The DOI matches its Crossref record; 133 of the 133 references it cites were found in a registry or an index.
The Immunomodulatory Functions of Mesenchymal Stromal/Stem Cells Mediated via Paracrine Activity
Open accessAbstract
Mesenchymal stromal/stem cells (MSCs) exist in almost all tissues, possessing the potential to differentiate into specialized cell types and exert immunomodulatory functions. Thus, they have attracted much attention as a promising therapeutic candidate. Recent studies have demonstrated that paracrine signaling is mainly responsible for the involvement of MSCs in the modulation of immune responses and the progression of diseases. Through release of secretome consisting of a diverse range of cytokines, chemokines, and extracellular vesicles (EVs), MSCs convey regulatory messages to recipient immune cells in the microenvironment. In this review, we focus on the recent advances in how MSCs contribute to immunomodulation through the secretion of paracrine factors. The further improved understanding of the molecular mechanism underlying the interactions between MSCs and immune cells highlights the paracrine biology of MSCs in the modulation of the immune microenvironment and promotes the clinical application of MSCs in regenerative medicine and immune diseases.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Figures
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“by releasing IL-6 [42], TSG-6 [62] and superoxide dismutase (SOD3) [63], BM-MSCs can reduce apoptosis of neutrophils that are resting or activated [42]”
From Mesenchymal stem cell secretome for regenerative medicine: Where do we stand? (2025) · cites this paper as [63]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Multilineage potential of adult human mesenchymal stem cells
Pittenger, M. F., Mackay, A. M., Beck, S. C., Jaiswal, R. K., Douglas, R., Mosca, J. D., Moorman, M. A., Simonetti, D. W., Craig, S., & Marshak, D. R. (1999) · Science · doi:10.1126/science.284.5411.143 · Cited by 21,052
Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles
Colombo, M., Raposo, G., & Théry, C. (2014) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101512-122326 · Cited by 6,186
Protective and pathogenic functions of macrophage subsets
Murray, P. J., & Wynn, T. A. (2011) · Nature Reviews Immunology · doi:10.1038/nri3073 · Cited by 5,269
Bone marrow cells regenerate infarcted myocardium
Orlic, D., Kajstura, J., Chimenti, S., Jakoniuk, I., Anderson, S. M., Li, B., Pickel, J. M., McKay, R. D. G., Nadal‐Ginard, B., Bodine, D. M., et al. (2001) · Nature · doi:10.1038/35070587 · Cited by 5,149
Macrophage biology in development, homeostasis and disease
Wynn, T. A., Chawla, A., & Pollard, J. W. (2013) · Nature · doi:10.1038/nature12034 · Cited by 4,684
Stöckl, S., Göttl, C., Grifka, J. K., & Grässel, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350089 · Cited by 4,670
Human mesenchymal stem cells modulate allogeneic immune cell responses
Aggarwal, S., & Pittenger, M. F. (2005) · Blood · doi:10.1182/blood-2004-04-1559 · Cited by 4,511
Kern, S., Eichler, H., Stoeve, J., Klüter, H., & Bieback, K. (2006) · STEM CELLS · doi:10.1634/stemcells.2005-0342 · Cited by 3,370
Di Nicola, M., Carlo-Stella, C., Magni, M., Milanesi, M., Longoni, P. D., Matteucci, P., Grisanti, S., & Gianni, A. M. (2002) · Blood · doi:10.1182/blood.v99.10.3838 · Cited by 3,226
Neutrophils in the activation and regulation of innate and adaptive immunity
Mantovani, A., Cassatella, M. A., Costantini, C., & Jaillon, S. (2011) · Nature reviews. Immunology · doi:10.1038/nri3024 · Cited by 3,159
Cited by
Sorted by citations
Mesenchymal Stem Cell Immunomodulation: Mechanisms and Therapeutic Potential
Song, N., Scholtemeijer, M., & Shah, K. (2020) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2020.06.009 · Cited by 948
Joo, H. S., Suh, J. H., Lee, H. J., Bang, E. S., & Lee, J. M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21030727 · Cited by 293
Markov, A. A., Thangavelu, L. P., Surendar, A., Zekiy, A. O., Jarahian, M., Chartrand, M. S., Pathak, Y. V., Marofi, F., Shamlou, S., & Hassanzadeh, A. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-021-02265-1 · Cited by 262
RetractedImmune response following traumatic spinal cord injury: Pathophysiology and therapies
Sterner, R. C., & Sterner, R. M. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1084101 · Cited by 258
Emergence of the Stem Cell Secretome in Regenerative Engineering
Daneshmandi, L., Shah, S., Jafari, T., Bhattacharjee, M., Momah, D., Shemshaki, N. S., Lo, K. W. ‐., & Laurencin, C. T. (2020) · Trends in biotechnology · doi:10.1016/j.tibtech.2020.04.013 · Cited by 232
Mesenchymal stem cell secretome for regenerative medicine: Where do we stand?
Trigo, C. M., Rodrigues, J. S., Camões, S. P., Solá, S., & Miranda, J. P. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2024.05.004 · Cited by 252
“In fact, the secretion of IL-10 is thought to affect the JAK1/STAT3 signaling pathway, as well as through the release of TNF-a , suppressing the MAPK and NF-j B signaling activation [63,76], signaling pathways which are involved in the production of pro-inflammatory modulators [77,78].”
InfluentialMesenchymal stem cells secretome: The cornerstone of cell-free regenerative medicine
González-González, A., García‐Sánchez, D., Dotta, M., Rodríguez-Rey, J. C., & Pérez-Campo, F. M. (2020) · World Journal of Stem Cells · doi:10.4252/wjsc.v12.i12.1529 · Cited by 211
Hassanzadeh, A., Rahman, H. S., Markov, A. A., Endjun, J. J., Zekiy, A. O., Chartrand, M. S., Beheshtkhoo, N., Kouhbanani, M. A. J., Marofi, F., Nikoo, M., et al. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-021-02378-7 · Cited by 198
MSC Based Therapies—New Perspectives for the Injured Lung
Behnke, J., Kremer, S., Shahzad, T., Chao, C., Böttcher‐Friebertshäuser, E., Morty, R. E., Bellusci, S., & Ehrhardt, H. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9030682 · Cited by 177
Miceli, V., Bulati, M., Iannolo, G., Zito, G., Gallo, A., & Conaldi, P. G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020763 · Cited by 182
Xia, Y., Ling, X., Hu, G., Zhu, Q., Zhang, J., Li, Q., Zhao, B., Wang, Y., & Deng, Z. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-01834-0 · Cited by 157
Yang, H., Wu, L., Deng, H., Chen, Y., Zhou, H., Liu, M., Wang, S., Li, Z., Zhu, L., & Lv, X. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-1731-x · Cited by 154
Heidari, N., Abbasi‐Kenarsari, H., Namaki, S., Baghaei, K., Zali, M. R., Khaligh, S. G., & Hashemi, S. M. (2021) · Journal of Cellular Physiology · doi:10.1002/jcp.30275 · Cited by 153
Ma, Z.-J., Yang, J.-J., Lu, Y.-B., Liu, Z.-Y., & Wang, X.-X. (2020) · World Journal of Stem Cells · doi:10.4252/wjsc.v12.i8.814 · Cited by 155
Huang, R., Qin, C., Wang, J., Hu, Y., Zheng, G., Qiu, G., Ge, M., Tao, H., Shu, Q., & Xu, J. (2019) · Aging · doi:10.18632/aging.102314 · Cited by 140
Mesenchymal stem cell-derived exosome: A tumor regulator and carrier for targeted tumor therapy
Zhang, F., Guo, J., Zhang, Z., Qian, Y., Wang, G., Duan, M., Zhao, H., Yang, Z., & Jiang, X. (2022) · Cancer Letters · doi:10.1016/j.canlet.2021.11.015 · Cited by 127
Recent advances to enhance the immunomodulatory potential of mesenchymal stem cells
Sarsenova, M., Kim, Y., Raziyeva, K., Kazybay, B., Ogay, V. B., & Saparov, A. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1010399 · Cited by 128
Mesenchymal stem cell therapy for severe COVID-19
Shi, L., Wang, L., Xu, R., Zhang, C., Xie, Y., Liu, K., Li, T., Hu, W., Zhen, C., & Wang, F. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00754-6 · Cited by 124
Rationale for the clinical use of adipose-derived mesenchymal stem cells for COVID-19 patients
Rogers, C. J., Harman, R. J., Bunnell, B. A., Schreiber, M. A., Xiang, C. C., Wang, F., Santidrián, A. F., & Minev, B. (2020) · Journal of Translational Medicine · doi:10.1186/s12967-020-02380-2 · Cited by 116
Wu, J., Piao, Y., Liu, Q., & Yang, X. (2021) · Cell Proliferation · doi:10.1111/cpr.13123 · Cited by 109
Immunomodulatory Mechanisms and Therapeutic Potential of Mesenchymal Stem Cells
Yang, G., Fan, X., Liu, Y., Jie, P., Mazhar, M., Liu, Y., Dechsupa, N., & Wang, L. (2023) · Stem Cell Reviews and Reports · doi:10.1007/s12015-023-10539-9 · Cited by 113
Pulido-Escribano, V., Torrecillas-Baena, B., Camacho-Cardeñosa, M., Dorado, G., Gálvez-Moreno, M. Á., & Casado‐Díaz, A. (2022) · World Journal of Stem Cells · doi:10.4252/wjsc.v14.i7.453 · Cited by 100
Nazerian, Y., Ghasemi, M., Yassaghi, Y., Nazerian, A., & Hashemi, S. M. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109428 · Cited by 96
Mesenchymal stem cell-derived exosomes as a new therapeutic strategy in the brain tumors
Ghasempour, E., Hesami, S., Movahed, E., Keshel, S. H., & Doroudian, M. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-03212-4 · Cited by 97
Batsali, A. K., Georgopoulou, Α., Mavroudi, I., Matheakakis, A., Pontikoglou, C. G., & Papadaki, H. Α. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9030856 · Cited by 93
Therapeutic potential of periodontal ligament stem cells
de Queiroz, A. C., Albuquerque‐Souza, E., GASPARONI, L. M., de França, B. N., Pelissari, C., Trierveiler, M., & Holzhausen, M. (2021) · World Journal of Stem Cells · doi:10.4252/wjsc.v13.i6.605 · Cited by 90
Kamińska, A., Radoszkiewicz, K., Rybkowska, P., Wędzińska, A., & Sarnowska, A. (2022) · Cells · doi:10.3390/cells11091464 · Cited by 95
Single-Cell Transcriptomic Analysis Reveals the Cellular Heterogeneity of Mesenchymal Stem Cells
Zhang, C., Han, X., Liu, J., Chen, L., Lei, Y., Chen, K., Si, J., Wang, T.-Y., Zhou, H. F., Zhao, X., et al. (2022) · Genomics Proteomics & Bioinformatics · doi:10.1016/j.gpb.2022.01.005 · Cited by 89
Diagnostic and Therapeutic Potential of Extracellular Vesicles
Kodam, S. P., & Ullah, M. (2021) · Technology in Cancer Research & Treatment · doi:10.1177/15330338211041203 · Cited by 85
Stroke treatment: Is exosome therapy superior to stem cell therapy?
Cai, Y., Liu, W., Lian, L., Xu, Y., Bai, X., Xu, S., & Zhang, J. (2020) · Biochimie · doi:10.1016/j.biochi.2020.09.025 · Cited by 71
Clinical Potential of Mesenchymal Stem Cell-Derived Exosomes in Bone Regeneration
Torrecillas-Baena, B., Pulido-Escribano, V., Dorado, G., Gálvez-Moreno, M. Á., Camacho-Cardeñosa, M., & Casado‐Díaz, A. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12134385 · Cited by 75
Shin, R. L.-Y., Lee, C., Shen, O. Y.-J., Xu, H., & Lee, O. K. (2021) · Stem Cells International · doi:10.1155/2021/8835156 · Cited by 70
Clua, L., Suau, R., Vañó‐Segarra, I., Ginés, I., Serena, C., & Manyé, J. (2024) · Clinical and Translational Medicine · doi:10.1002/ctm2.70075 · Cited by 78
Biological Cells as Therapeutic Delivery Vehicles
Bush, L. M., Healy, C. P., Javdan, S. B., Emmons, J. C., & Deans, T. L. (2020) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2020.11.008 · Cited by 65
Mesenchymal stem cell immunomodulation: in pursuit of controlling COVID-19 related cytokine storm
Song, N., Wakimoto, H., Rossignoli, F., Bhere, D., Ciccocioppo, R., Chen, K.-S., Khalsa, J. K., Mastrolia, I., Samarelli, A. V., Dominici, M., et al. (2021) · Stem Cells · doi:10.1002/stem.3354 · Cited by 62
He, X., Hong, W., Yang, H. J., Lei, H., Lu, T., Cai, H., Bi, Z., Pan, X., Liu, Y., Dai, L., et al. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00688-z · Cited by 62
Crippa, S., Santi, L., Bosotti, R., Porro, G., & Bernardo, M. E. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm9010002 · Cited by 59
Liu, H., Deng, S., Han, L., Ren, Y., Gu, J., He, L., Liu, T., & Yuan, Z. (2021) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2021.112163 · Cited by 59
Chen, W., Xie, G., Lu, Y., Wang, J., Feng, B., Wang, Q., Xu, K., & Bao, J. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.121260 · Cited by 56
Li, Y., Ren, X., Zhang, Z., Duan, Y., Li, H., Chen, S., Shao, H., Li, X., & Zhang, X. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-02780-9 · Cited by 57
Prakash, N., Kim, J., Jeon, J., Kim, S., Arai, Y., Bello, A. B., Park, H., & Lee, S.-H. (2023) · Biomaterials Research · doi:10.1186/s40824-023-00371-0 · Cited by 56
Hu, H., Li, H., Li, R., Liu, P., & Liu, H. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05450-x · Cited by 56
Mesenchymal Stem Cells in the Adult Human Liver: Hype or Hope?
Kholodenko, I. V., Kurbatov, L. K., Kholodenko, R. V., Manukyan, G. V., & Yarygin, K. N. (2019) · Cells · doi:10.3390/cells8101127 · Cited by 54
Paracrine Effects of Mesenchymal Stem Cells in Ischemic Stroke: Opportunities and Challenges
Taei, A. A., Khodabakhsh, P., Nasoohi, S., Farahmandfar, M., & Dargahi, L. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02967-4 · Cited by 52
Liu, S., Xu, X., Liang, S., Chen, Z., Zhang, Y., Qian, A., & Hu, L. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00619 · Cited by 51
Thisted, T., Smith, F. D., Mukherjee, A., Kleschenko, Y., Feng, F., Jiang, Z.-G., Eitas, T. K., Malhotra, K., Biesová, Z., Onumajuru, A. M., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-47256-x · Cited by 50
Adamo, A., Delfino, P., Gatti, A., Bonato, A., Kamga, P. T., Bazzoni, R., Ugel, S., Mercuri, A., Caligola, S., & Krampera, M. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.584232 · Cited by 50
Therapeutic role of mesenchymal stem cell-derived exosomes in respiratory disease
Zargar, M. J., Kaviani, S., Vasei, M., Zomorrod, M. S., Keshel, S. H., & Soleimani, M. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-02866-4 · Cited by 49
Engineered nasal cartilage for the repair of osteoarthritic knee cartilage defects
Rua, L. A., Mumme, M., Manferdini, C., Darwiche, S., Khalil, A. M., Hilpert, M., Buchner, D. A., Lisignoli, G., Occhetta, P., von Rechenberg, B., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.aaz4499 · Cited by 47
Rizzo, M. G., Best, T. M., Huard, J., Philippon, M. J., Hornicek, F. J., Duan, Z., Griswold, A. J., Kaplan, L. D., Hare, J. M., & Kouroupis, D. (2023) · Cells · doi:10.3390/cells12101421 · Cited by 48
Ryu, Y., Hwang, J. S., Noh, K. B., Park, S. H., Seo, J. H., & Shin, Y. J. (2023) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.64.13.29 · Cited by 49
Marrazzo, P., Pizzuti, V., Zia, S., Sargenti, A., Gazzola, D., Roda, B., Bonsi, L., & Alviano, F. (2021) · Antibiotics · doi:10.3390/antibiotics10070750 · Cited by 43
Applications of mesenchymal stem cells in ocular surface diseases: sources and routes of delivery
Soleimani, M., Masoumi, A., Momenaei, B., Cheraqpour, K., Koganti, R., Chang, A. Y., Ghassemi, M., & Djalilian, A. R. (2023) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2023.2175605 · Cited by 43
Wu, X., Zhu, H., Song, C., Tan, Q., Zhao, Y., & Shang, L. (2023) · Advanced Materials · doi:10.1002/adma.202309719 · Cited by 42
Ahmadi, M., Mahmoodi, M., Shoaran, M., Nazari‐Khanamiri, F., & Rezaie, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232213974 · Cited by 41
Yang, Y., Zhao, Y., Zhang, L., Zhang, F., & Li, L. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.655268 · Cited by 39
Abdelrazik, H., Giordano, E., Bròdano, G. B., Griffoni, C., FALCO, E. D., & Pelagalli, A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20215386 · Cited by 37
Crosstalk Between Mesenchymal Stromal Cells and Tumor-Associated Macrophages in Gastric Cancer
Zheng, P., & Li, W. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.571516 · Cited by 38
Shah, S., Esdaille, C. J., Bhattacharjee, M., Kan, H.-M., & Laurencin, C. T. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2116865118 · Cited by 37
Yadav, P., Vats, R., Bano, A., & Bhardwaj, R. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118588 · Cited by 36
Sources and Therapeutic Strategies of Mesenchymal Stem Cells in Regenerative Medicine
Kamal, M. M., Kassem, D. H., & Haider, K. H. (2022) · Springer eBooks · doi:10.1007/978-981-16-6016-0_2-1 · Cited by 36
Mesenchymal Stromal Cells in Viral Infections: Implications for COVID-19
Rocha, J. L. M., de Oliveira, W. C. F., Noronha, N. D. C., dos Santos, N. C. D., Covas, D. T., Picanço‐Castro, V., Swiech, K., & Malmegrim, K. C. R. (2020) · Stem Cell Reviews and Reports · doi:10.1007/s12015-020-10032-7 · Cited by 38
Liguori, T. T. A., Liguori, G. R., van Dongen, J. A., Moreira, L. F. P., & Harmsen, M. C. (2020) · Biomedical Materials · doi:10.1088/1748-605x/abcff9 · Cited by 35
Hodgson‐Garms, M., Moore, M., Martino, M. M., Kelly, K., & Frith, J. E. (2025) · npj Regenerative Medicine · doi:10.1038/s41536-024-00382-y · Cited by 41
Mesenchymal Stromal Cell Immunology for Efficient and Safe Treatment of Osteoarthritis
Najar, M., Martel‐Pelletier, J., Pelletier, J., & Fahmi, H. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.567813 · Cited by 38
Gonzalez‐Pujana, A., Igartua, M., Santos‐Vizcaíno, E., & Hernández, R. M. (2020) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2020.1714587 · Cited by 34
Bryk, M., Karnas, E., Mlost, J., Zuba‐Surma, E. K., & Starowicz, K. (2021) · British Journal of Pharmacology · doi:10.1111/bph.15569 · Cited by 34
Equilibrium among Inflammatory Factors Determines Human MSC-Mediated Immunosuppressive Effect
Suzdaltseva, Y. G., Goryunov, K. V., Silina, E. V., Manturova, N., Stupin, V. A., & Киселев, С. Л. (2022) · Cells · doi:10.3390/cells11071210 · Cited by 35
Lu, D., Jiao, X., Jiang, W., Yang, L., Gong, Q., Wang, X., Wei, M., & Gong, S. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115042 · Cited by 34
Crippa, S., Santi, L., Berti, M., Ponti, G. D., & Bernardo, M. E. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.663316 · Cited by 33
Mesenchymal Stem Cell-derived Exosomes: Novel Therapeutic Approach for Inflammatory Bowel Diseases
Tian, C., Yang, M., Xu, H., Zhu, M., Zhang, Y., Yao, J., Wang, L., Liang, Y., & Li, D. (2023) · Stem Cells International · doi:10.1155/2023/4245704 · Cited by 34
Mapping the Secretome of Dental Pulp Stem Cells Under Variable Microenvironmental Conditions
Bousnaki, M., Bakopoulou, A., Pich, A., Papachristou, E., Κritis, A., & Koidis, P. T. (2021) · Stem Cell Reviews and Reports · doi:10.1007/s12015-021-10255-2 · Cited by 33
Miao, Y., Liang, X., Chen, J., Liu, H., He, Z., Qin, Y., Liu, A., & Zhang, R. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107266 · Cited by 30
Haghighitalab, A., Matin, M. M., Amin, A., Minaee, S., Bidkhori, H. R., Doeppner, T. R., & Bahrami, A. R. (2021) · Scientific Reports · doi:10.1038/s41598-021-87153-7 · Cited by 33
Yudintceva, N. M., Mikhailova, N., Fedorov, V., Samochernykh, K. A., Vinogradova, T. I., Muraviov, A. N., & Shevtsov, M. A. (2022) · Bioengineering · doi:10.3390/bioengineering9110662 · Cited by 30
Dehnavi, S., Sadeghi, M., Afshari, J. T., & Mohammadi, M. (2023) · Cellular Immunology · doi:10.1016/j.cellimm.2023.104771 · Cited by 30
SARS-CoV-2 Infection: A Role for S1P/S1P Receptor Signaling in the Nervous System?
Meacci, E., Garcia‐Gil, M., & Pierucci, F. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186773 · Cited by 29
Fan, X., Xu, Z.-B., Li, C., Zhang, H., Peng, Y., He, B., Liu, X., Chen, D., Chen, D., Akdiş, C. A., et al. (2021) · Stem Cells · doi:10.1002/stem.3369 · Cited by 29
Wang, J., Liu, W., Yu, D., Yang, Z., Li, S., & Sun, X. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.749822 · Cited by 29
Jia, Z., Lv, Y., Zhang, W., Zhang, X., Li, F., Lu, X., & Zhao, S. (2022) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2703086 · Cited by 29
Mesenchymal Stem Cell Application and Its Therapeutic Mechanisms in Intracerebral Hemorrhage
Yang, G., Fan, X., Mazhar, M., Yang, S., Xu, H., Dechsupa, N., & Wang, L. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.898497 · Cited by 29
Yao, S., Liang, Z., Lee, Y. W., Yung, P. S. H., & Lui, P. P. Y. (2023) · The American Journal of Sports Medicine · doi:10.1177/03635465221135770 · Cited by 29
Extracellular vesicle-mediated cellular crosstalk in lung repair, remodelling and regeneration
Kadota, T., Fujita, Y., Araya, J., Ochiya, T., & Kuwano, K. (2022) · European Respiratory Review · doi:10.1183/16000617.0106-2021 · Cited by 33
Self-citationKang, J. Y., Oh, M., Joo, H., Park, H. S., Chae, D., Kim, J., Lee, H., Oh, I., & Yu, K. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9092913 · Cited by 28
Immunomodulation effect of mesenchymal stem cells in islet transplantation
Shrestha, M., Nguyen, T. T., Park, J., Choi, J. U., Yook, S., & Jeong, J. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112042 · Cited by 28
Matheakakis, A., Batsali, A. K., Papadaki, H. Α., & Pontikoglou, C. G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221810132 · Cited by 27
Romanelli, P., Bieler, L., Heimel, P., Škokić, S., Jakubecova, D., Kreutzer, C., Zaunmair, P., Smolčić, T., Benedetti, B., Rohde, E., et al. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.795008 · Cited by 28
Xu, K., Zhao, X., He, Y., Guo, H., & Zhang, Y. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1481617 · Cited by 26
Silva, K. D., Kumar, P., & Choonara, Y. E. (2025) · Wound Repair and Regeneration · doi:10.1111/wrr.13251 · Cited by 31
Yuan, S.-M., Yang, X., Zhang, S., Tian, W., & Yang, B. (2022) · World Journal of Stem Cells · doi:10.4252/wjsc.v14.i7.435 · Cited by 26
Liu, S., Li, L., Zhuang, J.-L., Li, M.-M., Ye, L., Chen, X., Lin, S., & Chen, C. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.950715 · Cited by 28
Kuca‐Warnawin, E., Janicka, I., Szczesny, P. J., Olesińska, M., Bonek, K., Głuszko, P., & Kontny, E. (2020) · Cell Transplantation · doi:10.1177/0963689720945682 · Cited by 25
Chronic wounds: pathological characteristics and their stem cell-based therapies
Wu, X., Zhu, H., Xu, Y., Kong, B., & Tan, Q. (2022) · Engineered Regeneration · doi:10.1016/j.engreg.2022.11.004 · Cited by 25
Ting, H.-K., Chen, C.-L., Meng, E., Cherng, J., Chang, S., Kao, C., Yang, M.-H., Leung, F.-S., & Wu, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22083987 · Cited by 24
Kulakov, A. A., Kogan, E. A., Brailovskaya, T., Vedyaeva, A., Zharkov, N. V., Krasilnikova, O., Крашенинников, М. Е., Baranovskii, D., Rasulov, T., & Klabukov, I. (2021) · Dentistry Journal · doi:10.3390/dj9090101 · Cited by 24
Qu, W., Wang, Z., Engelberg-Cook, E., Yan, D., Siddik, A. B., Bu, G., Allickson, J. G., Kubrova, E., Caplan, A. I., Hare, J. M., et al. (2022) · Stem Cells Translational Medicine · doi:10.1093/stcltm/szac032 · Cited by 26
Stem cell-based ischemic stroke therapy: Novel modifications and clinical challenges
Sun, Y., Jiang, X., & Gao, J. (2023) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2023.100867 · Cited by 25
Li, J., Xing, J., Lu, F., Chang, W., Liang, N., Li, J., Wang, Y., Li, X., Zhao, X., Hou, R., et al. (2020) · Acta Dermato Venereologica · doi:10.2340/00015555-3480 · Cited by 24
Gu, G., Lv, X., Liu, G., Zeng, R., Li, S., Chen, L., Liang, Z., Wang, H., Lu, F., Zhan, L., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.734040 · Cited by 21
Kim, R. L., Bang, J., Kim, J., Mo, Y., Kim, Y., Lee, C. G., Elias, J. A., Kim, H. Y., & Kang, H. (2022) · Scientific Reports · doi:10.1038/s41598-022-14027-x · Cited by 24
Metadata
- Authors
- Zhou, Y., Yamamoto, Y., Xiao, Z., & Ochiya, T.
- Affiliations
- State Key Laboratory of Digital Medical Engineering (CN)
- National Cancer Center Research Institute (JP)
- Tokyo Medical University (JP)
- Corresponding author
- Ochiya, Takahiro
- Venue
- Journal of Clinical Medicine
- Publisher
- MDPI AG
- Published
- 2019-07-12
- Volume
- 8
- Issue
- 7
- Pages
- 1025
- ISSN
- 2077-0383 (ISSN-L)
- PMC
- PMC6678920
- OpenAlex
- W2958669483
- Cited by
- 303
- References
- 133
- Citations by year
- 2026: 24 · 2025: 34 · 2024: 41 · 2023: 39 · 2022: 60 · 2021: 59 · 2020: 39 · 2019: 7
- FWCI
- 5.06
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Clinical Medicine (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Project for Cancer Research and Therapeutic Evolution (17cm0106402h0002)
- MEXT KAKENHI (Grant-in-Aid for Young Scientists (A)) (17H04991)
- China Scholarship Council (201706090122)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Keywords
- mesenchymal stem cells, immunomodulation, paracrine signaling, secretome, extracellular vesicles, cytokines, chemokines, immune microenvironment, regenerative medicine, immune disorders
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
