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Cited by 180

The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.

Cell Death in the Kidney

Open access
Priante, Giovanna, Gianesello, Lisa, Ceol, Monica, Del Prete, Dorella, Anglani, Franca·2019·International Journal of Molecular Sciences

Abstract

Apoptotic cell death is usually a response to the cell’s microenvironment. In the kidney, apoptosis contributes to parenchymal cell loss in the course of acute and chronic renal injury, but does not trigger an inflammatory response. What distinguishes necrosis from apoptosis is the rupture of the plasma membrane, so necrotic cell death is accompanied by the release of unprocessed intracellular content, including cellular organelles, which are highly immunogenic proteins. The relative contribution of apoptosis and necrosis to injury varies, depending on the severity of the insult. Regulated cell death may result from immunologically silent apoptosis or from immunogenic necrosis. Recent advances have enhanced the most revolutionary concept of regulated necrosis. Several modalities of regulated necrosis have been described, such as necroptosis, ferroptosis, pyroptosis, and mitochondrial permeability transition-dependent regulated necrosis. We review the different modalities of apoptosis, necrosis, and regulated necrosis in kidney injury, focusing particularly on evidence implicating cell death in ectopic renal calcification. We also review the evidence for the role of cell death in kidney injury, which may pave the way for new therapeutic opportunities.

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Metadata

Authors
Priante, G., Gianesello, L., Ceol, M., Del Prete, D., & Anglani, F.
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2019-07-23
Volume
20
Issue
14
Pages
3598
ISSN
1422-0067 (ISSN-L)
OpenAlex
W2963986056
Cited by
180
References
14
FWCI
5.73
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Cell Death in the Kidney. https://app.cochat.ai/papers/10.3390/ijms20143598
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Priante, G., Gianesello, L., Ceol, M., Del Prete, D., & Anglani, F. (2019). Cell Death in the Kidney. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms20143598

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