Regenerative Stem Cell Therapy for Neurodegenerative Diseases: An Overview
Open accessAbstract
Neurodegenerative diseases resulting from the progressive loss of structure and/or function of neurons contribute to different paralysis degrees and loss of cognition and sensation. The lack of successful curative therapies for neurodegenerative disorders leads to a considerable burden on society and a high economic impact. Over the past 20 years, regenerative cell therapy, also known as stem cell therapy, has provided an excellent opportunity to investigate potentially powerful innovative strategies for treating neurodegenerative diseases. This is due to stem cells’ capability to repair injured neuronal tissue by replacing the damaged or lost cells with differentiated cells, providing a conducive environment that is in favor of regeneration, or protecting the existing healthy neurons and glial cells from further damage. Thus, in this review, the various types of stem cells, the current knowledge of stem-cell-based therapies in neurodegenerative diseases, and the recent advances in this field are summarized. Indeed, a better understanding and further studies of stem cell technologies cause progress into realistic and efficacious treatments of neurodegenerative disorders.
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Many researchers have invested considerable effort into exploring regenerative cell therapy (stem cell therapy) to restore neuron loss during neurodegeneration and CNS injury.
“Many researchers have invested considerable effort into exploring regenerative cell therapy, also known as stem cell therapy, to restore neuron loss during neurodegeneration and CNS injury [107].”
From Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions (2024) · cites this paper as [107]
Section 3 states that investigators have made extensive efforts to produce neurons and glial cells from stem cells to treat neurodegenerative diseases, including replacing neural networks lost to disease. The Introduction describes repairing damaged tissue, but the passages found do not establish the same research effort specifically for CNS injury as a distinct condition. (LLM, conf=0.83)
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- Authors
- Sivandzade, F., & Cucullo, L.
- Affiliations
- Oakland University (US)
- Corresponding author
- Cucullo, Luca
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2021-02-22
- Volume
- 22
- Issue
- 4
- Pages
- 2153
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC7926761
- OpenAlex
- W3129268793
- Cited by
- 224
- References
- 153
- Citations by year
- 2026: 30 · 2025: 55 · 2024: 64 · 2023: 43 · 2022: 23 · 2021: 9
- FWCI
- 5.16
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institute on Drug Abuse (2R01-DA029121, 1R01-DA049737)
- National Institute of Neurological Disorders and Stroke (1R01NS117906)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Keywords
- stem cell therapy, neurodegenerative diseases, regenerative cell therapy, stem cell types, neuroprotection, glial cells, cell differentiation, paralysis, cognitive impairment
- MeSH terms
- Animals, Cell Differentiation, Humans, Neurons, Regeneration, Stem Cells, Neurodegenerative Diseases, Stem Cell Transplantation, Regenerative Medicine
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