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Cited by 64Silk-based biomaterials and applicationsBone Tissue Engineering MaterialsElectrospun Nanofibers in Biomedical Applications

A comprehensive review on silk fibroin as a persuasive biomaterial for bone tissue engineering

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Li, Minghui, You, Jiaqian, Qin, Qiuyue, Liu, Manxuan, Yang, Yixin, Jia, Kewen, Zhang, Yidi, Zhou, Yanmin·2023·International Journal of Molecular Sciences
DOI 10.3390/ijms24032660PMC PMC9917095
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Abstract

Bone tissue engineering (BTE) utilizes a special mix of scaffolds, cells, and bioactive factors to regulate the microenvironment of bone regeneration and form a three-dimensional bone simulation structure to regenerate bone tissue. Silk fibroin (SF) is perhaps the most encouraging material for BTE given its tunable mechanical properties, controllable biodegradability, and excellent biocompatibility. Numerous studies have confirmed the significance of SF for stimulating bone formation. In this review, we start by introducing the structure and characteristics of SF. After that, the immunological mechanism of SF for osteogenesis is summarized, and various forms of SF biomaterials and the latest development prospects of SF in BTE are emphatically introduced. Biomaterials based on SF have great potential in bone tissue engineering, and this review will serve as a resource for future design and research.

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Cited by

Sorted by citations

Authors
Li, M., You, J., Qin, Q., Liu, M., Yang, Y., Jia, K., Zhang, Y., & Zhou, Y.
Affiliations
Jilin University (CN)
Corresponding author
  • Zhang, Yidi
  • Zhou, Yanmin
ORCID
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2023-01-31
Volume
24
Issue
3
Pages
2660
ISSN
1422-0067 (ISSN-L)
DOI
10.3390/ijms24032660
PMC
PMC9917095
OpenAlex
W4318595800
Cited by
64
References
4
Citations by year
2026: 18 · 2025: 25 · 2024: 19 · 2023: 2
FWCI
1.13
Type
journal article
Language
en
Open access
Licence
Locations
  • International Journal of Molecular Sciences (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
National Natural Science Foundation of China (82071152)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Silk-based biomaterials and applications
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
  • Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
Keywords
silk fibroin, bone tissue engineering, bone regeneration, scaffolds, bone formation, immune mechanisms, biocompatibility, biodegradability, mechanical properties, biomaterials
MeSH terms
Biocompatible Materials, Bone and Bones, Fibroins, Osteogenesis, Tissue Engineering, Silk, Tissue Scaffolds

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