Analysis of Phenolic Compounds in Commercial Cannabis sativa L. Inflorescences Using UHPLC-Q-Orbitrap HRMS

The Abstract identifies four commercial C. sativa inflorescence cultivars, and Methods §3.2 says their samples were extracted with methanol. Results §2.3.1 reports phenolic contents in mg GAE/g, but the available passages give a range rather than an overall average of approximately 30 mg GAE/g. The comparison with the citing authors’ own results is not a finding attributed to this source. (LLM, conf=0.78)

Methods §3.1 lists all three compounds as analytical standards, and Results §2.2 reports measuring ferulic acid in the inflorescences. The passages available from our copy do not give the claimed averages of approximately 0.015, 0.015 and 0.023 mg/g; §2.2 instead specifies 19.7 mg/kg for ferulic acid in the Kompolti cultivar. They also do not establish a statistically significant difference from the citing study's values. (LLM, conf=0.78)

Section 2.2 identifies naringenin as a minor flavonoid detected in the analyzed Cannabis inflorescences, and Section 3.1 lists a naringenin standard used in the analysis. The passages in our copy do not give a naringenin concentration, so they do not substantiate the claimed 0.5–1.0 mg/kg level. (LLM, conf=0.84)

Section 2.2 reports cannflavin A and B in the analyzed hemp inflorescences at mean concentrations of 61.8 and 84.5 mg/kg, respectively, supporting that B was more abundant than A on average. The passages available from our copy do not give the claimed ranges of 20–130 and 12–215 mg/kg, or establish that B was the most abundant compound overall. (LLM, conf=0.82)

Section 2.2 reports cannabisin C as low as 0.003 mg/kg, cannabisin B at 0.4–0.5 mg/kg, and cannabisin A as generally more abundant. The stated upper limit does not match: the paper reports 2.86 mg/kg for cannabisin A, not 2.85 mg/kg. (LLM, conf=0.88)

Section 2.1 identifies kaempferol in Cannabis sativa inflorescence samples, and Section 2.2 says the flavonols were quantified. The passages in our copy do not give the claimed kaempferol range of 0.3–13.6 mg/kg or mean of about 5 mg/kg, so those figures are not verified. (LLM, conf=0.78)

Materials and Methods §3.1 lists luteolin-7-O-glucoside and apigenin-7-O-glucoside alongside luteolin and apigenin as analytical standards. Results and Discussion §2.2 says flavone glycosides and aglycones were quantified in the cannabis inflorescence samples, supporting their identification. The passages do not give their individual levels or establish that the glycosides were at levels comparable to luteolin and apigenin. (LLM, conf=0.78)

Section 2.2 reports flavonols in the assayed Cannabis inflorescences, and Section 3.1 lists quercetin among the analytical standards. The retrieved passages do not give the claimed 6.2–58.5 mg/kg range or approximately 16 mg/kg mean for quercetin; Section 2.2 instead gives different figures for the distinct compound quercetin-3-glucoside (page unavailable). (LLM, conf=0.82)

Section 2.2 reports catechin and epicatechin in the assayed Cannabis inflorescences, with mean concentrations of 53.3 and 66.2 mg/kg, respectively, broadly matching the cited approximations. It classifies them as flavanols, not dihydroflavonols, and the available passages do not substantiate the claimed concentration ranges. No page number is provided in our copy. (LLM, conf=0.88)

Section 2.1 identifies luteolin among the compounds analyzed, and Section 2.2 refers to cultivar-specific concentrations in Table 2. The passages available from our copy do not give luteolin means of 20 or 10 mg/kg; searches for luteolin and those concentrations did not retrieve the values. (LLM, conf=0.72)

Section 3.1 lists apigenin as an analytical standard, and Section 2.2 says flavonoid concentrations are reported in Table 2. The passages available from our copy do not give an apigenin mean; searches for apigenin and 6 mg/kg did not establish the claimed value. (LLM, conf=0.72)

The Results and Discussion (§2.2; page unavailable) says flavonoids were quantified across the cultivars, but the passages available from our copy do not give luteolin and apigenin concentrations or compare them. A search for both compounds found them listed as analytical standards in Materials and Methods (§3.1), not evidence that luteolin was more concentrated. (LLM, conf=0.70)