Biomimetic and osteogenic 3D silk fibroin composite scaffolds with nano MgO and mineralized hydroxyapatite for bone regeneration
Open accessAbstract
Artificial bioactive materials have received increasing attention worldwide in clinical orthopedics to repair bone defects that are caused by trauma, infections or tumors, especially dedicated to the multifunctional composite effect of materials. In this study, a weakly alkaline, biomimetic and osteogenic, three-dimensional composite scaffold (3DS) with hydroxyapatite (HAp) and nano magnesium oxide (MgO) embedded in fiber (F) of silkworm cocoon and silk fibroin (SF) is evaluated comprehensively for its bone repair potential in vivo and in vitro experiments, particularly focusing on the combined effect between HAp and MgO. Magnesium ions (Mg 2+ ) has long been proven to promote bone tissue regeneration, and HAp is provided with osteoconductive properties. Interestingly, the weak alkaline microenvironment from MgO may also be crucial to promote Sprague-Dawley (SD) rat bone mesenchymal stem cells (BMSCs) proliferation, osteogenic differentiation and alkaline phosphatase (ALP) activities. This SF/F/HAp/nano MgO (SFFHM) 3DS with superior biocompatibility and biodegradability has better mechanical properties, BMSCs proliferation ability, osteogenic activity and differentiation potential compared with the scaffolds adding HAp or MgO alone or neither. Similarly, corresponding meaningful results are also demonstrated in a model of distal lateral femoral defect in SD rat. Therefore, we provide a promising 3D composite scaffold for promoting bone regeneration applications in bone tissue engineering.
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A recent study showed that Mg2+ at an appropriate concentration stimulated hBMSC osteogenic proliferation and differentiation.
“a recent study showed that Mg2+ at an appropriate concentration stimulated hBMSC osteogenic proliferation and differentiation [52].”
From Exosome-functionalized magnesium-organic framework-based scaffolds with osteogenic, angiogenic and anti-inflammatory properties for accelerated bone regeneration. (2022) · cites this paper as [52]
The Discussion reports that scaffolds with an appropriate MgO content stimulated BMSC proliferation and osteogenic differentiation. But Materials and methods (Cell culture) identifies the cells as Sprague-Dawley rat BMSCs, not human BMSCs; the paper also attributes the effects to MgO-derived magnesium ions together with a weak alkaline microenvironment, rather than demonstrating an effect of Mg2+ alone. Page numbers were not available in our copy. (LLM, conf=0.90)
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Cites
Langer, R., & Vacanti, J. P. (1993) · Science · doi:10.1126/science.8493529 · Cited by 9,893 · see citing works
Porosity of 3D biomaterial scaffolds and osteogenesis
Karageorgiou, V., & Kaplan, D. L. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2005.02.002 · Cited by 6,639 · see citing works
Recent advances in bone tissue engineering scaffolds
Bose, S., Roy, M., & Bandyopadhyay, A. K. (2012) · Trends in biotechnology · doi:10.1016/j.tibtech.2012.07.005 · Cited by 2,217 · see citing works
Acidic extracellular microenvironment and cancer
Kato, Y., Ozawa, S., Miyamoto, C., Maehata, Y., Suzuki, A., Maeda, T., & Baba, Y. (2013) · Cancer Cell International · doi:10.1186/1475-2867-13-89 · Cited by 1,295 · see citing works
Zhang, Y., Xu, J., Ruan, Y. C., Yu, M. K., O'Laughlin, M., Wise, H., Chen, D., Tian, L., Shi, D., Wang, J., et al. (2016) · Nature Medicine · doi:10.1038/nm.4162 · Cited by 1,051 · see citing works
Zhao, D., Witte, F., Lu, F., Wang, J., Li, J., & Qin, L. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.10.017 · Cited by 951 · see citing works
de Grado, G. F., Keller, L., Idoux‐Gillet, Y., Wagner, Q., Musset, A., Benkirane-Jessel, N., Bornert, F., & Offner, D. (2018) · Journal of Tissue Engineering · doi:10.1177/2041731418776819 · Cited by 915 · see citing works
Porous 3-D Scaffolds from Regenerated Silk Fibroin
Nazarov, R., Jin, H., & Kaplan, D. L. (2004) · Biomacromolecules · doi:10.1021/bm034327e · Cited by 888 · see citing works
Bone tissue engineering: A review in bone biomimetics and drug delivery strategies
Porter, J. R., Ruckh, T. T., & Popat, K. C. (2009) · Biotechnology Progress · doi:10.1002/btpr.246 · Cited by 812 · see citing works
Poly(lactide-co-glycolide)/hydroxyapatite composite scaffolds for bone tissue engineering
Kim, S. S., Park, M. S., Jeon, O., Choi, C. Y., & Kim, B. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2005.08.016 · Cited by 766 · see citing works
Biodegradation of Silk Biomaterials
Cao, Y., & Wang, B. (2009) · International Journal of Molecular Sciences · doi:10.3390/ijms10041514 · Cited by 719 · see citing works
Bioactive Nanoengineered Hydrogels for Bone Tissue Engineering: A Growth-Factor-Free Approach
Xavier, J. R., Thakur, T., Desai, P. B., Jaiswal, M. K., Sears, N., Cosgriff‐Hernandez, E., Kaunas, R. R., & Gaharwar, A. K. (2015) · ACS Nano · doi:10.1021/nn507488s · Cited by 653 · see citing works
Yoshizawa, S., Brown, A., Barchowsky, A., & Sfeir, C. S. (2014) · Acta Biomaterialia · doi:10.1016/j.actbio.2014.02.002 · Cited by 578 · see citing works
Magnesium and Osteoporosis: Current State of Knowledge and Future Research Directions
Castiglioni, S., Cazzaniga, A., Albisetti, W., & Maier, J. A. M. (2013) · Nutrients · doi:10.3390/nu5083022 · Cited by 544 · see citing works
Matrix elasticity of void-forming hydrogels controls transplanted-stem-cell-mediated bone formation
Huebsch, N., Lippens, E., Lee, K., Mehta, M., Koshy, S. T., Darnell, M., Desai, R. M., Madl, C. M., Xu, M. M., Zhao, X., et al. (2015) · Nature Materials · doi:10.1038/nmat4407 · Cited by 525 · see citing works
Processing and biocompatibility evaluation of laser processed porous titanium
Xue, W., Krishna, B. V., Bandyopadhyay, A. K., & Bose, S. (2007) · Acta Biomaterialia · doi:10.1016/j.actbio.2007.05.009 · Cited by 471 · see citing works
Frohbergh, M. E., Katsman, A., Botta, G. P., Lazarovici, P., Schauer, C. L., Wegst, U. G. K., & Lelkes, P. I. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.09.009 · Cited by 412 · see citing works
High-strength silk protein scaffolds for bone repair
Mandal, B. B., Grinberg, A., Seok Gil, E., Panilaitis, B., & Kaplan, D. L. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1119474109 · Cited by 401 · see citing works
Ornamenting 3D printed scaffolds with cell-laid extracellular matrix for bone tissue regeneration
Pati, F., Song, T.-H., Rijal, G., Jang, J., Kim, S. W., & Cho, D. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.10.012 · Cited by 360 · see citing works
Bone tissue engineering via nanostructured calcium phosphate biomaterials and stem cells
Wang, P., Zhao, L., Liu, J., Weir, M. D., Zhou, X., & Xu, H. H. K. (2014) · Bone Research · doi:10.1038/boneres.2014.17 · Cited by 352 · see citing works
Hofmann, S., Hagenmüller, H., Koch, A., Müller, R., Vunjak‐Novakovic, G., Kaplan, D. L., Merkle, H. P., & Meinel, L. (2006) · Biomaterials · doi:10.1016/j.biomaterials.2006.10.019 · Cited by 349 · see citing works
Extracellular pH Regulates Bone Cell Function , ,
Arnett, T. R. (2008) · Journal of Nutrition · doi:10.1093/jn/138.2.415s · Cited by 349 · see citing works
Prucek, R., Tuček, J., Kilianová, M., Panáček, A., Kvı́tek, L., Filip, J., Kolář, M., Tomankova, K. B., & Zbořil, R. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.03.039 · Cited by 324 · see citing works
Ogose, A., Hotta, T., Kawashima, H., Kondo, N., Gu, W., Kamura, T., & Endo, N. (2004) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.30136 · Cited by 316 · see citing works
Yan, L., Oliveira, J. M., Oliveira, A. L., Caridade, S. G., Mano, J. F., & Reis, R. L. (2011) · Acta Biomaterialia · doi:10.1016/j.actbio.2011.09.037 · Cited by 294 · see citing works
Acidosis Inhibits Bone Formation by Osteoblasts In Vitro by Preventing Mineralization
Brandao‐Burch, A., Utting, J. C., Orriss, I. R., & Arnett, T. R. (2005) · Calcified Tissue International · doi:10.1007/s00223-004-0285-8 · Cited by 270 · see citing works
da Cunha, C. B., Klumpers, D. D., Li, A. W., Koshy, S. T., Weaver, J. C., Chaudhuri, O., Granja, P. L., & Mooney, D. J. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.06.047 · Cited by 269 · see citing works
Nucleation and growth of mineralized bone matrix on silk-hydroxyapatite composite scaffolds
Bhumiratana, S., Grayson, W. L., Castaneda, A., Rockwood, D. N., Gil, E. S., Kaplan, D. L., & Vunjak-Novakovic, G. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2010.12.058 · Cited by 265 · see citing works
Cheng, G., Yin, C., Tu, H., Jiang, S., Wang, Q., Zhou, X. M., Xing, X., Xie, C., Shi, X., Du, Y., et al. (2019) · ACS Nano · doi:10.1021/acsnano.8b06032 · Cited by 258 · see citing works
O’Donnell, M. D., & Hill, R. G. (2010) · Acta Biomaterialia · doi:10.1016/j.actbio.2010.01.006 · Cited by 234 · see citing works
Jang, H. L., Jin, K., Lee, J., Kim, Y., Nahm, S. H., Hong, K. S., & Nam, K. T. (2013) · ACS Nano · doi:10.1021/nn405246h · Cited by 227 · see citing works
Takahashi, Y., & Tabata, Y. (2004) · Journal of Biomaterials Science Polymer Edition · doi:10.1163/156856204322752228 · Cited by 217 · see citing works
Corrosion process of pure magnesium in simulated body fluid
Wang, Y., Wei, M., Gao, J., Hu, J., & Zhang, Y. (2007) · Materials Letters · doi:10.1016/j.matlet.2007.11.045 · Cited by 199 · see citing works
Hickey, D. J., Ercan, B., Sun, L., & Webster, T. J. (2014) · Acta Biomaterialia · doi:10.1016/j.actbio.2014.12.004 · Cited by 193 · see citing works
Effect of Local Alkaline Microenvironment on the Behaviors of Bacteria and Osteogenic Cells
Tan, J., Wang, D., Cao, H., Qiao, Y., Zhu, H., & Liu, X. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b15724 · Cited by 180 · see citing works
Díaz‐Tocados, J. M., Herencia, C., Martinez-Moreno, J. M., de Oca, A. M., Rodríguez-Ortiz, M. E., Vergara, N., Blanco, A., Steppan, S., Almadén, Y., Rodríguez, M., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-08379-y · Cited by 176 · see citing works
Kim, H., Che, L., Ha, Y., & Ryu, W. (2014) · Materials Science and Engineering C · doi:10.1016/j.msec.2014.04.012 · Cited by 171 · see citing works
Bone regeneration: importance of local pH—strontium-doped borosilicate scaffold
Shen, Y., Liu, W., Wen, C., Pan, H., Wang, T., Darvell, B. W., Lu, W. W., & Huang, W. (2012) · Journal of Materials Chemistry · doi:10.1039/c2jm16141a · Cited by 165 · see citing works
Characterization of titanium surfaces with calcium and phosphate and osteoblast adhesion
Feng, B., Weng, J., Yang, B., Qu, S., & Zhang, X. (2003) · Biomaterials · doi:10.1016/j.biomaterials.2003.10.044 · Cited by 156 · see citing works
Ko, E., Lee, J. S., Kim, H., Yang, S. Y., Yang, D., Yang, K., Lee, J., Shin, J., Yang, H. S., Ryu, W., et al. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b03328 · Cited by 150 · see citing works
Gupta, P., Adhikary, M., Moses, J. C., Kumar, M., Bhardwaj, N., & Mandal, B. B. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b11366 · Cited by 149 · see citing works
High magnesium inhibits human osteoblast differentiation in vitro
Leidi, M., Dellera, F., Mariotti, M., & Maier, J. A. M. (2011) · Magnesium Research · doi:10.1684/mrh.2011.0271 · Cited by 148 · see citing works
Wu, C., Chen, Z., Yi, D., Chang, J., & Xiao, Y. (2014) · ACS Applied Materials & Interfaces · doi:10.1021/am4060035 · Cited by 144 · see citing works
pH dependence of bone resorption: mouse calvarial osteoclasts are activated by acidosis
Meghji, S., Morrison, M. S., Henderson, B. E., & Arnett, T. R. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.280.1.e112 · Cited by 142 · see citing works
Mandal, B. B., & Kundu, S. C. (2008) · Macromolecular Bioscience · doi:10.1002/mabi.200800113 · Cited by 141 · see citing works
Mandal, B. B., & Kundu, S. C. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.05.064 · Cited by 132 · see citing works
Preparation of uniaxial multichannel silk fibroin scaffolds for guiding primary neurons
Zhang, Q., Zhao, Y., Yan, S., Yang, Y., Zhao, H., Li, M., Lu, S., & Kaplan, D. L. (2012) · Acta Biomaterialia · doi:10.1016/j.actbio.2012.03.033 · Cited by 132 · see citing works
Ratanavaraporn, J., Furuya, H., Kohara, H., & Tabata, Y. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2010.12.052 · Cited by 130 · see citing works
Alkaline biodegradable implants for osteoporotic bone defects—importance of microenvironment pH
Liu, W., Wang, T., Yang, C., Darvell, B. W., Wu, J., Lin, K., Chang, J., Pan, H., & Lu, W. W. (2015) · Osteoporosis International · doi:10.1007/s00198-015-3217-8 · Cited by 125 · see citing works
Çakır, B. A., Budama, L., Topel, Ö., & Hoda, N. (2012) · Colloids and Surfaces A Physicochemical and Engineering Aspects · doi:10.1016/j.colsurfa.2012.08.015 · Cited by 124 · see citing works
Zhang, X., Chen, Y., Han, J., Mo, J., Dong, P., Zhuo, Y.-H., & Feng, Y. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.06.172 · Cited by 120 · see citing works
Interfacial pH: A Critical Factor for Osteoporotic Bone Regeneration
Shen, Y., Liu, W., Lin, K., Pan, H., Darvell, B. W., Peng, S., Wen, C., Deng, L., Lu, W. W., & Chang, J. (2011) · Langmuir · doi:10.1021/la104876w · Cited by 109 · see citing works
Li, T., Sheng, Y., Huang, L., Chow, D. H. K., Chau, W. H., Tang, N., Ngai, T., Wu, C. C., Lü, J., & Qin, L. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.07.018 · Cited by 98 · see citing works
Antibacterial study of Mg(OH)2 nanoplatelets
Dong, C., Song, D., Cairney, J., Maddan, O. L., He, G., & Deng, Y. (2010) · Materials Research Bulletin · doi:10.1016/j.materresbull.2010.12.023 · Cited by 97 · see citing works
Ke, D., Tarafder, S., Vahabzadeh, S., & Bose, S. (2018) · Materials Science and Engineering C · doi:10.1016/j.msec.2018.10.073 · Cited by 91 · see citing works
Antibacterial effects of silver-doped hydroxyapatite thin films sputter deposited on titanium
Trujillo, N. A., Oldinski, R. A., Ma, H., Bryers, J. D., Williams, J. D., & Popat, K. C. (2012) · Materials Science and Engineering C · doi:10.1016/j.msec.2012.05.012 · Cited by 90 · see citing works
Quercetin Inlaid Silk Fibroin/Hydroxyapatite Scaffold Promotes Enhanced Osteogenesis
Song, J. E., Tripathy, N., Lee, D. H., Park, J. H., & Khang, G. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b08119 · Cited by 88 · see citing works
Ohara, N., Hayashi, Y., Yamada, S., Kim, S., Matsunaga, T., Yanagiguchi, K., & Ikeda, T. (2003) · Biomaterials · doi:10.1016/j.biomaterials.2003.08.022 · Cited by 73 · see citing works
Chen, R., Ho, M., Liao, M.-H., Lin, P.-I., Liu, S., & Yao, C. (2015) · International Journal of Nanomedicine · doi:10.2147/ijn.s90669 · Cited by 71 · see citing works
Kang, H., Wong, D. S. H., Yan, X., Jung, H. J., Kim, S., Lin, S., Wei, K., Li, G., Dravid, V. P., & Bian, L. (2017) · ACS Nano · doi:10.1021/acsnano.7b02857 · Cited by 71 · see citing works
Subaie, A. E. A., Emami, E., Tamimi, I., Laurenti, M., Eimar, H. A., Abdallah, M., & Tamimi, F. (2016) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.12506 · Cited by 64 · see citing works
Sudakaran, S. V., Venugopal, J. R., Vijayakumar, G. P., Abisegapriyan, S., Grace, A. N., & Ramakrishna, S. (2016) · Materials Science and Engineering C · doi:10.1016/j.msec.2016.10.050 · Cited by 64 · see citing works
Lee, D. H., Tripathy, N., Shin, J. H., Song, J. E., Geun, J., Min, K. D., Park, C. H., & Khang, G. (2016) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2016.11.002 · Cited by 61 · see citing works
Li, Q., Wang, D., Qiu, J., Peng, F., & Liu, X. (2018) · Biomaterials Science · doi:10.1039/c8bm00100f · Cited by 61 · see citing works
Ou, L., Lan, Y., Feng, Z., Feng, L., Yang, J., Liu, Y., Bian, L., Tan, J., Lai, R., & Guo, R. (2019) · Theranostics · doi:10.7150/thno.34676 · Cited by 60 · see citing works
Panda, N., Bissoyi, A., Pramanik, K., & Biswas, A. (2014) · Materials Science and Engineering C · doi:10.1016/j.msec.2014.12.010 · Cited by 45 · see citing works
Abdallah, M., Eimar, H., Bassett, D., Schnabel, M., Ciobanu, O., Nelea, V., McKee, M., Cerruti, M., & Tamimi, F. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.04.005 · Cited by 45 · see citing works
Mikami, Y., Tsuda, H., Akiyama, Y., Honda, M. J., Shimizu, N., Suzuki, N., & Komiyama, K. (2015) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-015-0719-6 · Cited by 40 · see citing works
Regeneration of Periosteum by Human Bone Marrow Stromal Cell Sheets
Syed-Picard, F. N., Shah, G. A., Costello, B. J., & Sfeir, C. S. (2014) · Journal of Oral and Maxillofacial Surgery · doi:10.1016/j.joms.2014.02.005 · Cited by 38 · see citing works
Magnesium, a drug of diverse use.
Akhtar, M. I., Ullah, H., & Hamid, M. (2011) · PubMed · Cited by 34 · see citing works
NPY and CGRP Inhibitor Influence on ERK Pathway and Macrophage Aggregation during Fracture Healing
Tang, P. C., Duan, C., Wang, Z., Wang, C., Meng, G., Lin, K. L., Yang, Q., & Yuan, Z. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000468405 · Cited by 31 · see citing works
TRPM7 and MagT1 in the osteogenic differentiation of human mesenchymal stem cells in vitro
Castiglioni, S., Romeo, V., Locatelli, L., Cazzaniga, A., & Maier, J. A. M. (2018) · Scientific Reports · doi:10.1038/s41598-018-34324-8 · Cited by 28 · see citing works
Castiglioni, S., Romeo, V., Locatelli, L., Zocchi, M., Zecchini, S., & Maier, J. A. M. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.03.178 · Cited by 22 · see citing works
Formulation of a covalently bonded hydroxyapatite and poly(ether ether ketone) composite
Hughes, E. A. B., Parkes, A., Williams, R. L., Jenkins, M. J., & Grover, L. M. (2018) · Journal of Tissue Engineering · doi:10.1177/2041731418815570 · Cited by 20 · see citing works
Jung, Y. R., Lee, E. K., Kim, D. H., Park, C. H., Park, M. H., Jeong, H. O., Yokozawa, T., Tanaka, T., Im, D., Kim, N. D., et al. (2015) · Journal of Natural Products · doi:10.1021/acs.jnatprod.5b00348 · Cited by 19 · see citing works
Song, J. E., Tripathy, N., Cha, S. R., Jeon, S. H., Kwon, S. Y., Suh, D. S., & Khang, G. (2017) · Journal of Biomaterials Science Polymer Edition · doi:10.1080/09205063.2017.1394712 · Cited by 16 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Kang, Y., Xu, C., Meng, L., Dong, X., Qi, M., & Jiang, D. (2022) · Bioactive materials · doi:10.1016/j.bioactmat.2022.02.012 · Cited by 253 · see citing works
Recent Trends in the Development of Bone Regenerative Biomaterials
Tang, G., Liu, Z., Liu, Y., Yu, J., Wang, X., Tan, Z., & Ye, X. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.665813 · Cited by 251 · see citing works
Advanced Strategies of Biomimetic Tissue‐Engineered Grafts for Bone Regeneration
Xie, C., Ye, J., Liang, R., Yao, X., Wu, X., Koh, Y. W., Wei, W., Zhang, X., & Ouyang, H. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202100408 · Cited by 174 · see citing works
Effects of Zinc, Magnesium, and Iron Ions on Bone Tissue Engineering
Chen, Z., Zhang, W., Wang, M., Backman, L. J., & Chen, J. (2022) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.2c00368 · Cited by 157 · see citing works
Hong, M.-H., Lee, J. H., Jung, H. S., Shin, H., & Shin, H. (2022) · Biomaterials Research · doi:10.1186/s40824-022-00288-0 · Cited by 143 · see citing works
Fendi, F., Abdullah, B., Suryani, S., Usman, A. N., & Tahir, D. (2024) · Bone · doi:10.1016/j.bone.2024.117075 · Cited by 130 · see citing works
Silk Fibroin Materials: Biomedical Applications and Perspectives
Giorgio, G. D., Matera, B., Vurro, D., Manfredi, E., Galstyan, V., Tarabella, G., Ghezzi, B., & D’Angelo, P. (2024) · Bioengineering · doi:10.3390/bioengineering11020167 · Cited by 128 · see citing works
Luo, Q., Yang, Y., Ho, C., Li, Z., Chiu, W., Li, A., Dai, Y., Li, W., & Zhang, X. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02555-9 · Cited by 113 · see citing works
Biomaterials for bone regeneration: an orthopedic and dentistry overview
Bastidas, J. G., Baldin, E. K., de Medeiros, T. G. S. L., Oliveira, L., Machado, G. M., Malfatti, C. D. F., & Pranke, P. H. L. (2021) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x2021e11055 · Cited by 103 · see citing works
Multi‐Dimensional Printing for Bone Tissue Engineering
Qu, M., Wang, C., Zhou, X., Libanori, A., Jiang, X., Xu, W., Zhu, S., Chen, Q., Sun, W., & Khademhosseini, A. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202001986 · Cited by 88 · see citing works
Resorbable Membranes for Guided Bone Regeneration: Critical Features, Potentials, and Limitations
Abtahi, S., Chen, X., Shahabi, S., & Nasiri, N. (2023) · ACS Materials Au · doi:10.1021/acsmaterialsau.3c00013 · Cited by 81 · see citing works
Multifunctional 3D Hierarchical Bioactive Green Carbon-Based Nanocomposites
Rabiee, N., Bagherzadeh, M., Ghadiri, A. M., Kiani, M., Fatahi, Y., Tavakolizadeh, M., Pourjavadi, A., Jouyandeh, M., Saeb, M. R., Mozafari, M., et al. (2021) · ACS Sustainable Chemistry & Engineering · doi:10.1021/acssuschemeng.1c00781 · Cited by 75 · see citing works
Chen, Y., Zhang, S., Bai, J., Yang, Y., Wang, Y., Yanling, Z., Jiang, W., Wang, J., Zhu, J., Zhu, C., et al. (2024) · Journal of Magnesium and Alloys · doi:10.1016/j.jma.2024.05.028 · Cited by 74 · see citing works
Application of Bioactive Materials for Osteogenic Function in Bone Tissue Engineering
Bai, Y., Wang, Z., He, X., Zhu, Y., Xu, X., Yang, H., Mei, G., Chen, S., Ma, B., & Zhu, R. (2024) · Small Methods · doi:10.1002/smtd.202301283 · Cited by 68 · see citing works
Inorganic Nanoparticles in Bone Healing Applications
Burdușel, A.-C., Gherasim, O., Andronescu, E., Grumezescu, A. M., & Ficai, A. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14040770 · Cited by 61 · see citing works
Biomimetic bone grafts and substitutes: A review of recent advancements and applications
Feroz, S., Cathro, P. R., Ivanovski, S., & Muhammad, N. (2023) · Biomedical Engineering Advances · doi:10.1016/j.bea.2023.100107 · Cited by 57 · see citing works
3D hydrogel/ bioactive glass scaffolds in bone tissue engineering: Status and future opportunities
Aldhaher, A., Shahabipour, F., Shaito, A. A., Al‐Assaf, S., Elnour, A. A. M., Sallam, E. B., Teimourtash, S., & Abdelgadir, A. E. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e17050 · Cited by 54 · see citing works
Silk fibroin-based scaffolds for wound healing applications with metal oxide nanoparticles
Radulescu, D.-M., Andronescu, E., Vasile, O. R., Ficai, A., & Vasile, B. S. (2024) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2024.105689 · Cited by 54 · see citing works
The Effect of Selenium Nanoparticles on the Osteogenic Differentiation of MC3T3-E1 Cells
Lee, S. C., Lee, N., Patel, K. D., Jang, T., Knowles, J. C., Kim, H., Lee, H., & Lee, J. (2021) · Nanomaterials · doi:10.3390/nano11020557 · Cited by 51 · see citing works
Novel approaches and biomaterials for bone tissue engineering: a focus on silk fibroin
Paladini, F., & Pollini, M. (2022) · Materials · doi:10.3390/ma15196952 · Cited by 51 · see citing works
Zhao, Z., Ma, X., Zhao, B., Tian, P., Ma, J., Kang, J., Zhang, Y., Guo, Y., & Sun, L. (2021) · Cell Proliferation · doi:10.1111/cpr.13043 · Cited by 48 · see citing works
Miszuk, J. M., Liang, Z., Hu, J., Sanyour, H. J., Hong, Z., Fong, H., & Sun, H. (2021) · ACS Applied Bio Materials · doi:10.1021/acsabm.1c00134 · Cited by 47 · see citing works
Mao, Y., Zhang, Y., Wang, Y., Zhou, T., Ma, B., & Zhou, P. (2023) · Regenerative Biomaterials · doi:10.1093/rb/rbad046 · Cited by 46 · see citing works
Application of Hydrogels as Sustained-Release Drug Carriers in Bone Defect Repair
Feng, Y., Guo, W., Hu, L., Yi, X., & Tang, F. (2022) · Polymers · doi:10.3390/polym14224906 · Cited by 45 · see citing works
Kim, H., Lee, J., Mandakhbayar, N., Jin, G., Kim, S.-J., Yoon, J., Jo, S. B., Park, J.-H., Singh, R. K., Jang, J., et al. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.120857 · Cited by 43 · see citing works
Meng, Z., Liu, Y., Xu, K., Sun, X., Yu, Q., Wu, Z., & Zhao, Z. (2021) · ACS Omega · doi:10.1021/acsomega.1c02903 · Cited by 42 · see citing works
Baneshi, N., Moghadas, B. K., Adetunla, A., Yusof, M. Y. P. M., Dehghani, M., Khandan, A., Saber‐Samandari, S., & Toghraie, D. S. (2021) · Journal of Materials Research and Technology · doi:10.1016/j.jmrt.2021.10.107 · Cited by 42 · see citing works
Biocompatible and functional inorganic magnesium ceramic particles for biomedical applications
Bedair, T. M. I., Heo, Y., Ryu, J., Bedair, H. M., Park, W., & Han, D. K. (2021) · Biomaterials Science · doi:10.1039/d0bm01934h · Cited by 40 · see citing works
Wang, B., Chen, H., Peng, S., Li, X., Liu, X., Ren, H., Yan, Y., & Zhang, Q. (2023) · Journal of Materials Chemistry B · doi:10.1039/d2tb02705d · Cited by 38 · see citing works
Porous hydroxyapatite scaffold orchestrated with bioactive coatings for rapid bone repair
Zhao, Y., Chen, H., Ran, K., Zhang, Y., Pan, H., Shangguan, J., Tong, M., Yang, J., Yao, Q., & Xu, H. (2022) · Biomaterials Advances · doi:10.1016/j.bioadv.2022.213202 · Cited by 35 · see citing works
Guo, B., Feng, X., Wang, Y., Wang, X., & He, Y. (2021) · Journal of Materials Chemistry B · doi:10.1039/d1tb00618e · Cited by 30 · see citing works
Zhao, B., He, J., Wang, F., Xing, R., Sun, B., & Zhou, Y. (2021) · Frontiers in Materials · doi:10.3389/fmats.2021.758599 · Cited by 30 · see citing works
Taye, M. B., Ningsih, H. S., & Shih, S. (2024) · Journal of Nanoparticle Research · doi:10.1007/s11051-024-05935-2 · Cited by 31 · see citing works
Tian, Y., Wu, Q., Li, F., Zhou, Y., Huang, D., Xie, R., Wang, X., Zheng, Z., & Li, G. (2021) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2021.112080 · Cited by 29 · see citing works
Tough Porous Silk Nanofiber‐Derived Cryogels with Osteogenic and Angiogenic Capacity for Bone Repair
Hou, J., Ding, Z., Zheng, X. M., Shen, Y., Lü, Q., & Kaplan, D. L. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202203050 · Cited by 28 · see citing works
Composite PCL Scaffold With 70% β-TCP as Suitable Structure for Bone Replacement
Ghezzi, B., Matera, B., Meglioli, M., Rossi, F., Duraccio, D., Faga, M. G., Zappettini, A., Macaluso, G. M., & Lumetti, S. (2024) · International Dental Journal · doi:10.1016/j.identj.2024.02.013 · Cited by 28 · see citing works
Wang, D., Zhang, P., Mei, X., & Chen, Z. (2021) · Regenerative Biomaterials · doi:10.1093/rb/rbab022 · Cited by 28 · see citing works
Gui, X., Zhang, B., Song, P., Su, Z., Gao, C., Xing, F., Liu, L., Wei, W., Hui, D., Gu, L., et al. (2024) · Applied Materials Today · doi:10.1016/j.apmt.2024.102085 · Cited by 28 · see citing works
Dental pulp stem cell-derived extracellular matrix: autologous tool boosting bone regeneration
Alksnė, M., Kalvaitytė, M., Šimoliūnas, E., Gendvilienė, I., Barasa, P., Rinkūnaitė, I., Kaupinis, A., Šeinin, D., Rutkūnas, V., & Bukelskienė, V. (2022) · Cytotherapy · doi:10.1016/j.jcyt.2022.02.002 · Cited by 28 · see citing works
Using scaffolds as drug delivery systems to treat bone tumor
Wang, C., Ma, Z., Yuan, K., & Ji, T. (2022) · Nanotechnology · doi:10.1088/1361-6528/ac5017 · Cited by 23 · see citing works
Niknam, Z., Azarbayjani, A. F., Rafiaei, S. M., Rasmi, Y., & Tayebi, L. (2024) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2024.105531 · Cited by 23 · see citing works
Natural polymers-based surface engineering of bone scaffolds – A review
Sathiya, K., Ganesamoorthi, S., Mohan, S., Shanmugavadivu, A., & Selvamurugan, N. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.136840 · Cited by 22 · see citing works
Al-Bishari, A. M., Al-Shaaobi, B. A., Al-Bishari, A. A., Al-Baadani, M. A., Yu, L., Shen, J., Cai, L., Shen, Y., Deng, Z., & Gao, P. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.975431 · Cited by 21 · see citing works
Ozaki, H., Hamai, R., Shiwaku, Y., Sakai, S., Tsuchiya, K., & Suzuki, O. (2021) · Science and Technology of Advanced Materials · doi:10.1080/14686996.2021.1916378 · Cited by 19 · see citing works
Scaffold-based bone tissue engineering in microgravity: potential, concerns and implications
Mochi, F., Scatena, E., Rius, D. R., Ginebra, M., & Gaudio, C. D. (2022) · npj Microgravity · doi:10.1038/s41526-022-00236-1 · Cited by 22 · see citing works
Li, X., You, R., Zhang, Q., Yan, S., Luo, Z., Qu, J., & Li, M. (2021) · Journal of Materials Chemistry B · doi:10.1039/d1tb00857a · Cited by 18 · see citing works
Bang, S.-J., Jun, S.-K., Kim, Y.-J., Ahn, J., Vu, H. T., Mandakhbayar, N., Han, M., Lee, J.-H., Kim, J., Kim, J., et al. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14061137 · Cited by 18 · see citing works
Biomimetic Strategies for Bone Regeneration: Smart Scaffolds and Multiscale Cues
Hossen, M., Khaleque, M. A., Lim, M.-S., Kang, J.-K., Kim, D.-K., Lee, H.-H., & Kim, Y. (2025) · Biomimetics · doi:10.3390/biomimetics11010012 · Cited by 17 · see citing works
Sculpting the Future of Bone: The Evolution of Absorbable Materials in Orthopedics
Wang, Z., Lv, Z., Cai, X., Wang, Y., Peng, B., Xu, H., Pang, H., Yang, X., Xu, J., Bian, Y., et al. (2026) · Advanced Materials · doi:10.1002/adma.202510848 · Cited by 23 · see citing works
Shao, Y., Wang, H., Zhu, Y., Peng, Y., Bai, F., Zhang, J., & Zhang, K. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c12470 · Cited by 15 · see citing works
Lin, J., Liu, L., Huang, S., Zheng, W., Liu, H., Bai, Z., Jiang, K., & Wang, X. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.03.056 · Cited by 15 · see citing works
Biosoluble ceramic fiber reinforced poly(L-lactic acid) bone scaffold: degradation and bioactivity
Shuai, C., Wang, Z., Zhang, H., Jia, J., Huang, L., Wang, D., Chen, S., & Feng, P. (2022) · npj Materials Degradation · doi:10.1038/s41529-022-00297-3 · Cited by 14 · see citing works
Bai, T., Thakur, A., Zheng, Y., Liu, W., Wang, L., Chen, M., Jia, Z., Yu, S., & Zhou, W. (2024) · Applied Materials Today · doi:10.1016/j.apmt.2023.102054 · Cited by 14 · see citing works
Gharivi, M., Saraei, M., Khachatourian, A. M., Nemati, A., & Gholipourmalekabadi, M. (2025) · Materials Chemistry and Physics · doi:10.1016/j.matchemphys.2025.130656 · Cited by 14 · see citing works
Liu, T., Yang, L., Zhang, Y., Zhao, M., Wen, Z., & Zhang, L. (2021) · Biotechnology Journal · doi:10.1002/biot.202000653 · Cited by 14 · see citing works
Zhang, Y., Chen, X., Li, Y., Bai, T., Li, C., Jiang, L., Liu, Y., Sun, C., & Zhou, W. (2021) · ACS Omega · doi:10.1021/acsomega.1c04734 · Cited by 13 · see citing works
Abdulmawjood, Y. F., & Thanoon, M. (2022) · Al-mağallaẗ al-ʻirāqiyyaẗ li-l-ʻulūm al-bayṭariyyaẗ/Iraqi journal of veterinary sciences · doi:10.33899/ijvs.2021.130500.1836 · Cited by 13 · see citing works
Nazir, F., Abbas, L., & Iqbal, M. (2021) · Applied Nanoscience · doi:10.1007/s13204-021-02223-6 · Cited by 13 · see citing works
Zaghian, M., Varshosaz, J., Rostami, M. R., & Mirian, M. (2024) · Materials Advances · doi:10.1039/d3ma00826f · Cited by 11 · see citing works
Hosseini, S. F., Galefi, A., Hosseini, S., Shaabani, A., Farrokhi, N., Jahanfar, M., Nourany, M., Homaeigohar, S., Alipour, A., & Shahsavarani, H. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.136303 · Cited by 11 · see citing works
Xu, T., Gao, S., Yang, N., Zhao, Q., Zhang, Y., Li, T., Liu, Z., & Han, B. (2024) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2024.1355019 · Cited by 10 · see citing works
Biomedical Applications of Magnesium Oxide Nanoparticles
Nagchowdhury, P., Krishna, M., & Patra, C. R. (2024) · Springer eBooks · doi:10.1007/978-981-97-0221-3_5 · Cited by 10 · see citing works
Kannan, P. R., Sangkert, S., Jiang, C., Li, Y., Zhao, R., Iqbal, M. Z., & Kong, X. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.143390 · Cited by 8 · see citing works
Zhang, P., Wang, T., Qian, J., Qin, H., Liu, P., Xiong, A., Udduttula, A., Wang, D., Zeng, H., & Chen, Y. (2024) · Regenerative Biomaterials · doi:10.1093/rb/rbae049 · Cited by 7 · see citing works
Boretti, G., Giordano, E., Ioniţă, M., Vlăsceanu, G. M., Sigurjónsson, Ó. E., Gargiulo, P., & Lovecchio, J. (2023) · Materials · doi:10.3390/ma16175898 · Cited by 7 · see citing works
UCNPs-labeled electrospun scaffolds used to monitor in vivo degradation and bone tissue regeneration
Sun, D., Sun, X., Li, D., Wang, M., Song, S., Liu, C., Ma, N., Yin, X., & Wang, C. (2024) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2024.113860 · Cited by 7 · see citing works
The Inhibitory Effect of RADKPS on Pyroptosis of Nucleus Pulposus-Derived Mesenchymal Stem Cells
Zhu, C., Zhou, Q., Tang, L., Xuan, A., Xu, C., Wang, Z., & Ruan, D. (2023) · Tissue Engineering Part A · doi:10.1089/ten.tea.2022.0212 · Cited by 7 · see citing works
Sneha, K. R., Sreeja, S., & Sailaja, G. S. (2021) · Biomedical Materials · doi:10.1088/1748-605x/ac01af · Cited by 7 · see citing works
Jawad, Z. S., Mohammed, F., & AL-Hassani, E. S. (2023) · Engineering and Technology Journal · doi:10.30684/etj.2023.138142.1375 · Cited by 7 · see citing works
Li, J., Sun, Y., Du, Y. L., Zhao, X., Wang, M., Ren, X., Sun, Q., Chen, J., & Zhang, W. (2026) · Advanced Functional Materials · doi:10.1002/adfm.202514053 · Cited by 6 · see citing works
Ghanbari, E., Mehdipour, A., Khazaei, M., Khoshfetrat, A. B., & Niknafs, B. (2022) · International Journal of Polymeric Materials · doi:10.1080/00914037.2022.2032707 · Cited by 6 · see citing works
Shaly, A. A., Priya, G. H., Mahendiran, M., & Linet, J. M. (2022) · Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · doi:10.1016/j.jmbbm.2022.105313 · Cited by 6 · see citing works
Lyu, R., Wang, T., Li, C., Cai, J., Yang, X. F., Wang, J., Shuai, Y., Mao, C., Jiang, T., & Yang, M. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.144603 · Cited by 5 · see citing works
Innocentini, M. D. D. M., Bueno, B. R. F., Urbaś, A., & Morawska-Chochół, A. (2024) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.4c00286 · Cited by 5 · see citing works
Qi, H., Liu, Y., Wu, L. Y., Liu, C., Ni, S., Liu, Q., Ni, X., & Sun, Q. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.838842 · Cited by 5 · see citing works
Huang, X., Zeng, J., & Wang, Y. (2022) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.35142 · Cited by 5 · see citing works
Hu, S., Yang, X., Wu, H., He, D., Zhu, Z., Ke, G., Zhu, J. Y., Cheng, X., & Wang, X. (2022) · Applied Materials Today · doi:10.1016/j.apmt.2022.101678 · Cited by 5 · see citing works
Panjla, A., Qayoom, I., Kumar, A., & Verma, S. K. (2021) · Chemical Communications · doi:10.1039/d1cc01985f · Cited by 4 · see citing works
Yang, G., Liu, X., Huang, T., Ding, R., & Wang, Y. (2022) · Tissue Engineering and Regenerative Medicine · doi:10.1007/s13770-022-00502-z · Cited by 4 · see citing works
Jeong, H., Subramanian, K., Lee, J., Byun, H., Shin, H., & Yun, J. (2025) · Biomaterials Science · doi:10.1039/d4bm01280a · Cited by 3 · see citing works
Thonglam, J., Nuntanaranont, T., Kong, X., & Meesane, J. (2025) · ACS Applied Bio Materials · doi:10.1021/acsabm.5c01184 · Cited by 2 · see citing works
Darvishi, N., Reiisi, S., & Shirian, S. (2025) · Journal of Biomaterials Applications · doi:10.1177/08853282251399589 · Cited by 2 · see citing works
Matera, B., Giorgio, G. D., Rupel, K., Turco, G., D’Angelo, P., & Ghezzi, B. (2026) · Ceramics International · doi:10.1016/j.ceramint.2026.01.443 · Cited by 2 · see citing works
Yu, Y., Zhang, Y., Dai, M., Tian, Y., Zhang, T., Liu, Y., Xu, J., & Wang, J. (2026) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.6c00050 · Cited by 2 · see citing works
Xiong, H., Cao, M., Yu, Y., Duan, X., Sun, L., Tang, L., & Fan, X. (2024) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2024.07.003 · Cited by 2 · see citing works
Advanced bio-nanoscaffold for bone tissue regeneration in animal model
Lakshmi, K., Varadharajan, V., Kanagasubbulakshmi, S., & Kadirvelu, K. (2022) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2022.103593 · Cited by 2 · see citing works
Efficacy of vancomycin-loaded Mg-hydroxyapatite scaffolds in chronic osteomyelitis
Shang, H., & Mei, W. (2024) · Materials Express · doi:10.1166/mex.2024.2628 · Cited by 1 · see citing works
Sadeghi, N., Shanei, F., Moradi, A., Shamosi, A., Zamani, S., & Salehi, M. (2025) · Journal of Biomaterials Applications · doi:10.1177/08853282251369228 · Cited by 1 · see citing works
Potential Sources of Biodegradable Polymers
Singh, S. K., & Chunglok, W. (2022) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9789815079302122010005 · Cited by 1 · see citing works
Luo, Q., Yang, Y., Ho, C., Li, Z., Chiu, W., Li, A., Dai, Y., Li, W., & Zhang, X. (2024) · Research Square · doi:10.21203/rs.3.rs-3852307/v1 · Cited by 1 · see citing works
Role of silk fibroin biomaterials as artificial ECM for 3D in vitro modeling
Ribeiro, V. P., Reis, R. L., & Oliveira, J. M. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-91821-3.00012-8
3D-Scaffold Design of Biodegradable Nanofibers for Tissue Regeneration and Drug Delivery
Khodir, W. K. W. A., & Yusof, M. R. (2024) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9789815179330124010016
Luo, Q., Yang, Y., Ho, C., Li, Z., Chiu, W., Li, A., Dai, Y., Li, W., & Zhang, X. (2024) · Figshare · doi:10.6084/m9.figshare.26725694
Xu, C., Zhao, Y., Zhan, J., Su, J., Li, X., Li, Y., Li, Y., Hu, T., Li, Z., Li, Y., et al. (2025) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbma.70001
Natural composites in orthopedics and dentistry
Mansour, A., Elmahdy, A. S., & El-sherbiny, I. M. (2026) · Elsevier eBooks · doi:10.1016/b978-0-323-95754-0.00014-6
Mandaliya, V. B. (2026) · Indian Journal of Orthopaedics · doi:10.1007/s43465-026-01825-y
Zou, M., Liu, Y., Luo, T., Yang, H., Liang, J., Tian, L., Sun, J., & Li, M. (2026) · RSC Advances · doi:10.1039/d6ra03809c
Silk Fibroin: A Multifunctional Natural Biomaterial for Emerging Biomedical Applications
Bhadra, P., Roy, B., Shaw, S., & Gangopadhyay, D. (2026) · Textile science and clothing technology · doi:10.1007/978-3-032-26880-8_8
Dash, S., & Mohanty, S. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-33455-9.00001-8
- Authors
- Wu, Z., Meng, Z., Wu, Q., Zeng, D., Guo, Z., Yao, J., Bian, Y., Gu, Y., Cheng, S., Peng, L., & Zhao, Y.
- Affiliations
- Hainan Medical University (CN)
- Taizhou Municipal Hospital (CN)
- School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China
- Corresponding author
- Peng, Lei
- Venue
- Journal of Tissue Engineering
- Publisher
- SAGE Publications
- Published
- 2020-01
- Volume
- 11
- Pages
- 2041731420967791-2041731420967791
- ISSN
- 2041-7314 (ISSN-L)
- PMC
- PMC7705190
- OpenAlex
- W3110553477
- Cited by
- 99
- References
- 76
- Citations by year
- 2026: 9 · 2025: 9 · 2024: 26 · 2023: 9 · 2022: 23 · 2021: 23
- FWCI
- 4.32
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Tissue Engineering (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (Grant No. 81460339, Grant No. 81772316, Grant No. 82060347)
- Hainan Provincial Foundation for Education Department (Grant No. Hnky2019ZD-28)
- Medical Health Science and Technology Project of Zhejiang Provincial Health Commission (2020KY365)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Materials Science › Biomaterials › Silk-based biomaterials and applications
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Keywords
- silk fibroin, hydroxyapatite, nano-MgO, bone regeneration, bone tissue engineering, bone mesenchymal stem cells, osteogenic differentiation, alkaline phosphatase activity, femoral defect, biocompatibility, biodegradability, mechanical properties
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