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Cited by 159

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Pre- and Post-Surgical Nutrition for Preservation of Muscle Mass, Strength, and Functionality Following Orthopedic Surgery

Hirsch, Katie R., Wolfe, Robert R., Ferrando, Arny A.·2021·Nutrients
DOI 10.3390/nu13051675
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Abstract

Nutritional status is a strong predictor of postoperative outcomes and is recognized as an important component of surgical recovery programs. Adequate nutritional consumption is essential for addressing the surgical stress response and mitigating the loss of muscle mass, strength, and functionality. Especially in older patients, inadequate protein can lead to significant muscle atrophy, leading to a loss of independence and increased mortality risk. Current nutritional recommendations for surgery primarily focus on screening and prevention of malnutrition, pre-surgical fasting protocols, and combating post-surgical insulin resistance, while recommendations regarding macronutrient composition and timing around surgery are less established. The goal of this review is to highlight oral nutrition strategies that can be implemented leading up to and following major surgery to minimize atrophy and the resultant loss of functionality. The role of carbohydrate and especially protein/essential amino acids in combating the surgical stress cascade and supporting recovery are discussed. Practical considerations for nutrient timing to maximize oral nutritional intake, especially during the immediate pre- and post- surgical periods, are also be discussed.

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Research works printed but not linked: 53

  1. Wischmeyer, 2018, American Society for Enhanced Recovery and Perioperative Quality Initiative Joint Consensus Statement on Nutrition Screening and Therapy Within a Surgical Enhanced Recovery Pathway, Anesth. Analg., 126, 1883, 10.1213/ANE.0000000000002743 · DOI · Paper page
  2. Correia, 2003, The impact of malnutrition on morbidity, mortality, length of hospital stay and costs evaluated through a multivariate model analysis, Clin. Nutr., 22, 235, 10.1016/S0261-5614(02)00215-7 · DOI · Paper page
  3. Thomas, 2016, Effects of malnutrition on complication rates, length of hospital stay, and revenue in elective surgical patients in the G-DRG-system, Nutrition, 32, 249, 10.1016/j.nut.2015.08.021 · DOI
  4. Geurden, 2015, The risk of malnutrition in community-living elderly on admission to hospital for major surgery, Acta Chir. Belg., 115, 341, 10.1080/00015458.2015.11681126 · DOI
  5. Corish, 2000, Protein–energy undernutrition in hospital in-patients, Br. J. Nutr., 83, 575, 10.1017/S000711450000074X · DOI · Paper page
  6. Yeung, 2017, Protein intakes are associated with reduced length of stay: A comparison between Enhanced Recovery After Surgery (ERAS) and conventional care after elective colorectal surgery, Am. J. Clin. Nutr., 106, 44, 10.3945/ajcn.116.148619 · DOI
  7. Aucoin, 2019, Emergency General Surgery in Older Adults: A Review, Anesthesiol. Clin., 37, 493, 10.1016/j.anclin.2019.04.008 · DOI
  8. Weimann, 2017, ESPEN guideline: Clinical nutrition in surgery, Clin. Nutr., 36, 623, 10.1016/j.clnu.2017.02.013 · DOI · Paper page
  9. Gillis, 2019, Pre-operative nutrition and the elective surgical patient: Why, how and what?, Anaesthesia, 74, 27, 10.1111/anae.14506 · DOI
  10. Demling, 2009, Nutrition, anabolism, and the wound healing process: An overview, Eplasty, 9, e9
  11. Cartwright, 2004, The metabolic response to stress: A case of complex nutrition support management, Crit. Care Nurs. Clin. N. Am., 16, 467, 10.1016/S0899-5885(04)00070-X · DOI
  12. Finney, 2003, Glucose control and mortality in critically ill patients, JAMA, 290, 2041, 10.1001/jama.290.15.2041 · DOI · Paper page
  13. Kilroe, 2020, Temporal Muscle-specific Disuse Atrophy during One Week of Leg Immobilization, Med. Sci. Sports Exerc., 52, 944, 10.1249/MSS.0000000000002200 · DOI
  14. Dreyer, 2013, Essential amino acid supplementation in patients following total knee arthroplasty, J. Clin. Invest., 123, 4654, 10.1172/JCI70160 · DOI
  15. Dreyer, 2018, Essential Amino Acid Supplementation Mitigates Muscle Atrophy After Total Knee Arthroplasty: A Randomized, Double-Blind, Placebo-Controlled Trial, JB JS Open Access, 3, e0006, 10.2106/JBJS.OA.18.00006 · DOI
  16. Henriksen, 2003, Effects of preoperative oral carbohydrates and peptides on postoperative endocrine response, mobilization, nutrition and muscle function in abdominal surgery, Acta Anaesthesiol. Scand., 47, 191, 10.1034/j.1399-6576.2003.00047.x · DOI
  17. Singh, 2010, Predictors of activity limitation and dependence on walking aids after primary total hip arthroplasty, J. Am. Geriatr. Soc., 58, 2387, 10.1111/j.1532-5415.2010.03182.x · DOI
  18. Hirsch, 2020, Nutritional Considerations and Strategies to Facilitate Injury Recovery and Rehabilitation, J. Athl. Train., 55, 918, 10.4085/1062-6050-550-19 · DOI · Paper page
  19. Burgess, L.C., Phillips, S.M., and Wainwright, T.W. (2018). What is the role of nutritional supplements in support of total hip replacement and total knee replacement surgeries? A systematic review. Nutrients, 10. · DOI
  20. Ackerman, 2020, How sweet is this? A review and evaluation of preoperative carbohydrate loading in the enhanced recovery after surgery model, Nutr. Clin. Pract., 35, 246, 10.1002/ncp.10427 · DOI
  21. Nygren, 2006, The metabolic effects of fasting and surgery, Best Pract. Res. Clin. Anaesthesiol., 20, 429, 10.1016/j.bpa.2006.02.004 · DOI
  22. Svanfeldt, 2007, Randomized clinical trial of the effect of preoperative oral carbohydrate treatment on postoperative whole-body protein and glucose kinetics, Br. J. Surg., 94, 1342, 10.1002/bjs.5919 · DOI
  23. Rothman, 1991, Quantitation of hepatic glycogenolysis and gluconeogenesis in fasting humans with 13C NMR, Science, 254, 573, 10.1126/science.1948033 · DOI · Paper page
  24. Schwarz, 2000, Effects of enteral carbohydrates on de novo lipogenesis in critically ill patients, Am. J. Clin. Nutr., 72, 940, 10.1093/ajcn/72.4.940 · DOI
  25. Soop, 2004, Randomized clinical trial of the effects of immediate enteral nutrition on metabolic responses to major colorectal surgery in an enhanced recovery protocol, Br. J. Surg., 91, 1138, 10.1002/bjs.4642 · DOI
  26. Svanfeldt, 2006, Postoperative parenteral nutrition while proactively minimizing insulin resistance, Nutrition, 22, 457, 10.1016/j.nut.2005.06.013 · DOI
  27. Rittig, 2016, Amino acid supplementation is anabolic during the acute phase of endotoxin-induced inflammation: A human randomized crossover trial, Clin. Nutr., 35, 322, 10.1016/j.clnu.2015.03.021 · DOI
  28. Azhar, G., Wei, J.Y., Schutzler, S.E., Coker, K., Gibson, R.V., Kirby, M.F., Ferrando, A.A., and Wolfe, R.R. Daily consumption of a spe-cially formulated essential amino acid-based dietary supplement improves physical performance in older adults with low physi-cal functioning. J. Gerontol. A Biol. Sci. Med. Sci., 2021. · DOI
  29. Baldissarro, 2016, The Hip Functional Retrieval after Elective Surgery May Be Enhanced by Supplemented Essential Amino Acids, BioMed Res. Int., 2016, 9318329, 10.1155/2016/9318329 · DOI
  30. Ferrando, 2013, Increased nitrogen intake following hip arthroplasty expedites muscle strength recovery, J. Aging Res. Clin. Pract., 2, 369
  31. Aquilani, R., Zuccarelli, G.C., Condino, A.M., Catani, M., Rutili, C., Del Vecchio, C., Pisano, P., Verri, M., Iadarola, P., and Viglio, S. (2017). Despite Inflammation, Supplemented Essential Amino Acids May Improve Circulating Levels of Albumin and Haemoglobin in Patients after Hip Fractures. Nutrients, 9. · DOI
  32. Jones, 2015, Improving rehabilitation after critical illness through outpatient physiotherapy classes and essential amino acid supplement: A randomized controlled trial, J. Crit. Care, 30, 901, 10.1016/j.jcrc.2015.05.002 · DOI
  33. Aquilani, 2019, Supplemented amino acids may enhance the walking recovery of elderly subjects after hip fracture surgery, Aging Clin. Exp. Res., 31, 157, 10.1007/s40520-018-0941-x · DOI
  34. Katsanos, 2009, Muscle protein synthesis and balance responsiveness to essential amino acids ingestion in the presence of elevated plasma free fatty acid concentrations, J. Clin. Endocrinol. Metab., 94, 2984, 10.1210/jc.2008-2686 · DOI
  35. Fitts, 2007, The deleterious effects of bed rest on human skeletal muscle fibers are exacerbated by hypercortisolemia and ameliorated by dietary supplementation, Am. J. Physiol. Cell Physiol., 293, C313, 10.1152/ajpcell.00573.2006 · DOI
  36. Park, 2020, Anabolic response to essential amino acid plus whey protein composition is greater than whey protein alone in young healthy adults, J. Int. Soc. Sports Nutr., 17, 9, 10.1186/s12970-020-0340-5 · DOI
  37. Soeters, P.B., Shenkin, A., Sobotka, L., Soeters, M.R., de Leeuw, P.W., and Wolfe, R.R. (2021). The anabolic role of the Warburg, Cori-cycle and Crabtree effects in health and disease. Clin. Nutr. · DOI
  38. Wolfe, 2018, Factors contributing to the selection of dietary protein food sources, Clin. Nutr., 37, 130, 10.1016/j.clnu.2017.11.017 · DOI
  39. Church, D.D., Hirsch, K.R., Park, S., Kim, I.Y., Gwin, J.A., Pasiakos, S.M., Wolfe, R.R., and Ferrando, A.A. (2020). Essential Amino Acids and Protein Synthesis: Insights into Maximizing the Muscle and Whole-Body Response to Feeding. Nutrients, 12. · DOI
  40. Wall, 2015, Strategies to maintain skeletal muscle mass in the injured athlete: Nutritional considerations and exercise mimetics, Eur. J. Sport Sci., 15, 53, 10.1080/17461391.2014.936326 · DOI · Paper page
  41. Burd, 2015, The Skeletal Muscle Anabolic Response to Plant- versus Animal-Based Protein Consumption, J. Nutr., 145, 1981, 10.3945/jn.114.204305 · DOI · Paper page
  42. Park, S., Church, D.D., Schutzler, S.E., Azhar, G., Kim, I.Y., Ferrando, A.A., and Wolfe, R.R. (2021). Metabolic evaluation of the Dietary Guideline’s ounce equivalents of protein food sources in young adults: A randomized controlled trial. J. Nutr., in press. · DOI
  43. Hevia-Larraín, V., Gualano, B., Longobardi, I., Gil, S., Fernandes, A.L., Costa, L.A., Pereira, R.M., Artioli, G.G., Phillips, S.M., and Roschel, H. (2021). High-Protein Plant-Based Diet Versus a Protein-Matched Omnivorous Diet to Support Resistance Training Adaptations: A Comparison Between Habitual Vegans and Omnivores. Sports Med., 1–14. · DOI · Paper page
  44. Provenza, 2020, Health-Promoting Compounds are Higher in Grass-Fed Meat and Milk, Front. Sustain. Food Syst., 4, 299
  45. Gorissen, 2018, Protein content and amino acid composition of commercially available plant-based protein isolates, Amino Acids, 50, 1685, 10.1007/s00726-018-2640-5 · DOI · Paper page
  46. Trommelen, 2019, The muscle protein synthetic response to meal ingestion following resistance-type exercise, Sports Med., 49, 185, 10.1007/s40279-019-01053-5 · DOI
  47. Brennan, J.L., Keerati, U.R.M., Yin, H., Daoust, J., Nonnotte, E., Quinquis, L., St-Denis, T., and Bolster, D.R. (2019). Differential Responses of Blood Essential Amino Acid Levels Following Ingestion of High-Quality Plant-Based Protein Blends Compared to Whey Protein-A Double-Blind Randomized, Cross-Over, Clinical Trial. Nutrients, 11. · DOI
  48. Chapman, 2016, Peri-operative nutrition, Anaesthesia, 71, 9, 10.1111/anae.13310 · DOI
  49. Gualano, 2011, Branched-chain amino acids supplementation enhances exercise capacity and lipid oxidation during endurance exercise after muscle glycogen depletion, J. Sports Med. Phys. Fit., 51, 82
  50. Aarsland, 2005, Exogenous amino acids stimulate human muscle anabolism without interfering with the response to mixed meal ingestion, Am. J. Physiol. Endocrinol. Metab., 288, E761, 10.1152/ajpendo.00291.2004 · DOI · Paper page
  51. Muyskens, 2019, Cellular and morphological changes with EAA supplementation before and after total knee arthroplasty, J. Appl. Physiol., 127, 531, 10.1152/japplphysiol.00869.2018 · DOI
  52. Hulmi, 2010, Effect of protein/essential amino acids and resistance training on skeletal muscle hypertrophy: A case for whey protein, Nutr. Metab., 7, 51, 10.1186/1743-7075-7-51 · DOI · Paper page
  53. Howard, 2020, Skeletal Muscle Disuse Atrophy and the Rehabilitative Role of Protein in Recovery from Musculoskeletal Injury, Adv. Nutr., 11, 989, 10.1093/advances/nmaa015 · DOI · Paper page

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Metadata

Authors
Hirsch, K. R., Wolfe, R. R., & Ferrando, A. A.
Venue
Nutrients
Publisher
MDPI AG
Published
2021-05-15
Volume
13
Issue
5
Pages
1675
ISSN
2072-6643
DOI
10.3390/nu13051675
Cited by
159
References
15
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)

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