The Immunomodulatory Functions of Mesenchymal Stromal/Stem Cells Mediated via Paracrine Activity

Multilineage potential of adult human mesenchymal stem cells

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Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

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Bone marrow cells regenerate infarcted myocardium

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Sox9 Modulates Proliferation and Expression of Osteogenic Markers of Adipose-Derived Stem Cells (ASC)

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Human mesenchymal stem cells modulate allogeneic immune cell responses

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Comparative Analysis of Mesenchymal Stem Cells from Bone Marrow, Umbilical Cord Blood, or Adipose Tissue

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Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli

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Neutrophils in the activation and regulation of innate and adaptive immunity

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Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells

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THE DEVELOPMENT OF FIBROBLAST COLONIES IN MONOLAYER CULTURES OF GUINEA‐PIG BONE MARROW AND SPLEEN CELLS

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Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study

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Graft-versus-host disease

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Mesenchymal stem cells reside in virtually all post-natal organs and tissues

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Bone marrow stromal cells attenuate sepsis via prostaglandin E2–dependent reprogramming of host macrophages to increase their interleukin-10 production

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Transplantation of Progenitor Cells and Regeneration Enhancement in Acute Myocardial Infarction (TOPCARE-AMI)

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Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts

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Clarification of the nomenclature for MSC: The International Society for Cellular Therapy position statement

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Repair of Infarcted Myocardium by Autologous Intracoronary Mononuclear Bone Marrow Cell Transplantation in Humans

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Intravenous hMSCs Improve Myocardial Infarction in Mice because Cells Embolized in Lung Are Activated to Secrete the Anti-inflammatory Protein TSG-6

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Human mesenchymal stem cells modulate B-cell functions

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Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells

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Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains

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Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase–mediated tryptophan degradation

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Mitochondrial transfer from bone-marrow–derived stromal cells to pulmonary alveoli protects against acute lung injury

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Mesenchymal stem cells: environmentally responsive therapeutics for regenerative medicine

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Administered mesenchymal stem cells protect against ischemic acute renal failure through differentiation-independent mechanisms.

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Evidence supporting paracrine hypothesis for Akt‐modified mesenchymal stem cell‐mediated cardiac protection and functional improvement

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Antigen-Presenting Function of the Macrophage

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Mesenchymal Stem Cells for Treatment of Therapy-Resistant Graft-versus-Host Disease

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Mesenchymal stem cells inhibit natural killer–cell proliferation, cytotoxicity, and cytokine production: role of indoleamine 2,3-dioxygenase and prostaglandin E2

Spaggiari, G. M., Capobianco, A., Abdelrazik, H., Becchetti, F., Mingari, M. C., & Moretta, L. (2007) · Blood · doi:10.1182/blood-2007-02-074997 · Cited by 1,139

Human Leukocyte Antigen-G5 Secretion by Human Mesenchymal Stem Cells Is Required to Suppress T Lymphocyte and Natural Killer Function and to Induce CD4+CD25highFOXP3+ Regulatory T Cells

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Mesenchymal stem cell-natural killer cell interactions: evidence that activated NK cells are capable of killing MSCs, whereas MSCs can inhibit IL-2-induced NK-cell proliferation

Spaggiari, G. M., Capobianco, A., Becchetti, S., Mingari, M. C., & Moretta, L. (2005) · Blood · doi:10.1182/blood-2005-07-2775 · Cited by 1,057

Interactions Between Human Mesenchymal Stem Cells and Natural Killer Cells

Sotiropoulou, P. A., Perez, S. A., Gritzapis, A. D., Baxevanis, C. N., & Papamichail, M. (2006) · Stem Cells · doi:10.1634/stemcells.2004-0359 · Cited by 956

Paracrine Mechanisms of Mesenchymal Stem Cell-Based Therapy: Current Status and Perspectives

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Microvesicles derived from human adult mesenchymal stem cells protect against ischaemia-reperfusion-induced acute and chronic kidney injury

Gatti, S., Bruno, S., Deregibus, M. C., Sordi, A., Cantaluppi, V., Tetta, C., & Camussi, G. (2011) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfr015 · Cited by 825

Mesenchymal Stromal Cells Modulate Macrophages in Clinically Relevant Lung Injury Models by Extracellular Vesicle Mitochondrial Transfer

Morrison, T. J., Jackson, M. V., Cunningham, E. K., Kissenpfennig, A., McAuley, D. F., O’Kane, C. M., & Krasnodembskaya, A. D. (2017) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201701-0170oc · Cited by 796

Mesenchymal Stem Cells Inhibit Generation and Function of Both CD34+-Derived and Monocyte-Derived Dendritic Cells

Nauta, A. J., Kruisselbrink, A. B., Lurvink, E. G. A., Willemze, R., & Fibbe, W. E. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.4.2080 · Cited by 741

Mesenchymal Stem Cells Secrete Immunologically Active Exosomes

Zhang, B., Yin, Y., Lai, R. C., Tan, S. S., Choo, A. B. H., & Lim, S. K. (2013) · Stem Cells and Development · doi:10.1089/scd.2013.0479 · Cited by 710

Mesenchymal Stem Cells Inhibit the Differentiation of Dendritic Cells Through an Interleukin-6-Dependent Mechanism

Djouad, F., Charbonnier, L., Bouffi, C., Louis‐Plence, P., Bony, C., Apparailly, F., Cantos, C., Jørgensen, C., & Noël, D. (2007) · Stem Cells · doi:10.1634/stemcells.2006-0548 · Cited by 683

Cell contact, prostaglandin E2 and transforming growth factor beta 1 play non-redundant roles in human mesenchymal stem cell induction of CD4+CD25Highforkhead box P3+ regulatory T cells

English, K., Ryan, J. M., Tobin, L., Murphy, M. J., Barry, F., & Mahon, B. P. (2009) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2009.03874.x · Cited by 674

Mesenchymal Stromal Cell Exosomes Ameliorate Experimental Bronchopulmonary Dysplasia and Restore Lung Function through Macrophage Immunomodulation

Willis, G. R., Fernandez‐Gonzalez, A., Anastas, J. N., Vitali, S. H., Liu, X., Ericsson, M., Kwong, A., Mitsialis, S. A., & Kourembanas, S. (2017) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201705-0925oc · Cited by 641

Interferon-γ does not break, but promotes the immunosuppressive capacity of adult human mesenchymal stem cells

Ryan, J. M., Barry, F., Murphy, M. J., & Mahon, B. P. (2007) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2007.03422.x · Cited by 617

Autologous mesenchymal stem cells for the treatment of secondary progressive multiple sclerosis: an open-label phase 2a proof-of-concept study

Connick, P., Kolappan, M., Crawley, C. R., Webber, D. J., Patani, R., Michell, A. W., Du, M., Luan, S., Altmann, D. R., Thompson, A. J., et al. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(11)70305-2 · Cited by 611

Mesenchymal Stem Cell-Derived Extracellular Vesicles as Mediators of Anti-Inflammatory Effects: Endorsement of Macrophage Polarization

Sicco, C. L., Reverberi, D., Balbi, C., Ulivi, V., Principi, E., Pascucci, L., Becherini, P., Bosco, M. C., Varesio, L., Franzin, C., et al. (2017) · Stem Cells Translational Medicine · doi:10.1002/sctm.16-0363 · Cited by 579

Autologous bone marrow-derived mesenchymal stromal cells in the treatment of fistulising Crohn's disease

Ciccocioppo, R., Bernardo, M. E., Sgarella, A., Maccario, R., Avanzini, M. A., Ubezio, C., Minelli, A., Alvisi, C., Vanoli, A., Calliada, F., et al. (2011) · Gut · doi:10.1136/gut.2010.214841 · Cited by 557

Mesenchymal stem cells in human second-trimester bone marrow, liver, lung, and spleen exhibit a similar immunophenotype but a heterogeneous multilineage differentiation potential.

Anker, P. S. I. `., Noort, W. A., Scherjon, S. A., der Keur, C. K., Kruisselbrink, A. B., van Bezooijen, R. L., Beekhuizen, W., Willemze, R., Kanhai, H. H. H., & Fibbe, W. E. (2003) · PubMed · Cited by 520

Human Mesenchymal Stem Cells Inhibit Neutrophil Apoptosis: A Model for Neutrophil Preservation in the Bone Marrow Niche

Raffaghello, L., Bianchi, G., Bertolotto, M. B., Montecucco, F., Busca, A., Dallegri, F., Ottonello, L. C., & Pistoia, V. (2007) · Stem Cells · doi:10.1634/stemcells.2007-0416 · Cited by 518

Mesenchymal‐stem‐cell‐derived exosomes accelerate skeletal muscle regeneration

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Effects of Mesenchymal Stem Cells on Differentiation, Maturation, and Function of Human Monocyte-Derived Dendritic Cells

Zhang, W., Ge, W., Li, C., You, S., Liao, L., Han, Q., Deng, W., & Zhao, R. C. H. (2004) · Stem Cells and Development · doi:10.1089/154732804323099190 · Cited by 492

Toll-Like Receptors 3 and 4 Are Expressed by Human Bone Marrow-Derived Mesenchymal Stem Cells and Can Inhibit Their T-Cell Modulatory Activity by Impairing Notch Signaling

Liotta, F., Angeli, R., Cosmi, L., Filì, L., Manuelli, C., Frosali, F., Mazzinghi, B., Maggi, L., Pasini, A., Lisi, V., et al. (2007) · Stem Cells · doi:10.1634/stemcells.2007-0454 · Cited by 492

Toll-like receptors and their ligands control mesenchymal stem cell functions

Pevsner‐Fischer, M., Morad, V., Cohen-Sfady, M., Rousso-Noori, L., Zanin‐Zhorov, A., Cohen, S. J., Cohen, I. R., & Zipori, D. (2006) · Blood · doi:10.1182/blood-2006-06-028704 · Cited by 484

Emerging insights into natural killer cells in human peripheral tissues

Björkström, N. K., Ljunggren, H., & Michaëlsson, J. (2016) · Nature reviews. Immunology · doi:10.1038/nri.2016.34 · Cited by 466

The therapeutic potential of mesenchymal stem cell‐derived extracellular vesicles

Katsuda, T., Kosaka, N., Takeshita, F., & Ochiya, T. (2013) · PROTEOMICS · doi:10.1002/pmic.201200373 · Cited by 432

Mesenchymal stem cell effects on T-cell effector pathways

Duffy, M. M., Ritter, T., Ceredig, R. H., & Griffin, M. D. (2011) · Stem Cell Research & Therapy · doi:10.1186/scrt75 · Cited by 430

Therapeutic potential of mesenchymal stem cell-derived microvesicles

Biancone, L., Bruno, S., Deregibus, M. C., Tetta, C., & Camussi, G. (2012) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfs168 · Cited by 401

Immunoregulation by Mesenchymal Stem Cells: Biological Aspects and Clinical Applications

Castro-Manrreza, M. E., & Montesinos, J. J. (2015) · Journal of Immunology Research · doi:10.1155/2015/394917 · Cited by 400

Mesenchymal Stromal Cells Ameliorate Experimental Autoimmune Encephalomyelitis by Inhibiting CD4 Th17 T Cells in a CC Chemokine Ligand 2-Dependent Manner

Rafei, M., Campeau, P. M., Aguilar‐Mahecha, A., Buchanan, M., Williams, P., Birman, E., Yuan, S., Young, Y. K., Boivin, M., Forner, K., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803962 · Cited by 384

CCR2-Dependent Recruitment of Macrophages by Tumor-Educated Mesenchymal Stromal Cells Promotes Tumor Development and Is Mimicked by TNFα

Ren, G., Zhao, X., Wang, Y., Zhang, X., Chen, X., Xu, C., Yuan, Z.-R., Roberts, A. I., Zhang, L., Zheng, H. B., et al. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.08.013 · Cited by 370

Human Placental Mesenchymal Stem Cells (pMSCs) Play a Role as Immune Suppressive Cells by Shifting Macrophage Differentiation from Inflammatory M1 to Anti-inflammatory M2 Macrophages

Abumaree, M., Jumah, M. A., Kalionis, B., Jawdat, D. M., Al-Khaldi, A., Abomaray, F., Fatani, A., Chamley, L., & Knawy, B. A. (2013) · Stem Cell Reviews and Reports · doi:10.1007/s12015-013-9455-2 · Cited by 368

Bone marrow mesenchymal stem cell transplantation in patients with multiple sclerosis: A pilot study

Yamout, B., Hourani, R. G., Salti, H. I., Barada, W., El-Hajj, T., Al-Kutoubi, A. O., Herlopian, A., Baz, E. M. K., Mahfouz, R. A., Hamdan-Khalil, R., et al. (2010) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2010.07.013 · Cited by 356

Protein synthesis and secretion in human mesenchymal cells derived from bone marrow, adipose tissue and Wharton’s jelly

Amable, P. R., Teixeira, M. V. T., Carias, R. B. V., Granjeiro, J. M., & Borojević, R. (2014) · Stem Cell Research & Therapy · doi:10.1186/scrt442 · Cited by 346

A Phase 2 Study of Allogeneic Mesenchymal Stromal Cells for Luminal Crohn's Disease Refractory to Biologic Therapy

Forbes, G. M., Sturm, M., Leong, R. W. L., Sparrow, M., Segarajasingam, D. S., Cummins, A. G., Phillips, M. R., & Herrmann, R. (2013) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2013.06.021 · Cited by 333

The therapeutic applications of multipotential mesenchymal/stromal stem cells in skeletal tissue repair

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Preserved β-Cell Function in Type 1 Diabetes by Mesenchymal Stromal Cells

Carlsson, P., Schwarcz, E., Korsgren, O., & Blanc, K. L. (2014) · Diabetes · doi:10.2337/db14-0656 · Cited by 325

Efficacy and Safety of Ex Vivo Cultured Adult Human Mesenchymal Stem Cells (Prochymal™) in Pediatric Patients with Severe Refractory Acute Graft-Versus-Host Disease in a Compassionate Use Study

Prasad, V. K., Lucas, K. G., Kleiner, G., Talano, J., Jacobsohn, D. A., Broadwater, G., Monroy, R. L., & Kurtzberg, J. (2010) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2010.04.014 · Cited by 316

Primary T Cell Expansion and Differentiation In Vivo Requires Antigen Presentation by B Cells

Crawford, A., MacLeod, M. K. L., Schumacher, T. N., Corlett, L., & Gray, D. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.6.3498 · Cited by 311

Treatment of refractory acute GVHD with third-party MSC expanded in platelet lysate-containing medium

Bonin, M. V., Stölzel, F., Goedecke, A., Richter, K., Wuschek, N., Hölig, K., Platzbecker, U., Illmer, T., Schaich, M. A., Schetelig, J., et al. (2008) · Bone Marrow Transplantation · doi:10.1038/bmt.2008.316 · Cited by 306

MiRNA-Sequence Indicates That Mesenchymal Stem Cells and Exosomes Have Similar Mechanism to Enhance Cardiac Repair

Shao, L., Zhang, Y., Lan, B.-B., Wang, J., Zhang, Z., Zhang, L., Xiao, P., Meng, Q., Geng, Y., Yu, X.-Y., et al. (2017) · BioMed Research International · doi:10.1155/2017/4150705 · Cited by 305

Cytokines produced by bone marrow cells can contribute to functional improvement of the infarcted heart by protecting cardiomyocytes from ischemic injury

Takahashi, M., Li, T., Suzuki, R., Kobayashi, T., Ito, H., Ikeda, Y., Matsuzaki, M., & Hamano, K. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00142.2006 · Cited by 293

Role of Toll‐Like Receptors on Human Adipose‐Derived Stromal Cells

Cho, H. H., Bae, Y. C., & Jung, J. S. (2006) · Stem Cells · doi:10.1634/stemcells.2006-0189 · Cited by 287

Mesenchymal Stromal Cell-Derived Extracellular Vesicles Attenuate Dendritic Cell Maturation and Function

Reis, M., Mavin, E., Nicholson, L., Green, K., Dickinson, A. M., & Wang, X.-N. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02538 · Cited by 286

Bone Marrow Stromal Cells: Characterization and Clinical Application

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Mesenchymal stem cell therapy in the treatment of osteoarthritis: reparative pathways, safety and efficacy – a review

Freitag, J., Bates, D., Boyd, R. L., Shah, K., Barnard, A., Huguenin, L., & Tenen, A. (2016) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-016-1085-9 · Cited by 283

The effect of mesenchymal stem cells on the viability, proliferation and differentiation of B-lymphocytes

Tabera, S., Perez-Simon, J. A., Diez-Campelo, M., Sanchez-Abarca, L. I., Blanco, B., Lopez, A., Benito, A., Ocio, E., Sanchez-Guijo, F. M., Canizo, C., et al. (2008) · Haematologica · doi:10.3324/haematol.12857 · Cited by 283

Murine mesenchymal stem cells suppress dendritic cell migration, maturation and antigen presentation

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Immunoregulatory Effects of Mesenchymal Stem Cell-Derived Extracellular Vesicles on T Lymphocytes

Fattore, A. D., Luciano, R., Pascucci, L., Goffredo, B. M., Giorda, E., Scapaticci, M., Fierabracci, A., & Muraca, M. (2015) · Cell Transplantation · doi:10.3727/096368915x687543 · Cited by 270

Mesenchymal stem cells impair in vivo T-cell priming by dendritic cells

Chiesa, S., Morbelli, S. D., Morando, S., Massollo, M., Marini, C., Bertoni, A., Frassoni, F., Tabera, S., Sambuceti, G., Traggiai, E., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1103650108 · Cited by 269

Allogeneic Human Mesenchymal Stem Cell Therapy (Remestemcel-L, Prochymal) as a Rescue Agent for Severe Refractory Acute Graft-versus-Host Disease in Pediatric Patients

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TNFα-activated mesenchymal stromal cells promote breast cancer metastasis by recruiting CXCR2+ neutrophils

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Transplantation of mesenchymal stem cells recruits trophic macrophages to induce pancreatic beta cell regeneration in diabetic mice

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