Cited by 538Genetics, Aging, and Longevity in Model OrganismsInflammasome and immune disordersAdvanced Glycation End Products research

An update on inflamm-aging: mechanisms, prevention, and treatment

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Xia, Shijin, Zhang, Xinyan, Zheng, Songbai, Khanabdali, Ramin, Kalionis, Bill, Wu, Junzhen, Wan, Wenbin, Tai, Xiantao·2016·Journal of Immunology Research

Abstract

Inflamm-aging is a challenging and promising new branch of aging-related research fields that includes areas such as immunosenescence. Increasing evidence indicates that inflamm-aging is intensively associated with many aging diseases, such as Alzheimer's disease, atherosclerosis, heart disease, type II diabetes, and cancer. Mounting studies have focused on the role of inflamm-aging in disease progression and many advances have been made in the last decade. However, the underlying mechanisms by which inflamm-aging affects pathological changes and disease development are still unclear. Here, we review studies of inflamm-aging that explore the concept, pathological features, mechanisms, intervention, and the therapeutic strategies of inflamm-aging in disease progression.

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  1. [73]Xia S. Shen Y. Yu W. Study on mechanism and intervention of inflamm-aging in rats Chinese Journal of Gerontology 2009 29 20 2595 2598

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Authors
Xia, S., Zhang, X., Zheng, S., Khanabdali, R., Kalionis, B., Wu, J., Wan, W., & Tai, X.
Affiliations
  • Fudan University (CN)
  • Chengdu Military General Hospital (CN)
  • Royal Women's Hospital (AU)
  • Yunnan University of Traditional Chinese Medicine (CN)
Corresponding author
  • Xia, Shijin
  • Zheng, Songbai
  • Tai, Xiantao
Venue
Journal of Immunology Research
Publisher
Wiley
Published
2016
Volume
2016
Pages
1-12
ISSN
  • 2314-7156 (ISSN-L)
  • 2314-8861
OpenAlex
W2462347288
Cited by
538
References
89
Citations by year
2026: 22 · 2025: 49 · 2024: 57 · 2023: 59 · 2022: 79 · 2021: 80 · 2020: 73 · 2019: 68 · 2018: 30 · 2017: 16 · 2016: 4 · 2012: 1
FWCI
3.94
Type
journal article
Language
en
Open access
Locations
  • Journal of Immunology Research (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Minerva Access (University of Melbourne) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Natural Science Foundation of China (81460748, 31171129, 81000859, 2013ZYJB0801)
  • Shanghai Municipal Commission of Health (81460748, 31171129, 81000859, 2013ZYJB0801)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
Keywords
inflammaging, immunosenescence, age-related diseases, Alzheimer's disease, atherosclerosis, heart disease, type 2 diabetes, cancer
MeSH terms
Aging, Animals, Disease Susceptibility, Humans, Inflammation, Oxidation-Reduction, Research, Stress, Physiological, Signal Transduction, Biomarkers, Cytokines

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