The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Cannabinoid Delivery Systems for Pain and Inflammation Treatment
Open accessAbstract
There is a growing body of evidence to suggest that cannabinoids are beneficial for a range of clinical conditions, including pain, inflammation, epilepsy, sleep disorders, the symptoms of multiple sclerosis, anorexia, schizophrenia and other conditions. The transformation of cannabinoids from herbal preparations into highly regulated prescription drugs is therefore progressing rapidly. The development of such drugs requires well-controlled clinical trials to be carried out in order to objectively establish therapeutic efficacy, dose ranges and safety. The low oral bioavailability of cannabinoids has led to feasible methods of administration, such as the transdermal route, intranasal administration and transmucosal adsorption, being proposed. The highly lipophilic nature of cannabinoids means that they are seen as suitable candidates for advanced nanosized drug delivery systems, which can be applied via a range of routes. Nanotechnology-based drug delivery strategies have flourished in several therapeutic fields in recent years and numerous drugs have reached the market. This review explores the most recent developments, from preclinical to advanced clinical trials, in the cannabinoid delivery field, and focuses particularly on pain and inflammation treatment. Likely future directions are also considered and reported.
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Citations
Cites
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“an unmet clinical need, where adequate pain relief is obtained using drugs with adverse effects on central nervous system side [28].”
BackgroundCannabinoids for Medical Use: A Systematic Review and Meta-analysis
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Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome
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Cited by
Fischer, B., Robinson, T., Bullen, C., Curran, V., Jutras-Aswad, D., Medina-Mora, M. E., Pacula, R. L., Rehm, J., Room, R., Brink, W. V. D., et al. (2022) · International Journal of Drug Policy · doi:10.1016/j.drugpo.2021.103381 · Cited by 236
Cannabis sativa: Much more beyond Δ9-tetrahydrocannabinol
Alves, P., Amaral, C., Teixeira, N., & Correia-da-Silva, G. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104822 · Cited by 135
Hemp seed (Cannabis sativa L.) enriched pasta: Physicochemical properties and quality evaluation
Teterycz, D., Sobota, A., Przygodzka, D., & Łysakowska, P. (2021) · PLOS ONE · doi:10.1371/journal.pone.0248790 · Cited by 79
Fairhurst, C., Kumar, R., Checketts, D., Tayo, B., & Turner, S. (2020) · Developmental Medicine & Child Neurology · doi:10.1111/dmcn.14548 · Cited by 53
Metadata
- Authors
- Bruni, N., Della Pepa, C., Oliaro-Bosso, S., Pessione, E., Gastaldi, D., & Dosio, F.
- Venue
- Molecules
- Publisher
- MDPI AG
- Published
- 2018-09-27
- Volume
- 23
- Issue
- 10
- Pages
- 2478
- ISSN
- 1420-3049 (ISSN-L)
- OpenAlex
- W2892769543
- Cited by
- 272
- References
- 26
- FWCI
- 14.61
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
