The DOI matches its Crossref record; 96 of the 96 references it cites were found in a registry or an index.
Cutaneous Wound Healing: An Update from Physiopathology to Current Therapies
Open accessAbstract
The skin is the biggest organ of human body which acts as a protective barrier against deleterious agents. When this barrier is damaged, the organism promotes the healing process with several molecular and cellular mechanisms, in order to restore the physiological structure of the skin. The physiological control of wound healing depends on the correct balance among its different mechanisms. Any disruption in the balance of these mechanisms can lead to problems and delay in wound healing. The impairment of wound healing is linked to underlying factors as well as aging, nutrition, hypoxia, stress, infections, drugs, genetics, and chronic diseases. Over the years, numerous studies have been conducted to discover the correct approach and best therapies for wound healing, including surgical procedures and non-surgical treatments such as topical formulations, dressings, or skin substitutes. Thus, this general approach is necessary to facilitate the direction of further studies. This work provides updated concepts of physiological mechanisms, the factors that can interfere, and updated treatments used in skin wound healing.
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Cites
Singer, A. J., & Clark, R. A. F. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909023411006 · Cited by 6,106
Factors affecting wound healing
Guo, S., & DiPietro, L. A. (2010) · Journal of Dental Research · doi:10.1177/0022034509359125 · Cited by 5,792
Wound repair and regeneration: Mechanisms, signaling, and translation
Eming, S. A., Martin, P., & Tomic-Canic, M. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3009337 · Cited by 3,562
Wound Healing Dressings and Drug Delivery Systems: A Review
Boateng, J. S., Matthews, K. H., Stevens, H. N. E., & Eccleston, G. M. (2008) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.21210 · Cited by 3,049
Wound Healing: A Cellular Perspective
Rodrigues, M., Kosaric, N., Bonham, C. A., & Gurtner, G. C. (2019) · Physiological Reviews · doi:10.1152/physrev.00067.2017 · Cited by 3,013
Inflammation in Wound Repair: Molecular and Cellular Mechanisms
Eming, S. A., Krieg, T., & Davidson, J. M. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700701 · Cited by 2,429
The skin: an indispensable barrier
Proksch, E., Brandner, J. M., & Jensen, J. (2008) · Experimental Dermatology · doi:10.1111/j.1600-0625.2008.00786.x · Cited by 2,054
Reinke, J. M., & Sorg, H. (2012) · European Surgical Research · doi:10.1159/000339613 · Cited by 1,898
Epithelialization in Wound Healing: A Comprehensive Review
Pastar, I., Stojadinovic, O., Yin, N. C., Ramirez, H., Nusbaum, A. G., Sawaya, A., Patel, S. B., Khalid, L., Isseroff, R. R., & Tomic-Canic, M. (2014) · Advances in Wound Care · doi:10.1089/wound.2013.0473 · Cited by 1,531
Skin Wound Healing Process and New Emerging Technologies for Skin Wound Care and Regeneration
Tottoli, E. M., Dorati, R., Genta, I., Chiesa, E., Pisani, S., & Conti, B. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12080735 · Cited by 1,340
Cited by
Falanga, V., Isseroff, R. R., Soulika, A. M., Romanelli, M., Margolis, D., Kapp, S., Granick, M., & Harding, K. (2022) · Nature Reviews Disease Primers · doi:10.1038/s41572-022-00377-3 · Cited by 1,020
Machado, P., Ribeiro, F. N., Giublin, F. C. W., Mieres, N. G., Tonin, F. S., Pontarolo, R., Sari, M. H. M., Lazo, R. E. L., & Ferreira, L. M. (2025) · Pharmaceuticals · doi:10.3390/ph18050704 · Cited by 44
Kim, T., Heo, S., Han, J. S., & Jung, W. (2023) · Cell Biochemistry and Function · doi:10.1002/cbf.3840 · Cited by 21
Master Student, F. O. V. M., Rukyat, H., Paramanandi, D. A., Master Student, F. O. V. M., Widyarini, S., Departement of Pathology, F. O. V. M., Kristianingrum, Y. P., & Departement of Pathology, F. O. V. M. (2025) · World's Veterinary Journal · doi:10.54203/scil.2025.wvj12 · Cited by 1
Metadata
- Authors
- Gushiken, L. F. S., Beserra, F. P., Bastos, J. K., Jackson, C. J., & Pellizzon, C. H.
- Venue
- Life
- Publisher
- MDPI AG
- Published
- 2021-07-07
- Volume
- 11
- Issue
- 7
- Pages
- 665
- ISSN
- 2075-1729 (ISSN-L)
- OpenAlex
- W3178018615
- Cited by
- 292
- References
- 96
- FWCI
- 17.77
- Type
- journal article
- Language
- en
- Open access
- gold
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- Gushiken, L. F. S., Beserra, F. P., Bastos, J. K., Jackson, C. J., & Pellizzon, C. H. (2021). Cutaneous Wound Healing: An Update from Physiopathology to Current Therapies. Life. https://doi.org/10.3390/life11070665
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
