Cited by 212Adipokines, Inflammation, and Metabolic DiseasesAlzheimer's disease research and treatmentsRegulation of Appetite and Obesity

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Obesity as a Risk Factor for Dementia and Alzheimer’s Disease: The Role of Leptin

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Flores-Cordero, Juan Antonio, Pérez-Pérez, Antonio, Jiménez-Cortegana, Carlos, Alba, Gonzalo, Flores-Barragán, Alfonso, Sánchez-Margalet, Víctor·2022·International Journal of Molecular Sciences

DOI 10.3390/ijms23095202PMC PMC9099768

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Abstract

Obesity is a growing worldwide health problem, affecting many people due to excessive saturated fat consumption, lack of exercise, or a sedentary lifestyle. Leptin is an adipokine secreted by adipose tissue that increases in obesity and has central actions not only at the hypothalamic level but also in other regions and nuclei of the central nervous system (CNS) such as the cerebral cortex and hippocampus. These regions express the long form of leptin receptor LepRb, which is the unique leptin receptor capable of transmitting complete leptin signaling, and are the first regions to be affected by chronic neurocognitive deficits, such as mild cognitive impairment (MCI) and Alzheimer’s Disease (AD). In this review, we discuss different leptin resistance mechanisms that could be implicated in increasing the risk of developing AD, as leptin resistance is frequently associated with obesity, which is a chronic low-grade inflammatory state, and obesity is considered a risk factor for AD. Key players of leptin resistance are SOCS3, PTP1B, and TCPTP whose signalling is related to inflammation and could be worsened in AD. However, some data are controversial, and it is necessary to further investigate the underlying mechanisms of the AD-causing pathological processes and how altered leptin signalling affects such processes.

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1 retracted

RETRACTED: Leptin attenuates BACE1 expression and amyloid-β genesis via the activation of SIRT1 signaling pathway
Marwarha, G., Raza, S., Meiers, C., & Ghribi, O. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.05.015 · Cited by 107
Retracted
Inflammation and metabolic disorders
Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199
Inflammation in atherosclerosis
Libby, P. (2002) · Nature · doi:10.1038/nature01323 · Cited by 8,315
Neuroinflammation in Alzheimer's disease: current evidence and future directions
Calsolaro, V., & Edison, P. (2016) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2016.02.010 · Cited by 1,726
Identification of SOCS-3 as a Potential Mediator of Central Leptin Resistance
Bjørbæk, C., Elmquist, J. K., Frantz, J. D., Shoelson, S. E., & Flier, J. S. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80062-3 · Cited by 1,014
Activation of Downstream Signals by the Long Form of the Leptin Receptor
Banks, A. S., Davis, S. M., Bates, S. H., & Myers, M. G. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.19.14563 · Cited by 797
Nocturnal rise of leptin in lean, obese, and non-insulin-dependent diabetes mellitus subjects.
Sinha, M. K., Ohannesian, J. P., Heiman, M. L., Kriauciunas, A., Stephens, T. W., Magosin, S., Marco, C. C., & Caro, J. F. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118551 · Cited by 780
Brain structure and obesity
Raji, C. A., Ho, A. J., Parikshak, N., Becker, J. T., López, O. L., Kuller, L. H., Hua, X., Leow, A., Toga, A. W., & Thompson, P. M. (2009) · Human Brain Mapping · doi:10.1002/hbm.20870 · Cited by 685
Elevated body mass index is associated with executive dysfunction in otherwise healthy adults
Gunstad, J., Paul, R. H., Cohen, R. A., Tate, D. F., Spitznagel, M. B., & Gordon, E. (2007) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2006.05.001 · Cited by 668
Cognitive impairment following high fat diet consumption is associated with brain inflammation
Pistell, P. J., Morrison, C. D., Gupta, S., Knight, A. G., Keller, J. N., Ingram, D. K., & Bruce‐Keller, A. J. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2009.11.010 · Cited by 623

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Fietta and Delsante (2022, April 27). Focus on Adipokines—PubMed, Available online: https://pubmed.ncbi.nlm.nih.gov/24640423/.
(2022, April 27). Effect of Body Mass Index on Serum Leptin Levels—PubMed, Available online: https://pubmed.ncbi.nlm.nih.gov/23272432/.

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Strnadová, V., Pačesová, A., Charvát, V., Šmotková, Z., Železná, B., Kuneš, J., & Maletı́nská, L. (2024) · Bioscience Reports · doi:10.1042/bsr20231385 · Cited by 8
Association of metabolic dysfunction‐associated fatty liver disease with white matter hyperintensity and cognitive decline: A longitudinal cohort study
Jung, I., Park, S. Y., Lee, D. Y., Cho, H. J., Lee, S. K., Seo, J. A., Kim, N. H., Shin, C., & Yu, J. H. (2025) · Diabetes Obesity and Metabolism · doi:10.1111/dom.16232 · Cited by 8
Parietin from lichen: extraction, characterization, and in silico, in vitro, and in vivo evaluation of its protective effects against inflammation, oxidative stress, and neutrophil infiltration in diabetic rat tissues
Abdella, F. I. A., Alanazi, T. Y. A., Alreshidi, M. A., Al-Enazy, H. D. A., Alshammari, H. K., & Hamden, K. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118277 · Cited by 8
Adult-Onset CNS Sulfatide Deficiency Causes Sex-Dependent Metabolic Disruption in Aging
Qiu, S., He, S., Wang, J., Wang, H., Bhattacharjee, A., Li, X., Saeed, M., Dupree, J. L., & Han, X. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310483 · Cited by 7
The Levels of Leptin, Cystatin C, Neuropilin-1 and Tau Protein in Relation to Dietary Habits in Patients with Alzheimer’s Disease
Bogdan, S., Puścion‐Jakubik, A., Klimiuk, K., Socha, K., Kochanowicz, J., & Gorodkiewicz, E. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12216855 · Cited by 9
Uric acid levels and their association with vascular dementia and Parkinson’s disease dementia: a meta-analysis
Li, Q., Cen, K., Cui, Y., Xu, F., & Hou, X. (2023) · Neurological Sciences · doi:10.1007/s10072-023-06620-3 · Cited by 8
Revisiting the Effect of Leptin on Alzheimer Disease and Parkinson Disease: The Role of Insulin Sensitivity
Guo, X., Tang, P., Zhang, X., & Li, R. (2024) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgae136 · Cited by 6
Impact of visceral adiposity index on cognitive impairment and cognitive trajectories in Chinese middle-aged and older adults
Chen, S., Zhou, M., Han, L., Ma, R., Jiang, X., Yang, Z., Du, Y., & Yang, Y. (2025) · Frontiers in Public Health · doi:10.3389/fpubh.2025.1612801 · Cited by 8
Changes in Expression of Key Genes in Alzheimer’s Disease: A Specific Brain Tissue Change
Rasmussen, L. T., de Lábio, R. W., dos Santos, M. P., Fredi, B. M., Chagas, E. F. B., Chen, E., Turecki, G., Smith, M. D. A. C., & Payão, S. L. M. (2024) · The Journals of Gerontology Series A · doi:10.1093/gerona/glae023 · Cited by 7
Reduction of Neuroinflammation as a Common Mechanism of Action of Anorexigenic and Orexigenic Peptide Analogues in the Triple Transgenic Mouse Model of Alzheimer´s Disease
Mengr, A., Šmotková, Z., Pačesová, A., Železná, B., Kuneš, J., & Maletı́nská, L. (2025) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-025-10174-w · Cited by 7
Obesity and Cognitive Function: Leptin Role Through Blood–Brain Barrier and Hippocampus
Al-Suhaimi, E. A., Rubaish, A. A., Al-Dossary, H. A., Homeida, M. A., Shehzad, A., & Homeida, A. M. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05262-0 · Cited by 6
Hypertension and Alzheimer's disease: Pathological interplay, comorbidity risks, and new strategies for synergistic management
Wei, X., Li, L. Y., Zhao, G., Luan, Y., Wang, Q., & Ning, W. (2025) · Clinical and Experimental Hypertension · doi:10.1080/10641963.2025.2595154 · Cited by 6
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Alilou, S., Valizadeh, P., KamaliZonouzi, S., Salabat, D., Jannatdoust, P., Amanollahi, M., Rashidi, F., Rezaie, S., Delavari, S., & Aarabi, M. H. (2024) · Brain Behavior and Immunity Integrative · doi:10.1016/j.bbii.2024.100092 · Cited by 7
Infections, genetics, and Alzheimer's disease: Exploring the pathogenic factors for innovative therapies
Kordi, R., Andrews, T. J., & Hicar, M. D. (2025) · Virology · doi:10.1016/j.virol.2025.110523 · Cited by 6
Clinical Predictors of Cognitive Impairment in a Cohort of Patients with Older Age Bipolar Disorder
Elefante, C., Brancati, G. E., Beatino, M. F., Nerli, B. F., D’Alessandro, G., Fustini, C., Marro, D., Pistolesi, G., Baldacci, F., Ceravolo, R., et al. (2025) · Brain Sciences · doi:10.3390/brainsci15040349 · Cited by 5
Accelerometer-measured physical activity, sedentary behavior, and incident neuropsychiatric diseases: a large prospective cohort study of 73411 participants
Wu, J.-Y., Li, Y., Zhang, D., Gao, P., Fu, Y., Zhang, W., Feng, J., Zhang, Y.-R., Cheng, W., & Yu, J. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03268-7 · Cited by 6
How air pollution influences the difference between overweight and obesity: a comprehensive analysis of direct and indirect correlations
Yu, M., Xie, J., & Liu, Y. (2024) · Frontiers in Public Health · doi:10.3389/fpubh.2024.1403197 · Cited by 5
Influence of diet and exercise on leukocyte telomere length, markers of oxidative stress and inflammation in rats
Tilekli, M. M., Yılmaz, A. K., Yasul, Y., Çon, N., Mercan, S., & Tek, N. A. (2024) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2024.104947 · Cited by 5
The Metabolically Obese, Normal-Weight Phenotype in Young Rats Is Associated with Cognitive Impairment and Partially Preventable with Leptin Intake during Lactation
Cifre, M., Palou, A., & Oliver, P. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms25010228 · Cited by 5
Adiponectin Gene Polymorphisms: A Case–Control Study on Their Role in Late-Onset Alzheimer’s Disease Risk
Javor, J., Ďurmanová, V., Klučková, K., Párnická, Z., Radošinská, D., Šutovský, S., Vašečková, B., Režnáková, V., Králová, M., Gmitterová, K., et al. (2024) · Life · doi:10.3390/life14030346 · Cited by 6
Putative Molecular Mechanisms Underpinning the Inverse Roles of Mitochondrial Respiration and Heme Function in Lung Cancer and Alzheimer’s Disease
Afsar, A., & Li, Z. (2024) · Biology · doi:10.3390/biology13030185 · Cited by 4
Long-term trends in Alzheimer’s disease and other dementias deaths with high body mass index in China from 1990 to 2019, and projections up to 2042
Tao, M., Guo, H., Ji, X., Wang, W., Yuan, H., & Peng, H. (2024) · Archives of Public Health · doi:10.1186/s13690-024-01273-w · Cited by 5
Astrocytes at the intersection of ageing, obesity, and neurodegeneration
Firth, W., Pye, K. R., & Potter, P. G. W. (2024) · Clinical Science · doi:10.1042/cs20230148 · Cited by 5
Polymers for the treatment of Alzheimer’s disease
Zhu, Y., Xu, H., Yu, C., Jiang, W., Hou, X., Ma, M., & Wu, J. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1512941 · Cited by 5
Cerebrometabolic Health
Tanashyan, M. M., & Антонова, К. В. (2025) · Annals of Clinical and Experimental Neurology · doi:10.17816/acen.1359 · Cited by 5
A Comprehensive Review on Preclinical Alzheimer's Disease Models: Evaluating their Clinical Relevance
Kushwaha, V., & Sahu, K. K. (2024) · Current Pharmaceutical Biotechnology · doi:10.2174/0113892010331845240802073645 · Cited by 5
Metabolically Healthy Obesity Is Characterized by a Distinct Proteome Signature
Mir, F. A., Abdesselem, H., Cyprian, F. S., Iskandarani, A., Doudin, A., Shraim, M. A., Alkhalaf, B. M., Alkasem, M., Abdalhakam, I., Bensmail, I., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26052262 · Cited by 5
Andrographolide modulates glucose metabolism in visceral adipose tissue in an Alzheimer's disease obese mouse model
Ormazabal, P., Gherardelli, C., Pinto, C., Servili, E., Méndez‐Orellana, C., Wong, G. W., Contreras, R., Cisternas, P., & Inestrosa, N. C. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.110607 · Cited by 4
Effect of Carbohydrate Type on Brain Composition and Senescence in Aging, Hyperinsulinemia-prone OBESE LA/Ntul//-cp Rats
Tulp, O. L. (2023) · Asian Journal of Medicine and Health · doi:10.9734/ajmah/2023/v21i8841 · Cited by 4
Polypharmacy in psychiatry and weight gain: longitudinal study of 832 patients hospitalized for depression or schizophrenia, along with data of 3180 students from Europe, the U.S., South America, and China
Stassen, H. H., Bachmann, S., Bridler, R., Cattapan, K., & Seifritz, E. (2024) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-024-01767-2 · Cited by 4
Spotlight on plasticity-related genes: Current insights in health and disease
Brandt, N., Köper, F., Hausmann, J., & Bräuer, A. U. (2024) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2024.108687 · Cited by 4
Body Composition and Alzheimer’s Disease: A Holistic Review
Frank, G., Gualtieri, P., Cianci, R., Caldarelli, M., Palma, R., Santis, G. D. D., Porfilio, C., Nicoletti, F., Bigioni, G., & di Renzo, L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25179573 · Cited by 3

Authors: Flores-Cordero, J. A., Pérez-Pérez, A., Jiménez-Cortegana, C., Alba, G., Flores-Barragán, A., & Sánchez-Margalet, V.
Affiliations: Hospital Universitario Virgen Macarena (ES)
Department of Medical Biochemistry and Molecular Biology and Immunology, Medical School, Virgen Macarena University Hospital, University of Seville, Av. Sánchez Pizjuan 4, 41009 Sevilla, Spain
ORCID: Flores-Cordero, Juan Antonio
Pérez-Pérez, Antonio
Jiménez-Cortegana, Carlos
Sánchez-Margalet, Víctor
Venue: International Journal of Molecular Sciences
Publisher: MDPI AG
Published: 2022-05-06
Volume: 23
Issue: 9
Pages: 5202
ISSN: 1422-0067 (ISSN-L)
DOI: 10.3390/ijms23095202
PMC: PMC9099768
OpenAlex: W4229030955
Cited by: 212
References: 156
Citations by year: 2026: 30 · 2025: 64 · 2024: 64 · 2023: 45 · 2022: 9
FWCI: 7.23
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: International Journal of Molecular Sciences (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Deposito de Investigacion Universidad de Sevilla (University of Seville) (submittedVersion, cc-by)
RISalud Institutional Health Repository of Andalucía (submittedVersion, cc-by)
Funders: PAIDI CTS-151 Junta de Andalucia, Spain
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords: obesity, Alzheimer's disease, dementia, leptin, leptin resistance, adipokines, SOCS3, PTP1B, TCPTP, neuroinflammation, mild cognitive impairment, hippocampus, cerebral cortex, hypothalamus, low-grade inflammation
MeSH terms: Alzheimer Disease, Humans, Obesity, Risk Factors, Leptin, Receptors, Leptin

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Obesity as a Risk Factor for Dementia and Alzheimer’s Disease: The Role of Leptin

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