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Cited by 212Adipokines, Inflammation, and Metabolic DiseasesAlzheimer's disease research and treatmentsRegulation of Appetite and Obesity

The DOI matches its Crossref record; 156 of the 156 references it cites were found in a registry or an index.

Obesity as a Risk Factor for Dementia and Alzheimer’s Disease: The Role of Leptin

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Flores-Cordero, Juan Antonio, Pérez-Pérez, Antonio, Jiménez-Cortegana, Carlos, Alba, Gonzalo, Flores-Barragán, Alfonso, Sánchez-Margalet, Víctor·2022·International Journal of Molecular Sciences
DOI 10.3390/ijms23095202PMC PMC9099768
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Abstract

Obesity is a growing worldwide health problem, affecting many people due to excessive saturated fat consumption, lack of exercise, or a sedentary lifestyle. Leptin is an adipokine secreted by adipose tissue that increases in obesity and has central actions not only at the hypothalamic level but also in other regions and nuclei of the central nervous system (CNS) such as the cerebral cortex and hippocampus. These regions express the long form of leptin receptor LepRb, which is the unique leptin receptor capable of transmitting complete leptin signaling, and are the first regions to be affected by chronic neurocognitive deficits, such as mild cognitive impairment (MCI) and Alzheimer’s Disease (AD). In this review, we discuss different leptin resistance mechanisms that could be implicated in increasing the risk of developing AD, as leptin resistance is frequently associated with obesity, which is a chronic low-grade inflammatory state, and obesity is considered a risk factor for AD. Key players of leptin resistance are SOCS3, PTP1B, and TCPTP whose signalling is related to inflammation and could be worsened in AD. However, some data are controversial, and it is necessary to further investigate the underlying mechanisms of the AD-causing pathological processes and how altered leptin signalling affects such processes.

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Research works printed but not linked: 2

  1. Fietta and Delsante (2022, April 27). Focus on Adipokines—PubMed, Available online: https://pubmed.ncbi.nlm.nih.gov/24640423/.
  2. (2022, April 27). Effect of Body Mass Index on Serum Leptin Levels—PubMed, Available online: https://pubmed.ncbi.nlm.nih.gov/23272432/.

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Metadata

Authors
Flores-Cordero, J. A., Pérez-Pérez, A., Jiménez-Cortegana, C., Alba, G., Flores-Barragán, A., & Sánchez-Margalet, V.
Affiliations
  • Hospital Universitario Virgen Macarena (ES)
  • Department of Medical Biochemistry and Molecular Biology and Immunology, Medical School, Virgen Macarena University Hospital, University of Seville, Av. Sánchez Pizjuan 4, 41009 Sevilla, Spain
ORCID
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2022-05-06
Volume
23
Issue
9
Pages
5202
ISSN
1422-0067 (ISSN-L)
DOI
10.3390/ijms23095202
PMC
PMC9099768
OpenAlex
W4229030955
Cited by
212
References
156
Citations by year
2026: 30 · 2025: 64 · 2024: 64 · 2023: 45 · 2022: 9
FWCI
7.23
Type
journal article
Language
en
Open access
Licence
Locations
  • International Journal of Molecular Sciences (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Deposito de Investigacion Universidad de Sevilla (University of Seville) (submittedVersion, cc-by)
  • RISalud Institutional Health Repository of Andalucía (submittedVersion, cc-by)
Funders
PAIDI CTS-151 Junta de Andalucia, Spain
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords
obesity, Alzheimer's disease, dementia, leptin, leptin resistance, adipokines, SOCS3, PTP1B, TCPTP, neuroinflammation, mild cognitive impairment, hippocampus, cerebral cortex, hypothalamus, low-grade inflammation
MeSH terms
Alzheimer Disease, Humans, Obesity, Risk Factors, Leptin, Receptors, Leptin

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