Melatonin prevents obesity through modulation of gut microbiota in mice

Xu, Pengfei; Wang, Jialin; Hong, Fan; Wang, Sheng; Jin, Xi; Xue, Tingting; Jia, Li; Zhai, Yonggong

doi:10.1111/jpi.12399

Cited by 282Gut microbiota and healthCircadian rhythm and melatoninRegulation of Appetite and Obesity

Melatonin prevents obesity through modulation of gut microbiota in mice

Xu, Pengfei, Wang, Jialin, Hong, Fan, Wang, Sheng, Jin, Xi, Xue, Tingting, Jia, Li, Zhai, Yonggong·2017·Journal of Pineal Research

DOI 10.1111/jpi.12399

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Abstract

Excess weight and obesity are severe public health threats worldwide. Recent evidence demonstrates that gut microbiota dysbiosis contributes to obesity and its comorbidities. The body weight‐reducing and energy balancing effects of melatonin have been reported in several studies, but to date, no investigations toward examining whether the beneficial effects of melatonin are associated with gut microbiota have been carried out. In this study, we show that melatonin reduces body weight, liver steatosis, and low‐grade inflammation as well as improving insulin resistance in high fat diet (HFD)‐fed mice. High‐throughput pyrosequencing of the 16S rRNA demonstrated that melatonin treatment significantly changed the composition of the gut microbiota in mice fed an HFD. The richness and diversity of gut microbiota were notably decreased by melatonin. HFD feeding altered 69 operational taxonomic units (OTU s) compare with a normal chow diet (NCD) group, and melatonin supplementation reversed 14 OTU s to the same configuration than those present in the NCD group, thereby impacting various functions, in particular through its ability to decrease the Firmicutes‐to‐Bacteroidetes ratio and increase the abundance of mucin‐degrading bacteria Akkermansia, which is associated with healthy mucosa. Taken together, our results suggest that melatonin may be used as a probiotic agent to reverse HFD‐induced gut microbiota dysbiosis and help us to gain a better understanding of the mechanisms governing the various melatonin beneficial effects.

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Different animal studies emphasize the beneficial effects of melatonin in obesity management.
“Different animal studies emphasize the beneficial effects of melatonin in the obesity management. 13-17”
From Melatonin supplementation improves glycemic hemostasis, lipid profile, and adipokine concentrations of obese women: A double-blind randomized clinical trial (2024) · cites this paper as [17]
Growing evidence showed that melatonin supplementation decreased weight in animals.
“Growing evidence showed that melatonin supplementation decreased weight in animals. 17,36-38”
From Melatonin supplementation improves glycemic hemostasis, lipid profile, and adipokine concentrations of obese women: A double-blind randomized clinical trial (2024) · cites this paper as [17]

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Balancing Herbal Medicine and Functional Food for Prevention and Treatment of Cardiometabolic Diseases through Modulating Gut Microbiota
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Melatonin protected cardiac microvascular endothelial cells against oxidative stress injury via suppression of IP3R-[Ca2+]c/VDAC-[Ca2+]m axis by activation of MAPK/ERK signaling pathway
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Melatonin alleviates weanling stress in mice: Involvement of intestinal microbiota
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Chitosan oligosaccharides improve the disturbance in glucose metabolism and reverse the dysbiosis of gut microbiota in diabetic mice
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Therapeutic potential of melatonin related to its role as an autophagy regulator: A review
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Melatonin mitigates aflatoxin B1‐induced liver injury via modulation of gut microbiota/intestinal FXR/liver TLR4 signaling axis in mice
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Circadian Rhythms, Disease and Chronotherapy
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Current Evidence on the Role of the Gut Microbiome in ADHD Pathophysiology and Therapeutic Implications
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Circadian rhythms and obesity: Timekeeping governs lipid metabolism
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Linking Obesity with Colorectal Cancer: Epidemiology and Mechanistic Insights
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Mitochondria: the birth place, battle ground and the site of melatonin metabolism in cells
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Melatonin mediates mucosal immune cells, microbial metabolism, and rhythm crosstalk: A therapeutic target to reduce intestinal inflammation
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Microbiota Features Associated With a High-Fat/Low-Fiber Diet in Healthy Adults
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Mechanisms of Melatonin in Obesity: A Review
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The opportunities and challenges of peroxisome proliferator-activated receptors ligands in clinical drug discovery and development
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Melatonin ameliorates ochratoxin A induced liver inflammation, oxidative stress and mitophagy in mice involving in intestinal microbiota and restoring the intestinal barrier function
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Akkermansia muciniphila alleviates <scp>high‐fat‐diet</scp> ‐related metabolic‐associated fatty liver disease by modulating gut microbiota and bile acids
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Neurodegenerative and Neurodevelopmental Diseases and the Gut-Brain Axis: The Potential of Therapeutic Targeting of the Microbiome
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Bioaerosol is an important transmission route of antibiotic resistance genes in pig farms
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Diammonium Glycyrrhizinate Protects against Nonalcoholic Fatty Liver Disease in Mice through Modulation of Gut Microbiota and Restoration of Intestinal Barrier
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Administration of Exogenous Melatonin Improves the Diurnal Rhythms of the Gut Microbiota in Mice Fed a High-Fat Diet
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Melatonin Signaling a Key Regulator of Glucose Homeostasis and Energy Metabolism
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Beneficial effects of flaxseed polysaccharides on metabolic syndrome via gut microbiota in high-fat diet fed mice
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Effect of melatonin supplementation on oxidative stress parameters: A systematic review and meta-analysis
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The Role of PPAR and Its Cross-Talk with CAR and LXR in Obesity and Atherosclerosis
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Impact of Melatonin on Skeletal Muscle and Exercise
Stacchiotti, A., Favero, G., & Rodella, L. F. (2020) · Cells · doi:10.3390/cells9020288 · Cited by 115 · see citing works
Melatonin Orchestrates Lipid Homeostasis through the Hepatointestinal Circadian Clock and Microbiota during Constant Light Exposure
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Melatonin Ameliorates Hepatic Ferroptosis in NAFLD by Inhibiting ER Stress via the MT2/cAMP/PKA/IRE1 Signaling Pathway
Guan, Q., Wang, Z., Hu, K., Cao, J., Dong, Y., & Chen, Y. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.85883 · Cited by 102 · see citing works
Tryptophan metabolites in depression: Modulation by gut microbiota
Lukić, I., Ivković, S., Mitić, M., & Adžić, M. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.987697 · Cited by 110 · see citing works
Eurotium cristatum , a potential probiotic fungus from Fuzhuan brick tea, alleviated obesity in mice by modulating gut microbiota
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One water-soluble polysaccharide from Ginkgo biloba leaves with antidepressant activities via modulation of the gut microbiome
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Melatonin Treatment Alleviates Spinal Cord Injury-Induced Gut Dysbiosis in Mice
Jing, Y., Yang, D., Bai, F., Zhang, C., Qin, C., Li, D., Wang, L., Yang, M., Chen, Z., & Li, J. (2019) · Journal of Neurotrauma · doi:10.1089/neu.2018.6012 · Cited by 87 · see citing works
Arabinoxylan Attenuates Type 2 Diabetes by Improvement of Carbohydrate, Lipid, and Amino Acid Metabolism
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Nutritional modulation of the intestinal microbiota; future opportunities for the prevention and treatment of neuroimmune and neuroinflammatory disease
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Melatonin Alleviates Neuroinflammation and Metabolic Disorder in DSS-Induced Depression Rats
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Melatonin controls microbiota in colitis by goblet cell differentiation and antimicrobial peptide production through Toll-like receptor 4 signalling
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The interaction of Akkermansia muciniphila with host-derived substances, bacteria and diets
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Punicic acid ameliorates obesity and liver steatosis by regulating gut microbiota composition in mice
Yuan, G., Tan, M., & Chen, X. (2021) · Food & Function · doi:10.1039/d1fo01152a · Cited by 76 · see citing works
Melatonin reduces intramuscular fat deposition by promoting lipolysis and increasing mitochondrial function
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Gut microbiota mediates the protective effects of dietary β‐hydroxy‐β‐methylbutyrate (HMB) against obesity induced by high‐fat diets
Duan, Y., Zhong, Y., Xiao, H., Zheng, C., Song, B., Wang, W., Guo, Q., Li, Y., Han, H. L., Gao, J., et al. (2019) · The FASEB Journal · doi:10.1096/fj.201900665rr · Cited by 75 · see citing works
Towards a comprehensive theory of obesity and a healthy diet: The causal role of oxidative stress in food addiction and obesity
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Increasing Nrf2 Activity as a Treatment Approach in Neuropsychiatry
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Melatonin alleviates titanium nanoparticles induced osteolysis via activation of butyrate/GPR109A signaling pathway
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Is there a relationship between intestinal microbiota, dietary compounds, and obesity?
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Gut microbiota: a potential manipulator for host adipose tissue and energy metabolism
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Effects of Chronic Intermittent Hypoxia and Chronic Sleep Fragmentation on Gut Microbiome, Serum Metabolome, Liver and Adipose Tissue Morphology
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Reduced delivery of epididymal adipocyte‐derived exosomal resistin is essential for melatonin ameliorating hepatic steatosis in mice
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Effects of in vitro digestion and fermentation of Nostoc commune Vauch. polysaccharides on properties and gut microbiota
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Intestinal Sulfation Is Essential to Protect Against Colitis and Colonic Carcinogenesis
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Glycolipid Metabolism and Metagenomic Analysis of the Therapeutic Effect of a Phenolics-Rich Extract from Noni Fruit on Type 2 Diabetic Mice
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Significance of Melatonin in the Regulation of Circadian Rhythms and Disease Management
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Melatonin supplementation in the management of obesity and obesity-associated disorders: A review of physiological mechanisms and clinical applications
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Melatonin in the colon modulates intestinal microbiota in response to stress and sleep deprivation
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Linking circadian rhythms to microbiome-gut-brain axis in aging-associated neurodegenerative diseases
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Melatonin, mitochondria, and the metabolic syndrome
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Effects of melatonin on cardiovascular risk factors and metabolic syndrome: a comprehensive review
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Gut microbiota mediates the effects of curcumin on enhancing Ucp1-dependent thermogenesis and improving high-fat diet-induced obesity
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Microbial-Derived Tryptophan Metabolites and Their Role in Neurological Disease: Anthranilic Acid and Anthranilic Acid Derivatives
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ApoE-Dependent Protective Effects of Sesamol on High-Fat Diet-Induced Behavioral Disorders: Regulation of the Microbiome-Gut–Brain Axis
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Seabuckthorn (Hippophaë rhamnoides) Freeze-Dried Powder Protects against High-Fat Diet-Induced Obesity, Lipid Metabolism Disorders by Modulating the Gut Microbiota of Mice
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Bacteriostatic Potential of Melatonin: Therapeutic Standing and Mechanistic Insights
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Anti-inflammatory effect of luteolin is related to the changes in the gut microbiota and contributes to preventing the progression from simple steatosis to nonalcoholic steatohepatitis
Sun, W., Yang, J., Dou, H.-Y., Li, G.-Q., Li, X., Shen, L., & Ji, H. (2021) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2021.104966 · Cited by 62 · see citing works
Progress of linking gut microbiota and musculoskeletal health: casualty, mechanisms, and translational values
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Da-Chai-Hu Decoction Ameliorates High Fat Diet-Induced Nonalcoholic Fatty Liver Disease Through Remodeling the Gut Microbiota and Modulating the Serum Metabolism
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DBZ is a putative PPARγ agonist that prevents high fat diet-induced obesity, insulin resistance and gut dysbiosis
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Regulation of gut microbiota and intestinal metabolites by Poria cocos oligosaccharides improves glycolipid metabolism disturbance in high-fat diet-fed mice
Zhu, L., Ye, C., Hu, B., Xia, H., Bian, Q., Liu, Y., Kong, M., Zhou, S., & Liu, H. (2022) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2022.109019 · Cited by 62 · see citing works
The effect of melatonin on treatment of patients with non-alcoholic fatty liver disease: a randomized double blind clinical trial
Bahrami, M., Cheraghpour, M., Jafarirad, S., Alavinejad, P., Asadi, F., Hekmatdoost, A., Mohammadi, M., & Yari, Z. (2020) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2020.102452 · Cited by 60 · see citing works
Circadian disruption-induced metabolic syndrome in mice is ameliorated by oat β-glucan mediated by gut microbiota
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Gut microbiota-derived melatonin from Puerariae Lobatae Radix-resistant starch supplementation attenuates ischemic stroke injury via a positive microbial co-occurrence pattern
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Melatonin promotes gut anti-oxidative status in perinatal rat by remodeling the gut microbiome
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Melatonin–Microbiome Two-Sided Interaction in Dysbiosis-Associated Conditions
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Gut microbiota contributes to bisphenol A-induced maternal intestinal and placental apoptosis, oxidative stress, and fetal growth restriction in pregnant ewe model by regulating gut-placental axis
Zhang, H., Zha, X., Zhang, B., Zheng, Y., Elsabagh, M., Wang, H., & Wang, M. (2024) · Microbiome · doi:10.1186/s40168-024-01749-5 · Cited by 60 · see citing works
Novel high‐docosahexaenoic‐acid tuna oil supplementation modulates gut microbiota and alleviates obesity in high‐fat diet mice
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Lactobacillus plantarum prevents obesity via modulation of gut microbiota and metabolites in high-fat feeding mice
Li, X., Huang, Y., Song, L., Xiao, Y., Lu, S., Xu, J., Li, J., & Ren, Z. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.104103 · Cited by 57 · see citing works
Pu-erh Tea Restored Circadian Rhythm Disruption by Regulating Tryptophan Metabolism
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Morchella esculenta mushroom polysaccharide attenuates diabetes and modulates intestinal permeability and gut microbiota in a type 2 diabetic mice model
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Rosa rugosa polysaccharide attenuates alcoholic liver disease in mice through the gut-liver axis
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Melatonin: Both a Messenger of Darkness and a Participant in the Cellular Actions of Non-Visible Solar Radiation of Near Infrared Light
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Propionate alleviates high-fat diet-induced lipid dysmetabolism by modulating gut microbiota in mice
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Effects of High-Fat Diet During Childhood on Precocious Puberty and Gut Microbiota in Mice
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Effects of Melatonin on Lipid Metabolism and Circulating Irisin in Sprague-Dawley Rats with Diet-Induced Obesity
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Melatonin as a Mediator of the Gut Microbiota–Host Interaction: Implications for Health and Disease
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Melatonin Promotes Cheliped Regeneration, Digestive Enzyme Function, and Immunity Following Autotomy in the Chinese Mitten Crab, Eriocheir sinensis
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Authors: Xu, P., Wang, J., Hong, F., Wang, S., Jin, X., Xue, T., Jia, L., & Zhai, Y.
Affiliations: Beijing Normal University (CN)
Beijing Key Laboratory of Gene Resource and Molecular Development College of Life Sciences Beijing Normal University Beijing China
Corresponding author: Zhai, Yonggong
ORCID: Xu, Pengfei
Wang, Jialin
Jin, Xi
Zhai, Yonggong
Venue: Journal of Pineal Research
Publisher: Wiley
Published: 2017-03-10
Volume: 62
Issue: 4
ISSN: 0742-3098 (ISSN-L)
1600-079X
DOI: 10.1111/jpi.12399
OpenAlex: W2587996254
Cited by: 281
References: 65
Citations by year: 2026: 9 · 2025: 17 · 2024: 28 · 2023: 36 · 2022: 48 · 2021: 51 · 2020: 36 · 2019: 27 · 2018: 21 · 2017: 8
FWCI: 10.28
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Pineal Research (publishedVersion)
PubMed (publishedVersion)
Funders: National Natural Science Foundation of China (31571164, 31271207)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords: melatonin, obesity, gut microbiota, dysbiosis, high-fat diet, body weight, hepatic steatosis, insulin resistance, low-grade inflammation, Akkermansia, Firmicutes/Bacteroidetes ratio, mucin-degrading bacteria, probiotics
MeSH terms: Firmicutes, Bacillota, Gastrointestinal Microbiome, Animals, Central Nervous System Depressants, Fatty Liver, Inflammation, Insulin Resistance, Male, Melatonin, Mice, Inbred C57BL, Obesity, Blotting, Western, Weight Gain, Glucose Intolerance, Probiotics, Bacteroidetes, Mice, Diet, High-Fat

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Melatonin prevents obesity through modulation of gut microbiota in mice

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