The DOI matches its Crossref record; 156 of the 156 references it cites were found in a registry or an index.
Obesity as a Risk Factor for Dementia and Alzheimer’s Disease: The Role of Leptin
Open accessAbstract
Obesity is a growing worldwide health problem, affecting many people due to excessive saturated fat consumption, lack of exercise, or a sedentary lifestyle. Leptin is an adipokine secreted by adipose tissue that increases in obesity and has central actions not only at the hypothalamic level but also in other regions and nuclei of the central nervous system (CNS) such as the cerebral cortex and hippocampus. These regions express the long form of leptin receptor LepRb, which is the unique leptin receptor capable of transmitting complete leptin signaling, and are the first regions to be affected by chronic neurocognitive deficits, such as mild cognitive impairment (MCI) and Alzheimer’s Disease (AD). In this review, we discuss different leptin resistance mechanisms that could be implicated in increasing the risk of developing AD, as leptin resistance is frequently associated with obesity, which is a chronic low-grade inflammatory state, and obesity is considered a risk factor for AD. Key players of leptin resistance are SOCS3, PTP1B, and TCPTP whose signalling is related to inflammation and could be worsened in AD. However, some data are controversial, and it is necessary to further investigate the underlying mechanisms of the AD-causing pathological processes and how altered leptin signalling affects such processes.
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“The AD risk is greatly increased by the APOE ε4 allele.”
From Recent Advances in Therapeutics for the Treatment of Alzheimer’s Disease (2024) · cites this paper as [44]
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“A person with one copy of this allele is more likely to be affected than a person with two copies [42,43,44].”
From Recent Advances in Therapeutics for the Treatment of Alzheimer’s Disease (2024) · cites this paper as [44]
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1 retracted
Marwarha, G., Raza, S., Meiers, C., & Ghribi, O. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.05.015 · Cited by 107
RetractedInflammation and metabolic disorders
Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199
Inflammation in atherosclerosis
Libby, P. (2002) · Nature · doi:10.1038/nature01323 · Cited by 8,315
Neuroinflammation in Alzheimer's disease: current evidence and future directions
Calsolaro, V., & Edison, P. (2016) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2016.02.010 · Cited by 1,726
Identification of SOCS-3 as a Potential Mediator of Central Leptin Resistance
Bjørbæk, C., Elmquist, J. K., Frantz, J. D., Shoelson, S. E., & Flier, J. S. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80062-3 · Cited by 1,014
Activation of Downstream Signals by the Long Form of the Leptin Receptor
Banks, A. S., Davis, S. M., Bates, S. H., & Myers, M. G. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.19.14563 · Cited by 797
Nocturnal rise of leptin in lean, obese, and non-insulin-dependent diabetes mellitus subjects.
Sinha, M. K., Ohannesian, J. P., Heiman, M. L., Kriauciunas, A., Stephens, T. W., Magosin, S., Marco, C. C., & Caro, J. F. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118551 · Cited by 780
Raji, C. A., Ho, A. J., Parikshak, N., Becker, J. T., López, O. L., Kuller, L. H., Hua, X., Leow, A., Toga, A. W., & Thompson, P. M. (2009) · Human Brain Mapping · doi:10.1002/hbm.20870 · Cited by 685
Elevated body mass index is associated with executive dysfunction in otherwise healthy adults
Gunstad, J., Paul, R. H., Cohen, R. A., Tate, D. F., Spitznagel, M. B., & Gordon, E. (2007) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2006.05.001 · Cited by 668
Cognitive impairment following high fat diet consumption is associated with brain inflammation
Pistell, P. J., Morrison, C. D., Gupta, S., Knight, A. G., Keller, J. N., Ingram, D. K., & Bruce‐Keller, A. J. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2009.11.010 · Cited by 623
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Research works printed but not linked: 2
- Fietta and Delsante (2022, April 27). Focus on Adipokines—PubMed, Available online: https://pubmed.ncbi.nlm.nih.gov/24640423/.
- (2022, April 27). Effect of Body Mass Index on Serum Leptin Levels—PubMed, Available online: https://pubmed.ncbi.nlm.nih.gov/23272432/.
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Comorbidity in Alzheimer’s disease
Ajagbe͓, A. O., Mobolaji, A. A., Fakorede, S., Oyeleye, B. S., Ajenikoko, M. K., & Abijo, A. Z. (2026) · International review of neurobiology · doi:10.1016/bs.irn.2026.08.021
Mulligan, M. D., Wang, R., Yang, Q., Beiser, A., Maillard, P., Satizábal, C. L., Ghosh, S., Tanner, J. A., Johnson, K. A., DeCarli, C. S., et al. (2026) · Journal of Alzheimer s Disease · doi:10.1177/13872877261480733
Adhikari, S., Carlyle, B. C., & de Wet, H. (2026) · The Journal of Precision Medicine Health and Disease · doi:10.1016/j.premed.2026.100057
Knezović, A., Krsnik, A., Homolak, J., Perhoč, A. B., Deškin, A., Virag, D., Šalković‐Petrišić, M., & Barilar, J. O. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.106982
Brain health in older adults: At the crossroads of frailty and resilience
Hossain, M. S., & Praticò, D. (2026) · Journal of Alzheimer s Disease Reports · doi:10.1177/25424823261493062
Zeynali, F., Delfan, M., Rahimpour, M., Ayed, K., Laher, I., Hackney, A. C., & Zouhal, H. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-06242-8
Molecular and genetic basis of alzheimer’s disease and emerging treatment Modalities
Varshney, H., & Siddique, Y. H. (2026) · Neurodegenerative Disease Management · doi:10.1080/17582024.2026.2739332
Changjian, W., Furui, W., Yanyu, F., Yü, Y., & Wei, J. (2026) · Experimental Neurology · doi:10.1016/j.expneurol.2026.116058
Jacquier‐Sarlin, M. R., Seignobos, M., Rauzier, L., Schaack, B., Laurin, D., & Buisson, A. (2026) · Frontiers in Neuroscience · doi:10.3389/fnins.2026.1963040
Rezek, M. B. M., Ivanich, K. L., Aware, C. B., Lin, A., & Wan, C. (2026) · British Journal Of Nutrition · doi:10.1017/s000711452610871x
Boutari, C., & Mantzoros, C. S. (2026) · Metabolism · doi:10.1016/j.metabol.2026.156812
Metadata
- Authors
- Flores-Cordero, J. A., Pérez-Pérez, A., Jiménez-Cortegana, C., Alba, G., Flores-Barragán, A., & Sánchez-Margalet, V.
- Affiliations
- Hospital Universitario Virgen Macarena (ES)
- Department of Medical Biochemistry and Molecular Biology and Immunology, Medical School, Virgen Macarena University Hospital, University of Seville, Av. Sánchez Pizjuan 4, 41009 Sevilla, Spain
- ORCID
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2022-05-06
- Volume
- 23
- Issue
- 9
- Pages
- 5202
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC9099768
- OpenAlex
- W4229030955
- Cited by
- 212
- References
- 156
- Citations by year
- 2026: 30 · 2025: 64 · 2024: 64 · 2023: 45 · 2022: 9
- FWCI
- 7.23
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Deposito de Investigacion Universidad de Sevilla (University of Seville) (submittedVersion, cc-by)
- RISalud Institutional Health Repository of Andalucía (submittedVersion, cc-by)
- Funders
- PAIDI CTS-151 Junta de Andalucia, Spain
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- obesity, Alzheimer's disease, dementia, leptin, leptin resistance, adipokines, SOCS3, PTP1B, TCPTP, neuroinflammation, mild cognitive impairment, hippocampus, cerebral cortex, hypothalamus, low-grade inflammation
- MeSH terms
- Alzheimer Disease, Humans, Obesity, Risk Factors, Leptin, Receptors, Leptin
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