Protective Effect of Sulfated Polysaccharides from Celluclast-Assisted Extract of Hizikia fusiforme Against Ultraviolet B-Induced Skin Damage by Regulating NF-κB, AP-1, and MAPKs Signaling Pathways In Vitro in Human Dermal Fibroblasts
Open accessAbstract
Our previous study evaluated the antioxidant activities of sulfated polysaccharides from Celluclast-assisted extract of Hizikia fusiforme (HFPS) in vitro in Vero cells and in vivo in zebrafish. The results showed that HFPS possesses strong antioxidant activity and suggested the potential photo-protective activities of HFPS. Hence, in the present study, we investigated the protective effects of HFPS against ultraviolet (UV) B-induced skin damage in vitro in human dermal fibroblasts (HDF cells). The results indicate that HFPS significantly reduced intracellular reactive oxygen species (ROS) level and improved the viability of UVB-irradiated HDF cells in a dose-dependent manner. Furthermore, HFPS significantly inhibited intracellular collagenase and elastase activities, remarkably protected collagen synthesis, and reduced matrix metalloproteinases (MMPs) expression by regulating nuclear factor kappa B (NF-κB), activator protein 1 (AP-1), and mitogen-activated protein kinases (MAPKs) signaling pathways in UVB-irradiated HDF cells. These results suggest that HFPS possesses strong UV protective effect, and can be a potential ingredient in the pharmaceutical and cosmetic industries.
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Polysaccharides inhibit collagen degradation by inhibiting the expression of MMP-1 and MMP-9, maintaining a stable collagen ratio, repairing skin structure, and maintaining skin moisture content.
“Finally, polysaccharides inhibit collagen degradation by inhibiting the expression of enzymes such as MMP–1 and MMP–9, maintaining a stable collagen ratio, repairing skin structure, and maintaining skin moisture content [116,117,118,119,120,121].”
From Diet and Skin Aging—From the Perspective of Food Nutrition (2020) · cites this paper as [117]
Polysaccharides such as agaric polysaccharides, Lycium polysaccharides, algal polysaccharides, lingzhi polysaccharides, and mushroom polysaccharides alleviate skin aging.
“Polysaccharides such as agaric polysaccharides, Lycium polysaccharides, algal polysaccharides, lingzhi polysaccharides, and mushroom polysaccharides have been found to alleviate skin aging.”
From Diet and Skin Aging—From the Perspective of Food Nutrition (2020) · cites this paper as [117]
Oral polysaccharides regulate the expression of Bcl-2, Bax, and Caspase-3 by activating Nrf2/ARE and other pathways, and inhibit apoptosis.
“They regulate the expression of Bcl–2, Bax, and Caspase–3 by activating Nrf2/ARE and other pathways, and inhibit apoptosis.”
From Diet and Skin Aging—From the Perspective of Food Nutrition (2020) · cites this paper as [117]
Oral polysaccharides enhance skin antioxidant enzyme activity, remove ROS, and reduce oxidative damage.
“Mechanistically, oral polysaccharides enhance skin antioxidant enzyme activity, remove ROS, and reduce oxidative damage.”
From Diet and Skin Aging—From the Perspective of Food Nutrition (2020) · cites this paper as [117]
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- Authors
- Wang, L., Lee, W., Oh, J. Y., Cui, Y. R., Ryu, B., & Jeon, Y.-J.
- Affiliations
- Jeju National University (KR)
- Nakdonggang National Institute of Biological Resources (KR)
- Corresponding author
- Ryu, BoMi
- Jeon, You-Jin
- Venue
- Marine Drugs
- Publisher
- MDPI AG
- Published
- 2018-07-17
- Volume
- 16
- Issue
- 7
- Pages
- 239
- ISSN
- 1660-3397 (ISSN-L)
- PMC
- PMC6071090
- OpenAlex
- W2884733982
- Cited by
- 141
- References
- 49
- Citations by year
- 2026: 11 · 2025: 11 · 2024: 40 · 2023: 13 · 2022: 17 · 2021: 18 · 2020: 19 · 2019: 12
- FWCI
- 13.25
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Marine Drugs (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Jeju National University
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Health Sciences › Medicine › Pharmacology › Fungal Biology and Applications
- Keywords
- sulfated polysaccharides, Hizikia fusiformis, UV-B radiation, human dermal fibroblasts, reactive oxygen species, collagen synthesis, matrix metalloproteinases, NF-κB signaling, AP-1 signaling, MAPK signaling, antioxidant activity, marine algae
- MeSH terms
- Cell Line, Fibroblasts, Humans, Pancreatic Elastase, Plant Extracts, Polysaccharides, Skin, Ultraviolet Rays, Signal Transduction, Skin Aging, NF-kappa B, Collagenases, Reactive Oxygen Species, Transcription Factor AP-1, Protective Agents, Matrix Metalloproteinases, Mitogen-Activated Protein Kinases, Sargassum
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