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Cited by 87melanin and skin pigmentationSkin Protection and AgingDermatologic Treatments and Research

Skin Pigmentation Abnormalities and Their Possible Relationship with Skin Aging

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Lee, Ai-Young·2021·International Journal of Molecular Sciences
DOI 10.3390/ijms22073727PMC PMC8038212
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Abstract

Skin disorders showing abnormal pigmentation are often difficult to manage because of their uncertain etiology or pathogenesis. Abnormal pigmentation is a common symptom accompanying aging skin. The association between skin aging and skin pigmentation abnormalities can be attributed to certain inherited disorders characterized by premature aging and abnormal pigmentation in the skin and some therapeutic modalities effective for both. Several molecular mechanisms, including oxidative stress, mitochondrial DNA mutations, DNA damage, telomere shortening, hormonal changes, and autophagy impairment, have been identified as involved in skin aging. Although each of these skin aging-related mechanisms are interconnected, this review examined the role of each mechanism in skin hyperpigmentation or hypopigmentation to propose the possible association between skin aging and pigmentation abnormalities.

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  • Abundant melanin pigmentation and thicker dermis might help shroud wrinkles, but indirect DNA lesions and oxidative stress are catalyzed by the availability of more melanin pigments.

    “Abundant melanin pigmentation and thicker dermis layer might help to shroud wrinkles, but indirect DNA lesions and oxidative stress are catalyzed by the availability of more melanin pigments”

    From Skin protection from solar ultraviolet radiation using natural compounds: a review (2024) · cites this paper as Lee 2021

    Section 2 says pheomelanin is phototoxic and promotes UV-induced damage, supporting a limited link between a type of melanin and skin damage. It also says eumelanin is photoprotective. The Introduction mentions wrinkles but does not say pigmentation or a thicker dermis conceals them; sections 3.1 and 3.2 do not establish that more melanin catalyzes oxidative stress or indirect DNA lesions. (LLM, conf=0.82)

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Authors
Lee, A.-Y.
Affiliations
Dongguk University Ilsan Hospital (KR)
Corresponding author
Lee, Ai-Young
ORCID
Lee, Ai-Young
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2021-04-02
Volume
22
Issue
7
Pages
3727
ISSN
1422-0067 (ISSN-L)
DOI
10.3390/ijms22073727
PMC
PMC8038212
OpenAlex
W3146011931
Cited by
87
References
164
Citations by year
2026: 16 · 2025: 21 · 2024: 15 · 2023: 18 · 2022: 16 · 2021: 1
FWCI
1.57
Type
journal article
Language
en
Open access
Licence
Locations
  • International Journal of Molecular Sciences (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (No. NRF 2018R1A5A2023127)
  • a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number : HP20C0131)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
  • Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
Keywords
skin aging, skin pigmentation disorders, hyperpigmentation, hypopigmentation, premature aging, oxidative stress, mitochondrial DNA mutations, DNA damage, telomere shortening, hormonal changes, autophagy dysfunction, hereditary skin disease
MeSH terms
Autophagy, DNA Damage, Humans, Melanins, Melatonin, Skin Pigmentation, Skin Aging, Oxidative Stress, Telomere Shortening

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