The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
A Historical Overview of Natural Products in Drug Discovery
Open accessAbstract
Historically, natural products have been used since ancient times and in folklore for the treatment of many diseases and illnesses. Classical natural product chemistry methodologies enabled a vast array of bioactive secondary metabolites from terrestrial and marine sources to be discovered. Many of these natural products have gone on to become current drug candidates. This brief review aims to highlight historically significant bioactive marine and terrestrial natural products, their use in folklore and dereplication techniques to rapidly facilitate their discovery. Furthermore a discussion of how natural product chemistry has resulted in the identification of many drug candidates; the application of advanced hyphenated spectroscopic techniques to aid in their discovery, the future of natural product chemistry and finally adopting metabolomic profiling and dereplication approaches for the comprehensive study of natural product extracts will be discussed.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Natural products as sources of new drugs over the last 25 years
Newman, D. J., & Cragg, G. M. (2007) · Journal of Natural Products · doi:10.1021/np068054v · Cited by 5,517
The role of natural product chemistry in drug discovery
Butler, M. S. (2004) · Journal of Natural Products · doi:10.1021/np040106y · Cited by 1,381
The influence of natural products upon drug discovery (Antiquity to late 1999)
Newman, D. J., Cragg, G. M., & Snader, K. M. (2000) · Natural Product Reports · doi:10.1039/a902202c · Cited by 1,293
Further Observations on Penicillin
Abraham, E. P., Chain, E., Fletcher, C. M., Gardner, A. D., Heatley, N. G., Jennings, M. A., & Florey, H. W. (1941) · The Lancet · doi:10.1016/s0140-6736(00)72122-2 · Cited by 821
Trimurtulu, G., Ohtani, I., Patterson, G. M. L., Moore, R. E., Corbett, T. H., Valeriote, F. A., & Demchik, L. (1994) · Journal of the American Chemical Society · doi:10.1021/ja00090a020 · Cited by 303
Ethnopharmacology and systems biology: A perfect holistic match
Verpoorte, R., Choi, Y. H., & Kim, H. K. (2005) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2005.05.033 · Cited by 296 · cited 1×
“Ultimately this enables the construction of a complex database of the metabolome [154–156].”
BackgroundYotsu-Yamashita, M., Haddock, R. L., & Yasumoto, T. (1993) · Journal of the American Chemical Society · doi:10.1021/ja00056a048 · Cited by 125
Cited by
Essential oils as antimicrobials in food systems – A review
Calo, J. R., Crandall, P. G., O'Bryan, C. A., & Ricke, S. C. (2015) · Food Control · doi:10.1016/j.foodcont.2014.12.040 · Cited by 1,140
Dynamic modulation of the gut microbiota and metabolome by bacteriophages in a mouse model
Hsu, B. B., Gibson, T. E., Yeliseyev, V., Liu, Q., Lyon, L., Bry, L., Silver, P. A., & Gerber, G. K. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2019.05.001 · Cited by 573
Date Palm Tree (Phoenix dactylifera L.): Natural Products and Therapeutic Options
Al-Alawi, R. A., Al-Mashiqri, J. H., Al-Nadabi, J. S. M., Al-Shihi, B. I., & Baqi, Y. (2017) · Frontiers in Plant Science · doi:10.3389/fpls.2017.00845 · Cited by 336
Sartori, S. B., & Singewald, N. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.107402 · Cited by 236
Microalgae in modern cancer therapy: current knowledge
Abd El-Hack, M. E., Abdelnour, S., Alagawany, M., Abdo, M., Sakr, M. A., Khafaga, A. F., Mahgoub, S. A., Elnesr, S. S., & Gebriel, M. G. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.12.069 · Cited by 206
The use of plant extracts and their phytochemicals for control of toxigenic fungi and mycotoxins
Makhuvele, R., Naidu, K., Gbashi, S., Thipe, V. C., Adebo, O. A., & Njobeh, P. B. (2020) · Heliyon · doi:10.1016/j.heliyon.2020.e05291 · Cited by 176
Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants
van Breemen, R. B., Muchiri, R. N., Bates, T. A., Weinstein, J. B., Leier, H. C., Farley, S., & Tafesse, F. G. (2022) · Journal of Natural Products · doi:10.1021/acs.jnatprod.1c00946 · Cited by 135
Nanotechnology for delivery of natural therapeutic substances: a review
Saka, R., & Chella, N. (2021) · Environmental Chemistry Letters · doi:10.1007/s10311-020-01103-9 · Cited by 74
Lone, S. A., Khan, S., & Ahmad, A. (2020) · Archives of Microbiology · doi:10.1007/s00203-019-01781-2 · Cited by 32
Molimau-Samasoni, S., Woolner, V. H., Foliga, S. T., Robichon, K., Patel, V., Andreassend, S. K., Sheridan, J. P., Te Kawa, T., Gresham, D., Miller, D., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2100880118 · Cited by 20
Dumitru, C. N., Mariana, L., Budacu, C. C., Mitea, G., Radu, M. D., Dumitru, A. O., Lupoae, A., Tatu, A., & Topor, G. (2025) · Dentistry Journal · doi:10.3390/dj13050222 · Cited by 17
Wallen-Russell, C., Pearlman, N., Wallen-Russell, S., Cretoiu, D., Thompson, D. C., & Voinea, S. C. (2023) · Microorganisms · doi:10.3390/microorganisms11112784 · Cited by 14
Metadata
- Authors
- Dias, D. A., Urban, S., & Roessner, U.
- Venue
- Metabolites
- Publisher
- MDPI AG
- Published
- 2012-04-16
- Volume
- 2
- Issue
- 2
- Pages
- 303-336
- ISSN
- 2218-1989 (ISSN-L)
- OpenAlex
- W2033588393
- Cited by
- 1,958
- References
- 7
- FWCI
- 21.68
- Type
- journal article
- Language
- en
- Open access
- gold
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
