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Cited by 38Antifungal resistance and susceptibilityYeasts and Rust Fungi StudiesFungal Infections and Studies

Candida auris in Dog Ears

Open access
Yadav, Anamika, Wang, Yue, Jain, Kusum, Panwar, Vijay Amrit Raj, Kaur, Hardeep, Kasana, Vikas, Xu, Jianping, Chowdhary, Anuradha·2023·Journal of Fungi
DOI 10.3390/jof9070720PMC PMC10381908
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Abstract

Candida auris is an emerging global public health threat and is resistant to most antifungal agents. Though fungi are significant pathogens for animals, the role of C. auris in animal health remains unexplored. Here, we analysed the microbial cultures of skin and ear swabs of 87 dogs in Delhi and performed fungal meta-barcode sequencing of ear and skin samples of 7 dogs with confirmed otitis externa (OE). Overall, 4.5% of dogs (4/87) with chronic skin infections contained evidence of C. auris in their ear canal (n = 3) and on their skin surface (n = 1). Of the three OE dogs with C. auris infection/colonisation, a diversity of fungi was observed, and their meta-barcode ITS sequence reads for C. auris ranged from 0.06% to 0.67%. Whole-genome sequencing of six C. auris strains obtained in culture from two dogs showed relatedness with Clade I clinical strains. The report highlights the isolation of C. auris from an animal source; however, the routes of transmission of this yeast to dogs and the clinical significance of transmission between dogs and humans remain to be investigated.

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  • C. auris-positive dog ears exhibited reduced abundance of Malassezia species.

    “Similarly, C. auris-positive dog ears exhibited reduced abundance of Malassezia species [70].”

    From Host–Candida auris interactions in the skin (2026) · cites this paper as [70]

    The Results (page unavailable) report a seeming negative correlation between C. auris and Malassezia ITS-read abundance among three C. auris-positive dogs. That supports a possible association, but the paper does not establish that C. auris-positive dog ears generally had reduced Malassezia abundance compared with negative ears; it also reports wide variation among C. auris-negative dogs. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

  • Skin microbial communities can restrict bacterial pathogens through metabolic competition and immune modulation.

    “Since skin microbial communities can restrict bacterial pathogens through metabolic competition and immune modulation [69–72]”

    From Host–Candida auris interactions in the skin (2026) · cites this paper as [70]

    The Results report microbial colonisation of dogs’ skin and ears, but do not show that those communities restrict bacterial pathogens. Searches for metabolic competition and immune modulation found no passage addressing either proposed mechanism. (LLM, conf=0.75)

    Experimental — accuracy not yet measured

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Research works printed but not linked: 21

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Authors
Yadav, A., Wang, Y., Jain, K., Panwar, V. A. R., Kaur, H., Kasana, V., Xu, J., & Chowdhary, A.
Affiliations
  • University of Delhi (IN)
  • McMaster University (CA)
  • In-Patient Department, Sanjay Gandhi Animal Care Centre, New Delhi 110027, India
Corresponding author
Chowdhary, Anuradha
ORCID
Venue
Journal of Fungi
Publisher
MDPI AG
Published
2023-06-30
Volume
9
Issue
7
Pages
720
ISSN
2309-608X (ISSN-L)
DOI
10.3390/jof9070720
PMC
PMC10381908
OpenAlex
W4382983069
Cited by
38
References
4
Citations by year
2026: 11 · 2025: 10 · 2024: 14 · 2023: 3
FWCI
7.87
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Fungi (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Canadian Institute for Advanced Research
  • McMaster University
  • University Grants Commission (16-9/2019)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
  • Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
Keywords
Candida auris, dogs, otitis externa, canine fungal infection, antifungal resistance, fungal diversity, ITS sequencing, whole genome sequencing, clade 1, zoonotic transmission, skin infections, emerging fungal pathogens

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