Cited by 716Sirtuins and Resveratrol in MedicinePhytochemicals and Antioxidant ActivitiesAlcohol Consumption and Health Effects

The DOI matches its Crossref record; 222 of the 226 references it cites were found in a registry or an index.

Potential Adverse Effects of Resveratrol: A Literature Review

Open access

Shaito, Abdullah, Posadino, Anna Maria, Younes, Nadin, Hasan, Hiba, Halabi, Sarah, Alhababi, Dalal, Al-Mohannadi, Anjud, Abdel-Rahman, Wael M, Eid, Ali H., Nasrallah, Gheyath K., Pintus, Gianfranco·2020·International Journal of Molecular Sciences

DOI 10.3390/ijms21062084PMC PMC7139620

Open this paper in CoChat — free account

Abstract

Due to its health benefits, resveratrol (RE) is one of the most researched natural polyphenols. Resveratrol’s health benefits were first highlighted in the early 1990s in the French paradox study, which opened extensive research activity into this compound. Ever since, several pharmacological activities including antioxidant, anti-aging, anti-inflammatory, anti-cancerous, anti-diabetic, cardioprotective, and neuroprotective properties, were attributed to RE. However, results from the available human clinical trials were controversial concerning the protective effects of RE against diseases and their sequelae. The reason for these conflicting findings is varied but differences in the characteristics of the enrolled patients, RE doses used, and duration of RE supplementation were proposed, at least in part, as possible causes. In particular, the optimal RE dosage capable of maximizing its health benefits without raising toxicity issues remains an area of extensive research. In this context, while there is a consistent body of literature on the protective effects of RE against diseases, there are relatively few reports investigating its possible toxicity. Indeed, toxicity and adverse effects were reported following consumption of RE; therefore, extensive future studies on the long-term effects, as well as the in vivo adverse effects, of RE supplementation in humans are needed. Furthermore, data on the interactions of RE when combined with other therapies are still lacking, as well as results related to its absorption and bioavailability in the human body. In this review, we collect and summarize the available literature about RE toxicity and side effects. In this process, we analyze in vitro and in vivo studies that have addressed this stilbenoid. These studies suggest that RE still has an unexplored side. Finally, we discuss the new delivery methods that are being employed to overcome the low bioavailability of RE.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.3390/ijms21062084

Cites

222 of 222 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

1 retracted

RETRACTED: Resveratrol Inhibits the Migration and Metastasis of MDA-MB-231 Human Breast Cancer by Reversing TGF-β1-Induced Epithelial-Mesenchymal Transition
Sun, Y., Zhou, Q., Lu, Y.-Y., Zhang, H., Chen, Q., Zhao, M., & Su, S.-B. (2019) · Molecules · doi:10.3390/molecules24061131 · Cited by 174
Retracted
Free radicals, metals and antioxidants in oxidative stress-induced cancer
Valko, M., Rhodes, C. J., Moncol, J., Izakovic, M., & Mazur, M. (2006) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2005.12.009 · Cited by 6,680
Resveratrol improves health and survival of mice on a high-calorie diet
Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K., et al. (2006) · Nature · doi:10.1038/nature05354 · Cited by 4,290
Therapeutic potential of resveratrol: the in vivo evidence
Baur, J. A., & Sinclair, D. A. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2060 · Cited by 3,958
Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress
Cai, H., & Harrison, D. G. (2000) · Circulation Research · doi:10.1161/01.res.87.10.840 · Cited by 3,839
Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations
Müller, R. H., Radtke, M., & Wissing, S. A. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00118-7 · Cited by 2,116
HIGH ABSORPTION BUT VERY LOW BIOAVAILABILITY OF ORAL RESVERATROL IN HUMANS
Walle, T., Hsieh, F., DeLegge, M. H., Oatis, J. E., & Walle, U. K. (2004) · Drug Metabolism and Disposition · doi:10.1124/dmd.104.000885 · Cited by 1,893
WNT and β-catenin signalling: diseases and therapies
Moon, R. T., Kohn, A. D., Ferrari, G. V. D., & Kaykas, A. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1427 · Cited by 1,763
Role of ROS and RNS Sources in Physiological and Pathological Conditions
Meo, S. D., Reed, T. T., Venditti, P., & Víctor, V. M. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/1245049 · Cited by 1,712
Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies
Williamson, G., & Manach, C. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.1.243s · Cited by 1,340
Oxidative stress and apoptosis
Kannan, K., & Jain, S. K. (2000) · Pathophysiology · doi:10.1016/s0928-4680(00)00053-5 · Cited by 1,312
Oxidants and human disease: some new concepts 1
Halliwell, B. B. (1987) · The FASEB Journal · doi:10.1096/fasebj.1.5.2824268 · Cited by 1,205
Resveratrol: A Double-Edged Sword in Health Benefits
Salehi, B., Mishra, A. P., Nigam, M., Şener, B., Kılıç, M., Sharifi‐Rad, M., Fokou, P. V. T., Martins, N. A., & Sharifi‐Rad, J. (2018) · Biomedicines · doi:10.3390/biomedicines6030091 · Cited by 1,195
The Role of Nitric Oxide on Endothelial Function
Tousoulis, D., Kampoli, A.-M., Tentolouris Nikolaos Papageorgiou, C., & Stefanadis, C. (2012) · Current Vascular Pharmacology · doi:10.2174/157016112798829760 · Cited by 1,012
The therapeutic potential of resveratrol: a review of clinical trials
Berman, A. Y., Motechin, R. A., Wiesenfeld, M. Y., & Holz, M. K. (2017) · npj Precision Oncology · doi:10.1038/s41698-017-0038-6 · Cited by 931
Properties of Resveratrol: In Vitro and In Vivo Studies about Metabolism, Bioavailability, and Biological Effects in Animal Models and Humans
Gambini, J., Inglés, M., González, G. O., López-Grueso, R., Bonet-Costa, V., Gimeno-Mallench, L., Mas‐Bargues, C., Abdelaziz, K. M., Gómez‐Cabrera, M. C., Viña, J., et al. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/837042 · Cited by 779
Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose–response framework
Calabrese, E. J., Bachmann, K. A., Bailer, A. J., Bolger, P. M., Borak, J. B., Cai, L., Nina Cedergreen, G., Cherian, M. G., Chiueh, C. C., Clarkson, T. W., et al. (2007) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2007.02.015 · Cited by 751
Resveratrol as an antioxidant and pro-oxidant agent: mechanisms and clinical implications
Alarcón‐de‐la‐Lastra, C., & Villegas, I. (2007) · Biochemical Society Transactions · doi:10.1042/bst0351156 · Cited by 740
Repeat Dose Study of the Cancer Chemopreventive Agent Resveratrol in Healthy Volunteers: Safety, Pharmacokinetics, and Effect on the Insulin-like Growth Factor Axis
Brown, V. A., Patel, K. R., Viskaduraki, M., Crowell, J. A., Perloff, M., Booth, T. D., Vasilinin, G., Sen, A., Schinas, A. M., Piccirilli, G., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-2364 · Cited by 695
Resveratrol as an anti-cancer agent: A review
Rauf, A., Imran, M., Butt, M. S., Nadeem, M., Peters, D. G., & Mubarak, M. S. (2016) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2016.1263597 · Cited by 684
Resveratrol scavenges reactive oxygen species and effects radical-induced cellular responses
Leonard, S. S., Xia, C., Jiang, B.-H., Stinefelt, B. M., KLANDORF, H., Harris, G. K., & Shi, X. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.08.105 · Cited by 683
Resveratrol bioavailability and toxicity in humans
Cottart, C., Nivet‐Antoine, V., Laguillier, C., & Beaudeux, J. (2009) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200900437 · Cited by 592
Resveratrol and cancer: focus on in vivo evidence
Carter, L. G., D'Orazio, J. A., & Pearson, K. J. (2014) · Endocrine Related Cancer · doi:10.1530/erc-13-0171 · Cited by 540
Formation and Biological Targets of Quinones: Cytotoxic versus Cytoprotective Effects
Bolton, J. L., & Dunlap, T. L. (2016) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.6b00256 · Cited by 538
Health benefits of resveratrol: Evidence from clinical studies
Singh, A. P., Singh, R., Verma, S. S., Rai, V., Kaschula, C. H., Maiti, P., & Gupta, S. C. (2019) · Medicinal Research Reviews · doi:10.1002/med.21565 · Cited by 523
Cancer chemopreventive and therapeutic potential of resveratrol: Mechanistic perspectives
Kundu, J. K., & Surh, Y. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.03.057 · Cited by 480
Resveratrol and Clinical Trials: The Crossroad from In Vitro Studies to Human Evidence
Tomé‐Carneiro, J., Larrosa, M., González‐Sarrías, A., Tomás-Barberán, F. A., García‐Conesa, M., & Espı́n, J. C. (2013) · Current Pharmaceutical Design · doi:10.2174/13816128113199990407 · Cited by 467
Resveratrol and Cardiovascular Diseases
Bonnefont‐Rousselot, D. (2016) · Nutrients · doi:10.3390/nu8050250 · Cited by 463
High-Dose Resveratrol Supplementation in Obese Men
Poulsen, M. M., Vestergaard, P. F., Clasen, B. F., Radko, Y., Christensen, L. P., Stødkilde-Jørgensen, H., Møller, N., Jessen, N., Pedersen, S. B., & Jørgensen, J. O. L. (2013) · Diabetes · doi:10.2337/db12-0975 · Cited by 455
Phase I Randomized, Double-Blind Pilot Study of Micronized Resveratrol (SRT501) in Patients with Hepatic Metastases—Safety, Pharmacokinetics, and Pharmacodynamics
Howells, L. M., Berry, D. P., Elliott, P. J., Jacobson, E. W., Hoffmann, E. C., Hegarty, B., Brown, K., Steward, W. P., & Gescher, A. J. (2011) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-11-0148 · Cited by 447
In vivo and in vitro metabolism of trans-resveratrol by human gut microbiota
Bode, L. M., Bunzel, D., Huch, M., Cho, G., Ruhland, D., Bunzel, M., Bub, A., Franz, C. M. A. P., & Kulling, S. E. (2013) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.049379 · Cited by 404
Resveratrol, a remarkable inhibitor of ribonucleotide reductase
Fontecave, M., Lepoivre, M., Elleingand, E. F., Gerez, C., & Guittet, O. (1998) · FEBS Letters · doi:10.1016/s0014-5793(97)01572-x · Cited by 383
Interactions of gut microbiota with dietary polyphenols and consequences to human health
Tomás-Barberán, F. A., Selma, M. V., & Espı́n, J. C. (2016) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000314 · Cited by 372
Cardioprotection by resveratrol: A human clinical trial in patients with stable coronary artery disease
Magyar, K., Halmosi, R., Pálfi, A., Fehér, G., Czopf, L., Fulop, A., Battyány, I., Sümegi, B., Tóth, K., & Szabados, E. (2012) · Clinical Hemorheology and Microcirculation · doi:10.3233/ch-2011-1424 · Cited by 364
Antiplatelet activity of synthetic and natural resveratrol in red wine.
Bertelli, A., Giovannini, L., Giannessi, D., MIGLIORI, M., Bernini, W., Fregoni, M., & Bertelli, A. A. A. (1995) · PubMed · Cited by 361
Health benefits of resveratrol administration
Galiniak, S., Aebisher, D., & Bartusik‐Aebisher, D. (2019) · Acta Biochimica Polonica · doi:10.18388/abp.2018_2749 · Cited by 349
Mitochondrial (Dys)function and Insulin Resistance: From Pathophysiological Molecular Mechanisms to the Impact of Diet
Sergi, D., Naumovski, N., Heilbronn, L. K., Abeywardena, M., O’Callaghan, N., Lionetti, L., & Luscombe-Marsh, N. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00532 · Cited by 347 · cited 1×
“Indeed, RE was reported to be able to maintain or enhance human cerebrovascular functions [14], modulate in vitro angiogenesis through the expression of vascular endothelial growth factor (VEGF) and the formation of new vascular networks [15], stimulate human immune cell functions [16], promote rat cell viability and…”
Background
Stability and solubility of trans-resveratrol are strongly influenced by pH and temperature
Zupančič, Š., Lavrič, Z., & Kristl, J. (2015) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2015.04.002 · Cited by 346
Resveratrol Modulates Drug- and Carcinogen-Metabolizing Enzymes in a Healthy Volunteer Study
Chow, H. ‐. S., Garland, L. L., Hsu, C., Vining, D. R., Chew, W. M., Miller, J. A., Perloff, M., Crowell, J. A., & Alberts, D. S. (2010) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-09-0155 · Cited by 333
Resveratrol: How Much Wine Do You Have to Drink to Stay Healthy?
Weiskirchen, S., & Weiskirchen, R. (2016) · Advances in Nutrition · doi:10.3945/an.115.011627 · Cited by 323
Human, Rat, and Mouse Metabolism of Resveratrol
Yu, C., Shin, Y. G., Chow, A. W., Li, Y., Kosmeder, J. W., Lee, Y. S., Hirschelman, W. H., Pezzuto, J. M., Mehta, R. G., & van Breemen, R. B. (2002) · Pharmaceutical Research · doi:10.1023/a:1021414129280 · Cited by 322
Resveratrol-Associated Renal Toxicity
Crowell, J. A. (2004) · Toxicological Sciences · doi:10.1093/toxsci/kfh263 · Cited by 321
Bioavailability oftrans-resveratrol from red wine in humans
Vitaglione, P., Sforza, S., Galaverna, G., Ghidini, C., Caporaso, N., Vescovi, P. P., Fogliano, V., & Marchelli, R. (2005) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200500002 · Cited by 319
Resveratrol protects primary rat hepatocytes against oxidative stress damage:
Rubiolo, J. A., Mithieux, G., & Vega, F. V. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.06.067 · Cited by 317
Cardiovascular effects and molecular targets of resveratrol
Li, H., Xia, N., & Förstermann, U. (2012) · Nitric Oxide · doi:10.1016/j.niox.2011.12.006 · Cited by 302
Resveratrol: from enhanced biosynthesis and bioavailability to multitargeting chronic diseases
Pannu, N., & Bhatnagar, A. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.11.075 · Cited by 298
The Daily Oral Administration of High Doses of trans-Resveratrol to Rats for 28 Days Is Not Harmful
Juan, M. E., Vinardell, M. P., & Planas, J. M. (2002) · Journal of Nutrition · doi:10.1093/jn/132.2.257 · Cited by 293
Metabolism and pharmacokinetics of resveratrol and pterostilbene
Wang, P., & Sang, S. (2018) · BioFactors · doi:10.1002/biof.1410 · Cited by 290
De novo production of resveratrol from glucose or ethanol by engineered Saccharomyces cerevisiae
Li, M., Kildegaard, K. R., Chen, Y., Prado, A. R., Borodina, I., & Nielsen, J. (2015) · Metabolic Engineering · doi:10.1016/j.ymben.2015.08.007 · Cited by 286
Resveratrol commonly displays hormesis: Occurrence and biomedical significance
Calabrese, E. J., Mattson, M. P., & Calabrese, V. (2010) · Human & Experimental Toxicology · doi:10.1177/0960327110383625 · Cited by 283
Distribution of [14C]-trans-resveratrol, a cancer chemopreventive polyphenol, in mouse tissues after oral administration
Vitrac, X., Desmoulière, A., Brouillaud, B., Krisa, S., Deffieux, G., Barthe, N., Rosenbaum, J., & Mérillon, J. (2003) · Life Sciences · doi:10.1016/s0024-3205(03)00096-1 · Cited by 280
Results of a phase I pilot clinical trial examining the effect of plant-derived resveratrol and grape powder on Wnt pathway target gene expression in colonic mucosa and colon cancer
Holcombe, R. F., Nguyen, A., Martínez, Stamos, M. J., Moyer, M. P., Planutis, K., Hope, & Holcombe, R. F. (2009) · Cancer Management and Research · doi:10.2147/cmar.s4544 · Cited by 278
Resveratrol for breast cancer prevention and therapy: Preclinical evidence and molecular mechanisms
Sinha, D., Sarkar, N., Biswas, J., & Bishayee, A. (2016) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2015.11.001 · Cited by 265
Pharmacokinetics in mice and growth-inhibitory properties of the putative cancer chemopreventive agent resveratrol and the synthetic analogue trans 3,4,5,4′-tetramethoxystilbene
Sale, S., Verschoyle, R. D., Boocock, D. J., Jones, D. J. L., Wilsher, N. E., Ruparelia, K. C., Potter, G. A., Farmer, P. B., Steward, W. P., & Gescher, A. J. (2004) · British Journal of Cancer · doi:10.1038/sj.bjc.6601568 · Cited by 260
Resveratrol, Metabolic Syndrome, and Gut Microbiota
Chaplin, A. M. L., Carpéné, C., & Mercader, J. (2018) · Nutrients · doi:10.3390/nu10111651 · Cited by 256
Resveratrol enhances proliferation and osteoblastic differentiation in human mesenchymal stem cells via ER-dependent ERK1/2 activation
Dai, Z., Li, Y., Quarles, L. D., Song, T., Pan, W., Zhou, H., & Xiao, Z. (2007) · Phytomedicine · doi:10.1016/j.phymed.2007.04.003 · Cited by 255
Health Effects of Resveratrol: Results from Human Intervention Trials
Ramírez-Garza, S. L., Santos, E. P. L., Marhuenda‐Muñoz, M., Storniolo, C. E., Tresserra‐Rimbau, A., Vallverdú‐Queralt, A., & Lamuela-Raventós, R. M. (2018) · Nutrients · doi:10.3390/nu10121892 · Cited by 254
Transport, stability, and biological activity of resveratrol
Delmas, D., Aires, V., Limagne, E., Dutartre, P., Mazué, F., Ghiringhelli, F., & Latruffe, N. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05871.x · Cited by 252
Resveratrol is a Peroxidase-mediated Inactivator of COX-1 but Not COX-2
Szewczuk, L. M., Forti, L., Stivala, L. A., & Penning, T. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m314302200 · Cited by 240
Resveratrol in cardiovascular health and disease
Petrovski, G., Gurusamy, N., & Das, D. K. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05843.x · Cited by 232
Potent induction of cellular antioxidants and phase 2 enzymes by resveratrol in cardiomyocytes: protection against oxidative and electrophilic injury
Cao, Z., & Li, Y. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.02.031 · Cited by 229
A phase 2 study of SRT 501 (resveratrol) with bortezomib for patients with relapsed and or refractory multiple myeloma
Popat, R., Plesner, T., Davies, F. E., Cook, G., Cook, M. A., Elliott, P. J., Jacobson, E. W., Gumbleton, T., Oakervee, H. E., & Cavenagh, J. D. (2012) · British Journal of Haematology · doi:10.1111/bjh.12154 · Cited by 228
Cancer Chemoprevention and Apoptosis Mechanisms Induced by Dietary Polyphenolics
G. Galati, Teng, S., Moridani, M. Y., Chan, T. S., & O'Brien, P. J. (2000) · Drug metabolism and drug interactions · doi:10.1515/dmdi.2000.17.1-4.311 · Cited by 224
Results of a phase I pilot clinical trial examining the effect of plant-derived resveratrol and grape powder on Wnt pathway target gene expression in colonic mucosa and colon cancer.
Nguyen, A. V., Martinez, M. E., Stamos, M. J., Moyer, M. P., Planutis, K., Hope, C., & Holcombe, R. F. (2009) · PubMed Central · Cited by 216
Anti-Inflammatory and Antioxidant Effects of Resveratrol in Healthy Smokers A Randomized, Double-Blind, Placebo-Controlled, Cross-Over Trial
Bo, S., Ciccone, G., Castiglione, A., Gambino, R., Michieli, F. D., Villois, P., Durazzo, M., Cavallo‐Perin, P., & Cassader, M. (2013) · Current Medicinal Chemistry · doi:10.2174/0929867311320100009 · Cited by 209
Antioxidant Effects of Resveratrol in Cardiovascular, Cerebral and Metabolic Diseases
Carrizzo, A., Forte, M., Damato, A., Trimarco, V., Salzano, F., Bartolo, M., Maciag, A., Puca, A. A., & Vecchione, C. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.07.021 · Cited by 203
Polyphenols synergistically inhibit oxidative stress in subjects given red and white wine
Pignatelli, P., Ghiselli, A., Buchetti, B., Carnevale, R., Natella, F., Germanò, G., Fimognari, F., Santo, S. D., Lenti, L., & Violi, F. (2005) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2005.10.025 · Cited by 201
Quantitation of trans-resveratrol and detection of its metabolites in human plasma and urine by high performance liquid chromatography
Boocock, D. J., Patel, K. R., Faust, G. E. S., Normolle, D. P., Marczylo, T. H., Crowell, J. A., Brenner, D. E., Booth, T. D., Gescher, A. J., & Steward, W. P. (2006) · Journal of Chromatography B · doi:10.1016/j.jchromb.2006.10.017 · Cited by 199
Resveratrol directly targets COX‐2 to inhibit carcinogenesis
Zykova, T. A., Zhu, F., Zhai, X., Ma, W., Ermakova, S. P., Lee, K. W., Bode, A. M., & Dong, Z. (2008) · Molecular Carcinogenesis · doi:10.1002/mc.20437 · Cited by 191
Improved chemical stability and cellular antioxidant activity of resveratrol in zein nanoparticle with bovine serum albumin-caffeic acid conjugate
Fan, Y., Liu, Y., Gao, L., Zhang, Y., & Yi, J. (2018) · Food Chemistry · doi:10.1016/j.foodchem.2018.04.055 · Cited by 183
Effects of resveratrol on human immune cell function
Falchetti, R., Fuggetta, M. P., Lanzilli, G., Tricarico, M., & Ravagnan, G. (2001) · Life Sciences · doi:10.1016/s0024-3205(01)01367-4 · Cited by 182
Therapeutic Versatility of Resveratrol Derivatives
Nawaz, W., Zhou, Z.-Q., Deng, S., Ma, X., Ma, X., Li, C., & Shu, X. H. (2017) · Nutrients · doi:10.3390/nu9111188 · Cited by 180
Cancer chemoprevention: Evidence of a nonlinear dose response for the protective effects of resveratrol in humans and mice
Cai, H., Scott, E. N., Kholghi, A. O. A., Andreadi, C., Rufini, A., Karmokar, A., Britton, R. G., Horner‐Glister, E., Greaves, P., Jawad, D., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aaa7619 · Cited by 179
Quantification of free and protein‐bound trans‐resveratrol metabolites and identification of trans‐resveratrol‐C/O‐conjugated diglucuronides – Two novel resveratrol metabolites in human plasma
Burkon, A., & Somoza, V. (2008) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700290 · Cited by 179
Simple spectrophotometric assessment of the trans-/cis-resveratrol ratio in aqueous solutions
Camont, L., Cottart, C., Rhayem, Y., Nivet‐Antoine, V., Djelidi, R., Collin, F., Beaudeux, J., & Bonnefont‐Rousselot, D. (2008) · Analytica Chimica Acta · doi:10.1016/j.aca.2008.12.003 · Cited by 178
Pharmacokinetics of resveratrol metabolic profile in healthy humans after moderate consumption of red wine and grape extract tablets
Rotchés-Ribalta, M., Andrés‐Lacueva, C., Estruch, R., Escribano, E., & Urpí-Sardà, M. (2012) · Pharmacological Research · doi:10.1016/j.phrs.2012.08.001 · Cited by 177
Transport of resveratrol, a cancer chemopreventive agent, to cellular targets: plasmatic protein binding and cell uptake
Jannin, B., Menzel, M., Berlot, J., Delmas, D., Lançon, A., & Latruffe, N. (2004) · Biochemical Pharmacology · doi:10.1016/j.bcp.2004.04.028 · Cited by 175
Resveratrol: From Basic Science to the Clinic
Cucciolla, V., Borriello, A., Oliva, A., Galletti, P., Zappia, V., & Ragione, F. D. (2007) · Cell Cycle · doi:10.4161/cc.6.20.4815 · Cited by 174
Levels of Selenium, Zinc, Copper, and Antioxidant Enzyme Activity in Patients with Leukemia
Zuo, X., Chen, J., Zhou, X., Li, X. Z., & Mei, G. Y. (2006) · Biological Trace Element Research · doi:10.1385/bter:114:1:41 · Cited by 174
Resveratrol: Twenty Years of Growth, Development and Controversy
Pezzuto, J. M. (2018) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2018.176 · Cited by 173
Resveratrol Brain Delivery for Neurological Disorders Prevention and Treatment
Andrade, S., Ramalho, M. J., Pereira, M. D. C., & Loureiro, J. A. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01261 · Cited by 173
A Review of Resveratrol as a Potent Chemoprotective and Synergistic Agent in Cancer Chemotherapy
Xiao, Q., Zhu, W., Feng, W., Lee, S. S., Leung, A. W., Shen, J., Gao, L., & Xu, C. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01534 · Cited by 172
trans-Resveratrol, a Natural Antioxidant from Grapes, Increases Sperm Output in Healthy Rats
Juan, M. E., González-Pons, E., Munuera, T., Ballester, J., Rodríguez-Gil, J. E., & Planas, J. M. (2005) · Journal of Nutrition · doi:10.1093/jn/135.4.757 · Cited by 169
Human hepatic cell uptake of resveratrol: involvement of both passive diffusion and carrier-mediated process
Lançon, A., Delma, D., Osman‐Ponchet, H., Thenot, J. P., & Latruffe, N. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.02.164 · Cited by 167
Resveratrol, at Concentrations Attainable with Moderate Wine Consumption, Stimulates Human Platelet Nitric Oxide Production3
Gresele, P., Pignatelli, P., Guglielmini, G., Carnevale, R., Mezzasoma, A. M., Ghiselli, A., Momi, S., & Violi, F. (2008) · Journal of Nutrition · doi:10.1093/jn/138.9.1602 · Cited by 166
Grapes (Vitis vinifera) as a Potential Candidate for the Therapy of the Metabolic Syndrome
Akaberi, M., & Hosseinzadeh, H. (2016) · Phytotherapy Research · doi:10.1002/ptr.5570 · Cited by 164
Resveratrol-loaded PLGA nanoparticles: enhanced stability, solubility and bioactivity of resveratrol for non-alcoholic fatty liver disease therapy
Wan, S., Zhang, L., Quan, Y., & Wei, K. (2018) · Royal Society Open Science · doi:10.1098/rsos.181457 · Cited by 155
Plasma, urine and tissue levels of trans- and cis-resveratrol (3,4',5-trihydroxystilbene) after short-term or prolonged administration of red wine to rats.
Bertelli, A., Giovannini, L., Stradi, R. D., Bertelli, A., & Tillement, J. P. (1996) · PubMed · Cited by 152
Resveratrol reduces amyloid-beta (Aβ1–42)-induced paralysis through targeting proteostasis in an Alzheimer model of Caenorhabditis elegans
Regitz, C., Fitzenberger, E., Mahn, F. L., Dußling, L. M., & Wenzel, U. (2015) · European Journal of Nutrition · doi:10.1007/s00394-015-0894-1 · Cited by 152
Drug interaction potential of resveratrol
Detampel, P., Beck, M., Krähenbühl, S., & Huwyler, J. (2012) · Drug Metabolism Reviews · doi:10.3109/03602532.2012.700715 · Cited by 146
Strategies to Improve Resveratrol Systemic and Topical Bioavailability: An Update
Intagliata, S., Modica, M. N., Santagati, L. M., & Montenegro, L. (2019) · Antioxidants · doi:10.3390/antiox8080244 · Cited by 144
Resveratrol toxicity: Effects on risk factors for atherosclerosis and hepatic oxidative stress in standard and high-fat diets
Rocha, K. K. R., Souza, G. A., Ebaid, G., Seiva, F. R. F., Cataneo, A. C., & Novelli, E. L. B. (2009) · Food and Chemical Toxicology · doi:10.1016/j.fct.2009.03.010 · Cited by 143
Sulphation of resveratrol, a natural compound present in wine, and its inhibition by natural flavonoids
Santi, C. D., Pietrabissa, A., Spisni, R., Mosca, F., & Pacifici, G. M. (2000) · Xenobiotica · doi:10.1080/004982500433282 · Cited by 141
Resveratrol as Add-on Therapy in Subjects With Well-Controlled Type 2 Diabetes: A Randomized Controlled Trial
Timmers, S., de Ligt, M., Phielix, E., van de Weijer, T., Hansen, J., Moonen‐Kornips, E., Schaart, G., Kunz, I., Hesselink, M. K. C., Schrauwen‐Hinderling, V. B., et al. (2016) · Diabetes Care · doi:10.2337/dc16-0499 · Cited by 139
Effects of Resveratrol against Lung Cancer: In Vitro and In Vivo Studies
Yousef, M., Vlachogiannis, I. A., & Tsiani, E. (2017) · Nutrients · doi:10.3390/nu9111231 · Cited by 138
Involvement of cytochrome P450 1A2 in the biotransformation of trans-resveratrol in human liver microsomes
Piver, B., Fer, M., Vitrac, X., Mérillon, J., Dréano, Y., Berthou, F., & Lucas, D. (2004) · Biochemical Pharmacology · doi:10.1016/j.bcp.2004.05.008 · Cited by 136
Development of resveratrol-conjugated gold nanoparticles: interrelationship of increased resveratrol corona on anti-tumor efficacy against breast, pancreatic and prostate cancers
Thipe, V. C., Amiri, K. P., Bloebaum, P., Raphael, A. K., Khoobchandani, M., Katti, K. K., Jurisson, S. S., & Katti, K. V. (2019) · International Journal of Nanomedicine · doi:10.2147/ijn.s204443 · Cited by 136
High Doses of Synthetic Antioxidants Induce Premature Senescence in Cultivated Mesenchymal Stem Cells
Kornienko, J. S., Smirnova, I. S., Pugovkina, N. A., Ivanova, J. S., Shilina, M. A., Grinchuk, T. M., Shatrova, A. N., Aksenov, N. D., Zenin, V. V., Nikolsky, N. N., et al. (2019) · Scientific Reports · doi:10.1038/s41598-018-37972-y · Cited by 135
Uptake of Diet Resveratrol into the Human Low-Density Lipoprotein. Identification and Quantification of Resveratrol Metabolites by Liquid Chromatography Coupled with Tandem Mass Spectrometry
Urpí-Sardà, M., Jáuregui, O., Lamuela-Raventós, R. M., Jaeger, W., Miksits, M., Covas, M., & Andrés‐Lacueva, C. (2005) · Analytical Chemistry · doi:10.1021/ac0484272 · Cited by 133
Effects of Resveratrol on the Mechanisms of Antioxidants and Estrogen in Alzheimer’s Disease
Kong, D., Yan, Y., He, X., Yang, H., Liang, B., Wang, J., He, Y., Ding, Y., & Yu, H. (2019) · BioMed Research International · doi:10.1155/2019/8983752 · Cited by 132
Resveratrol provides late-phase cardioprotection by means of a nitric oxide- and adenosine-mediated mechanism
Bradamante, S., Barenghi, L., Piccinini, F., Bertelli, A. A. E., de Jonge, R., Beemster, P. W. T., & de Jong, J. W. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01441-9 · Cited by 129
Subchronic oral toxicity and cardiovascular safety pharmacology studies of resveratrol, a naturally occurring polyphenol with cancer preventive activity
Johnson, W. D., Morrissey, R. L., Usborne, A. L., Kapetanović, I. M., Crowell, J. A., Muzzio, M., & McCormick, D. L. (2011) · Food and Chemical Toxicology · doi:10.1016/j.fct.2011.08.023 · Cited by 123
Resveratrol Exerts Dosage and Duration Dependent Effect on Human Mesenchymal Stem Cell Development
Peltz, L., Gómez, J., Marquez, M., Alencastro, F., Atashpanjeh, N., Quang, T., Bach, T., & Zhao, Y. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037162 · Cited by 123
High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death
Fox, J. T., Sakamuru, S., Huang, R., Teneva, N., Simmons, S. O., Xia, M., Tice, R. R., Austin, C. P., & Myung, K. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1114278109 · Cited by 122
Resveratrol-induced cyclooxygenase-2 facilitates p53-dependent apoptosis in human breast cancer cells
Tang, H.-Y., Shih, A., Cao, H., Davis, F. B., Davis, P. J., & Lin, H. (2006) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-06-0216 · Cited by 120
Resveratrol promotes atherosclerosis in hypercholesterolemic rabbits
Wilson, T. E., Knight, T. J., Beitz, D. C., Lewis, D. S., & Engen, R. L. (1996) · Life Sciences · doi:10.1016/0024-3205(96)00260-3 · Cited by 117
Toxicogenomics of resveratrol in rat liver
Hebbar, V., Shen, G., Hu, R., Kim, B.-R., Chen, C., Korytko, P. J., Crowell, J. A., LEVINE, B. S., & Kong, A.-N. T. (2005) · Life Sciences · doi:10.1016/j.lfs.2004.10.039 · Cited by 115
Oxygen Radical-mediated Reduction in Basal and Agonist-evoked NO Release in Isolated Rat Heart
Paolocci, N., Biondi, R., Bettini, M., Lee, C.-I., Berlowitz, C. O., Rossi, R., Xia, Y., Ambrosio, G., Abbate, A. L., Kass, D. A., et al. (2001) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2000.1334 · Cited by 113
Pro-oxidant and pro-apoptotic activity of polyphenol extract from Annurca apple and its underlying mechanisms in human breast cancer cells
D’Angelo, S., Martino, E., Ilisso, C. P., Bagarolo, M. L., Porcelli, M., & Cacciapuoti, G. (2017) · International Journal of Oncology · doi:10.3892/ijo.2017.4088 · Cited by 109
Resveratrol induced reactive oxygen species and endoplasmic reticulum stress‑mediated apoptosis, and cell cycle arrest in the A375SM malignant melanoma cell line
Heo, J., Kim, S., Hwang, K., Kang, J., & Choi, K. (2018) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2018.3732 · Cited by 107
Galactosylated PLGA nanoparticles for the oral delivery of resveratrol: enhanced bioavailability and in vitro anti-inflammatory activity
Siu, F., Ye, S., Lin, H., & Li, S. (2018) · International Journal of Nanomedicine · doi:10.2147/ijn.s164235 · Cited by 104
Resveratrol Protects Vascular Endothelial Cells from High Glucose–Induced Apoptosis through Inhibition of NADPH Oxidase Activation–Driven Oxidative Stress
Chen, F., Qian, L., Deng, B., Liu, Z., Zhao, Y., & Le, Y. (2013) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12131 · Cited by 101
Intestinal UGTs as potential modifiers of pharmacokinetics and biological responses to drugs and xenobiotics
Ritter, J. K. (2007) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.3.1.93 · Cited by 95
3,5,4′-Trimethoxystilbene, a natural methoxylated analog of resveratrol, inhibits breast cancer cell invasiveness by downregulation of PI3K/Akt and Wnt/β-catenin signaling cascades and reversal of epithelial–mesenchymal transition
Tsai, J., Hsu, L., Lin, C., Hong, H.-M., Pan, M., Way, T., & Chen, W. J. (2013) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2013.07.019 · Cited by 94
Low dose resveratrol improves cerebrovascular function in type 2 diabetes mellitus
Wong, R. H. X., Nealon, R. S., Scholey, A. B., & Howe, P. R. C. (2016) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2016.03.003 · Cited by 92
Piceatannol Exerts Anti-Obesity Effects in C57BL/6 Mice through Modulating Adipogenic Proteins and Gut Microbiota
Tung, Y., Lin, Y.-H., Chen, H.-J., Chou, S.-C., Cheng, A., Nagabhushanam, K., Ho, C., & Pan, M. (2016) · Molecules · doi:10.3390/molecules21111419 · Cited by 92
Stereospecific determination of cis‐ and trans‐resveratrol in rat plasma by HPLC: application to pharmacokinetic studies
Chen, X., He, H., Wang, G., Yang, B., Ren, W., Ma, L., & Yu, Q. (2007) · Biomedical Chromatography · doi:10.1002/bmc.747 · Cited by 91
Formation and biological targets of botanical o-quinones
Bolton, J. L., Dunlap, T. L., & Dietz, B. M. (2018) · Food and Chemical Toxicology · doi:10.1016/j.fct.2018.07.050 · Cited by 91
Modulation of NF-κB activation by resveratrol in LPS treated human intestinal cells results in downregulation of PGE2 production and COX-2 expression
Cianciulli, A., Calvello, R., Cavallo, P., Dragone, T., Carofiglio, V. E., & Panaro, M. A. (2012) · Toxicology in Vitro · doi:10.1016/j.tiv.2012.06.015 · Cited by 90
Pro‐oxidant Activity of Low Doses of Resveratrol Inhibits Hydrogen Peroxide—Induced Apoptosis
Ahmad, K. A., Clement, M., & Pervaiz, S. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1299.067 · Cited by 90
Resveratrol alters human endothelial cells redox state and causes mitochondrial-dependent cell death
Posadino, A. M., Cossu, A., Giordo, R., Zinellu, A., Sotgia, S., Vardeu, A., Hoa, P. T., Nguyen, L. H. V., Carru, C., & Pintus, G. (2015) · Food and Chemical Toxicology · doi:10.1016/j.fct.2015.01.017 · Cited by 90
Self-citation
NADPH oxidases 1 and 4 mediate cellular senescence induced by resveratrol in human endothelial cells
Schilder, Y. D. C., Heiß, E. H., Schachner, D., Ziegler, J., Reznicek, G., Sorescu, D., & Dirsch, V. M. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.03.013 · Cited by 88
Comparison of trace element concentrations in cancerous and noncancerous human endometrial and ovary tissues
Yaman, M., Kaya, G., & Şimşek, M. (2006) · International Journal of Gynecological Cancer · doi:10.1111/j.1525-1438.2006.00742.x · Cited by 86
Resveratrol Enhances Apoptotic and Oxidant Effects of Paclitaxel through TRPM2 Channel Activation in DBTRG Glioblastoma Cells
Öztürk, Y., Günaydın, C., YALÇIN, F. Z., Nazıroğlu, M., & Braidy, N. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/4619865 · Cited by 84
Resveratrol Induces Pro-Oxidant Effects and Time-Dependent Resistance to Cytotoxicity in Activated Hepatic Stellate Cells
Martins, L. A. M., Coelho, B. P., Behr, G., Pettenuzzo, L. F., Souza, I. C. C., Moreira, J. C. F., Borojevic, R., Gottfried, C., & Guma, F. C. R. (2014) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-013-9703-8 · Cited by 82
Flavin Oxidase-Induced ROS Generation Modulates PKC Biphasic Effect of Resveratrol on Endothelial Cell Survival
Posadino, A. M., Giordo, R., Cossu, A., Nasrallah, G. K., Shaito, A. A., Abou-Saleh, H., Eid, A. H., & Pintus, G. (2019) · Biomolecules · doi:10.3390/biom9060209 · Cited by 82
Self-citation
Resveratrol induces DNA damage in colon cancer cells by poisoning topoisomerase II and activates the ATM kinase to trigger p53-dependent apoptosis
Demoulin, B., Hermant, M., Castrogiovanni, C., Staudt, C., & Dumont, P. (2015) · Toxicology in Vitro · doi:10.1016/j.tiv.2015.04.015 · Cited by 81
Resveratrol Mobilizes Endogenous Copper in Human Peripheral Lymphocytes Leading to Oxidative DNA Breakage: A Putative Mechanism for Chemoprevention of Cancer
Hadi, S. M., Ullah, M. F., Azmi, A. S., Ahmad, A., Shamim, U., Zubair, H., & Khan, H. Y. (2010) · Pharmaceutical Research · doi:10.1007/s11095-010-0055-4 · Cited by 81
Akt Downregulation by Flavin Oxidase–Induced ROS Generation Mediates Dose-Dependent Endothelial Cell Damage Elicited by Natural Antioxidants
Pasciu, V., Posadino, A. M., Cossu, A., Sanna, B., Tadolini, B., Gaspa, L., Marchisio, A., Dessole, S., Capobianco, G., & Pintus, G. (2009) · Toxicological Sciences · doi:10.1093/toxsci/kfp301 · Cited by 79
Self-citation
Resveratrol opposite effects on rat tissue lipoperoxidation: pro-oxidant during day-time and antioxidant at night
Gadacha, W., Ben‐Attia, M., Bonnefont‐Rousselot, D., Aouani, E., Ghanem‐Boughanmi, N., & Touitou, Y. (2009) · Redox Report · doi:10.1179/135100009x466131 · Cited by 77
Natural Stilbenoids Have Anti-Inflammatory Properties in Vivo and Down-Regulate the Production of Inflammatory Mediators NO, IL6, and MCP1 Possibly in a PI3K/Akt-Dependent Manner
Eräsalo, H., Hämäläinen, M., Leppänen, T., Mäki‐Opas, I., Laavola, M., Haavikko, R., Yli‐Kauhaluoma, J. T., & Moilanen, E. (2018) · Journal of Natural Products · doi:10.1021/acs.jnatprod.7b00384 · Cited by 77
Resveratrol exerts dose-dependent anti-fibrotic or pro-fibrotic effects in kidneys: A potential risk to individuals with impaired kidney function
Liu, S., Zhao, M., Zhou, Y., Wang, C., Yuan, Y., Li, L., Bresette, W., Chen, Y., Cheng, J., Lu, Y., et al. (2018) · Phytomedicine · doi:10.1016/j.phymed.2018.12.024 · Cited by 77
A Systematic Review on Natural Antioxidant Properties of Resveratrol
Colica, C., Milanović, M., Milić, N., Aiello, V., LORENZO, A. D., & Abenavoli, L. (2018) · Natural Product Communications · doi:10.1177/1934578x1801300923 · Cited by 77
Resveratrol Binding to Human Serum Albumin
N’soukpoé-Kossi, C. N., St-Louis, C., Beauregard, M., Subirade, M., Carpentier, R., Hotchandani, S., & Tajmir‐Riahi, H. A. (2006) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2006.10507120 · Cited by 76
Resveratrol modulates angiogenesis through the GSK3β/β-catenin/TCF-dependent pathway in human endothelial cells
Wang, H., Zhou, H., Zou, Y., Liu, Q., Guo, C., Gao, G., Shao, C., & Gong, Y. (2010) · Biochemical Pharmacology · doi:10.1016/j.bcp.2010.07.034 · Cited by 74
Bioavailability of resveratrol: Possibilities for enhancement
de Vries, K., Strydom, M. A., & Steenkamp, V. (2017) · Journal of Herbal Medicine · doi:10.1016/j.hermed.2017.09.002 · Cited by 74
Piceatannol induces heme oxygenase-1 expression in human mammary epithelial cells through activation of ARE-driven Nrf2 signaling
Lee, H.-H., Park, S., Almazari, I., Kim, E. H., Na, H., & Surh, Y. (2010) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2010.06.011 · Cited by 73
Antiproliferative Activity of Methylated Analogues of E- and Z-Resveratrol
Cardile, V., Chillemi, R., Lombardo, L., Sciuto, S., Spatafora, C., & Tringali, C. (2007) · Zeitschrift für Naturforschung C · doi:10.1515/znc-2007-3-406 · Cited by 72
Resveratrol exhibits a strong cytotoxic activity in cultured cells and has an antiviral action against polyomavirus: potential clinical use
Berardi, V., Ricci, F., Castelli, M., Galati, G., & Risuleo, G. (2009) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/1756-9966-28-96 · Cited by 72
Hormetic response of resveratrol against cardioprotection.
Juhász, B., Mukherjee, S., & Das, D. K. (2010) · Europe PMC (PubMed Central) · Cited by 71
Protein kinase CK2 modulates apoptosis induced by resveratrol and epigallocatechin-3-gallate in prostate cancer cells
Ahmad, K. A., Harris, N. H., Johnson, A. D., Lindvall, H. C. N., Wang, G., & Ahmed, K. (2007) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-06-0491 · Cited by 71
Biphasic activity of resveratrol on indomethacin-induced gastric ulcers
Dey, A., Guha, P., Chattopadhyay, S., & Bandyopadhyay, S. K. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.02.027 · Cited by 70
Resveratrol has anti-thyroid effects both in vitro and in vivo
Giuliani, C., Iezzi, M., Ciolli, L., Hysi, A., Bucci, I., Santo, S. D., Rossi, C., Zucchelli, M., & Napolitano, G. (2017) · Food and Chemical Toxicology · doi:10.1016/j.fct.2017.06.044 · Cited by 70
Resveratrol promotes oxidative stress to drive DLC1 mediated cellular senescence in cancer cells
Ji, S., Zheng, Z., Liu, S., Ren, G., Gao, J., Zhang, Y., & Li, G. (2018) · Experimental Cell Research · doi:10.1016/j.yexcr.2018.06.031 · Cited by 70
Resveratrol as a Multifunctional Topical Hypopigmenting Agent
Na, J., Shin, J. W., Choi, H.-R., Kwon, S., & Park, K.-C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20040956 · Cited by 70
Higher dose of resveratrol elevated cardiovascular disease risk biomarker levels in overweight older adults – A pilot study
Mankowski, R. T., You, L., Buford, T. W., Leeuwenburgh, C., Manini, T. M., Schneider, S., Qiu, P., & Anton, S. D. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.110821 · Cited by 70
P-gp, MRP2 and OAT1/OAT3 mediate the drug-drug interaction between resveratrol and methotrexate
Jia, Y., Liu, Z., Wang, C., Meng, Q., Huo, X., Liu, Q., Sun, H., Sun, P., Yang, X., Ma, X., et al. (2016) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2016.06.030 · Cited by 67
Resveratrol Increases Anti‐Proliferative Activity of Bestatin Through Downregulating P‐Glycoprotein Expression Via Inhibiting PI3K/Akt/mTOR Pathway in K562/ADR Cells
Wang, L., Wang, C., Jia, Y., Liu, Z., Shu, X. H., & Liu, K. (2015) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25407 · Cited by 66
Amphiphilic properties of (−)-epicatechin and their significance for protection of cells against peroxynitrite
Schröeder, P., Klotz, L., & Sies, H. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)01132-x · Cited by 66
Characteristics of Patients with Cystic Fibrosis: Experience in a Large Referral Children's Hospital in Tehran, Iran.
Khatami, G., Mir-Nasseri, M., Seyghali, F., Allah-Verdi, B., & Yourdkhani, F. (2010) · Europe PMC (PubMed Central) · Cited by 65
Resveratrol and Quercetin Administration Improves Antioxidant DEFENSES and reduces Fatty Liver in Metabolic Syndrome Rats
Rubio-Ruiz, M. E., Guarner‐Lans, V., Cano-Martı́nez, A., Díaz‐Díaz, E., Manzano-Pech, L., Gamas-Magaña, A., Castrejón-Téllez, V., Tapia-Cortina, C., & Pérez-Torres, I. (2019) · Molecules · doi:10.3390/molecules24071297 · Cited by 65
Resveratrol-Loaded Albumin Nanoparticles with Prolonged Blood Circulation and Improved Biocompatibility for Highly Effective Targeted Pancreatic Tumor Therapy
Geng, T., Zhao, X., Ma, M., Zhu, G., & Yin, L. (2017) · Nanoscale Research Letters · doi:10.1186/s11671-017-2206-6 · Cited by 63
Resveratrol promotes neuroprotection and attenuates oxidative and nitrosative stress in the small intestine in diabetic rats
Ferreira, P. E. B., Beraldi, E. J., Borges, S. C., Natali, M. R. M., & Buttow, N. C. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.06.030 · Cited by 62
Pro‐ulcer effects of resveratrol in mice with indomethacin‐induced gastric ulcers are reversed by l ‐arginine
Guha, P., Dey, A., Chatterjee, A., Chattopadhyay, S., & Bandyopadhyay, S. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00572.x · Cited by 60
Piceatannol attenuates hydrogen-peroxide- and peroxynitrite-induced apoptosis of PC12 cells by blocking down-regulation of Bcl-XL and activation of JNK
Kim, H. J., Lee, K. W., Kim, M.-S., & Lee, H. J. (2007) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2007.06.001 · Cited by 60
Effects of 90 Days of Resveratrol Supplementation on Cognitive Function in Elders: A Pilot Study
Anton, S. D., Ebner, N. C., Dzierzewski, J. M., Zlatar, Z. Z., Gurka, M. J., Dotson, V. M., Kirton, J. W., Mankowski, R. T., Marsiske, M., & Manini, T. M. (2018) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2017.0398 · Cited by 60
Resveratrol induces membrane and DNA disruption via pro-oxidant activity against Salmonella typhimurium
Lee, W., & Lee, D. G. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.05.138 · Cited by 59
Effects of resveratrol on growth and function of rat ovarian granulosa cells
Ortega, I., Wong, D. H., Villanueva, J. A., Cress, A. B., Sokalska, A., Stanley, S. D., & Dulęba, A. J. (2012) · Fertility and Sterility · doi:10.1016/j.fertnstert.2012.08.004 · Cited by 57
Resveratrol sequentially induces replication and oxidative stresses to drive p53-CXCR2 mediated cellular senescence in cancer cells
Li, B., Hou, D., Guo, H., Zhou, H., Zhang, S., Xu, X., Liu, Q., Zhang, X., Zou, Y., Gong, Y., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-00315-4 · Cited by 54
Resveratrol induces cell death through ROS‑dependent downregulation of Notch1/PTEN/Akt signaling in ovarian cancer cells
Kim, T. H., Park, J. Y., & Woo, J. (2019) · Molecular Medicine Reports · doi:10.3892/mmr.2019.9962 · Cited by 54
Resveratrol induces downregulation of DNA repair genes in MCF-7 human breast cancer cells
León-Galicia, I., Díaz‐Chávez, J., Garcı́a-Villa, E., Uribe-Figueroa, L., Hidalgo‐Miranda, A., Herrera, L. A., Álvarez-Ríos, E., Garcı́a-Mena, J., & Gariglio, P. (2012) · European Journal of Cancer Prevention · doi:10.1097/cej.0b013e328353edcb · Cited by 53
Red Wine, Resveratrol and Atrial Fibrillation
Stephan, L. S., Almeida, E. D., Markoski, M. M., Garavaglia, J., & Marcadenti, A. (2017) · Nutrients · doi:10.3390/nu9111190 · Cited by 53
Resveratrol Attenuates Oxidative Stress Induced by Balloon Injury in the Rat Carotid Artery Through Actions on the ERK1/2 and NF-Kappa B Pathway
Zhang, J., Chen, J., Yang, J. M., Xu, C., Pu, P., Ding, J., & Jiang, H. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000343364 · Cited by 52
Antioxidant and pro-oxidant actions of resveratrol on human serum albumin in the presence of toxic diabetes metabolites: Glyoxal and methyl-glyoxal
Arcanjo, N. M. O., Luna, C., Madruga, M. S., & Estévez, M. (2018) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2018.06.007 · Cited by 52
Combination of glucan, resveratrol and vitamin C demonstrates strong anti-tumor potential.
Větvička, V., & Větvičková, J. (2012) · PubMed · Cited by 51
Effect of resveratrol on the pharmacokinetics of oral and intravenous nicardipine in rats: possible role of P-glycoprotein inhibition by resveratrol
Choi, J., Choi, B.-C., & Kang, K. W. (2009) · Die Pharmazie · doi:10.31083/ph.2008.8683 · Cited by 50
Inhibition of mammalian DNA polymerases by resveratrol: mechanism and structural determinants
Locatelli, G. A., Savio, M., Forti, L., Shevelev, I., Ramadan, K., Stivala, L. A., Vannini, V., Hübscher, U., Spadari, S., & Maga, G. (2005) · Biochemical Journal · doi:10.1042/bj20050094 · Cited by 49
Unique synergistic formulation of curcumin, epicatechin gallate and resveratrol, tricurin, suppresses HPV E6, eliminates HPV+ cancer cells, and inhibits tumor progression
Mukherjee, S., Debata, P. R., Hussaini, R., Chatterjee, K., Baidoo, J., Sampat, S., Szerszen, A., Navarra, J. P., Fata, J. E., Severinova, E., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.16648 · Cited by 49
Involvement of UDP-Glucuronosyltransferases and Sulfotransferases in the Excretion and Tissue Distribution of Resveratrol in Mice
Böhmdorfer, M., Szakmary, A., Schiestl, R. H., Vaquero, J., Riha, J., Brenner, S., Thalhammer, T., Szekeres, T., & Jäger, W. R. (2017) · Nutrients · doi:10.3390/nu9121347 · Cited by 49
Resveratrol, a naturally occurring polyphenol, induces sister chromatid exchanges in a Chinese hamster lung (CHL) cell line
Matsuoka, A., Furuta, A., Ozaki, M., Fukuhara, K., & Miyata, N. (2001) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/s1383-5718(01)00184-x · Cited by 48
Piceatannol Attenuates Renal Fibrosis Induced by Unilateral Ureteral Obstruction via Downregulation of Histone Deacetylase 4/5 or p38-MAPK Signaling
Choi, S. Y., Piao, Z. H., Jin, L., Kim, J. H., Kim, G. R., Ryu, Y., Lin, M. Q., Kim, H.-S., Kee, H. J., & Jeong, M. H. (2016) · PLoS ONE · doi:10.1371/journal.pone.0167340 · Cited by 48
The haptenation theory of vitiligo and melanoma rejection: a close‐up
Westerhof, W., Manini, P., Napolitano, A., & d’Ischia, M. (2011) · Experimental Dermatology · doi:10.1111/j.1600-0625.2010.01200.x · Cited by 46
Effects of long-term treatment with resveratrol and subcutaneous and oral estradiol administration on pituitary function in rats
Bottner, M. B., Christoffel, J., Jarry, H., & Wuttke, W. (2006) · Journal of Endocrinology · doi:10.1677/joe.1.06535 · Cited by 46
Correlation of Reactive Oxygen Species Levels with Resveratrol Sensitivities of Anaplastic Thyroid Cancer Cells
Zheng, X., Jia, B., Tian, X., Song, X., Wu, M., Kong, Q., Li, H., & Liu, J. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/6235417 · Cited by 46
Cytometric Analysis of Cytotoxicity of Polyphenols and Related Phenolics to Rat Thymocytes: Potent Cytotoxicity of Resveratrol to Normal Cells
Fujimoto, A., Sakanashi, Y., Matsui, H., Oyama, T. B., Nishimura, Y. H., Masuda, T., & Oyama, Y. (2009) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2009.00386.x · Cited by 44
Effects of resveratrol on eNOS in the endothelium and the perivascular adipose tissue
Xia, N., Förstermann, U., & Li, H. (2017) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13397 · Cited by 44
Resveratrol and Cancer Treatment: Is Hormesis a Yet Unsolved Matter?
Borriello, A., Bencivenga, D., Caldarelli, I., Tramontano, A., Borgia, A., Pirozzi, A. V. A., Oliva, A., & Ragione, F. D. (2013) · Current Pharmaceutical Design · doi:10.2174/1381612811319300007 · Cited by 43
High-fructose corn syrup-induced hepatic dysfunction in rats: improving effect of resveratrol
Sadı, G., Ergin, V., Yılmaz, G., Pektaş, M. B., Yıldırım, O. G., Menevşe, A., & Akar, F. (2014) · European Journal of Nutrition · doi:10.1007/s00394-014-0765-1 · Cited by 43
Different Redox Response Elicited by Naturally Occurring Antioxidants in Human Endothelial Cells
Giordo, R., Cossu, A., Pasciu, V., Hoa, P. T., Posadino, A. M., & Pintus, G. (2013) · The Open Biochemistry Journal · doi:10.2174/1874091x01307010044 · Cited by 43
Self-citation
Cardioprotection by resveratrol: a review of effects/targets in cultured cells and animal tissues.
WU, J. M., Hsieh, T., & Wang, Z. (2011) · PubMed · Cited by 42
Resveratrol Provides Cardioprotection after Ischemia/reperfusion Injury via Modulation of Antioxidant Enzyme Activities.
Mokni, M., Hamlaoui, S., Karkouch, I., Amri, M., Marzouki, L., Limam, F., & Aouani, E. (2013) · Europe PMC (PubMed Central) · Cited by 42
Resveratrol Inhibits Alpha-Melanocyte-Stimulating Hormone Signaling, Viability, and Invasiveness in Melanoma Cells
Chen, Y.-J., Chen, Y.-Y., Lin, Y., Hu, H.-Y., & Liao, H. (2013) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2013/632121 · Cited by 42
Stability oftrans-Resveratrol Associated with Transport Proteins
Pantusa, M., Bartucci, R., & Rizzuti, B. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf405584a · Cited by 41
Resveratrol inhibits cell growth by inducing cell cycle arrest in activated hepatic stellate cells
de Souza, I. C. C., Martins, L. A. M., Coelho, B. P., Grivicich, I., Guaragna, R. M. V. D. C., Gottfried, C., Borojević, R., & Guma, F. T. C. R. (2008) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-008-9781-x · Cited by 41
Human serum albumin-resveratrol complex formation: Effect of the phenolic chemical structure on the kinetic and thermodynamic parameters of the interactions
Rezende, J. D. P., Hudson, E. A., de Paula, H. M. C., Meinel, R. S., da Silva, A. D., da Silva, L. H. M., & Pires, A. C. D. S. (2019) · Food Chemistry · doi:10.1016/j.foodchem.2019.125514 · Cited by 40
Resveratrol: a supplementation for men or for mice?
Ponzo, V., Soldati, L., & Bo, S. (2014) · Journal of Translational Medicine · doi:10.1186/1479-5876-12-158 · Cited by 38
Rhododenol-induced leukoderma in a mouse model mimicking Japanese skin
Abe, Y., Okamura, K., Kawaguchi, M., Hozumi, Y., Aoki, H., Kunisada, T., Ito, S., Wakamatsu, K., Matsunaga, K., & Suzuki, T. (2015) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2015.10.011 · Cited by 37
Targeting Cancer Via Resveratrol-Loaded Nanoparticles Administration: Focusing on In Vivo Evidence
Paiva‐Santos, A. C., Pereira, I., Magalhães, M., Pereira‐Silva, M., Caldas, M., Ferreira, L., Figueiras, A., Ribeiro, A. J., & Veiga, F. (2019) · The AAPS Journal · doi:10.1208/s12248-019-0325-y · Cited by 37
Effects of Piceatannol and Resveratrol on Sirtuins and Hepatic Inflammation in High-Fat Diet-Fed Mice
Lee, H. J., Kang, M.-G., Yun, H. S., Kim, Y. M., Lim, Y., & Yang, S. J. (2019) · Journal of Medicinal Food · doi:10.1089/jmf.2018.4261 · Cited by 37
Resveratrol Suppresses the Inducible Expression of CYP3A4 Through the Pregnane X Receptor
Deng, R., Xu, C., Chen, X., Chen, P., Wang, Y., Zhou, X., Jin, J., Niu, L., Ying, M.-J., Huang, M., et al. (2014) · Journal of Pharmacological Sciences · doi:10.1254/jphs.14132fp · Cited by 36
Trans-Resveratrol Enhances the Anticoagulant Activity of Warfarin in a Mouse Model
Chiba, T., Kimura, Y., Suzuki, S., Tatefuji, T., & Umegaki, K. (2016) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.31765 · Cited by 36
TriCurin, a novel formulation of curcumin, epicatechin gallate, and resveratrol, inhibits the tumorigenicity of human papillomavirus-positive head and neck squamous cell carcinoma
Piao, L., Mukherjee, S., Chang, Q., Xie, X., Li, H., Castellanos, M. R., Banerjee, P., Iqbal, H. A., Ivancic, R. J., Wang, X., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.10620 · Cited by 36
Low dose resveratrol ameliorates mitochondrial respiratory dysfunction and enhances cellular reprogramming
Mizuguchi, Y., Hatakeyama, H., Sueoka, K., Tanaka, M., & Goto, Y.-I. (2017) · Mitochondrion · doi:10.1016/j.mito.2016.12.006 · Cited by 35
Biological effects of combined resveratrol and vitamin D3 on ovarian tissue
Uberti, F., Morsanuto, V., Aprile, S., Ghirlanda, S., Stoppa, I., Cochis, A., Grosa, G., Rimondini, L., & Molinari, C. (2017) · Journal of Ovarian Research · doi:10.1186/s13048-017-0357-9 · Cited by 34
Piceatannol inhibits phorbol ester-induced expression of COX-2 and iNOS in HR-1 hairless mouse skin by blocking the activation of NF-κB and AP-1
Liu, L., Li, J., Kundu, J. K., & Surh, Y. (2014) · Inflammation Research · doi:10.1007/s00011-014-0777-6 · Cited by 33
DJ-1 preserving mitochondrial complex I activity plays a critical role in resveratrol–mediated cardioprotection against hypoxia/reoxygenation–induced oxidative stress
Zhang, Y., Li, X., Zhao, L., Duan, G., Xiao, L., & Chen, H. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.12.094 · Cited by 33
Resveratrol Inhibits Sodium/Iodide Symporter Gene Expression and Function in Rat Thyroid Cells
Giuliani, C., Bucci, I., Santo, S. D., Rossi, C., Grassadonia, A., Mariotti, M., Piantelli, M., Monaco, F., & Napolitano, G. (2014) · PLoS ONE · doi:10.1371/journal.pone.0107936 · Cited by 32
Resveratrol Potentiates Effect of Simvastatin on Inhibition of Mevalonate Pathway in Human Endometrial Stromal Cells
Villanueva, J. A., Sokalska, A., Cress, A. B., Ortega, I., Bruner‐Tran, K. L., Osteen, K. G., & Dulęba, A. J. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-3387 · Cited by 32
Effects of berberine, curcumin, resveratrol alone and in combination with chemotherapeutic drugs and signal transduction inhibitors on cancer cells—Power of nutraceuticals
McCubrey, J. A., Abrams, S. L., Lertpiriyapong, K., Cocco, L., Ratti, S., Martelli, A. M., Candido, S., Libra, M., Murata, R. M., Rosalen, P. L., et al. (2017) · Advances in Biological Regulation · doi:10.1016/j.jbior.2017.09.012 · Cited by 32
Identification of Resveratrol, an Herbal Compound, as an Activator of the Calcium-Activated Chloride Channel, TMEM16A
Chai, R., Chen, Y., Yuan, H., Wang, X., Guo, S., Qi, J., Zhang, H., Zhan, Y., & An, H. (2017) · The Journal of Membrane Biology · doi:10.1007/s00232-017-9975-9 · Cited by 31

Flagged first, then by citations

4 of the 226 references couldn’t be matched to a known paper.

Research works printed but not linked: 2

Takaoka, 1939, Resveratrol, a new phenolic compound, from Veratrum grandiflorum, J. Chem. Soc. Jpn., 60, 1090
Sotoudehmanesh, 2010, Methotrexate hepatotoxicity in patients with rheumatoid arthritis, Middle East J. Dig. Dis., 2, 104

Sorted by citations

Targeting cellular senescence with senotherapeutics: senolytics and senomorphics
Zhang, L. J., Pitcher, L. E., Prahalad, V., Niedernhofer, L. J., & Robbins, P. D. (2022) · FEBS Journal · doi:10.1111/febs.16350 · Cited by 674
Plant Phenolics: Bioavailability as a Key Determinant of Their Potential Health-Promoting Applications
Cosme, P., Rodríguez, A. B., Espino, J., & Garrido, M. (2020) · Antioxidants · doi:10.3390/antiox9121263 · Cited by 420
Mediterranean Diet as an Antioxidant: The Impact on Metabolic Health and Overall Wellbeing
Gantenbein, K. V., & Kanaka-Gantenbein, C. (2021) · Nutrients · doi:10.3390/nu13061951 · Cited by 288
Anti-Obesity Effects of Polyphenol Intake: Current Status and Future Possibilities
Boccellino, M., & D’Angelo, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21165642 · Cited by 283
Plant Polyphenols and Their Potential Benefits on Cardiovascular Health: A Review
Iqbal, I., Wilairatana, P., Saqib, F., Nasir, B., Wahid, M., Latif, M. F., Iqbal, A., Naz, R., & Mubarak, M. S. (2023) · Molecules · doi:10.3390/molecules28176403 · Cited by 271

See all 716

Authors: Shaito, A., Posadino, A. M., Younes, N., Hasan, H., Halabi, S., Alhababi, D., Al-Mohannadi, A., Abdel-Rahman, W. M., Eid, A. H., Nasrallah, G. K., & Pintus, G.
Affiliations: Lebanese International University (LB)
University of Sassari (IT)
Qatar University (QA)
Justus-Liebig-Universität Gießen (DE)
American University of Beirut (LB)
Department of Medical Laboratory Sciences, College of Health Sciences and Sharjah Institute for Medical Research, University of Sharjah, Sharjah P.O Box: 27272, United Arab Emirates
Corresponding author: Eid, Ali H.
Nasrallah, Gheyath K.
Pintus, Gianfranco
ORCID: Shaito, Abdullah
Posadino, Anna Maria
Younes, Nadin
Hasan, Hiba
Al-Mohannadi, Anjud
Abdel-Rahman, Wael M
Eid, Ali H.
Nasrallah, Gheyath K.
Pintus, Gianfranco
Venue: International Journal of Molecular Sciences
Publisher: MDPI AG
Published: 2020-03-18
Volume: 21
Issue: 6
Pages: 2084
ISSN: 1422-0067 (ISSN-L)
DOI: 10.3390/ijms21062084
PMC: PMC7139620
OpenAlex: W3011177534
Cited by: 716
References: 226
Citations by year: 2026: 104 · 2025: 147 · 2024: 125 · 2023: 116 · 2022: 107 · 2021: 83 · 2020: 31
FWCI: 10.47
Type: journal article
Language: en
Open access: gold
dx.doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: International Journal of Molecular Sciences (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
UnissResearch (Università degli Studi di Sassari) (submittedVersion, cc-by)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Figshare (submittedVersion, cc-by)
Qatar University QSpace (Qatar University) (submittedVersion)
Funders: Qatar University (IRCC#181)
Topics: Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Keywords: resveratrol, toxicity, adverse effects, stilbenoids, natural polyphenols, bioavailability, drug interactions, dosage, French paradox, cardioprotection, neuroprotection, anti-inflammatory activity, antioxidant activity, anticancer effects, anti-diabetic effects, anti-aging effects, delivery methods
MeSH terms: Resveratrol, Humans

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Potential Adverse Effects of Resveratrol: A Literature Review

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks