An update on inflamm-aging: mechanisms, prevention, and treatment
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Inflamm-aging is a challenging and promising new branch of aging-related research fields that includes areas such as immunosenescence. Increasing evidence indicates that inflamm-aging is intensively associated with many aging diseases, such as Alzheimer's disease, atherosclerosis, heart disease, type II diabetes, and cancer. Mounting studies have focused on the role of inflamm-aging in disease progression and many advances have been made in the last decade. However, the underlying mechanisms by which inflamm-aging affects pathological changes and disease development are still unclear. Here, we review studies of inflamm-aging that explore the concept, pathological features, mechanisms, intervention, and the therapeutic strategies of inflamm-aging in disease progression.
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Many existing data demonstrate the key role of foods as regulators of immune response and inflammatory status, hence as possible modulators of the rate of immunosenescence, particularly inflamm-aging.
“Many existing data demonstrate the key role of foods as regulators of immune response and inflammatory status, hence as possible modulators of the rate of immunosenescence, particularly inflamm-aging (11, 80).”
From Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019) · cites this paper as [80]
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“…mediators, concomitantly with the adoption of lifestyle factors, including smoking, obesity, alcohol, lack of exercise, and exposure to ultraviolet radiation, are known to increase the risk for age-related multi-organ/system diseases (Figure 1) [15,19–22] and premature morbidity and mortality.”
Del Bo', C., Bernardi, S., Cherubini, A., Porrini, M., Gargari, G., Hidalgo-Liberona, N., González-Domínguez, R., Zamora-Ros, R., Peron, G., Marino, M., et al. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2020.12.014 · Cited by 133 · see citing works
Impact of resistance training on the autophagy-inflammation-apoptosis crosstalk in elderly subjects
Mejías-Peña, Y., Estébanez, B., Rodriguez-Miguelez, P., Fernandez-Gonzalo, R., Almar, M., de Paz, J. A., González-Gallego, J., & Cuevas, M. J. (2017) · Aging · doi:10.18632/aging.101167 · Cited by 102 · see citing works
“In fact, impaired autophagy can trigger the appearance of a pro-inflammatory phenotype tissue (or inflammaging) and the inflammasome activation [10, 11].”
BackgroundOvercoming immune dysfunction in the elderly: trained immunity as a novel approach
Bulut, O., Kilic, G., Domínguez-Andrés, J., & Netea, M. G. (2020) · International Immunology · doi:10.1093/intimm/dxaa052 · Cited by 99 · see citing works
A panoramic view of cell population dynamics in mammalian aging
Zhang, Z., Schaefer, C., Jiang, W., Lu, Z., Lee, J., Sziraki, A., Abdulraouf, A., Wick, B., Haeussler, M., Li, Z., et al. (2025) · Science · doi:10.1126/science.adn3949 · Cited by 95 · see citing works
Frailty is associated with elevated CRP trajectories and higher numbers of neutrophils and monocytes
Samson, L. D., Boots, A. M. H., Verschuren, W. M. M., Picavet, H. S. J., Engelfriet, P., & Buisman, A.-M. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.110674 · Cited by 77 · see citing works
Acylated Ghrelin as a Multi-Targeted Therapy for Alzheimer's and Parkinson's Disease
Reich, N., & Hölscher, C. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.614828 · Cited by 48 · see citing works
Giunta, S., Wei, Y., Xu, K., & Xia, S. (2022) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.13686 · Cited by 27 · see citing works
Self-citationAgeing in human parturition: impetus of the gestation clock in the decidua†
Wijaya, J. C., Khanabdali, R., Georgiou, H. M., & Kalionis, B. (2020) · Biology of Reproduction · doi:10.1093/biolre/ioaa113 · Cited by 12 · see citing works
Self-citation
- Authors
- Xia, S., Zhang, X., Zheng, S., Khanabdali, R., Kalionis, B., Wu, J., Wan, W., & Tai, X.
- Affiliations
- Fudan University (CN)
- Chengdu Military General Hospital (CN)
- Royal Women's Hospital (AU)
- Yunnan University of Traditional Chinese Medicine (CN)
- Corresponding author
- Xia, Shijin
- Zheng, Songbai
- Tai, Xiantao
- ORCID
- Venue
- Journal of Immunology Research
- Publisher
- Wiley
- Published
- 2016
- Volume
- 2016
- Pages
- 1-12
- ISSN
- 2314-7156 (ISSN-L)
- 2314-8861
- PMC
- PMC4963991
- OpenAlex
- W2462347288
- Cited by
- 538
- References
- 89
- Citations by year
- 2026: 22 · 2025: 49 · 2024: 57 · 2023: 59 · 2022: 79 · 2021: 80 · 2020: 73 · 2019: 68 · 2018: 30 · 2017: 16 · 2016: 4 · 2012: 1
- FWCI
- 3.94
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Journal of Immunology Research (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Minerva Access (University of Melbourne) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (81460748, 31171129, 81000859, 2013ZYJB0801)
- Shanghai Municipal Commission of Health (81460748, 31171129, 81000859, 2013ZYJB0801)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Keywords
- inflammaging, immunosenescence, age-related diseases, Alzheimer's disease, atherosclerosis, heart disease, type 2 diabetes, cancer
- MeSH terms
- Aging, Animals, Disease Susceptibility, Humans, Inflammation, Oxidation-Reduction, Research, Stress, Physiological, Signal Transduction, Biomarkers, Cytokines
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