Cited by 258Probiotics and Fermented FoodsGut microbiota and healthAnimal Nutrition and Physiology

Lactobacillus and Bifidobacterium Improves Physiological Function and Cognitive Ability in Aged Mice by the Regulation of Gut Microbiota

Ni, Yinhua, Yang, Xin, Zheng, Liujie, Wang, Zhe, Wu, Lianxin, Jiang, Jinlu, Yang, Tianqi, Ma, Lingyan +1 more·2019·Molecular Nutrition & Food Research

Abstract

SCOPE: Age-related degeneration is associated with imbalances of gut microbiota and its related immune system, thus gut microbiota dysbiosis is considered to be a key target to improve senescence. The potential roles of probiotics on physiological function and cognitive ability in aged mice are investigated in this study. METHODS AND RESULTS: Lactobacillus casei LC122 or Bifidobacterium longum BL986, are orally administrated for 12 weeks, and the anti-aging effects, as well as the composition and function of gut microbiota, are investigated in aged mice. Probiotics supplementation ameliorates hepatic lipid accumulation, enhances muscle strength and function, attenuates oxidative stress and inflammation in peripheral tissues, and improves gut barrier function. These results are associated with improved learning and memory ability as assessed by behavioral tests and upregulation of neurodegenerative and neurotrophic factors expressions in hippocampus. Moreover, the diversity and composition of gut microbiota are altered in aged mice, and both probiotics treatment display distinguished features of gut microbiota. Comparisons of two probiotic strains reveal significant differences in the taxa at family and genus level, leading to the functional profile change of the microbial community. CONCLUSION: L. casei LC122 and B. longum BL986 might be used as novel and promising anti-aging agents in human.

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Crossref · 10.1002/mnfr.201900603

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  • Animal studies have demonstrated that administration of probiotics such as Lactobacillus plantarum, L. rhamnosus, and B. longum can have anxiolytic and antidepressive effects and can impact aspects of cognitive function.

    “Animal studies have demonstrated that administration of probiotics (e.g., Lactobacillus plantarum, L. rhamnosus, B. longum) can have anxiolytic and antidepressive effects (222, 223) and can impact aspects of cognitive function (224).”
  • Oral administration of Lactobacillus casei LC122 and Bifidobacterium ongum BL986 for 12 weeks enhances muscle strength and function in C57BL/6 mice.

    “Oral administration of Lactobacillus casei LC122 and Bifidobacterium ongum BL986 for 12 weeks enhances muscle strength and function in C57BL/6 mice [161].”

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Authors
Ni, Y., Yang, X., Zheng, L., Wang, Z., Wu, L., Jiang, J., Yang, T., Ma, L., & Fu, Z.
Affiliations
Zhejiang University of Technology (CN)
Corresponding author
Fu, Zhengwei
Venue
Molecular Nutrition & Food Research
Publisher
Wiley
Published
2019-09-25
Volume
63
Issue
22
Pages
e1900603-e1900603
ISSN
  • 1613-4125 (ISSN-L)
  • 1613-4133
OpenAlex
W2969326780
Cited by
255
References
49
Citations by year
2026: 18 · 2025: 38 · 2024: 51 · 2023: 47 · 2022: 45 · 2021: 35 · 2020: 19 · 2019: 2
FWCI
19.49
Type
journal article
Language
en
Open access
closed
Locations
  • Molecular Nutrition & Food Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
Keywords
probiotics, Lactobacillus casei, Bifidobacterium longum, gut microbiota, aging, cognitive function, learning and memory, hepatic lipid accumulation, muscle strength, oxidative stress, inflammation, intestinal barrier, hippocampus, neurotrophic factors, aged mice
MeSH terms
Gastrointestinal Microbiome, Bifidobacterium longum, Aging, Animals, Cognition, Lacticaseibacillus casei, Learning, Male, Memory, Mice, Inbred C57BL, Probiotics, Mice, Microbiota

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