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Worldwide Heterogeneity of Food Allergy: Focus on Peach Allergy in Southern Italy

D’Aiuto, Valentina, Mormile, Ilaria, Granata, Francescopaolo, Napolitano, Filomena, Lamagna, Laura, Della Casa, Francesca, de Paulis, Amato, Rossi, Francesca Wanda·2024·Journal of Clinical Medicine
DOI 10.3390/jcm13113259PMC PMC11173152
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Abstract

Food allergy (FA) has shown an increasing prevalence in the last decades, becoming a major public health problem. However, data on the prevalence of FA across the world are heterogeneous because they are influenced by several factors. Among IgE-mediated FA, an important role is played by FA related to plant-derived food which can result from the sensitization to a single protein (specific FA) or to homologous proteins present in different foods (cross-reactive FA) including non-specific lipid transfer proteins (nsLTPs), profilins, and pathogenesis-related class 10 (PR-10). In addition, the clinical presentation of FA is widely heterogeneous ranging from mild symptoms to severe reactions up to anaphylaxis, most frequently associated with nsLTP-related FA (LTP syndrome). Considering the potential life-threatening nature of nsLTP-related FA, the patient’s geographical setting should always be taken into account; thereby, it is highly recommended to build a personalized approach for managing FA across the world in the precision medicine era. For this reason, in this review, we aim to provide an overview of the prevalence of nsLTP-mediated allergies in the Mediterranean area and to point out the potential reasons for the different geographical significance of LTP-driven allergies with a particular focus on the allergenic properties of food allergens and their cross reactivity.

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Figure 1 Percentage of sensitization of patients to all tested plant-derived foods (N = 915).
Figure 1 Percentage of sensitization of patients to all tested plant-derived foods (N = 915).CC BY · PubMed Central
Figure 2 Most prevalent allergic sensitization in different geographical areas of the world.
Figure 2 Most prevalent allergic sensitization in different geographical areas of the world.CC BY · PubMed Central

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Metadata

Authors
D’Aiuto, V., Mormile, I., Granata, F., Napolitano, F., Lamagna, L., Della Casa, F., de Paulis, A., & Rossi, F. W.
Venue
Journal of Clinical Medicine
Publisher
MDPI AG
Published
2024-05-31
Volume
13
Issue
11
Pages
3259
ISSN
2077-0383
DOI
10.3390/jcm13113259
PMC
PMC11173152
Cited by
7
References
1
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)

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