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Vitamin A Metabolism and Adipose Tissue Biology
Open accessAbstract
In recent years, the importance of vitamin A in adipose tissue biology, obesity and type II diabetes has become apparent. This review focuses on recent developments within the area of vitamin A and adipose tissue biology. Adipose tissue has an active vitamin A metabolism as it not only stores vitamin A but retinol is also converted to its active metabolite retinoic acid. Several mouse models point to a relationship between vitamin A metabolism and the development of adiposity. Similarly, in vitro studies provide new molecular mechanisms for the function of different forms of vitamin A and retinol- or retinoic acid-binding proteins in adipose tissue.
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“The highest amounts of vitamin A are stored in the liver, but it is also found in adipose tissue, lungs and the RPE [2,3,4,5,6].”
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“Vitamin A is an essential micronutrient, which means that the human body cannot synthesize it on its own and must be ingested.”
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Metadata
- Authors
- Frey, S. K., & Vogel, S.
- Affiliations
- Columbia University (US)
- Corresponding author
- Vogel, Silke
- ORCID
- Vogel, Silke
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2011-01-06
- Volume
- 3
- Issue
- 1
- Pages
- 27-39
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC3257733
- OpenAlex
- W2149014180
- Cited by
- 123
- References
- 68
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 7 · 2023: 9 · 2022: 14 · 2021: 10 · 2020: 11 · 2019: 6 · 2018: 3 · 2017: 7 · 2016: 10 · 2015: 9 · 2014: 13 · 2013: 8 · 2012: 6
- FWCI
- 1.01
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Atmosphere (cc-by)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Keywords
- vitamin A metabolism, adipose tissue, obesity, type 2 diabetes, retinoic acid, retinol, retinol-binding protein, adipose tissue biology, adiposity
- MeSH terms
- Adipose Tissue, Animals, Tretinoin, Vitamin A, Receptors, Retinoic Acid, Mice, Knockout, Adiposity, Mice, Rats, Retinol-Binding Proteins, Cellular
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