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Propionibacterium acnes Strain Populations in the Human Skin Microbiome Associated with Acne

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Fitz-Gibbon, Sorel, Tomida, Shuta, Chiu, Bor-Han, Nguyen, Lin, Du, Christine, Liu, Minghsun, Elashoff, David, Erfe, Marie C., Loncaric, Anya, Kim, Jenny, Modlin, Robert L., Miller, Jeff F., Sodergren, Erica, Craft, Noah, Weinstock, George M., Li, Huiying·2013·Journal of Investigative Dermatology
DOI 10.1038/jid.2013.21
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Abstract

The human skin microbiome plays important roles in skin health and disease. However, bacterial population structure and diversity at the strain level is poorly understood. We compared the skin microbiome at the strain level and genome level of Propionibacterium acnes, a dominant skin commensal, between 49 acne patients and 52 healthy individuals by sampling the pilosebaceous units on their noses. Metagenomic analysis demonstrated that while the relative abundances of P. acnes were similar, the strain population structures were significantly different in the two cohorts. Certain strains were highly associated with acne and other strains were enriched in healthy skin. By sequencing 66 previously unreported P. acnes strains and comparing 71 P. acnes genomes, we identified potential genetic determinants of various P. acnes strains in association with acne or health. Our analysis suggests that acquired DNA sequences and bacterial immune elements may play roles in determining virulence properties of P. acnes strains and some could be future targets for therapeutic interventions. This study demonstrates a previously unreported paradigm of commensal strain populations that could explain the pathogenesis of human diseases. It underscores the importance of strain level analysis of the human microbiome to define the role of commensals in health and disease.

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Research works printed but not linked: 39

  1. Bek-Thomsen, 2008, Acne is not associated with yet-uncultured bacteria, J Clin Microbiol, 46, 3355, 10.1128/JCM.00799-08 · DOI
  2. Bik, 2010, Bacterial diversity in the oral cavity of 10 healthy individuals, ISME J, 4, 962, 10.1038/ismej.2010.30 · DOI · Paper page
  3. Bojar, 2004, Acne and Propionibacterium acnes, Clin Dermatol, 22, 375, 10.1016/j.clindermatol.2004.03.005 · DOI · Paper page
  4. Borodovsky, 1993, Recognition of genes in DNA sequence with ambiguities, Biosystems, 30, 161, 10.1016/0303-2647(93)90068-N · doi:10.1016/0303-2647(93)90068-n
  5. Bruggemann, 2004, The complete genome sequence of Propionibacterium acnes, a commensal of human skin, Science, 305, 671, 10.1126/science.1100330 · DOI · Paper page
  6. Chase-Topping, 2008, Super-shedding and the link between human infection and livestock carriage of Escherichia coli O157, Nat Rev Microbiol, 6, 904, 10.1038/nrmicro2029 · DOI · Paper page
  7. Chen, 2010, Molecular analysis of repeated methicillin-resistant Staphylococcus aureus infections in children, PLoS One, 5, e14431, 10.1371/journal.pone.0014431 · DOI
  8. Coates, 2002, Prevalence of antibiotic-resistant propionibacteria on the skin of acne patients: 10-year surveillance data and snapshot distribution study, Br J Dermatol, 146, 840, 10.1046/j.1365-2133.2002.04690.x · DOI · Paper page
  9. Cogen, 2008, Skin microbiota: a source of disease or defence?, Br J Dermatol, 158, 442, 10.1111/j.1365-2133.2008.08437.x · DOI · Paper page
  10. Cunliffe, 2002, Looking back to the future - acne, Dermatology, 204, 167, 10.1159/000057876 · DOI
  11. Dominguez-Bello, 2010, Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns, Proc Natl Acad Sci USA, 107, 11971, 10.1073/pnas.1002601107 · DOI · Paper page
  12. Dreno, 2011, Development and evaluation of a Global Acne Severity Scale (GEA Scale) suitable for France and Europe, J Eur Acad Dermatol Venereol, 25, 43, 10.1111/j.1468-3083.2010.03685.x · DOI · Paper page
  13. Dreno, 2001, Erythromycin-resistance of cutaneous bacterial flora in acne, Eur J Dermatol, 11, 549
  14. Ewing, 1998, Base-calling of automated sequencer traces using phred. I. Accuracy assessment, Genome Res, 8, 175, 10.1101/gr.8.3.175 · DOI · Paper page
  15. Fierer, 2008, The influence of sex, handedness, and washing on the diversity of hand surface bacteria, Proc Natl Acad Sci USA, 105, 17994, 10.1073/pnas.0807920105 · DOI · Paper page
  16. Fuller, 2002, Identification of a streptolysin S-associated gene cluster and its role in the pathogenesis of Streptococcus iniae disease, Infect Immun, 70, 5730, 10.1128/IAI.70.10.5730-5739.2002 · DOI
  17. Gao, 2007, Molecular analysis of human forearm superficial skin bacterial biota, Proc Natl Acad Sci USA, 104, 2927, 10.1073/pnas.0607077104 · DOI · Paper page
  18. Gordon, 1998, Consed: a graphical tool for sequence finishing, Genome Res, 8, 195, 10.1101/gr.8.3.195 · DOI · Paper page
  19. Grice, 2009, Topographical and temporal diversity of the human skin microbiome, Science, 324, 1190, 10.1126/science.1171700 · DOI · Paper page
  20. Grissa, 2007, CRISPRFinder: a web tool to identify clustered regularly interspaced short palindromic repeats, Nucleic Acids Res, 35, W52, 10.1093/nar/gkm360 · DOI · Paper page
  21. Haas, 2011, Chimeric 16S rRNA sequence formation and detection in Sanger and 454-pyrosequenced PCR amplicons, Genome Res, 21, 494, 10.1101/gr.112730.110 · DOI · Paper page
  22. Hansra, 2011, Cutaneous community-acquired and hospital-acquired methicillin-resistant Staphylococcus aureus, Dermatol Ther, 24, 263, 10.1111/j.1529-8019.2011.01402.x · DOI
  23. Hinnebusch, 1993, Linear plasmids and chromosomes in bacteria, Mol Microbiol, 10, 917, 10.1111/j.1365-2958.1993.tb00963.x · DOI · Paper page
  24. Horvath, 2010, CRISPR/Cas, the immune system of bacteria and archaea, Science, 327, 167, 10.1126/science.1179555 · DOI · Paper page
  25. Humar, 2002, Streptolysin S and necrotising infections produced by group G streptococcus, Lancet, 359, 124, 10.1016/S0140-6736(02)07371-3 · doi:10.1016/s0140-6736(02)07371-3
  26. Kachlany, 2000, Nonspecific adherence by Actinobacillus actinomycetemcomitans requires genes widespread in bacteria and archaea, J Bacteriol, 182, 6169, 10.1128/JB.182.21.6169-6176.2000 · DOI · Paper page
  27. Leyden, 2001, The evolving role of Propionibacterium acnes in acne, Semin Cutan Med Surg, 20, 139, 10.1053/sder.2001.28207 · DOI
  28. Lomholt, 2010, Population genetic analysis of Propionibacterium acnes identifies a subpopulation and epidemic clones associated with acne, PLoS One, 5, e12277, 10.1371/journal.pone.0012277 · DOI · Paper page
  29. Makarova, 2011, Evolution and classification of the CRISPR-Cas systems, Nat Rev Microbiol, 9, 467, 10.1038/nrmicro2577 · DOI · Paper page
  30. McDowell, 2011, A novel multilocus sequence typing scheme for the opportunistic pathogen Propionibacterium acnes and characterization of type I cell surface-associated antigens, Microbiology, 157, 1990, 10.1099/mic.0.049676-0 · DOI
  31. Nizet, 2000, Genetic locus for streptolysin S production by group A streptococcus, Infect Immun, 68, 4245, 10.1128/IAI.68.7.4245-4254.2000 · DOI · Paper page
  32. Ross, 1998, 16S rRNA mutation associated with tetracycline resistance in a gram-positive bacterium, Antimicrob Agents Chemother, 42, 1702, 10.1128/AAC.42.7.1702 · DOI · Paper page
  33. Ross, 2001, Phenotypic and genotypic characterization of antibiotic-resistant Propionibacterium acnes isolated from acne patients attending dermatology clinics in Europe, the U.S.A., Japan and Australia, Br J Dermatol, 144, 339, 10.1046/j.1365-2133.2001.03956.x · DOI
  34. Schreiner, 2003, Tight-adherence genes of Actinobacillus actinomycetemcomitans are required for virulence in a rat model, Proc Natl Acad Sci USA, 100, 7295, 10.1073/pnas.1237223100 · DOI · Paper page
  35. Tamura, 2007, MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0, Mol Biol Evol, 24, 1596, 10.1093/molbev/msm092 · DOI · Paper page
  36. Tarr, 2005, Shiga-toxin-producing Escherichia coli and haemolytic uraemic syndrome, Lancet, 365, 1073
  37. Webster, 1995, Inflammation in acne vulgaris, J Am Acad Dermatol, 33, 247, 10.1016/0190-9622(95)90243-0 · DOI
  38. White, 1998, Recent findings in the epidemiologic evidence, classification, and subtypes of acne vulgaris, J Am Acad Dermatol, 39, S34, 10.1016/S0190-9622(98)70442-6 · DOI · Paper page
  39. Zerbino, 2008, Velvet: algorithms for de novo short read assembly using de Bruijn graphs, Genome Res, 18, 821, 10.1101/gr.074492.107 · DOI · Paper page

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Metadata

Authors
Fitz-Gibbon, S., Tomida, S., Chiu, B.-H., Nguyen, L., Du, C., Liu, M., Elashoff, D., Erfe, M. C., Loncaric, A., Kim, J., Modlin, R. L., Miller, J. F., Sodergren, E., Craft, N., Weinstock, G. M., & Li, H.
Venue
Journal of Investigative Dermatology
Publisher
Elsevier BV
Published
2013-09
Volume
133
Issue
9
Pages
2152-2160
ISSN
0022-202X (ISSN-L)
DOI
10.1038/jid.2013.21
OpenAlex
W2015156802
Cited by
775
References
8
FWCI
46.03
Type
journal article
Language
en
Open access
bronze
Licence

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CoChat. (2026). Citation check: Propionibacterium acnes Strain Populations in the Human Skin Microbiome Associated with Acne. https://app.cochat.ai/papers/10.1038/jid.2013.21
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Fitz-Gibbon, S., Tomida, S., Chiu, B.-H., Nguyen, L., Du, C., Liu, M., Elashoff, D., Erfe, M. C., Loncaric, A., Kim, J., Modlin, R. L., Miller, J. F., Sodergren, E., Craft, N., Weinstock, G. M., & Li, H. (2013). Propionibacterium acnes Strain Populations in the Human Skin Microbiome Associated with Acne. Journal of Investigative Dermatology. https://doi.org/10.1038/jid.2013.21

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