Cited by 250Seaweed-derived Bioactive CompoundsPhytochemicals and Antioxidant ActivitiesMarine and coastal plant biology

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Antioxidant Activity of Hawaiian Marine Algae

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Kelman, Dovi, Posner, Ellen Kromkowski, McDermid, Karla J., Tabandera, Nicole K., Wright, Patrick R., Wright, Anthony D.·2012·Marine Drugs

DOI 10.3390/md10020403PMC PMC3297004

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Abstract

Marine algae are known to contain a wide variety of bioactive compounds, many of which have commercial applications in pharmaceutical, medical, cosmetic, nutraceutical, food and agricultural industries. Natural antioxidants, found in many algae, are important bioactive compounds that play an important role against various diseases and ageing processes through protection of cells from oxidative damage. In this respect, relatively little is known about the bioactivity of Hawaiian algae that could be a potential natural source of such antioxidants. The total antioxidant activity of organic extracts of 37 algal samples, comprising of 30 species of Hawaiian algae from 27 different genera was determined. The activity was determined by employing the FRAP (Ferric Reducing Antioxidant Power) assays. Of the algae tested, the extract of Turbinaria ornata was found to be the most active. Bioassay-guided fractionation of this extract led to the isolation of a variety of different carotenoids as the active principles. The major bioactive antioxidant compound was identified as the carotenoid fucoxanthin. These results show, for the first time, that numerous Hawaiian algae exhibit significant antioxidant activity, a property that could lead to their application in one of many useful healthcare or related products as well as in chemoprevention of a variety of diseases including cancer.

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Figure 1 Total antioxidant activity of organic extracts of Hawaiian algae presented as mean FRAP values in μM per μg extract. Error bars ± SD. The different colors represent the different algal groups. In cases where there are more than one sample of the same species collected at a different date or location (see Table 1), the date and/or location code was added. Hilo for Richardson’s Ocean Park; Ninole,for Punaluu Beach Park; Four-mile for Four-mile Beach Park; King’s, for King’s Landing.CC BY · PubMed Central

Figure 2 Bioassay-guided fractionation of Turbinaria ornata and the isolation of fucoxanthin as the active antioxidant: (a) Preperative HPLC chromatogram of T. ornata methanol extract; relative absorbance at 254 nm is presented. The peak that correlates to fraction 18 is indicated; (b) Total antioxidant activity of fractions collected from the preperative HPLC of T. ornata extract, presented as mean FRAP value in µM. Error bars ± SD; (c) The UV-visible absorbance spectrum corresponding to the HPLC peak of purified fraction 18. λmax at 264 and 449 nm are indicated; and, (d) Chemical structure of fucoxanthin, the major antioxidant component of T. ornata extract.CC BY · PubMed Central

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The Ferric Reducing Ability of Plasma (FRAP) as a Measure of “Antioxidant Power”: The FRAP Assay
Benzie, I. F. F., & Strain, J. (1996) · Analytical Biochemistry · doi:10.1006/abio.1996.0292 · Cited by 23,027 · cited 1×
“Antioxidant activity of algal extracts was determined using the ferric reducing antioxidant power (FRAP) assay, modified from the Benzie and Strain protocol [40,41].”
Method
Marine natural products
Faulkner, D. J. (1990) · Natural Product Reports · doi:10.1039/np9900700269 · Cited by 4,880
[2] Ferric reducing/antioxidant power assay: Direct measure of total antioxidant activity of biological fluids and modified version for simultaneous measurement of total antioxidant power and ascorbic acid concentration
Benzie, I. F. F., & Strain, J. (1999) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(99)99005-5 · Cited by 3,940 · cited 1×
“Antioxidant activity of algal extracts was determined using the ferric reducing antioxidant power (FRAP) assay, modified from the Benzie and Strain protocol [40,41].”
Method
Antioxidant defence mechanisms: From the beginning to the end (of the beginning)
Halliwell, B. B. (1999) · Free Radical Research · doi:10.1080/10715769900300841 · Cited by 1,023 · cited 1×
“By donating an electron, antioxidants neutralize free radicals that would otherwise oxidize biomolecules leading to cell death and tissue damage [6–8].”
Background
Metabolites from algae with economical impact
Cardozo, K. H. M., Guaratini, T., Barros, M. P., Falcão, V. D. R., Tonon, Â. P., Lopes, N. P., Campos, S. C. G., Torres, M. A., Souza, A. D. O., Colepicolo, P., et al. (2006) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2006.05.007 · Cited by 960
Carotenoids in Algae: Distributions, Biosyntheses and Functions
Takaichi, S. (2011) · Marine Drugs · doi:10.3390/md9061101 · Cited by 839
Fucoxanthin, a Marine Carotenoid Present in Brown Seaweeds and Diatoms: Metabolism and Bioactivities Relevant to Human Health
Peng, J., Yuan, J.-P., Wu, C.-F., & Wang, J.-H. (2011) · Marine Drugs · doi:10.3390/md9101806 · Cited by 820
Medicinal and pharmaceutical uses of seaweed natural products: A review
Smit, A. J. (2004) · Journal of Applied Phycology · doi:10.1023/b:japh.0000047783.36600.ef · Cited by 806 · cited 2×
“Algae from the three groupings traditionally known as Chlorophyta (green algae), Rhodophyta (red algae), and Phaeophyta (brown algae) produce compounds with varying bioactivities [4].”
Background
Oxidative stress and apoptosis: Impact on cancer therapy
Ozben, T. (2007) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.20874 · Cited by 751 · cited 1×
“By donating an electron, antioxidants neutralize free radicals that would otherwise oxidize biomolecules leading to cell death and tissue damage [6–8].”
Background
Fucoxanthin from edible seaweed, Undaria pinnatifida, shows antiobesity effect through UCP1 expression in white adipose tissues
Maeda, H., Hosokawa, M., Sashima, T., Funayama, K., & Miyashita, K. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.05.002 · Cited by 647 · cited 1×
“This unique carotenoid was found to possess potent anti-inflammatory, anticancer, anti-obese, anti-diabetic, anti-angiogenic, anti-malarial, and antioxidant activities, as well as protective effects on the liver, blood vessels of the brain, bones, skin, and eyes, including chemoprevention of a variety of diseases incl…”
Background
Radical Scavenging and Singlet Oxygen Quenching Activity of Marine Carotenoid Fucoxanthin and Its Metabolites
Sachindra, N. M., Sato, E., Maeda, H., Hosokawa, M., Niwano, Y., Kohno, M., & Miyashita, K. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf071848a · Cited by 516 · cited 1×
“Fucoxanthin was shown to have a much higher antioxidant activity than other antioxidants, including tocopherols, and this higher activity is assumed to be due to the presence of the allenic moiety [26].”
Background
Marine natural products
Blunt, J. W., Copp, B. R., Munro, M. H. G., Northcote, P. T., & Prinsep, M. R. (2010) · Natural Product Reports · doi:10.1039/c005001f · Cited by 483
Reactive oxygen species: response of algal cells
Mallick, N., & Mohn, F. H. (2000) · Journal of Plant Physiology · doi:10.1016/s0176-1617(00)80189-3 · Cited by 449 · cited 1×
“, fatty acids) and resist oxidation during storage, indicating the presence of protective antioxidant defense systems in their cells [5,6].”
Background
In vitro antioxidant activities of three selected brown seaweeds of India
Chandini, S., Ganesan, P., & Bhaskar, N. (2007) · Food Chemistry · doi:10.1016/j.foodchem.2007.08.081 · Cited by 423 · cited 1×
“ornata from India have also been shown to possess significant antioxidant activity [16,17].”
Background
Marine natural products
Faulkner, D. J. (2001) · Natural Product Reports · doi:10.1039/b009029h · Cited by 416
Nutritional composition of edible Hawaiian seaweeds
McDermid, K. J., & Stuercke, B. (2003) · Journal of Applied Phycology · doi:10.1023/b:japh.0000004345.31686.7f · Cited by 346 · cited 3×
“oxysperma reported here, combined with its known antiviral and anticoagulant activities [32,33], as well as its high caloric value [14], makes it a potential valuable natural resource for the pharmaceutical, medicine, food, and aquaculture industries worthy of further research.”
Background
Antioxidant activities and phenolics content of eight species of seaweeds from north Borneo
Matanjun, P., Mohamed, S., Mustapha, N. M., Muhammad, K., & Ming, C. H. (2008) · Journal of Applied Phycology · doi:10.1007/s10811-007-9264-6 · Cited by 342 · cited 1×
“, fatty acids) and resist oxidation during storage, indicating the presence of protective antioxidant defense systems in their cells [5,6].”
Background
Marine Red Algae of the Hawaiian Islands
Moe, R. L., & Abbott, I. A. (1999) · Taxon · doi:10.2307/1223671 · Cited by 338 · cited 2×
“In the Hawaiian Islands there are approximately 520 reported species of marine algae [12,13], very few of which have been investigated biochemically in any way.”
Background
Antioxidant activity of mycosporine-like amino acids isolated from three red macroalgae and one marine lichen
de la Coba, F., Aguilera, J., Figueroa, F. L., de Gálvez, M. V., & Herrera, E. (2009) · Journal of Applied Phycology · doi:10.1007/s10811-008-9345-1 · Cited by 302
Antioxidants from macroalgae: potential applications in human health and nutrition
Cornish, M. L., & Garbary, D. J. (2010) · ALGAE · doi:10.4490/algae.2010.25.4.155 · Cited by 290 · cited 12×
“The detected antioxidant compounds in algae from these genera and others have potential anti-aging, dietary, anti-inflammatory, antibacterial, antifungal, cytotoxic, anti-malarial, anti-proliferative, and anticancer properties [10,11].”
BackgroundInfluential
In vitro antioxidant and in vivo anti-inflammatory potential of crude polysaccharide from Turbinaria ornata (Marine Brown Alga)
Subash, A., Raghavendran, H. R. B., Sunil, A. G., Gayathri, V., Ramakrishnan, G., & Vasanthi, H. R. (2009) · Food and Chemical Toxicology · doi:10.1016/j.fct.2009.09.036 · Cited by 281 · cited 2×
“ornata from India have also been shown to possess significant antioxidant activity [16,17].”
Background
ChemInform Abstract: Marine Natural Products
Faulkner, D. J. (1995) · ChemInform · doi:10.1002/chin.199504291 · Cited by 272
Antioxidant activities in tropical marine macroalgae from the Yucatan Peninsula, Mexico
Zubia, M., Robledo, D., & Freile‐Pelegrín, Y. (2007) · Journal of Applied Phycology · doi:10.1007/s10811-006-9152-5 · Cited by 262
Fucoxanthin induces apoptosis in human leukemia HL-60 cells through a ROS-mediated Bcl-xL pathway
Kim, K., Heo, S., Kang, S., Ahn, G., & Jeon, Y. (2010) · Toxicology in Vitro · doi:10.1016/j.tiv.2010.05.023 · Cited by 213 · cited 1×
“This unique carotenoid was found to possess potent anti-inflammatory, anticancer, anti-obese, anti-diabetic, anti-angiogenic, anti-malarial, and antioxidant activities, as well as protective effects on the liver, blood vessels of the brain, bones, skin, and eyes, including chemoprevention of a variety of diseases incl…”
Background
Polysaccharides from Turbinaria conoides: Structural features and antioxidant capacity
Chattopadhyay, N., Ghosh, T., Sinha, S., Chattopadhyay, K., Karmakar, P., & Ray, B. (2009) · Food Chemistry · doi:10.1016/j.foodchem.2009.05.069 · Cited by 176 · cited 3×
“conoides’ antioxidant activity have been isolated and identified as fucoidan, laminaran, and alginate [18].”
Background
Seaweed carotenoid, fucoxanthin, as a multi-functional nutrient.
Maeda, H., Tsukui, T., Sashima, T., Hosokawa, M., & Miyashita, K. (2008) · PubMed · Cited by 149
Antiangiogenic Activity of Brown Algae Fucoxanthin and Its Deacetylated Product, Fucoxanthinol
Sugawara, T., Matsubara, K., Akagi, R., Mori, M., & Hirata, T. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf062204q · Cited by 148
Antioxidative properties of brown algae polyphenolics and their perspectives as chemopreventive agents against vascular risk factors
Kang, K., Park, Y.-J., Hwang, H. J., Kim, S. H., Lee, J. G., & Shin, H. (2003) · Archives of Pharmacal Research · doi:10.1007/bf02976957 · Cited by 142 · cited 1×
“[30] have shown that polyphenols are the major antioxidants in several species of Korean brown algae.”
Background
Marine Green and Brown Algae of the Hawaiian Islands
Abbott, I. A., & Huisman, J. M. (2004) · Cited by 135
Comparative effects of β-carotene and fucoxanthin on retinol deficiency induced oxidative stress in rats
Sangeetha, R. K., Bhaskar, N., & Baskaran, V. (2009) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-009-0145-y · Cited by 126 · cited 1×
“This unique carotenoid was found to possess potent anti-inflammatory, anticancer, anti-obese, anti-diabetic, anti-angiogenic, anti-malarial, and antioxidant activities, as well as protective effects on the liver, blood vessels of the brain, bones, skin, and eyes, including chemoprevention of a variety of diseases incl…”
Background
Chemical structure and antiviral activity of the sulfated heterorhamnan isolated from the green seaweed Gayralia oxysperma
Cassolato, J. E. F., Noseda, M. D., Pujol, C. A., Pellizzari, F., Damonte, E. B., & Duarte, M. E. R. (2008) · Carbohydrate Research · doi:10.1016/j.carres.2008.09.014 · Cited by 124 · cited 1×
“oxysperma reported here, combined with its known antiviral and anticoagulant activities [32,33], as well as its high caloric value [14], makes it a potential valuable natural resource for the pharmaceutical, medicine, food, and aquaculture industries worthy of further research.”
Background
Vegetables antioxidant losses during industrial processing and refrigerated storage
Murcia, M. A., Jiménez, A. M., & Martínez‐Tomé, M. (2009) · Food Research International · doi:10.1016/j.foodres.2009.04.012 · Cited by 90 · cited 1×
“months of storage has been reported [35].”
Structural characterization of an anticoagulant-active sulfated polysaccharide isolated from green alga Monostroma latissimum
Li, H., Mao, W., Zhang, X., Qi, X., Chen, Y., Chen, Y., Xu, J. F., Zhao, C., Hou, Y., Yang, Y., et al. (2011) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2011.02.042 · Cited by 89
Antioxidant Activities of Chlorophyta and Phaeophyta from Jeju Island
Heo, S., Cha, S.-H., Lee, K.-W., Cho, S.-M. K., & Jeon, Y.-J. (2005) · ALGAE · doi:10.4490/algae.2005.20.3.251 · Cited by 68 · cited 1×
“Gayralia nitidum (formerly Monostroma nitidum) from Jeju Island, Korea has been reported to show antioxidant activity [28].”
Background
Cancer chemoprevention by natural carotenoids and their related compounds
Nishino, H. (1995) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240590829 · Cited by 62 · cited 1×
“This unique carotenoid was found to possess potent anti-inflammatory, anticancer, anti-obese, anti-diabetic, anti-angiogenic, anti-malarial, and antioxidant activities, as well as protective effects on the liver, blood vessels of the brain, bones, skin, and eyes, including chemoprevention of a variety of diseases incl…”
Background
In Vitro Antioxidant and Antimicrobial Activities of Two Hawaiian Marine Limu : Ulva fasciata (Chlorophyta) and Gracilaria salicornia (Rhodophyta)
VIJAYAVEL, K., & Martinez, J. A. (2010) · Journal of Medicinal Food · doi:10.1089/jmf.2009.0287 · Cited by 53 · cited 2×
“The overall aim of this type of research is discovery of compounds and/or extracts that can counteract free radical-induced and other oxidative stress processes, and in so doing decrease the incidence of human diseases directly related to these processes [9].”
Background
Screening for antioxygenic compounds in marine algae and bromophenols as effective principles in a red alga Polysiphonia ulceolate.
Fujimoto, K., Ohmura, H., & Kaneda, T. (1985) · NIPPON SUISAN GAKKAISHI · doi:10.2331/suisan.51.1139 · Cited by 31
Hawaiian Reef Plants
Huisman, J. M., Abbott, I. A., & Smith, C. M. (2007) · Murdoch University Research Portal · Cited by 30
Acutilols, potent herbivore feeding deterrents from the tropical brown alga, Dictyota acutiloba
Hardt, I. H., Fenical, W., Cronin, G., & Hay, M. E. (1996) · Phytochemistry · doi:10.1016/0031-9422(96)00221-x · Cited by 24 · cited 1×
“The tropical brown alga, Dictyota acutiloba, from Kauai Island was shown to contain a compound with potent antiherbivore activity [15].”
Background
Antioxidant efficacy of extracts from a variety of seaweeds in a cellular system
Kim, Y. A., Kong, C. S., Um, Y. R., Lee, J. I., Nam, T., & Seo, Y. (2008) · Ocean Science Journal · doi:10.1007/bf03022429 · Cited by 22 · cited 1×
“flabelliformis have been found to exhibit antioxidant activity [37].”
Background
Seaweed polysaccharides with anticancer potential
Wang, H., Chiu, L. C. M., Ooi, V. E. C., & Ang, P. O. (2008) · Botanica Marina · doi:10.1515/bot.2008.041 · Cited by 18 · cited 1×
“clathratus inhibited the growth of human and monkey cancer cells, suppressed tumors, and demonstrated antioxidant activity [29].”
Background
Prevention of endothelial dysfunction in streptozotocin-induced diabetic rats by Sargassum echinocarpum extract
Firdaus, M., Astawan, M., Muchtadi, D., Wresdiyati, T., Waspadji, S., & Karyono, S. S. (2010) · Medical Journal of Indonesia · doi:10.13181/mji.v19i1.382 · Cited by 17 · cited 1×
“not unlikely that its extract could have pharmaceutical and medicinal applications, as already evidenced by extracts of non-Hawaiian species being reported to ameliorate oxidative stress and reverse endothelial dysfunction in diabetic rats [31].”
Background
PHYTOCHEMICAL CHARACTERIZATION AND ANTIMICROBIAL EFFICIENCY OF SEAWEED SAMPLES, ULVA FASCIATA AND CHAETOMORPHA ANTENNINA.
Dhasarathan, P., & Theriappan, P. (2011) · International Journal of Pharma and Bio Sciences · Cited by 13

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Authors: Kelman, D., Posner, E. K., McDermid, K. J., Tabandera, N. K., Wright, P. R., & Wright, A. D.
Affiliations: University of Hawaii at Hilo (US)
University of Freiburg (DE)
Corresponding author: Wright, Anthony D.
ORCID: McDermid, Karla J.
Wright, Patrick R.
Venue: Marine Drugs
Publisher: MDPI AG
Published: 2012-02-15
Volume: 10
Issue: 2
Pages: 403-416
ISSN: 1660-3397 (ISSN-L)
DOI: 10.3390/md10020403
PMC: PMC3297004
OpenAlex: W2079779859
Cited by: 250
References: 43
Citations by year: 2026: 8 · 2025: 13 · 2024: 12 · 2023: 22 · 2022: 30 · 2021: 24 · 2020: 30 · 2019: 23 · 2018: 21 · 2017: 13 · 2016: 9 · 2015: 13 · 2014: 12 · 2013: 16 · 2012: 4
FWCI: 21.08
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/3.0/ (vor)
Locations: Marine Drugs (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Physical Sciences › Earth and Planetary Sciences › Oceanography › Marine and coastal plant biology
Keywords: antioxidant activity, marine algae, Turbinaria ornata, fucoxanthin, carotenoids, bioassay-guided fractionation, oxidative damage, chemoprevention, natural antioxidants
MeSH terms: Phaeophyceae, Chlorophyta, Rhodophyta, Antioxidants, Hawaii, Pacific Ocean, Species Specificity, Xanthophylls, Drug Discovery

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Antioxidant Activity of Hawaiian Marine Algae

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