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Chitosan Based Polyelectrolyte Complexes as Potential Carrier Materials in Drug Delivery Systems

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Hamman, Josias H.·2010·Marine Drugs
DOI 10.3390/md8041305
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Abstract

Chitosan has been the subject of interest for its use as a polymeric drug carrier material in dosage form design due to its appealing properties such as biocompatibility, biodegradability, low toxicity and relatively low production cost from abundant natural sources. However, one drawback of using this natural polysaccharide in modified release dosage forms for oral administration is its fast dissolution rate in the stomach. Since chitosan is positively charged at low pH values (below its pKa value), it spontaneously associates with negatively charged polyions in solution to form polyelectrolyte complexes. These chitosan based polyelectrolyte complexes exhibit favourable physicochemical properties with preservation of chitosan’s biocompatible characteristics. These complexes are therefore good candidate excipient materials for the design of different types of dosage forms. It is the aim of this review to describe complexation of chitosan with selected natural and synthetic polyanions and to indicate some of the factors that influence the formation and stability of these polyelectrolyte complexes. Furthermore, recent investigations into the use of these complexes as excipients in drug delivery systems such as nano- and microparticles, beads, fibers, sponges and matrix type tablets are briefly described.

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Cited by

Metadata

Authors
Hamman, J. H.
Venue
Marine Drugs
Publisher
MDPI AG
Published
2010-04-19
Volume
8
Issue
4
Pages
1305-1322
ISSN
1660-3397 (ISSN-L)
DOI
10.3390/md8041305
OpenAlex
W2072018844
Cited by
569
References
0
FWCI
17.68
Type
journal article
Language
en
Open access
gold
Licence
creativecommons.org/licenses/by/3.0/ (vor)

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