The DOI matches its Crossref record; 117 of the 117 references it cites were found in a registry or an index.
Cellulose-Based Hydrogels as Sustained Drug-Delivery Systems
Open accessAbstract
Hydrogels, three-dimensional (3D) polymer networks, present unique properties, like biocompatibility, biodegradability, tunable mechanical properties, sensitivity to various stimuli, the capacity to encapsulate different therapeutic agents, and the ability of controlled release of the drugs. All these characteristics make hydrogels important candidates for diverse biomedical applications, one of them being drug delivery. The recent achievements of hydrogels as safe transport systems, with desired therapeutic effects and with minimum side effects, brought outstanding improvements in this area. Moreover, results from the utilization of hydrogels as target therapy strategies obtained in clinical trials are very encouraging for future applications. In this regard, the review summarizes the general concepts related to the types of hydrogel delivery systems, their properties, the main release mechanisms, and the administration pathways at different levels (oral, dermal, ocular, nasal, gastrointestinal tract, vaginal, and cancer therapy). After a general presentation, the review is focused on recent advances in the design, preparation and applications of innovative cellulose-based hydrogels in controlled drug delivery.
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Cites
Designing hydrogels for controlled drug delivery
Li, J., & Mooney, D. J. (2016) · Nature Reviews Materials · doi:10.1038/natrevmats.2016.71 · Cited by 4,832
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Hydrogels in pharmaceutical formulations
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Hydrogels in drug delivery: Progress and challenges
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Biomedical applications of hydrogels: A review of patents and commercial products
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Controlled drug delivery vehicles for cancer treatment and their performance
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Hydrogels in controlled release formulations: Network design and mathematical modeling
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Polymers for Drug Delivery Systems
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The development of microgels/nanogels for drug delivery applications
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Thermosensitive sol-gel reversible hydrogels
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Cited by
Zöller, K., To, D., & Bernkop-Schnürch, A. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2024.122718 · Cited by 266
Metadata
- Authors
- Ciolacu, D. E., Nicu, R., & Ciolacu, F.
- Venue
- Materials
- Publisher
- MDPI AG
- Published
- 2020-11-21
- Volume
- 13
- Issue
- 22
- Pages
- 5270
- ISSN
- 1996-1944 (ISSN-L)
- OpenAlex
- W3106602699
- Cited by
- 257
- References
- 117
- FWCI
- 6.67
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
