Cited by 357Antifungal resistance and susceptibilityReproductive tract infections researchYeasts and Rust Fungi Studies

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Vulvovaginal Candidiasis: A Current Understanding and Burning Questions

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Willems, Hubertine M. E., Ahmed, Salman S., Liu, Junyan, Xu, Zhenbo, Peters, Brian M.·2020·Journal of Fungi

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Abstract

Candida albicans, along with other closely related Candida species, are the primary causative agents of vulvovaginal candidiasis (VVC)—a multifactorial infectious disease of the lower female reproductive tract resulting in pathologic inflammation. Unlike other forms of candidiasis, VVC is a disease of immunocompetent and otherwise healthy women, most predominant during their child-bearing years. While VVC is non-lethal, its high global incidence and profound negative impact on quality-of-life necessitates further understanding of the host and fungal factors that drive disease pathogenesis. In this review, we cover the current state of our understanding of the epidemiology, host response, fungal pathogenicity mechanisms, impact of the microbiome, and novel approaches to treatment of this most prevalent human candidal infection. We also offer insight into the latest advancements in the VVC field and identify important questions that still remain.

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Authors: Willems, H. M. E., Ahmed, S. S., Liu, J., Xu, Z., & Peters, B. M.
Affiliations: University of Tennessee Health Science Center (US)
South China University of Technology (CN)
Corresponding author: Peters, Brian M.
ORCID: Willems, Hubertine M. E.
Ahmed, Salman S.
Liu, Junyan
Xu, Zhenbo
Peters, Brian M.
Venue: Journal of Fungi
Publisher: MDPI AG
Published: 2020-02-25
Volume: 6
Issue: 1
Pages: 27
ISSN: 2309-608X (ISSN-L)
DOI: 10.3390/jof6010027
PMC: PMC7151053
OpenAlex: W3007795453
Cited by: 357
References: 148
Citations by year: 2026: 48 · 2025: 61 · 2024: 56 · 2023: 64 · 2022: 65 · 2021: 41 · 2020: 20
FWCI: 2.24
Type: journal article
Language: en
Open access: gold
dx.doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Journal of Fungi (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Institute of Allergy and Infectious Diseases (AI134796, AI141829)
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
Life Sciences › Immunology and Microbiology › Microbiology › Yeasts and Rust Fungi Studies
Keywords: vaginal candidiasis, Candida species, host immune response, vaginal microbiota, antifungal therapy, quality of life

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Vulvovaginal Candidiasis: A Current Understanding and Burning Questions

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