chaturvedi, R. K. (2021) · Current Pharmaceutical Design · doi:10.2174/1381612827666211115154450 · Cited by 4
Plasma levels of soluble RAGE, AGEs and AOPPs at the early stage of amyotrophic lateral sclerosis: A preliminary study
Juranek, J. K., Osowski, A., Wojtkiewicz, J., & Banach, M. D. (2023) · Polymers in Medicine · doi:10.17219/pim/175544 · Cited by 4
Self-citation
Role of Receptor for Advanced Glycation End-Products in Endometrial Cancer: A Review
Zglejc‐Waszak, K., Jóźwik, M., Thoene, M. A., & Wojtkiewicz, J. (2024) · Cancers · doi:10.3390/cancers16183192 · Cited by 5
Self-citation
Predicting ALS progression using Autoregressive deep learning models
Papaiz, F., Júnior, M. E. T. D., Valentim, R. A. D. M., Fernandes, F. R. D. S., dos Santos, J. P. Q., de Morais, A. H. F., Correia, F. B., & Arrais, J. P. (2025) · Intelligence-Based Medicine · doi:10.1016/j.ibmed.2025.100247 · Cited by 3
The Effect of RAGE-Diaph1 Signaling Inhibition on the Progression of Peripheral Neuropathy in Diabetic Mice
Zglejc‐Waszak, K., Korytko, A., Kordas, B., Pomianowski, A., Lewczuk, B., Wojtkiewicz, J., Wa̧sowicz, K., Babińska, I., Mukherjee, K., & Juranek, J. K. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262211182 · Cited by 3
Self-citation
Cutting-edge treatments in amyotrophic lateral sclerosis: the role of molecular pathogenesis in targeted therapies
Raoufinia, R., Alyari, G., Nia, A. T., Abbaszadegan, M. R., Mahmoudi, A., Shafaeibajestan, S., Saburi, E., Tavakol‐Afshari, J., Hassani, M., Jamali, F., et al. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04781-w · Cited by 4
The influence of environmental risk factors in the development of ALS in the Mediterranean Island of Cyprus
Mitsi, E., Christodoulou, C. C., Nicolaou, P., Christodoulou, K., & Zamba-Papanicolaou, E. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1264743 · Cited by 5
Examining ALS: reformed PCA and random forest for effective detection of ALS
Alqahtani, A., Alsubai, S., Sha, M., & Dutta, A. K. (2024) · Journal Of Big Data · doi:10.1186/s40537-024-00951-4 · Cited by 3
Hemizygous Granzyme A Mice Expressing the hSOD1G93A Transgene Show Slightly Extended Lifespan
Moreno‐Martínez, L., Santiago, L., de la Torre, M., Calvo, A. C., Pardo, J., & Osta, R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113554 · Cited by 5
1,2-Dehydropyrrolizidine Alkaloids: Their Potential as a Dietary Cause of Sporadic Motor Neuron Diseases
Edgar, J. A., Molyneux, R. J., & Colegate, S. M. (2022) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.1c00384 · Cited by 2
Headache types and characteristics in patients with Amyotrophic Lateral Sclerosis
Soliman, R., Fahmy, N. A., & Swelam, M. S. (2025) · The Journal of Headache and Pain · doi:10.1186/s10194-025-01987-4 · Cited by 2
Molecular therapeutic strategies in neurodegenerative diseases and injury
Tora, M. S., Texakalidis, P., Greven, A., Faraj, R. R., Gendreau, J. L., Liang, Z., Federici, T., & Boulis, N. M. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-818084-6.00012-x · Cited by 2
Impact of occupational categories on the incidence of amyotrophic lateral sclerosis in Sardinia Island, Italy
Pierri, V., Borghero, G., Pili, F. M. G., Ercoli, T., Gigante, A. F., Lecca, L. I., Vasta, R., Campagna, M., Chiò, A., & Defazio, G. (2022) · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration · doi:10.1080/21678421.2022.2153606 · Cited by 1
Racial and ethnic disparities in ALS: a longitudinal electronic health records study
Kuo, T., Reynolds, T., Chen, L., Park, C., Rascati, K. L., & Godley, P. J. (2025) · Therapeutic Advances in Neurological Disorders · doi:10.1177/17562864251365001 · Cited by 1
Safety and efficacy of the Atalante exoskeleton in the rehabilitation of French patients with amyotrophic lateral sclerosis: a prospective, monocentric, open, uncontrolled, interventional protocol, EXALS
Trad, G., Lenglet, T., Ledoux, I., Querin, G., Blancho, S., Marchand‐Pauvert, V., Hogrel, J., & Pradat, P. (2026) · BMJ Open · doi:10.1136/bmjopen-2025-109620 · Cited by 1
Targeting metabolic dysfunction in amyotrophic lateral sclerosis: therapeutic potential of GLP-1 receptor agonists
Helal, M. M., Almosilhy, N. A., Abo‐elnour, D. E., Jaffal, R., Allam, E. G., Almosilhy, M. A., Batarseh, S. F., & Meshref, M. M. (2026) · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration · doi:10.1080/21678421.2026.2627901 · Cited by 2
Exploring the Lived Experiences of Individuals with Amyotrophic Lateral Sclerosis (ALS): A Qualitative Study and Conceptual Model of Signs, Symptoms, and Functional Impacts
Nowell, W. B., McGale, N., Levy, O. A., Wilding, S., Heinrich, P., Patel, N. C., Andrews, J. A., & Rofail, D. (2026) · Neurology and Therapy · doi:10.1007/s40120-026-00895-2 · Cited by 2
Mortality From Amyotrophic Lateral Sclerosis in Finland 1987–2022
Laine, M., Raitanen, J. A., & Auvinen, A. P. (2026) · European Journal of Neurology · doi:10.1111/ene.70586 · Cited by 1
Amyotrophic lateral sclerosis
Vacca, V. M. (2019) · Nursing Critical Care · doi:10.1097/01.ccn.0000612832.74020.6e · Cited by 1
Emerging Drugs for Amyotrophic Lateral Sclerosis
Boucher, M., & Mierzwinski‐Urban, M. (2022) · Canadian Journal of Health Technologies · doi:10.51731/cjht.2022.274 · Cited by 1
Fertility Does Not Alter Disease Progression in ALS Patients of Childbearing Age: A Three Centers Retrospective Analysis in Southern China
Yang, B., Huang, S., Zheng, Y., Hou, X., Lin, J., Peng, Y., Du, B., & Yao, X. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.895321 · Cited by 1
Esclerose Lateral Amiotrófica
Tozani, F. D. D., & de Siqueira, E. C. (2023) · Revista Eletrônica Acervo Médico · doi:10.25248/reamed.e12006.2023 · Cited by 1
Dynamic analysis of muscles and the internal structure of the peripheral nerve as biomarkers of amyotrophic lateral sclerosis: A pilot study with ultrasound imaging
López-Navarro, C., Serrano-Valero, M., Fages-Caravaca, E. M., Martínez-Payá, J. J., del Baño-Aledo, M. E., & Ríos-Díaz, J. (2023) · Neurología (English Edition) · doi:10.1016/j.nrleng.2021.10.007 · Cited by 1
Amyotrophic Lateral Sclerosis: When Nerve Cells Run Out of Power
Quatorze, M., Silva, F. S. G., Duarte, A. I., Cardoso, J. A., Caetano, C., Ramalho‐Santos, J., Oliveira, P. J., & Amaral, S. V. (2023) · Frontiers for Young Minds · doi:10.3389/frym.2023.974736 · Cited by 1
Effect of Leptin Treatment in a Mouse Model of Tdp-43 ProteinopathyPreprint
Ferrer-Donato, Á., Contreras, A., Fernández, P., & Fernández-Martos, C. M. (2021) · Preprints.org · doi:10.20944/preprints202104.0041.v1
Animal Models of ALS – Current and Future Perspectives
Déziel, R., Marriott, A. L., Kay, D. G., & Gill, D. A. (2021) · Wiley eBooks · doi:10.1002/9781119745532.ch8
Análisis dinámico muscular y de la estructura interna del nervio periférico como biomarcadores para la esclerosis lateral amiotrófica: estudio piloto mediante ecografía
López-Navarro, C., Serrano-Valero, M., Fages-Caravaca, E. M., Martínez-Payá, J. J., del Baño-Aledo, M. E., & Ríos-Díaz, J. (2022) · Neurología · doi:10.1016/j.nrl.2021.10.008
Analysis of STMN2 CA repeats in italian ALS patients shows no association
Doronzio, P. N., Lattante, S., Marangi, G., Martello, F., Conte, A., Bisogni, G., Bernardo, D., Patanella, A. K., Meleo, E., Zollino, M., et al. (2022) · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration · doi:10.1080/21678421.2022.2102430 · Cited by 1
Electrophysiological Changes of Motor Neurons in a hESC Model of Sporadic and Familial Amyotrophic Lateral Sclerosis
Moon, E. F. (2022) · doi:10.14418/wes01.2.363
The role of TDP-43 protein in amyotrophic lateral sclerosis
Włodarczyk, P., Witczak, M., Gajewska, A., Chady, T., & Piotrowski, I. (2022) · Journal of Medical Science · doi:10.20883/medical.e710
No cause-effect relationships between psychiatric disorders and amyotrophic lateral sclerosis: a bidirectional Mendelian randomization studyPreprint
Huang, Z., Wen, Y., Tian, Y., Zou, H., Chen, A., Chen, J., Xie, H., Chen, J., Xiong, F., & Gao, X. (2023) · Research Square · doi:10.21203/rs.3.rs-2573779/v1
Effect of Pesticides on Nervous System or Neural Health
Chavan, S., & Mehta, M. (2022) · Asian Pacific Journal of Health Sciences · doi:10.21276/apjhs.2022.9.4s.49
Amyotrophic Lateral Sclerosis Patients’ Preferences on Riluzole Treatment in EuropePreprint
Ludolph, A. C., Grandjean, H., Reviers, E., Cardosi, L., Russ, H., & Silani, V. (2023) · Research Square · doi:10.21203/rs.3.rs-2701278/v1
Eficácia de intervenções imunomoduladoras para o tratamento da Esclerose Lateral Amiotrófica (ELA)
Neto, A. C. T., Macedo, G. M. L. B., Carnib, L. A. D. A., Carvalho, R. M. D., Rodrigues, É. P. D. S. M., Lima, J. B., Barreira, D. L. D. C., Maia, F. S. C. D. V., Vilarinho, A. V. D. S., Diniz, E. M. S., et al. (2023) · Brazilian Journal of Health Review · doi:10.34119/bjhrv6n3-141
Mesenchymal Stem Cells and their Applications against Neurodegenerative Disorders
Bahrini, I. (2023) · Springer eBooks · doi:10.1007/978-981-99-3848-3_5
Theme 05 - Human Cell Biology and Pathology
(2023) · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration · doi:10.1080/21678421.2023.2260195
Association between DPP6 gene rs10260404 polymorphism and increased risk of sporadic amyotrophic lateral sclerosis (sALS): a meta-analysis
Miah, M. M., Zinnia, M. A., Tabassum, N., & Islam, A. B. M. M. K. (2024) · Neurological Sciences · doi:10.1007/s10072-024-07401-2
Rehabilitación basada en ejercicio físico en pacientes con esclerosis lateral amiotrófica
Gaitán-Caicedo, S. A., & Ruíz, D. M. C. (2024) · Revista Colombiana de Medicina Física y Rehabilitación · doi:10.28957/rcmfr.413
Gene Therapy for Neurodegeneration in Glaucoma
Karl, J. J., & Tseng, H. C. (2024) · Essentials in ophthalmology/Essentials ophthalmology · doi:10.1007/978-981-99-4436-1_21
Effect of Environmental Personal Exposure on Amyotrophic Lateral Sclerosis Disease Progression
Bosoni, P., Aiello, I., Manera, U., Gromicho, M., Alves, I., Camillo, B. D., de Carvalho, M. A., Chiò, A., Bellazzi, R., & Dagliati, A. (2025) · IEEE International Conference on Healthcare Informatics (ICHI) · doi:10.1109/ichi64645.2025.00029
A Qualitive Investigation of Geographic Disparities in Genetic Testing and Care Access for Amyotrophic Lateral Sclerosis: Insights From Patient Journey Mapping
Sethi, N., Levy, O. A., Richardson, A., Harari, O., & Sellati, R. (2026) · Patient Preference and Adherence · doi:10.2147/ppa.s566747
Corticospinal propagation of full-length TDP-43 toxicity drives brain-to-muscle pathologyPreprint
Marongiu, J., Crippa, V., Marzi, I., Porcedda, C., Gagliani, M. C., Brivio, A., Palmas, M. F., Etzi, M., Serra, M., Aminzadeh, K., et al. (2026) · Research Square · doi:10.21203/rs.3.rs-10681556/v1

Authors: Nowicka, N., Juranek, J., Juranek, J. K., & Wojtkiewicz, J.
Affiliations: University of Warmia and Mazury in Olsztyn (PL)
Institute of Psychology (PL)
Corresponding author: Nowicka, Natalia
Wojtkiewicz, Joanna
ORCID: Nowicka, Natalia
Juranek, Jakub
Juranek, Judyta K.
Wojtkiewicz, Joanna
Venue: International Journal of Molecular Sciences
Publisher: MDPI AG
Published: 2019-05-28
Volume: 20
Issue: 11
Pages: 2616
ISSN: 1422-0067 (ISSN-L)
DOI: 10.3390/ijms20112616
PMC: PMC6600314
OpenAlex: W2947955929
Cited by: 106
References: 154
Citations by year: 2026: 11 · 2025: 10 · 2024: 11 · 2023: 22 · 2022: 17 · 2021: 12 · 2020: 20 · 2019: 3
FWCI: 1.74
Type: journal article
Language: en
Open access: gold
dx.doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: International Journal of Molecular Sciences (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders: Narodowym Centrum Nauki (OPUS/2017/25/B/NZ4/00435)
Topics: Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Hereditary Neurological Disorders
Keywords: amyotrophic lateral sclerosis, risk factors, genetic risk factors, environmental risk factors, SOD1, C9orf72, TDP-43, TBK1, motor neuron degeneration, stem cell therapy, experimental treatment, clinical trials
MeSH terms: Superoxide Dismutase-1, C9orf72 Protein, Amyotrophic Lateral Sclerosis, Animals, DNA-Binding Proteins, Humans, Genetic Therapy, Genetic Predisposition to Disease, Molecular Targeted Therapy

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Risk Factors and Emerging Therapies in Amyotrophic Lateral Sclerosis

Abstract

Overview

Integrity signals

Figures

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks