Cited by 212Adipokines, Inflammation, and Metabolic DiseasesAlzheimer's disease research and treatmentsRegulation of Appetite and Obesity

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Obesity as a Risk Factor for Dementia and Alzheimer’s Disease: The Role of Leptin

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Flores-Cordero, Juan Antonio, Pérez-Pérez, Antonio, Jiménez-Cortegana, Carlos, Alba, Gonzalo, Flores-Barragán, Alfonso, Sánchez-Margalet, Víctor·2022·International Journal of Molecular Sciences

DOI 10.3390/ijms23095202PMC PMC9099768

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Abstract

Obesity is a growing worldwide health problem, affecting many people due to excessive saturated fat consumption, lack of exercise, or a sedentary lifestyle. Leptin is an adipokine secreted by adipose tissue that increases in obesity and has central actions not only at the hypothalamic level but also in other regions and nuclei of the central nervous system (CNS) such as the cerebral cortex and hippocampus. These regions express the long form of leptin receptor LepRb, which is the unique leptin receptor capable of transmitting complete leptin signaling, and are the first regions to be affected by chronic neurocognitive deficits, such as mild cognitive impairment (MCI) and Alzheimer’s Disease (AD). In this review, we discuss different leptin resistance mechanisms that could be implicated in increasing the risk of developing AD, as leptin resistance is frequently associated with obesity, which is a chronic low-grade inflammatory state, and obesity is considered a risk factor for AD. Key players of leptin resistance are SOCS3, PTP1B, and TCPTP whose signalling is related to inflammation and could be worsened in AD. However, some data are controversial, and it is necessary to further investigate the underlying mechanisms of the AD-causing pathological processes and how altered leptin signalling affects such processes.

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Fietta and Delsante (2022, April 27). Focus on Adipokines—PubMed, Available online: https://pubmed.ncbi.nlm.nih.gov/24640423/.
(2022, April 27). Effect of Body Mass Index on Serum Leptin Levels—PubMed, Available online: https://pubmed.ncbi.nlm.nih.gov/23272432/.

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Authors: Flores-Cordero, J. A., Pérez-Pérez, A., Jiménez-Cortegana, C., Alba, G., Flores-Barragán, A., & Sánchez-Margalet, V.
Affiliations: Hospital Universitario Virgen Macarena (ES)
Department of Medical Biochemistry and Molecular Biology and Immunology, Medical School, Virgen Macarena University Hospital, University of Seville, Av. Sánchez Pizjuan 4, 41009 Sevilla, Spain
ORCID: Flores-Cordero, Juan Antonio
Pérez-Pérez, Antonio
Jiménez-Cortegana, Carlos
Sánchez-Margalet, Víctor
Venue: International Journal of Molecular Sciences
Publisher: MDPI AG
Published: 2022-05-06
Volume: 23
Issue: 9
Pages: 5202
ISSN: 1422-0067 (ISSN-L)
DOI: 10.3390/ijms23095202
PMC: PMC9099768
OpenAlex: W4229030955
Cited by: 212
References: 156
Citations by year: 2026: 30 · 2025: 64 · 2024: 64 · 2023: 45 · 2022: 9
FWCI: 7.23
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: International Journal of Molecular Sciences (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Deposito de Investigacion Universidad de Sevilla (University of Seville) (submittedVersion, cc-by)
RISalud Institutional Health Repository of Andalucía (submittedVersion, cc-by)
Funders: PAIDI CTS-151 Junta de Andalucia, Spain
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords: obesity, Alzheimer's disease, dementia, leptin, leptin resistance, adipokines, SOCS3, PTP1B, TCPTP, neuroinflammation, mild cognitive impairment, hippocampus, cerebral cortex, hypothalamus, low-grade inflammation
MeSH terms: Alzheimer Disease, Humans, Obesity, Risk Factors, Leptin, Receptors, Leptin

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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Obesity as a Risk Factor for Dementia and Alzheimer’s Disease: The Role of Leptin

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks