Confirmation of fifth Candida auris clade by whole genome sequencing
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Candida auris has emerged globally as a multidrug-resistant pathogen causing outbreaks in health care facilities. Whole genome sequencing (WGS) analysis has identified four major clades, while earlier WGS data from a single Iranian isolate suggested the existence of a potential fifth clade. Here, we confirm the existence of this fifth clade by providing WGS data of another four Iranian isolates. These clade V isolates differed less than 100 single-nucleotide polymorphisms (SNPs) between each other, while they were separated from the other clades by more than 200,000 SNPs. Two of these isolates were resistant to fluconazole and were found to harbour mutations in the TAC1b and ERG11 genes.
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C. auris isolates have been implicated in nosocomial outbreaks worldwide, with 5 distinct clades classified by region of independent emergence.
“C. auris isolates have been implicated in nosocomial outbreaks worldwide, with 5 distinct clades classified by region of independent emergence.”
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Genetic Diversity of Human Fungal Pathogens
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Finding Candida auris in public metagenomic repositories
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Fast and Accurate Identification of Candida auris by High Resolution Mass Spectrometry
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Clorgyline Analogs Synergize with Azoles against Drug Efflux in Candida auris
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Differential susceptibility of Candida (Candidozyma) auris clades to surface disinfectants
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Development of a Recombinase-Aided Amplification Assay for the Rapid Detection of Candida auris
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Should all hospitalised patients colonised with Candida auris be considered for isolation?
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Clonal outbreak of Candida vulturna in a paediatric oncology ward in Maranhão, Brazil
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Vertebrate and invertebrate animal infection models of Candida auris pathogenicity
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Self-citationShort-term evolution and dispersal patterns of fluconazole-resistance in Candida auris clade III
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Updated Genomic Epidemiologic Description of Candida (Candidozyma) auris , United States
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An Autochthonous Susceptible Candida auris Clade I Otomycosis Case in Iran
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The Importance of Candida auris in Skin
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A clinical and molecular analysis of Candidozyma auris strains from Romania, 2022–2023
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Spruijtenburg, B., Meis, J., van Rhijn, N., Čurdová, M., Kašperová, E., Vašek, P., Bartoníčková, L., Kubele, J., Olišarová, P., Svobodová, K., et al. (2025) · Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · doi:10.2807/1560-7917.es.2025.30.45.2500285 · Cited by 5 · see citing works
Self-citationA study of genomic complexity underlying multidrug resistance in Candida auris strains in Thailand
Opassathian, K., Boonmee, N., Swangkaew, S., Jenjaroenpun, P., Wongsurawat, T., Kruasuwan, W., Ngamskulrungroj, P., & Mitrpant, C. (2025) · Scientific Reports · doi:10.1038/s41598-025-25386-6 · Cited by 6 · see citing works
Clonal Dissemination of Candida auris Clinical Isolates in Northern Italy, 2021
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Global characteristics and trends in research on Candida auris
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Microbiological Characteristics and Drug Resistance Rates of Candida auris Isolates in Japan
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Self-citationFirst report of Candidozyma auris (Candida auris) in a cat: A case of persistent shedding
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- Authors
- Spruijtenburg, B., Badali, H., Abastabar, M., Mirhendi, H., Khodavaisy, S., Sharifisooraki, J., Taghizadeh Armaki, M., de Groot, T., & Meis, J. F.
- Affiliations
- Radboud University Medical Center (NL)
- The University of Texas at San Antonio (US)
- Mazandaran University of Medical Sciences (IR)
- Isfahan University of Medical Sciences (IR)
- Tehran University of Medical Sciences (IR)
- Islamic Azad University, Tehran (IR)
- Babol University of Medical Sciences
- Canisius Wilhelmina Hospital
- Corresponding author
- Meis, Jacques F.
- ORCID
- Venue
- Emerging Microbes & Infections
- Publisher
- Informa UK Limited
- Published
- 2022-10-18
- Volume
- 11
- Issue
- 1
- Pages
- 2405-2411
- ISSN
- 2222-1751 (ISSN-L)
- PMC
- PMC9586689
- OpenAlex
- W4297229549
- Cited by
- 164
- References
- 44
- Citations by year
- 2026: 37 · 2025: 30 · 2024: 57 · 2023: 39 · 2022: 1
- FWCI
- 15.49
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Emerging Microbes & Infections (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Radboud Repository (Radboud University) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion, other-oa)
- Funders
- Canisius Wilhelmina Hospital
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Keywords
- Candida auris, fungal clades, multidrug resistance, fluconazole resistance, ERG11 mutations, single nucleotide polymorphisms, Iranian isolates, whole genome sequencing
- MeSH terms
- Whole Genome Sequencing, Candida auris, Antifungal Agents, Candida, Candidiasis, Humans, Iran, Microbial Sensitivity Tests, Fluconazole, Polymorphism, Single Nucleotide
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