Cited by 132Toxic Organic Pollutants ImpactGenomics, phytochemicals, and oxidative stressPharmacogenetics and Drug Metabolism

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Aryl Hydrocarbon Receptor in Oxidative Stress as a Double Agent and Its Biological and Therapeutic Significance

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Grishanova, Alevtina Y., Perepechaeva, Maria L.·2022·International Journal of Molecular Sciences

DOI 10.3390/ijms23126719PMC PMC9224361

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Abstract

The aryl hydrocarbon receptor (AhR) has long been implicated in the induction of a battery of genes involved in the metabolism of xenobiotics and endogenous compounds. AhR is a ligand-activated transcription factor necessary for the launch of transcriptional responses important in health and disease. In past decades, evidence has accumulated that AhR is associated with the cellular response to oxidative stress, and this property of AhR must be taken into account during investigations into a mechanism of action of xenobiotics that is able to activate AhR or that is susceptible to metabolic activation by enzymes encoded by the genes that are under the control of AhR. In this review, we examine various mechanisms by which AhR takes part in the oxidative-stress response, including antioxidant and prooxidant enzymes and cytochrome P450. We also show that AhR, as a participant in the redox balance and as a modulator of redox signals, is being increasingly studied as a target for a new class of therapeutic compounds and as an explanation for the pathogenesis of some disorders.

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Authors: Grishanova, A. Y., & Perepechaeva, M. L.
Affiliations: Federal Research Center of Fundamental and Translational Medicine (RU)
Corresponding author: Perepechaeva, Maria L.
ORCID: Grishanova, Alevtina Y.
Perepechaeva, Maria L.
Venue: International Journal of Molecular Sciences
Publisher: MDPI AG
Published: 2022-06-16
Volume: 23
Issue: 12
Pages: 6719
ISSN: 1422-0067 (ISSN-L)
DOI: 10.3390/ijms23126719
PMC: PMC9224361
OpenAlex: W4283017800
Cited by: 130
References: 379
Citations by year: 2026: 38 · 2025: 39 · 2024: 32 · 2023: 19 · 2022: 2
FWCI: 2.24
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: International Journal of Molecular Sciences (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: budgetary financing project (FGMU-2022-0004, N1021050601082-2-1.6.4;3.1.6)
Topics: Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
Keywords: aryl hydrocarbon receptor, oxidative stress, xenobiotic metabolism, cytochrome P450, antioxidant enzymes, redox signaling, transcriptional regulation, therapeutic target, pathogenesis
MeSH terms: Gene Expression Regulation, Humans, Xenobiotics, Reactive Oxygen Species, Receptors, Aryl Hydrocarbon, Oxidative Stress

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Aryl Hydrocarbon Receptor in Oxidative Stress as a Double Agent and Its Biological and Therapeutic Significance

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