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Lactobacillus plantarum GKM3 Promotes Longevity, Memory Retention, and Reduces Brain Oxidation Stress in SAMP8 Mice

Lin, Shih-Wei, Tsai, You-Shan, Chen, Yen-Lien, Wang, Ming-Fu, Chen, Chin-Chu, Lin, Wen-Hsin, Fang, Tony J.·2021·Nutrients
DOI 10.3390/nu13082860PMC PMC8401498
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Abstract

(1) Background: An age-related cognitive decline is commonly affecting the life of elderly with symptoms involved in progressive impairments to memory and learning. It has been proposed that probiotics could modulate age-related neurological disorders via the gut–brain axis. (2) Methods: To investigate the anti-aging effect of probiotic Lactobacillus plantarum GKM3, both survival tests and cognitive experiments were conducted in the SAMP8 mice model. The six-month-old SAMP8 (n = 20 in each gender) were fed with probiotic GKM3 at a dosage of 5.1 × 109 and 1.0 × 109 cfu/ kg B.W./day until their natural death. Then, the life span was investigated. Three-month-old SAMP8 (n = 10 in each gender) were administered GKM3 for 14 weeks. Then, the behavior tests and oxidation parameters were recorded. (3) Results: GKM3 groups showed significantly increased latency in the passive avoidance test and time of successful avoidance in the active avoidance test. The TBARS and 8-OHdG from mice brains also showed a significant reduction in the groups treated with GKM3. In addition, lower accumulation of the amyloid-β protein was found in SAMP8 mice brains with the supplement of GKM3. (4) Conclusions: These results indicated that L. plantarum GKM3 delayed the process of aging, alleviated age-related cognitive impairment, and reduced oxidative stress.

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Metadata

Authors
Lin, S.-W., Tsai, Y.-S., Chen, Y.-L., Wang, M.-F., Chen, C.-C., Lin, W.-H., & Fang, T. J.
Affiliations
  • Department of Food Science and Biotechnology, National Chung Hsing University, Taichung 402204, Taiwan
  • Biotech Research Institute, Grape King Bio Ltd., Taoyuan 325002, Taiwan
  • Department of Food and Nutrition, Providence University, Taichung 433303, Taiwan
  • Institute of Food Science and Technology, National Taiwan University, Taipei 106319, Taiwan
  • Department of Pharmacy, China Medical University, Taichung 404333, Taiwan
ORCID
Venue
Nutrients
Publisher
MDPI AG
Published
2021-08-20
Volume
13
Issue
8
Pages
2860
ISSN
2072-6643
DOI
10.3390/nu13082860
PMC
PMC8401498
Cited by
53
References
6
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)

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