The DOI matches its Crossref record; 222 of the 226 references it cites were found in a registry or an index.
Potential Adverse Effects of Resveratrol: A Literature Review
Open accessAbstract
Due to its health benefits, resveratrol (RE) is one of the most researched natural polyphenols. Resveratrol’s health benefits were first highlighted in the early 1990s in the French paradox study, which opened extensive research activity into this compound. Ever since, several pharmacological activities including antioxidant, anti-aging, anti-inflammatory, anti-cancerous, anti-diabetic, cardioprotective, and neuroprotective properties, were attributed to RE. However, results from the available human clinical trials were controversial concerning the protective effects of RE against diseases and their sequelae. The reason for these conflicting findings is varied but differences in the characteristics of the enrolled patients, RE doses used, and duration of RE supplementation were proposed, at least in part, as possible causes. In particular, the optimal RE dosage capable of maximizing its health benefits without raising toxicity issues remains an area of extensive research. In this context, while there is a consistent body of literature on the protective effects of RE against diseases, there are relatively few reports investigating its possible toxicity. Indeed, toxicity and adverse effects were reported following consumption of RE; therefore, extensive future studies on the long-term effects, as well as the in vivo adverse effects, of RE supplementation in humans are needed. Furthermore, data on the interactions of RE when combined with other therapies are still lacking, as well as results related to its absorption and bioavailability in the human body. In this review, we collect and summarize the available literature about RE toxicity and side effects. In this process, we analyze in vitro and in vivo studies that have addressed this stilbenoid. These studies suggest that RE still has an unexplored side. Finally, we discuss the new delivery methods that are being employed to overcome the low bioavailability of RE.
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“A high-dose administration of resveratrol in animal experiments showed proinflammatory and cytotoxic effects.”
From Mediterranean Diet as an Antioxidant: The Impact on Metabolic Health and Overall Wellbeing (2021) · cites this paper as [129]
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“In addition, pharmacokinetic interactions have been described, mainly due to CYP450 induction, which may affect the pharmacokinetics of other drugs [129].”
From Mediterranean Diet as an Antioxidant: The Impact on Metabolic Health and Overall Wellbeing (2021) · cites this paper as [129]
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4 of the 226 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
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Metadata
- Authors
- Shaito, A., Posadino, A. M., Younes, N., Hasan, H., Halabi, S., Alhababi, D., Al-Mohannadi, A., Abdel-Rahman, W. M., Eid, A. H., Nasrallah, G. K., & Pintus, G.
- Affiliations
- Lebanese International University (LB)
- University of Sassari (IT)
- Qatar University (QA)
- Justus-Liebig-Universität Gießen (DE)
- American University of Beirut (LB)
- Department of Medical Laboratory Sciences, College of Health Sciences and Sharjah Institute for Medical Research, University of Sharjah, Sharjah P.O Box: 27272, United Arab Emirates
- Corresponding author
- Eid, Ali H.
- Nasrallah, Gheyath K.
- Pintus, Gianfranco
- ORCID
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2020-03-18
- Volume
- 21
- Issue
- 6
- Pages
- 2084
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC7139620
- OpenAlex
- W3011177534
- Cited by
- 716
- References
- 226
- Citations by year
- 2026: 104 · 2025: 147 · 2024: 125 · 2023: 116 · 2022: 107 · 2021: 83 · 2020: 31
- FWCI
- 10.47
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- UnissResearch (Università degli Studi di Sassari) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Qatar University QSpace (Qatar University) (submittedVersion)
- Funders
- Qatar University (IRCC#181)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Keywords
- resveratrol, toxicity, adverse effects, stilbenoids, natural polyphenols, bioavailability, drug interactions, dosage, French paradox, cardioprotection, neuroprotection, anti-inflammatory activity, antioxidant activity, anticancer effects, anti-diabetic effects, anti-aging effects, delivery methods
- MeSH terms
- Resveratrol, Humans
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