The DOI matches its Crossref record; 81 of the 81 references it cites were found in a registry or an index.
Health Benefits of Quercetin in Age-Related Diseases
Open accessAbstract
Polyphenols are the known group of phytochemicals that essentially consists of phenolic rings. These are the plant product present in varied fruits and vegetables. These secondary metabolites perform a protective function in plants from environmental and biological stress. When consumed as a human diet these are also known to prevent various age-associated diseases. Polyphenols are known to possess antioxidant properties and protect against oxidative stress. The literature survey was carried out using databases such as PubMed, Science direct and Springer. The research articles from last 10–12 years were selected for this review based on its relevancy with the topic. The articles selected was mainly focused on quercetin and its health benefits. The present review highlights the main functions of a flavonoid, quercetin. Quercetin is among the widely occurring polyphenol, found abundantly in nature. It is commonly present in different plant products. Onion is known to have the highest quantity of quercetin. This plant compound is possessed antioxidant properties and is considered to have a protective function against aging. It is known to be present in both free and conjugated forms. Quercetin has anti-oxidative, anti-inflammatory, anti-proliferative, anti-carcinogenic, anti-diabetic, and anti-viral properties. The molecule is lipophilic and can easily cross the BBB (Blood-Brain Barrier) and hence protects from neurodegenerative diseases. Various in vivo and in vitro studies have demonstrated the role of quercetin and here a detailed review of quercetin as a curative agent in neurodegeneration, diabetes, cancer, and inflammation has been carried out. Studies have proved that quercetin plays a crucial role in the prevention of age-related disorders. Quercetin is a potent antioxidant which is currently being used in various pharmaceuticals. Properties of quercetin can be further explored in various other disorders. Nanoformulations and liposomal formulations of quercetin can be made to treat other age associated diseases.
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Citations
Cites
Chemistry and biochemistry of dietary polyphenols
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Health effects of quercetin: From antioxidant to nutraceutical
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Oxidative Stress and Inflammation: What Polyphenols Can Do for Us?
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Quercetin, Inflammation and Immunity
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The Immunomodulatory and Anti-Inflammatory Role of Polyphenols
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Important Flavonoids and Their Role as a Therapeutic Agent
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Antioxidant Activities of Quercetin and Its Complexes for Medicinal Application
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Bioactivity of dietary polyphenols: The role of metabolites
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Cited by
Valotto Neto, L. J., Reverete de Araujo, M., Moretti Junior, R. C., Mendes Machado, N., Joshi, R. K., dos Santos Buglio, D., Barbalho Lamas, C., Direito, R., Fornari Laurindo, L., Tanaka, M., et al. (2024) · Antioxidants · doi:10.3390/antiox13040393 · Cited by 146
Battaglia-Vieni, A., Marchant, V., Tejedor-Santamaria, L., García-Caballero, C., Flores-Salguero, E., Ruiz-Torres, M. P., Rayego-Mateos, S., Sanz, A. B., Ortiz, A., & Ruiz-Ortega, M. (2025) · Pharmaceuticals · doi:10.3390/ph18060822 · Cited by 6
Metadata
- Authors
- Deepika, & Maurya, P. K.
- Venue
- Molecules
- Publisher
- MDPI AG
- Published
- 2022-04-13
- Volume
- 27
- Issue
- 8
- Pages
- 2498
- ISSN
- 1420-3049 (ISSN-L)
- OpenAlex
- W4224042448
- Cited by
- 447
- References
- 81
- FWCI
- 33.78
- Type
- journal article
- Language
- en
- Open access
- gold
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